Chu-Chung Huang

Chu-Chung Huang’s research focuses on depicting brain structural and functional aging trajectories using non-invasive magnetic resonance imaging techniques. Given that the brain structure is fundamental to cognitive function, it is important to understand the interaction between gray matter, as the information processing units, and white matter, as the signal pathways. A deeper understanding of brain structural connectome might provide insight into cognition, as well as the development of neurodegenerative diseases and mental illness. Therefore, Dr. Huang’s primary research goal is to integrate the most advanced neuroimaging methods, including cortical morphometry, diffusion MRI, and quantitative imaging techniques, to reconstruct the human brain networks and related metrics as the probe for brain performance, with the aim of providing objective biomarker for brain health status evaluation at different stages of human lifespan.

1.      Zhao Z#, Huang CC#, Yuan S#, Zhang J, Lin CP, Lu J*, Duffau H, Wu J. Convergence of the arcuate fasciculus and third branch of the superior longitudinal fasciculus with direct cortical stimulation-induced speech arrest area in the anterior ventral precentral gyrus. J Neurosurg. 2023 Mar 3:1-12. doi: 10.3171/2023.1.JNS222575. Online ahead of print.

2.      Zhang Y, Huang CC*, Zhao J, Liu Y, Xia M, Wang X, Wei D, Chen Y, Liu B, Zheng Y, Wu Y, Chen T, Cheng Y, Xu X, Gong Q, Si T, Qiu S, Cheng J, Tang Y, Wang F, Qiu J, Xie P, Li L, He Y, Lin CP; DIDA-Major Depressive Disorder Working Group; Zac Lo CY*. Resting-state functional connectivity of the raphe nuclei in major depressive Disorder: A Multi-site study. Neuroimage Clin. 2023;37:103359. doi: 10.1016/j.nicl.2023.103359. Epub 2023 Feb 24.

3.      Hsu CH, Chong ST, Kung YC, Kuo KT, Huang CC*, Lin CP*. Integrated diffusion image operator (iDIO): A pipeline for automated configuration and processing of diffusion MRI data. Hum Brain Mapp. 2023 Feb 21. doi: 10.1002/hbm.26239. Online ahead of print.

4.      Wang L, Ma Q, Sun X, Xu Z, Zhang J, Liao X, Wang X, Wei D, Chen Y, Liu B, Huang CC, Zheng Y, Wu Y, Chen T, Cheng Y, Xu X, Gong Q, Si T, Qiu S, Lin CP, Cheng J, Tang Y, Wang F, Qiu J, Xie P, Li L, He Y; DIDA-MDD Working Group; Xia M, Zhang Y. Frequency-resolved connectome alterations in major depressive disorder: A multisite resting fMRI study. J Affect Disord. 2023 May 1;328:47-57. doi: 10.1016/j.jad.2023.01.104. Epub 2023 Feb 11.

5.      Zhang Y, Xiang Q, Huang CC, Zhao J, Liu Y, Lin CP, Liu D, Lo CZ. Short-term Medication Effects on Brain Functional Activity and Network Architecture in First-Episode psychosis: a longitudinal fMRI study. Brain Imaging Behav. 2023 Apr;17(2):137-148. doi: 10.1007/s11682-022-00704-y. Epub 2023 Jan 17

6.      Wang L, Lin H, Zhao Z, Chen L, Wu L, Liu T, Li J, Huang CC, Peng Y, Lo CZ, Gao X. Sex disparity of cerebral white matter hyperintensity in the hypertensive elderly: The Shanghai Changfeng study. Hum Brain Mapp. 2023 Apr 1;44(5):2099-2108. doi: 10.1002/hbm.26196. Epub 2022 Dec 30.

7.      Rolls ET, Rauschecker JP, Deco G, Huang CC, Feng J. Auditory cortical connectivity in humans. Cereb Cortex. 2022 Dec 27:bhac496. doi: 10.1093/cercor/bhac496. Online ahead of print.

8.      Rolls ET, Deco G, Huang CC, Feng J. Human amygdala compared to orbitofrontal cortex connectivity, and emotion. Prog Neurobiol. 2023 Jan;220:102385. doi: 10.1016/j.pneurobio.2022.102385. Epub 2022 Nov 25. PMID: 36442728

9.      Rolls ET, Deco G, Huang CC, Feng J. Prefrontal and somatosensory-motor cortex effective connectivity in humans. Cereb Cortex. 2023 Apr 4;33(8):4939-4963. doi: 10.1093/cercor/bhac391.

10.   Rolls ET, Wirth S, Deco G, Huang CC, Feng J. The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation. Hum Brain Mapp. 2022 Sep 30. doi: 10.1002/hbm.26089. Epub ahead of print. PMID: 36178249.

11.   Huang CC, Lin CP, Toba K, Xu D. Editorial: Measurable brain and cognitive reserve: The implication of neuroimaging biomarkers in the normal aging process. Front Aging Neurosci. 2022 Sep 13;14:1020435. doi: 10.3389/fnagi.2022.1020435. PMID: 36177480.

12.   Rolls ET, Deco G, Huang CC, Feng J. The human language effective connectome. Neuroimage. 2022. doi: 10.1016/j.neuroimage.2022.119352. Epub 2022 Jun 2.

13.   Rolls ET, Deco G, Huang CC, Feng J. The effective connectivity of the human hippocampal memory system. Cereb Cortex. 2022 Aug 22;32(17):3706-3725. doi: 10.1093/cercor/bhab442. PMID: 35034120.

14.   Rolls ET, Deco G, Huang CC, Feng J. Multiple cortical visual streams in humans. Cereb Cortex. 2022 Jul 14:bhac276. doi: 10.1093/cercor/bhac276. Epub ahead of print. PMID: 35834308.

15.   Huang CC, Chou KH, Lee WJ, Yang AC, Tsai SJ, Chen LK, Chung CP, Lin CP. Brain white matter hyperintensities-predicted age reflects neurovascular health in middle-to-old aged subjects. Age & Ageing. 2022 May 1;51(5):afac106. doi: 10.1093/ageing/afac106.

16.   Xia M, Liu J, Mechelli A, Sun X, Ma Q, Wang X, Wei D, Chen Y, Liu B, Huang CC, Zheng Y, Wu Y, Chen T, Cheng Y, Xu X, Gong Q, Si T, Qiu S, Lin CP, Cheng J, Tang Y, Wang F, Qiu J, Xie P, Li L; DIDA-MDD Working Group, He Y. Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes. Mol Psychiatry. 2022 Mar 25. doi: 10.1038/s41380-022-01519-5. Epub ahead of print.

17.   Huang CC, Rolls ET, Feng J, Lin CP. An extended Human Connectome Project multimodal parcellation atlas of the human cortex and subcortical areas. Brain Struct Funct. 2022 Apr;227(3):763-778. Epub 2021 Nov 17. doi: 10.1007/s00429-021-02421-6.

18.   Fan Q, Eichner C, Afzali M, Mueller L, Tax CMW, Davids M, Mahmutovic M, Keil B, Bilgic B, Setsompop K, Lee HH, Tian Q, Maffei C, Ramos-Llordén G, Nummenmaa A, Witzel T, Yendiki A, Song YQ, Huang CC, Lin CP, Weiskopf N, Anwander A, Jones DK, Rosen BR, Wald LL, Huang SY. Mapping the Human Connectome using Diffusion MRI at 300 mT/m Gradient Strength: Methodological Advances and Scientific Impact. Neuroimage. 2022 Feb 22:118958. doi: 10.1016/j.neuroimage.2022.118958. Epub ahead of print.

19.   Dai Y, Liu Y, Zhang L, Ren T, Wang H, Yu J, Liu X, Chen Z, Deng L, Tao M, Tan H, Huang CC, Zhang J, Luo Q, Feng J, Cao M, Li F. Shanghai Autism Early Development: An Integrative Chinese ASD Cohort. Neurosci Bull. 2022 Jun 23. doi: 10.1007/s12264-022-00904-y. Epub ahead of print. PMID: 35739378.

20.   Lee IT#, Huang CC#, Hsu PC, Lin CP, Tsai PY. Resting-State Network Changes Following Transcranial Magnetic Stimulation in Patients With Aphasia—A Randomized Controlled Study. Neuromodulation. 2021. In press.

21.   Rolls ET, Deco G, Huang CC, Feng J. The Effective Connectivity of the Human Hippocampal Memory System. Cereb Cortex. 2022 Jan 17:bhab442. doi: 10.1093/cercor/bhab442. Epub ahead of print.

22.   Huang CC, Rolls ET, Hsu CH, Feng J, Lin CP. Extensive Cortical Connectivity of the Human Hippocampal Memory System: Beyond the What and Where Dual Stream Model. Cerebral Cortex. 2021 May 19;bhab113. doi: 10.1093/cercor/bhab113.

23.   Hsu CH, Huang CC, Tsai SJ, Chen LK, Li HC, Lo CZ, Lin CP. Differential age trajectories of white matter changes between sexes correlate with cognitive performances. Brain Connect. 2021.

24.   Huang CC, Hsu CH, Zhou FL, Kusmia S, Drakesmith M, Parker GJM, Lin CP, Jones DK. Validating pore size estimates in a complex microfiber environment on a human MRI system. Magn Reson Med. 2021.

25.   Lin HY#, Huang CC