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陈缙泉

教授 博士生导师

精密光谱科学与技术国家重点实验室      

个人资料

  • 部门: 精密光谱科学与技术国家重点实验室
  • 毕业院校: 俄亥俄州立大学
  • 学位: 博士
  • 学历: 研究生
  • 邮编:
  • 联系电话: 021-54836099
  • 传真:
  • 电子邮箱: jqchen@lps.ecnu.edu.cn
  • 办公地址: 闵行校区光学大楼B213
  • 通讯地址:

教育经历

2007/08-2012/08,美国俄亥俄州立大学,博士

2003/09-2007/06,南京大学,学士

工作经历

2015/10-至今,华东师范大学,精密光谱科学与技术国家重点实验室,教授

2013/09-2015/09,美国埃默里大学,博士后研究员,合作导师:Tianquan Lian

2012/08-2013/08,美国蒙大拿州立大学,博士后研究员, 合作导师:Bern Kohler

个人简介

陈缙泉,现任华东师范大学精密光谱科学与技术国家重点实验室教授。2003-2007年在南京大学进行了本科阶段的学习,后于2007-2012年在美国俄亥俄州立大学 (The Ohio State University) 取得博士学位。然后于2012-2013年在美国蒙大拿州立大学 (Montana State University) 2013-2015年在埃默里大学 (Emory University) 进行了两阶段博士后研究工作。主要研究方向是采用飞秒瞬态光谱研究生物大分子中激发态动力学过程,近年来工作已在 Science, Journal of the American Chemical Society, Chemical Science, Angewandte Chemie International Edition, Journal of Physical ChemistryPhysical Chemistry Chemical Physics等期刊发表,目前共发表论文130余篇。2019年入选上海市青年科技启明星计划。目前担任上海市生物物理学会副理事长,《Chinese Journal of Chemical Physics》青年编委。

社会兼职

上海市生物物理学会副理事长

Chinese Journal of Chemical Physics青年编委


研究方向


研究兴趣:


激发态超快动力学,生物光子学, 生物传感, 生物探针, 生物成像, DNA损伤与修复, 飞秒激光光谱

招生与培养

开授课程

分子光谱学

物理实验(五)

生物光子学导论

科研项目

1.国家自然科学基金重大研究计划重点项目,92156024,基于飞秒圆二色光谱和飞秒圆偏振发光光谱对手性传递机制和规律的研究,主持

2.国家自然科学基金面上项目,21873030,化学修饰核酸分子电子激发态动力学特性的研究,主持

3.国家自然科学基金重大研究计划重点项目,91850202,新型宽场超分辨及超高速光学显微成像基础研究与应用,参与

4.国家自然科学基金面上项目,11674101,基于宽带飞秒瞬态光谱对DNA电子激发态的研究,主持


学术成果

70. Wang, X.; Martinez-Fernandez, L.; Zhang, Y.; Wu, P.; Kohler, B.*; Improta, R.*; Chen, J.*; Ultrafast Formation of a Delocalized Triplet-Excited State In an Epigenetically Modified DNA Duplex under Direct UV Excitation, Journal of the American Chemical Society, 2024, 146: 1839-1848.


69. Wu, P.; Wang, X.*; Pan, H.; Chen, J.*; Wavelength dependent excited state dynamics observed in canonical pyrimidine nucleosides, Journal of Photochemistry and Photobiology, 2023, 18, 100211.


68. Wang, D.; Wang, X.*; Jin, P.; Zhou, Y., Jia, M.; Pan, H.; Sun, Z.; Chen, J.*; Distinct doorway states lead to triplet excited state generation in epigenetic RNA nucleosides, Physical Chemistry Chemical Physics, 2023, 25: 15153–15161.


67. Jin, X.; Guo, S.; Wang, X.; Cong, M.; Chen, J.*; Zhang, Z.*, Su, J.; Qu, D.; Tian, H.*; Sequential Multistep Excited-State Structural Transformations in N,N’-Diphenyl-dihydrodibenzo[a,c]phenazine Fluorophores, Angewandte Chemie International Edition, 2023, 62,e202305572.


66. Han, Y.; Jia, Y.*; Wang, X.; Chen, Z.; Jin, P.; Jia, M.; Pan, H.; Sun, Z.; Chen, J.*; Ultrafast  excited state dynamics of two non-emissive flavonoids that undergo  excited state intramolecular proton transfer in solution, Chemical Physics Letters, 2023, 811: 140189.


65. Jin, P.; Wang, J.; Wang, X.; Jia, M.; Pan, H.; Mei, Y.*, Chen, J.*; Tracking the Early Stage of Triplet-Induced Photodamage in a DNA Dimer and Oligomer Containing 5‑Methylcytosine, Journal of Physical Chemistry B, 2023, 127(31): 6878-6886 (Journal front coverarticle).


64. Li, H.; Cao, S.; Zhang, S., Chen, J.*; Xu, J.*; Ultrafast proton coupled electron transfer between tryptophan and tyrosine in peptides Trp-Pron-Tyr, Chinese Journal of Chemical Physics, 2023, 36(4): 384-396 (Journal front coverarticle).


63. An,  Q.; Xing, Y.; Pu, R.; Jia, M.; Chen, Y.; Hu, A.; Zhang, S.; Yu, N.; Du, J.; Zhang, Y.; Chen, J.*; Liu, W.*; Hong, X.*; Zuo, Z.*; Identification of Alkoxy Radicals as Hydrogen Atom Transfer Agents in Ce-Catalyzed C−H Functionalization, Journal of the American Chemical Society, 2023, 145: 359−376.


62. Han, Y.; Wang, X.*; He, X.; Jia, M.; Pan,  H.; Chen, J.*;  Excited State Kinetics of Benzo[a]pyrene Is Affected by Oxygen and DNA, Molecules, 2023, 28, 5269.


61. Zhou, J.; Jia, Y.*; Wang, X.; Jia, M.; Pan, H.; Sun, Z.; Chen, J.*; Excited-State Dynamics of Proflavine after Intercalation into DNA Duplex, Molecules, 2022, 27, 8157.


60. Wu, P.; Wang, X.; Pan, H.; Chen, J.*; Direct Observation of Excitation Wavelength-Dependent Ultrafast Intersystem Crossing in Cytosine Nucleoside Solution, Journal of Physical Chemistry B, 2022, 126(40): 7975-7980.


59. Wang, D.; Wang, X.*; Jiang, Y.; Cao, S.; Jin, P.; Pan, H.; Sun, H.; Sun, Z.; Chen, J.*; Excited State Dynamics of Methylated Guanosine Derivatives Revealed by Femtosecond Time-resolved Spectroscopy, Photochemistry and Photobiology, 2022, 98: 1008–1016.


58. Chen, L.; Jiang, X.; Lv, M.; Wang, X.; Zhao, P.; Zhang, M.; Lv, G.; Wu, J.; Liu, Y.; Yang, Y.*; Chen, J.*; Bu, W.* Reductive-damage-induced intracellular maladaptation for cancer electronic interference therapy, Chem 2022, 8 (3), 866-879.


57. Jin, P.; Wang, X.*; Pan, H.; Chen, J.* One order of magnitude increase of triplet state lifetime observed in deprotonated form selenium substituted uracil, Phys. Chem. Chem. Phys. 2022, 24, 875-882.


56. Wang, Y.; Zhou, Q.; He, X.; Zhang, Y.; Tan, H.; Xu, J.; Wang, C.*; Wang, W.; Luo, X.; Chen, J.*, Xu, L.* Dithienylethene metallodendrimers with high photochromic efficiency, Chin. Chem. Lett. 2022, 33 (3), 1613-1618.


55. 王雪力,潘海峰,陈缙泉* 表观遗传修饰核酸碱基的超快激发态动力学研究,物理学进展 202141199-208.


54. Wang, X.; Martinez-Fernandez, L.; Zhang, Y.; Improta, R.*; Kohler, B.*; Xu, J.; Chen, J.* Solvent-dependent Stabilization of a Charge Transfer State is the Key to Ultrafast Triplet State Formation in an Epigenetic DNA Nucleoside, Chem. Eur. J. 2021, 27, 10932-10940.


53.  Liu, Y.; Pan, H.*; Xu, J.; Chen, J.* Long Chain Fatty Acid Affects Excited State Branching in Bilirubin-Human Serum Protein Complex, Chin. J. Chem. Phys. 2021, 34, 621-627.


52. Lv, M.; Lu, X.; Jiang, Y.; Sandoval-Salinas, M.; Casanova, D.*; Sun, H.; Sun, Z.; Xu, J.; Yang, Y.; Chen, J.* Near-Unity Triplet Generation Promoted via Spiro-Conjugation. Angewandte Chemie International Edition 2021, 61 (4), e202113190


51. Lv, M.; Wang,X.; Wang,D.; Li, X.; Liu, Y.; Pan, H.; Zhang, S.; Xu, J.; Chen, J.* Unravel the Role of Charge Transfer State during Ultrafast Intersystem Crossing in Compact Organic Chromophores. Phys. Chem. Chem. Phys. 2021, 23, 25455-25466 (Front inside cover).


50. Lv, M.; Wang, X.; Pan, H.; Chen, J.* Direct Observation of Ultrafast Access to a Solvent-Independent Singlet–Triplet Equilibrium State in Acridone Solutions. J. Phys. Chem. B 2021, 125, 13291–13297.


49. Zhang, K.; Wang, F.; Jiang, Y.; Wang, X.; Pan, H.; Sun, Z.; Sun, H.; Xu, J.; Chen, J.* New Insights about the Photostability of DNA/RNA Bases: Triplet nπ* State Leads to Effective Intersystem Crossing in Pyrimidinones. J. Phys. Chem. B 2021, 125, 2042-2049.

48. Xu, T.; Hu, Z.; Lv, M.; Zhou, Z.*; Xu, J.; Sun, Z.; Sun, H.; Chen, J.* Hydrogen Atom and Water Complex Determine the Excited State Dynamics of 8-Azaguanine. Chemical Physics 2021, 544, 111118


47. Lv, M.; Yu, Y.; Sandoval-Salinas, ME.; Xu, J.; Lei, Z.*; Casanova, D.*; Yang, Y.*; Chen, J.* Engineering  Charge Transfer State to Facilitate Spin‐orbit Charge Transfer  Intersystem Crossing in Spirobis [anthracene] diones Solution. Angewandte Chemie International Edition 2020, 59 (49), 22179-22184.


46. Sun, L.; He, X.; Yuan, Y.; Chen, J.*; Zhan, W.; Wang, X.; Zhao, Y.*; Han, X.* Tuning  Interfacial Sequence between Nitrogen-Doped Carbon Layer and Au  Nanoparticles on Metal-Organic Framework-Derived TiO2 to Enhance  Photocatalytic Hydrogen Production. Chemical Engineering Journal 2020, 397, 125468.


45. Shen,J.; Chen, Z.; Han, S.; Zhang, H.; Xu, H.*; Xu, C.; Ding,Z.; Yuan, R.; Chen, J.*; Long, J.* Plasmonic Electrons‐Driven Solar‐to‐Hydrocarbon Conversion over Au NR@ ZnO Core‐Shell Nanostructures. ChemCatChem 2020, 12 (11), 2989-2994


44. Zhao, L.; Chen, Y.; Yu, X.; Xing, X.; Chen, J.*; Song, J.*; Qu, J. Low-threshold  stimulated emission in perovskite quantum dots: single-exciton optical  gain induced by surface plasmon polaritons at room temperature. Journal of Materials Chemistry C 2020, 8, 5847-5855.


43. Liu, Y.; Chen, Z.; Wang, X.; Cao, S.; Xu, J.; Jimenez, R.*; Chen. J.* Ultrafast spectroscopy of biliverdin dimethyl ester in solution: pathways of excited-state depopulation. Physical Chemistry Chemical Physics2020, 22, 19903-19912.


42. Fu, L.; Wang, Z.; Liu,Y.; Wang, X.; Xu, R.; Liu, W.*; Chen, J.*; Xu, J. Observation of Triplet nπ* State in Ultrafast Intersystem Crossing of 6-Azathymine. Journal of Photochemistry and Photobiology A: Chemistry 2020, 396, 112491.


41. Xu, R.; Hu, Z.; Wang, X.; Liu, Y.; Zhou, Z.; Xu, J.; Sun, Z.; Sun, H.; Chen, J.* Intramolecular Charge Transfer in 5-Halogen Cytidines Revealed by Femtosecond Time-resolved Spectroscopy. J. Phys. Chem. B 2020, 124, 2560-2567.


40. Chen, Z.; Liu, Y.; He, X.*; Chen, J.* Ultrafast excited state dynamics of biliverdin dimethyl Ester coordinate with zinc ions. Chinese Journal of Chemical Physics 2020,33 (1), 69-74.


39. Cao, X.; Zhang, C.;   Gao, Z.; Liu, Y.; Zhao, Y.; Yang, Y.; Chen, J.*; Jimenez, R.*; Xu, J. Ultrafast internal conversion dynamics of bilirubin bound to unag and its n57a mutant. Phys. Chem. Chem. Phys. 2019, 21, 2365-2371.


38. Zhou, Z.; Wang, X.; Chen, J.*; Xu, J. Direct observation of intramolecular   charge transfer state in epigenetic nucleobase n6-methyladenine. Phys. Chem. Chem. Phys.2019, 21, 6878-6885.


37. Zhou, Z.; Hu, Z.; Zhang, X.; Jia, M.; Wang, X.; Su, H.; Sun, H.; Chen, J.*; Xu, J. pH controlled intersystem crossing and singlet oxygen generation of 8-azaadenine in aqueous solution. ChemPhysChem 2019, 20, 757-765.


36. He, X.; Zhao, L.; Zhou, Z.; Zhang, S.; Pan, H.; Chen, J.*; Xu, J.* Near unity charge separation efficiency leads to pure ultraviolet emission in few layer graphene nanosheets. Nanotechnology 2019, 30, 295201.


35. He, X.; Zhang, S.; Pan, H.; Chen, J.*; Xu, J.* Horizontally aggregation of monolayer reduced graphene oxide under deep uv irradiation in  solution. Nanoscale Research Letters 2019, 14, 117.


34. Wang, X.; Yu, Y.; Zhou, Z.; Liu, Y.; Yang, Y.; Xu, J.; Chen, J.* Ultrafast intersystem crossing in epigenetic DNA nucleoside 2′-deoxy-5-formylcytidine. J. Phys. Chem. B 2019, 123, 5782-5790.


33. Wang, F.; He, X.; Sun, L.; Chen, J.*; Wang, X.; Xu, J.; Han, X.* Engineering an n-doped tio2@n-doped c butterfly-like nanostructure with long-lived   photo-generated carriers for efficient photocatalytic selective amine   oxidation. Journal of Materials Chemistry A 2018, 6, 2091-2099.


32. Han, X.*; He, X.; Sun, L.; Han, X.; Zhan, W.; Xu, J.; Wang, X.; Chen, J.* Increasing effectiveness of photogenerated carriers by in situ  anchoring of cu2o  nanoparticles on a nitrogen-doped porous carbon  yolk–shell  cuboctahedral framework. ACS Catalysis 2018, 3348-3356.


31. He, H.; Xia, Y.; Qi, Y.; Wang, H.-Y.; Wang, Z.; Bao, J.; Zhang, Z.; Wu, F.-G.; Wang, H.; Chen, D., et al. A water-soluble, green-light triggered, and photo-calibrated nitric oxide donor for biological applications. Bioconjugate Chem. 2018, 29, 1194-1198.


30. Pilles, B. M.; Maerz, B.; Chen, J.; Bucher, D. B.; Gilch, P.; Kohler, B.; Zinth, W.; Fingerhut, B. P.; Schreier, W. J. Decay pathways of thymine revisited. J. Phys. Chem. A 2018, 122, 4819-4828.


29. Wang, X.; Zhou, Z.; Tang, Y.; Chen, J.*; Zhong, D.; Jianhua, X. Excited state decay pathways of   2′-deoxy-5-methylcytidine and deoxycytidine revisited in solution: A comprehensive kinetic study by femtosecond transient absorption. J. Phys. Chem. B 2018, 122, 7027-7037.


28. Zhao, L.; Chen, J.*; He, X.; Yu, X.; Yan, S.; Zhang, S.; Pan, H.; Xu, J. Solvent induced   fluorescence enhancement of graphene oxide studied by ultrafast spectroscopy. Chem. Phys. 2018, 508, 1-6.


27. He, H.; Liu, Y.; Zhou, Z.; Guo, C.; Wang, H.-Y.; Wang, Z.; Wang, X.;  Zhang,  Z.; Wu, F.-G.; Wang, H., et al. A photo-triggered and photo-calibrated nitric oxide donor: Rational design, spectral  characterizations, and  biological applications. Free Radical Biol. Med. 2018, 123, 1-7.


26. Luo, X.; Yang, H.; Wang, H.; Ye, Z.; Zhou, Z.; Gu, L.; Chen, J.; Xiao, Y.;   Liang, X.; Qian, X., et al. Highly sensitive hill-type small-molecule  ph  probe that recognizes the reversed ph gradient of cancer cells. Anal. Chem. 2018, 90, 5803-5809.


25. Jia, M.*; Zhou, Z.; Lv, M.; Chen, J.* Dual excited state deactivation pathways in tpz2: A centrosymmetric dye with both high fluorescence and triplet state quantum yield. Chin. Chem. Lett. 2018, 29, 1486-1488.


24. Yang, J.; Liu, X.; Zhang, Y.; Zheng, X.; He, X.; Wang, H.; Yue, F.; Braun, S.; Chen, J.; Xu, J., et al. Comprehensive understanding of  heat-induced  degradation of triple-cation mixed halide perovskite for a  robust solar  cell. Nano Energy 2018, 54, 218-226.


23. Feng, E.; Zheng, T.; He, X.; Chen, J.; Tian, Y. A novel ternary heterostructure with dramatic sers activity for evaluation of pd-l1 expression at the single-cell level. Science Advances 2018, 4, eaau3494.


22. Gong, T.; Li, P.; Sui, Q.; Chen, J.; Xu, J.; Gao, E.-Q. A stable electron-deficient metal–organic framework for colorimetric and luminescence sensing of phenols and anilines. Journal of Materials Chemistry A 2018, 6, 9236-9244.


21. Zhou, Z.; Zhou, X.; Wang, X.; Jiang, B.*; Li, Y.*; Chen, J.*; Xu, J. Ultrafast excited-state dynamics of cytosine aza-derivative and analogues. J. Phys. Chem. A 2017, 121, 2780-2789.


20. Zhao, L.; Yu, X.; Zhang, S.; He, X.; Li, L.; Jia, M.; Chang, M.; Pan, H.;   Chen, J.; Wang, W., et al. The phosphorescence and  excitation-wavelength  dependent fluorescence kinetics of large-scale  graphene oxide  nanosheets. RSC Advances 2017, 7, 22684-22691.


19. Han, X.; He, X.; Wang, F.; Chen, J.*; Xu, J.; Wang, X.; Han, X.* Engineering an n-doped cu2o@n-c interface with long-lived photo-generated carriers for efficient photoredox catalysts. Journal of Materials Chemistry A 2017, 5, 10220-10226.


18. Xing, X.; Zhao, L.; Zhang, Z.; Fang, L.; Fan, Z.; Liu, X.; Lin, X.; Xu, J.;   Chen, J.; Zhao, X., et al. Photoinduced terahertz conductivity and   carrier relaxation in thermal-reduced multilayer graphene oxide films. J. Phys. Chem. C 2017, 121, 2451-2458.


17. Pettinger, N. W.; Williams, R. E. A.; Chen, J.; Kohler, B. Crystallization   kinetics of cerium oxide nanoparticles formed by spontaneous,   room-temperature hydrolysis of cerium(iv) ammonium nitrate in light and   heavy water. Phys. Chem. Chem. Phys. 2017, 19, 3523-3531.


16. Chang, M.; Li, L.; Hu, H.; Hu, Q.; Wang, A.; Cao, X.; Yu, X.; Zhang, S.;  Zhao,  Y.; Chen, J., et al. Using fractional intensities of  time-resolved  fluorescence to sensitively quantify nadh/nad+ with  genetically encoded  fluorescent biosensors. Sci. Rep. 2017, 7, 4209.


15. Lei, Z.; Yue, P.; Wang, X.; Li, X.; Li, Y.; He, H.; Luo, X.; Meng, X.; Chen, J.*; Qian, X., et al. Tpz, a bright centrosymmetric two-photon  scaffold  for bioimaging. Chem. Commun. 2017, 53, 10938-10941.


Before join ECNU:


14. Chen, J.; Wu, K.; Rudshteyn, B.; Jia, Y.; Ding, W.; Xie, Z.; Batista, V. S.; Lian, T. Ultrafast photo-induced interfacial proton coupled  electron  transfer from cdse quantum dots to 4, 4'-bipyridine. J. Am. Chem. Soc. 2016, 138, 884-892.


13. Wu, K.; Liang, G.; Kong, D.; Chen, J.; Chen, Z.; Shan, X.; McBride, J. R.; Lian, T. Quasi-type II cuins 2/cds core/shell quantum dots. Chem. Sci. 2016, 7, 1238-1244.


12. Jia, Y.; Chen, J.; Wu, K.; Kaledin, A. L.; Musaev, D. G.; Xie, Z.; Lian, T. Enhancing photo-reduction quantum efficiency using quasi-type II core/shell quantum dots. Chem. Sci. 2016, 7, 4125-4133.


11. Li, Q.; Wu, K.; Chen, J.; Chen, Z.; McBride, J. R.; Lian, T. Size-independent exciton localization efficiency in colloidal cdse/cds core/crown nanosheet type-i heterostructures. ACS Nano 2016, 10, 3843-3851.


10. Wu, K.; Hill, L. J.; Chen, J.; McBride, J. R.; Pavlopoulos, N. G.; Richey, N. E.; Pyun, J.; Lian, T. Universal length-dependence of rod-to-seed exciton localization efficiency in type I and quasi type II cdse@ cds nanorods. ACS nano 2015, 9,4591-4599.


9. Wu, K; Chen, J.; McBride, J. R.; Lian, T. Efficient hot-electron transfer by a plasmon-induced interfacial charge-transfer transition. Science2015, 349 (6248), 632-635


8. Chen, J.; Zhang, Y.; Kohler, B. Excited states in DNA strands investigated by ultrafast laser spectroscopy. Top Curr Chem 2015, 356, 39-87.


7. Chen, J.; Kohler, B. Base stacking in adenosine dimers revealed by femtosecond transient absorption spectroscopy. J. Am. Chem. Soc. 2014, 136, 6362-6372.


6. Liu, R.; Dandu, N. K.; Chen, J.; Li, Y.; Li, Z.; Liu, S.; Wang, C.; Kilina, S.; Kohler, B.; Sun, W. Influence of different diimine (n^ n) ligands  on  the photophysics and reverse saturable absorption of heteroleptic cationic iridium (iii) complexes bearing cyclometalating 2-{3-[7-(benzothiazol-2-yl) fluoren-2-yl] phenyl} pyridine (c^ n)  ligands. J. Phys. Chem. C 2014, 118, 23233-23246.


5. Zhang, Y.; Chen, J.; Kohler, B. Hydrogen bond donors accelerate vibrational cooling of hot purine derivatives in heavy water. The journal of physical chemistry. A 2013, 117, 6771-80.


4. Chen, J.; Thazhathveetil, A. K.; Lewis, F. D.; Kohler, B. Ultrafast excited-state dynamics in hexaethyleneglycol-linked DNA homoduplexes made of A· T base pairs. J. Am. Chem. Soc. 2013, 135, 10290-10293.


3. Zhang, Y.; Dood, J.; Beckstead, A.; Chen, J.; Li, X.; Burrows, C. J.; Lu, Z.; Matsika, S.; Kohler, B. Ultrafast excited-state dynamics and  vibrational  cooling of 8-oxo-7, 8-dihydro-2’-deoxyguanosine in d2o. J. Phys. Chem. A 2013, 117, 12851–12857.


2. Pan, Z. Z.; Chen, J. Q.; Schreier, W. J.; Kohler, B.; Lewis, F. D. Thymine dimer photoreversal in purine-containing trinucleotides. J. Phys. Chem. B 2012, 116, 698-704.


1. Chen, J.; Kohler, B. Ultrafast nonradiative decay by hypoxanthine and several methylxanthines in aqueous and acetonitrile solution. Phys. Chem. Chem. Phys. 2012, 14, 10677-10682.

荣誉及奖励

2019年入选上海市青年科技启明星计划

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