赵琼

2006/09-2012/07，北京大学，博士研究生

2002/09-2006/07，华东师范大学，本科

2012/10-2016/10，香港中文大学，生命科学学院，博士后

2016/10-2019/04，香港中文大学，生命科学学院，副研究员

2020/07-至今，   华东师范大学，生命科学学院，研究员/博士生导师

赵琼博士，任华东师范大学生命科学学院研究员、博士生导师，课题组长。2006年本科毕业于华东师范大学，2012年获北京大学博士学位，2012-2019年在香港中文大学从事博士后及副研究员。课题组致力于植物细胞分子生物学研究，在植物内膜系统调控机制领域取得系列成果，相关研究发表在Plant Cell、Nature Communications, Nature Plants, Trends in Plant Science等国际期刊，累计发表SCI论文30余篇。主持并参与多项国家自然科学基金项目，曾入选华东师范大学紫江优秀青年学者计划和上海市浦江人才计划。

1.2025-至今，上海植物学会，理事

2.2022-至今，中国电子显微镜学会生物医学专委会，委员

3.2021-至今，世界苔藓植物学会(IAB)，会员

4.2021-至今，中国细胞生物学学会，会员

5.2021-2024，上海植物学会，监事

植物内膜系统调控机制、演化规律、合成生物学应用

聚焦植物细胞分化及环境响应的分子调控网络，以内膜系统为核心研究对象，通过整合遗传学、细胞生物学、合成生物学策略和人工智能工具，系统解析亚细胞结构动态与细胞功能调控机制，定向改造内膜系统的蛋白转运及细胞器调控网络，以开发高效植物底盘系统用于高值化合物生产。主要以拟南芥，苔藓等陆生植物为研究材料，具体进展：

3）泥炭藓细胞研究平台：构建了全球首个泥炭藓细胞研究体系，揭示了液泡在细胞分化中的核心作用，泥炭藓是探究内膜系统调控与二型细胞分化机制的理想模型。

1)   《植物生理学实验》，本科必修，春季学期(2021-至今)

2)   《细胞工程》，本科必修，春季学期(2024-至今)

3)   《演化细胞生物学》（中英双语），本科选修，秋季学期（2023-至今）

4)   《植物学研究进展》，植物学研究生必修，秋季学期（2020-至今）

5)   《植物学研究方法》，植物学研究生必修，春季学期（2021-至今）

1) 2024-2027，国家自然科学基金委面上项目，项目负责人

2) 2020-2022，上海市“浦江（A类）人才计划”，项目负责人

3) 2020-2026，华东师范大学“双百”人才计划，项目负责人

4) 2019-2022，国家自然科学基金委重大研究计划,《植物细胞器动态互作网络的建立：EXPO分泌体，自噬体和液泡》,主要参与人

5) 2017-2020，国家自然科学基金委面上项目,《FREE1 复合体在植物自噬途径中的功能研究》，主要参与人

发表论文（^#共同第一作者; *通讯作者; h-index: 18; 总引数：2605）

1)   Qun Su^#, Le Liu^#, Zhengsheng Hu, Tao Wang, Qiu-Qi Guo, Xinyi Liao, Yan Sha, Feng Li, Zhao Dong*, Shaokai Yang*, Ningjing Liu*, Qiong Zhao*. (2025) DeepD&Cchl: An AI tool for automated 3D single-cell chloroplast detection, counting, and cell type clustering. Frontiers in Plant Science. 16:1513953.(JCR Q1, IF_5y 5.3)

2)     Qun Su, Le Liu, Zhengsheng Hu, Tao Wang, Qiu-Qi Guo, Xinyi Liao, Yan Sha, Feng Li, Zhao Dong*, Shaokai Yang*, Ningjing Liu*, Qiong Zhao*. (2025) A Deep Learning-Based Tool for Detection and Counting of Chloroplasts in Single-Cell Images. The 39th Annual AAAI Conference on Artificial Intelligence, AAAI 2025. https://ai-2-ase.github.io/papers/31_Su.pdf (AAAI: Association for the Advancement of Artificial Intelligence，美国人工智能促进协会。AAAI年会是人工智能领域影响力大、涵盖方向最广泛的国际顶级学术会议之一，也是中国计算机学会（CCF）推荐的A类国际学术会议。第39届AAAI人工智能年度会议，于2025年2月在美国宾夕法尼亚州费城举行）

3)     Liu N., Guo Q., Shi F., Gao L., Liu Y., Wang Y., Gong Z., Liu H., Sun Y., Li B., Ni B., Zhu R., and Zhao Q.* (2024) Developmentally controlled subcellular remodeling and VND-initiated vacuole-executed PCD module shape xylem-like cells in peat moss.Communications Biology. 7, 1323，DOI：https://doi.org/10.1038/s42003-024-07003-w(JCR Q1, IF_5y 5.6)

4)       Wen H^#., Li Y^#., and Zhao Q.*(2024) Genetic Screening of Factors in the Plant Protein Secretion.Book: Plant Protein Secretion. Methods in Molecular Biology, Springer, DOI: 10.1007/978-1-0716-4059-3 (Book chapter)

5)       Shen C., Xu H., Huang W., Zhao Q.* and Zhu R.*. (2024) Is RNA editing truly absent in the complex thalloid liverworts (Marchantiopsida)? Evidence of extensive RNA editing from Cyathodium cavernarum. New Phytologist. doi: 10.1111/nph.19750 (JCR Q1, IF_5y 10.2)

6)       Hassani, D., Lu, Y., Ni, B., Zhu, R., Zhao, Q.*(2023). The endomembrane system: how does it contribute to plant secondary metabolism? Trends in Plant Science. 28 (11): 1222-1236. (JCR Q1, IF_5y 20.1)

7)       Zhu, Y., Zhao, Q., Cao, W., Huang, S., Ji, C., Zhang, W., Trujillo, M., ShenJ.* and Jiang L.*(2023) The plant-unique protein DRIF1 coordinates with SNX1 to regulate membrane protein homeostasis. Plant Cell.35 (12): 4217-4237 (JCR Q1, IF_5y 11.1)

8)       Zeng, Y^#., Liang, Z^#., Liu, Z^#., Li, B^#., Cui, Y., Gao, C., Shen, J., Wang, X., Zhao, Q., Zhuang, X., Erdmann, P.S., Wong, K.-B. and Jiang, L.*(2023). Recent advances in plant endomembrane research and new microscopical techniques. New Phytologist.240 (1): 41-60 (JCR Q1, IF_5y 10.2) 

9)       Su, Q., Liu, L., Hu, Z., Wang, T., Wang, H., Guo, Q., Liao, X., Dong, Z., Yang, S., Liu, N., Zhao, Q.* (2023) Unbiased Estimation of Chloroplast Number in Plant Cells Using Deep Learning Methods. bioRxiv 2023.12.17.572064;

10)       Neuhaus, J*, Pimpl, P*, Zhao, Q.* and Wang H.* (2023). Editorial: Regulation of plant organelle biogenesis and trafficking. Frontiers in Plant Science. 14:1211807.(JCR Q1, IF_5y 5.3)

11)       Liu, H., Shen, C., Hassani, D., Fang, W., Wang, Z., Lu, Y., Zhu, R., Zhao, Q.* (2022). Vacuoles in bryophytes: properties, biogenesis, and evolution. Frontiers in Plant Science. 13，863389.(JCR Q1, IF_5y 5.3)

12)     Huang, S., Liu, Z., Cao, W., Li, H., Zhang, W., Cui, Y., Hu, S., Luo, M., Zhu, Y., Zhao, Q., Xie, L., Gao, C., Xiao, S., Jiang, L.*(2022). The plant ESCRT component FREE1 regulates peroxisome-mediated turnover of lipid droplets in germinating Arabidopsis seedlings.Plant Cell 34(11):4255-4273(JCR Q1, IF_5y 11.1)

13)    Cui, Y.^#,*, Zhao, Q.^#, Hu, S.,and Jiang, L^*. (2020). How many models and how many vacuoles?Trends in Plant Science 25 (6): 538-548.(JCR Q1, IF_5y 20.1)

14)     Zhu, Y.^#, Ji, C.^#, Cao, W., Shen, J., Zhao, Q., Jiang, L.* (2020). Identification and characterization of unconventional membrane protein trafficking regulators in Arabidopsis: A genetic approach. Journal of Plant Physiology 252, 153229(JCR Q1, IF_5y 4.1)

15)     Zhao, Q. ^*, Zhu, Y., Cao, W., Shen, J., Cui, Y., Jiang, L. (2019). Genetic suppressor screen using an inducible FREE1-RNAi line to detect ESCRT genetic interactors in Arabidopsis thaliana. Book: The ESCRT Complexes, Methods in Molecular Biology, Springer, Volume 1998: 273-289 (Book chapter)

16)     Zhao, Q.^#,*,Shen, J.^#, Gao, C.^#, Cui, Y.^#, Wang, Y., Cui, J.,Cheng, L.,Cao, W., Zhu, Y., Huang, S., Zhou, Q., Leong, C., Leung, K., Chen, X., and Jiang, L.^*(2019). RST1 is a FREE1 suppressor that negatively regulates vacuolar trafficking in Arabidopsis. Plant Cell 31, 2152-2168.(JCR Q1, IF_5y 11.1)

17)     Li, H.^#, Li Y.^#, Zhao, Q.^#, Li, T., Wei, J., Li B., Shen, W., Yang, C., Zeng, Y., Rodriguez, P., Zhao, Y., Jiang, L.^*, Wang, X.^*, and Gao, C.^*(2019) The Plant ESCRT Component FREE1 Shuttles to the Nucleus to Attenuate Abscisic Acid Signaling. Nature Plants 5, 512–524. (JCR Q1, IF_5y 17.1)

18)     Cui, Y.^#,*, Cao, W.^#, He, Y.^#, Zhao, Q., Wakazaki, M., Zhuang, X., Gao, J., Zeng, Y., Gao, C., Ding, Y., Wong, H.Y., Wong, W.S., Lam, H.K., Wang, P., Ueda, T., Rojas-Pierce, M., Toyooka, K., Kang, B.H., and Jiang, L.^*(2019). A whole-cell electron tomography model of vacuole biogenesis in Arabidopsis root cells. Nature Plants 5, 95-105. (JCR Q1, IF_5y 17.1)

19)     Shen, J.^#, *, Zhao, Q.^#, Wang, X., Gao, C., Zhu, Y., Zeng, Y., and Jiang, L.^*(2018). A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis. Nature Communications 9, 3784. (JCR Q1, IF_5y 16.1)

20)     Wang, H.^#, Zhao, Q.^#, Fu, J., Wang, X., and Jiang, L.^*(2018). Re-assessment of biolistic transient expression: An efficient and robust method for protein localization studies in seedling-lethal mutant and juvenile plants. Plant Science 274, 2-7. (Cover Story) (JCR Q1, IF_5y 4.9)

21)     Cui, Y.^#, Zhao, Q.^#, Xie, H.T., Wong, W.S., Wang, X., Gao, C., Ding, Y., Tan, Y., Ueda, T., Zhang, Y., and Jiang, L.^*(2017). MONENSIN SENSITIVITY1 (MON1)/CALCIUM CAFFEINE ZINC SENSITIVITY1 (CCZ1)-Mediated Rab7 Activation Regulates Tapetal Programmed Cell Death and Pollen Development. Plant Physiology 173, 206-218. (JCR Q1, IF_5y 7.6)

22)     Shen, J.^#, Gao, C.^#, Zhao, Q., Lin, Y., Wang, X., Zhuang, X., and Jiang, L.^*(2016). AtBRO1 Functions in ESCRT-I Complex to Regulate Multivesicular Body Protein Sorting. Molecular Plant  9, 760-763. (JCR Q1, IF_5y 21.4)

23)     Belda-Palazon, B., Rodriguez, L., Fernandez, M.A., Castillo, M.C., Anderson, E.M., Gao, C., Gonzalez-Guzman, M., Peirats-Llobet, M., Zhao, Q., De Winne, N., Gevaert, K., De Jaeger, G., Jiang, L., Leon, J., Mullen, R.T., and Rodriguez, P.L.^*(2016). FYVE1/FREE1 Interacts with the PYL4 ABA Receptor and Mediates Its Delivery to the Vacuolar Degradation Pathway. Plant Cell 28, 2291-2311. (JCR Q1, IF_5y 11.1)

24)     Cui, Y., Gao, C., Zhao, Q., Jiang, L.^*(2016). Using Fluorescent Protein Fusions to Study Protein Subcellular Localization and Dynamics in Plant Cells. Book: High-Resolution Imaging of Cellular Proteins, Methods in Molecular Biology, Springer, Volume1474: 113-123. (Book chapter)

25)     Zhao, Q., Gao, C., Lee, P., Liu, L., Li, S., Hu, T., Shen, J., Pan, S., Ye, H., Chen, Y., Cao, W., Cui, Y., Zeng, P., Yu, S., Gao, Y., Chen, L., Mo, B., Liu, X., Xiao, S., Zhao, Y., Zhong, S., Chen, X., and Jiang, L.^*(2015). Fast-suppressor screening for new components in protein trafficking, organelle biogenesis and silencing pathway in Arabidopsis thaliana using DEX-inducible FREE1-RNAi plants. Journal of Genetics and Genomics 42, 319-330. (Cover Story) (JCR Q1, IF_5y 5.8)

26)     Zhang, X., Zhu, Y., Liu, X., Hong, X., Xu, Y., Zhu, P., Shen, Y., Wu, H., Ji, Y., Wen, X., Zhang, C., Zhao, Q., Wang, Y., Lu, J., and Guo, H.^*(2015). Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis.Science 348, 120-123. (JCR Q1, IF_5y 50.3)

27)     Gao, C.^#, Zhuang, X^#., Cui, Y., Fu, X., He, Y., Zhao, Q., Zeng, Y., Shen, J., Luo, M., and Jiang, L.^*(2015). Dual roles of an Arabidopsis ESCRT component FREE1 in regulating vacuolar protein transport and autophagic degradation. Proc Natl Acad Sci USA 112, 1886-1891. (JCR Q1, IF_5y 10.8)

28)     Gao, C., Zhao, Q., and Jiang, L.^*(2015). Vacuoles protect plants from high magnesium stress. Proc Natl Acad Sci USA112, 2931-2932. (JCR Q1, IF_5y 10.8)

29)     Gao, C., Luo, M., Zhao, Q., Yang, R., Cui, Y., Zeng, Y., Xia, J., and Jiang, L.^*(2014). A unique plant ESCRT component, FREE1, regulates multivesicular body protein sorting and plant growth. Current Biology 24, 2556-2563. (JCR Q1, IF_5y 9.8)

30)     Cui, Y., Zhao, Q., Gao, C., Ding, Y., Zeng, Y., Ueda, T., Nakano, A., and Jiang, L.^*(2014). Activation of the Rab7 GTPase by the MON1-CCZ1 Complex Is Essential for PVC-to-Vacuole Trafficking and Plant Growth in Arabidopsis. Plant Cell 26, 2080-2097. (JCR Q1, IF_5y 11.1)

31)     Wen, X.^#, Zhang, C.^#, Ji, Y.^#, Zhao, Q., He, W., An, F., Jiang, L., and Guo, H.^*(2012). Activation of ethylene signaling is mediated by nuclear translocation of the cleaved EIN2 carboxyl terminus. Cell Research 22, 1613-1616. (JCR Q1, IF_5y 36.4)

32)     Zhao, Q., and Guo, H.^*(2011). Paradigms and Paradox in the Ethylene Signaling Pathway and Interaction Network. Molecular Plant 4, 626-634. (JCR Q1, IF_5y 21.4)

33)     An, F.^#, Zhao, Q.^#, Ji, Y., Li, W., Jiang, Z., Yu, X., Zhang, C., Han, Y., He, W., Liu, Y., Zhang, S., Ecker, J.R., and Guo, H.^*(2010). Ethylene-Induced Stabilization of ETHYLENE INSENSITIVE3 and EIN3-LIKE1 Is Mediated by Proteasomal Degradation of EIN3 Binding F-Box 1 and 2 That Requires EIN2 in Arabidopsis. Plant Cell 22, 2384-2401. (JCR Q1, IF_5y 11.1)

34)       Zhong, S., Zhao, M., Shi, T., Shi, H., An, F., Zhao, Q., and Guo, H.^*(2009). EIN3/EIL1 cooperate with PIF1 to prevent photo-oxidation and to promote greening of Arabidopsis seedlings. Proc Natl Acad SciUSA 106, 21431-21436. (JCR Q1, IF_5y 10.8)