Wangxin

Awards and Honors

2016: Youth Pharmacologist Award of Chinese Pharmacological Society

2016: Outstanding Contribution in Reviewing PHYTOMEDICINE (International Journal of Phytotherapy and Phytopharmacology)

2015: Outstanding Contribution in Reviewing JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Additional Information

Journal Reviewer for （SCI*)

Journal of Pharmaceutical and Biomedical Analysis*; Journal of Translational Medicine*; Journal of Functional Foods*; Toxicology Research*; Diabetes, Obesity and Metabolism*; Journal of Natural Products*; Gene*; Biomedical Chromatography*; Journal of Chromatography B*; Phytomedicine*; Journal of Ethnopharmacology*; Current Drug Metabolism*; Journal of Pharmacy and Pharmacology*; Fitoterapia*; European Journal of Histochemistry*; Chemico-Biological Interactions*; Phytotherapy Research*; ‏ Plos One*; Molecules*; BioSystems*; European Journal of Integrative Medicine*; Current Pharmaceutical Analysis*; BMC Complementary and Alternative Medicine*; Current Nutrition & Food Science; Drug Metabolism and Drug Interactions; ISRN Biochemistry; BMC Research Notes; Austin Chromatography

Membership in Scientific Societies/ Professional Organizations:     

China Pharmacology Society

Sunrise Symposium for Drug Metabolism, Pharmacokinetics and Dynamics

The Hong Kong Pharmacology Society 

Xin Wang received his Ph.D. degree in pharmacology from the Chinese University of Hong Kong, Hong Kong, and postdoctoral training in the University of Texas Medical Branch, Galveston, Tex, USA. He has been working in the School of Life Sciences, ECNU, as an Associate Professor, since 2011. Dr. Wang has published more than 40 academic papers in international peer-reviewed journals. Meanwhile, he is dedicated to social activities and works as a Reviewer for SCI journals, such as Gene, Journal of Pharmaceutical and Biomedical Analysis, Journal of Pharmacy and Pharmacology, European Journal of Histochemistry, and Fitoterapia. Wang has been also involved in multiple programs of the Science and Technology Commission of Shanghai Municipality, National Natural Science Foundation, and National programs. His research fields include pharmacokinetics, including drug absorption, distribution, metabolism, and excretion; integrative approach for the study of anticancer effects of Chinese medicinal (CM) herbs, including chemical analysis, pharmacology, pharmacokinetics, adverse effect/toxicity, and quality control of CM herbs; and herb-drug interactions, in particular chemopreventive and synergistic anticancer effects of CM herbs in the combinational chemotherapy of anticancer drugs with CM herbs.

1.Pharmacology, especially novel models for drug metabolism, such as 3D organoids of transporter protein, CYP knockout rat and humanized rat mode

2.Pharmacokinetics of antitumor drugs, including drug absorption, distribution, metabolism and excretion

3.Drug-drug interaction studies involving Traditional Chinese Medicines (TCM) and other natural products with Western Medicines, and their pharmacological and toxicological significance.

He Y, Peng S, Wang J, Chen H, Cong X, Chen A, Hu M, Qin M, Wu H, Gao S, Wang L, Wang X^*, Yi Z^*, Liu M^*. Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nature Communications 2016, 7:13122.

Zhang L, Zhao J, Liang C, Liu M, Xu F^*, ‍‍Wang X‍‍^*. A novel biosensor based on intestinal 3D organoids for detecting the function of BCRP. Drug Delivery 2017, 24, 1453-1459.

Tang S, Chen A, Zhou X, Zeng L, Liu M, ‍‍Wang X‍‍^*. Assessment of the inhibition risk of shikonin on cytochrome P450 via cocktail inhibition assay. Toxicology Letters 2017, 281, 74-83.

Qin X, Lu J, Wang P, Xu P, Liu M, ‍‍Wang X‍‍^*. Cytochrome P450 3A selectively affects the pharmacokinetic interaction between erlotinib and docetaxel in rats. Biochemical Pharmacology 2017, 143,129-139.

Lu J, Shao Y, Qin X, Liu D, Chen A, Li D^*, Liu M^*, ‍‍Wang X‍‍^*. CRISPR knockout rat cytochrome P450 3A1/2 model for advancing drug metabolism and pharmacokinetics research. Scientific Reports 2017, 7，42922.

Qin X, Chen A, Lu J, Zhang YJ, Liu MY, Wang X^*. Evaluation of plasma stability and pharmacokinetics of parthenolide in rats with LC-MS/MS analysis. Acta Pharmaceutica Sinica 2017, 52, 609-614.

Lu J, Zhang Y, Sun M, Liu M, Wang X^*. Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein. Phytomedicine 2017, 26, 1-10.

Li JM, Li LY, Qin X, Ning LJ, Lu DL, Li DL, Zhang ML,Wang X^*, Du ZY*. Systemic regulation of L-carnitine in nutritional metabolism in zebrafish, Danio rerio. Scientific Reports 2017, 7, 40815.

Zhao J, Zeng Z, Sun J, Zhang Y, Li D, Zhang X, Liu M, ‍‍Wang ‍‍X‍‍‍‍^*. A Novel Model of P-Glycoprotein Inhibitor Screening Using Human Small Intestinal Organoids. Basic & Clinical Pharmacology & Toxicology 2017, 120, 250-255.

Wang X^*, Tang Y, Lu J, Shao Y, Qin X, Li Y, Wang L, Li D*, Liu M*. Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9. Biochemical Pharmacology 2016, 105, 80-90.

Qin X, Liu M, Wang X^*. New insights into the androgen biotransformation in prostate cancer: a regulatory network among androgen, androgen receptors and UGTs. Pharmacological Research 2016, 106, 114-22.

Chen A, Zhou X, Tang S, Liu M, Wang X^*. Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach.  Scientific Reports 2016, 6, 28482.

Zhang Y, Zeng Z, Zhao J, Li D, Liu M,Wang X^*. Measurement of Rhodamine 123 in Three-Dimensional Organoids: A Novel Model for P-Glycoprotein Inhibitor Screening.Basic & Clinical Pharmacology & Toxicology2016, 119, 349-352.

Qin M, Peng S, Liu N, Hu M, He Y, Li G, Chen H, He Y, Chen A, Wang X, Liu M, Chen Y, Yi Z. LG308, a novel synthetic compound with anti-microtubule activity in prostate cancer cells, exerts effective antitumor activity. J Pharmacol Exp Ther. 2015, 355, 473-483. 

Lu J, Ding T, Qin X, Liu M, Wang X^*. In vitro and in vivo evaluation of cucurbitacin E on rat hepatic CYP2C11 expression and activity using LC-MS/MS. Sci China Life Sci. 2015 Sep 9.doi：10.1007/s11427-015-4911-7. [Epub ahead of print]

Zheng C, Zhou W, Wang T, You P, Zhao Y, Yang Y, Wang X, Luo J, Chen Y, Liu M, Chen H. A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-Cells in Type 2 Diabetic Mice. PLoS One. 2015 Jul 24;10(7):e0134051. doi: 10.1371/journal.pone.0134051.

Chen A, Qin X, Lu J, Yi Z, Liu M, Wang X^*. Development of a validated LC-MS/MS method for the determination of ailanthone in rat plasma with application to pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis 2015, 102, 514-518.

Sun M, Tang Y, Ding T, Liu M, Wang X^*. Investigation of cytochrome P450 inhibitory properties of maslinic acid, a bioactive compound from Olea europaea L., and its structure-activity relationship. Phytomedicine 2015, 22, 56-65. doi: http://dx.doi.org/10.1016/j.phymed.2014.10.003.

Ding T, Zhang Y, Chen A, Tang Y, Liu M, Wang X^*(Corresponding author). Effects of Cucurbitacin E, a Tetracyclic Triterpene Compound from Cucurbitaceae, on the Pharmacokinetics and Pharmacodynamics of Warfarin in Rats. Basic & Clinical Pharmacology & Toxicology 2015, 116, 385-389. DOI: 10.1111/bcpt.12329

Yang F, Zhang T, Wu H, Yang Y, Liu N, Chen A, Li Q, Li J, Qin L, Jiang B, Wang X, Pang X, Yi Z, Liu M, Chen Y. Design and Optimization of Novel Hydroxamate-Based Histone Deacetylase Inhibitors of Bis-Substituted Aromatic Amides Bearing Potent Activities against Tumor Growth and Metastasis. Journal of Medicinal Chemistry 2014, 57, 9357-9369. DOI: 10.1021/jm5012148

Chen A, Qin X, Tang Y, Liu M, Wang X^*. Evaluation of enzyme inhibition kinetics in drug-drug interactions. Chemico-Biological Interactions 2014, 222, 133-134.

Lu J, Qin X, Liu M,Wang X^*. A note on CYP2J2-mediated terfenadine hydroxylation in human liver microsomes. Food and Chemical Toxicology 2014, 71, 284-285.

Sun M, Tang Y, Ding T, Liu M, Wang X^*. Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity. Fitoterapia 2014, 92, 1-8.

Wang X^*(Corresponding author), Yeung JH. Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture. Phytomedicine 2012, 19, 348-354.

Wang X^*(Corresponding author), Yeung JH. Inhibitory effect of tanshinones on rat CYP3A2 and CYP2C11 activity and its structure-activity relationship. Fitoterapia 2011, 82, 539-545.

Wang X^*(Corresponding author), Yeung JH. Effects of Salvia miltiorrhiza extract on the liver CYP3A activity in humans and rats. Phytotherapy Research 2011, 25, 1653-1659.

Wang X, Nanovskaya TN, Zhan Y, Abdel-Rahman SM, Hankins GD, Ahmed MS. Pharmacokinetics of metronidazole in pregnant patients with bacterial vaginosis. Journal of Maternal-Fetal and Neonatal Medicine 2011, 24, 444-448.

Wang X^*(Corresponding author), Yeung JH. Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats. Journal of Pharmacy and Pharmacology 2010, 62, 1077-1083.

Wang X, Zhan Y, Rytting E, Patrikeeva S, Nanovskaya T, Clark S, et al. Pharmacokinetics of famotidine during pregnancy and postpartum. Journal of Clinical Pharmacology 2010, 50, 1076.

Wang X, Cheung CM, Lee WY, Or PM, Yeung JH. Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro. Phytomedicine 2010, 17, 868-875.

Wang X, Lee WY, Zhou X, Or PM, Yeung JH. A pharmacodynamic– pharmacokinetic (PD–PK) study on the effects of Danshen (Salvia miltiorrhiza) on midazolam, a model CYP3A probe substrate, in the rat. Phytomedicine 2010, 17, 876-883.

Wang X, Lee WY, Or PM, Yeung JH. Pharmacokinetic interaction studies of tanshinones with tolbutamide, a model CYP2C11 probe substrate, using liver microsomes, primary hepatocytes and in vivo in the rat. Phytomedicine 2010, 17, 203-211.

Wang X, Lee WY, Or PM, Yeung JH. Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates. Phytomedicine 2009, 16, 712-725.