头像

王昕

  • 个人资料
    • 部门: 生命科学学院
    • 性别:
    • 专业技术职务: 教授 博士生导师
    • 毕业院校: 香港中文大学
    • 学位: 药理学博士
    • 学历: 博士后
    • 联系电话:
    • 电子邮箱: xwang@bio.ecnu.edu.cn
    • 办公地址: 生命科学学院
    • 通讯地址: 上海市东川路500号华东师大生命科学学院
    • 邮编: 200241
    • 传真: 021-54344922

    工作经历

    教育经历

    个人简介

    王昕 (https://www.x-mol.com/groups/wang_xin),华东师范大学生命科学学院教授,博士生导师。香港中文大学药理学博士,美国得州大学医学院博士后研究方向为药物代谢与代谢调控。荣获第二十二届施维雅青年药理学家奖第三届刘昌孝人才奖励基金优秀青年科技工作者奖第二十届中国药理学会青年药理学家奖。担任中国毒理学会药物毒理与安全性评价专业委员会委员、中国药理学会药物代谢专业委员会委员/青委副主委、上海药物代谢专业委员会委员、Front Pharmacol副主编J Pharm Biomed Anal编委Acta Pharmaceutica Sinica B和《药学学报》青年编委学术兼职。作为课题负责人承担国自然及省部级等课题13项,在国内外发表学术论文100篇,其中以通讯作者或第一作者在国际著名学术期刊Nat CommunBiochem PharmacolPharmacol ResDrug Metab Dispos,Acta Pharm Sin B,Toxicol Appl Pharmacol, Mol Pharmacol等发表SCI论文68篇,以共同作者在Nat Med, Cell Discov, EMBO Mol Med, J Med Chem等发表SCI论文11篇,申请发明专利13项,已授权8项,主编英文学术专著2部,参编专著4。为50个药理、植物医学、代谢及毒理学国际知名SCI学术期刊审稿,多次荣获国际药理学知名期刊J Pharm Biomed Anal国际植物医学知名期刊PhytomedicineJ Ethnopharmacol及国际食品科学知名期刊J Funct Foods颁发的杰出贡献奖。


    社会兼职

    中国药理学会药物代谢专业委员会委员

    中国药理学会药物代谢专业委员会青委副主任委员

    中国毒理学会青年委员会委员

    中国毒理学会药物毒理与安全性评价专业委员会委员

    上海药物代谢专业委员会委员

    药物代谢朝阳论坛委员

    国家自然科学基金委项目评审专家

    国家留学基金委项目评审专家

    瑞士国家科学基金会(Swiss National Science Foundation)生物学与医学项目评审专家

    上海市科委“科技创新行动计划”新药项目评审专家

    上海市科委“科技创新行动计划”科普专项医药项目评审专家

    上海市科学技术奖评审专家

    上海市自然科学基金项目评审专家

    浙江省自然科学基金项目评审专家

    教育部学位中心研究生学位论文评审专家

    中国教育在线学术桥人才评审专家

    上海市教委研究生学位论文评审专家

    上海市专利试点示范单位评审专家

    Journal of Pharmaceutical and Biomedical Analysis编委

    https://www.journals.elsevier.com/journal-of-pharmaceutical-and-biomedical-analysis/editorial-board/xin-wang

    Acta Pharmaceutica Sinica B和《药学学报》青年编委

    Frontiers in Pharmacology 副主编

    英国药理学会(BPS)会员

    美国药理与实验治疗学会(ASPET)会员

    中国生物化学与分子生物学会会员


    学术期刊特约审稿人Journal Reviewer for (SCI*)

    Kidney International*; Journal of Chromatography A*; Acta Pharmaceutica Sinica B*; British Journal of Pharmacology*; Journal of Pharmaceutical and Biomedical Analysis*; Biochemical Pharmacology*; Toxicology and Applied Pharmacology*; Acta Pharmacologica Sinica*; Journal of Translational Medicine*; Journal of Functional Foods*; Drug Metabolism and Disposition*; Toxicology Research*; Diabetes, Obesity and Metabolism*; Journal of Natural Products*; International Journal of Pharmaceutics*; European Journal of Pharmacology*; Regulatory Toxicology and Pharmacology*; Journal of Clinical Pharmacy and Therapeutics*; PloS One*; Gene*; Endocrine*; Molecular BioSystems*; Current Drug Metabolism*; Biomedical Chromatography*; Journal of Chromatography B*; Phytomedicine*; Journal of Ethnopharmacology*; Basic & Clinical Pharmacology & Toxicology*; Journal of Pharmacy and Pharmacology*; Fitoterapia*; European Journal of Histochemistry*; Chemico-Biological Interactions*; Phytotherapy Research*; Cancer Chemotherapy and Pharmacology*; BMC Complementary and Alternative Medicine*; BioSystems*; Molecules*; Planta Medica*; Biomedicine & Pharmacotherapy*; Immunopharmacology And Immunotoxicology*; Oncotarget; Biopharmaceutics & Drug Disposition*; Environmental Toxicology and Pharmacology*; European Journal of Integrative Medicine*; ‏European Journal of Drug Metabolism and Pharmacokinetics*; Xenobiotica*; Pharmaceutics*; Frontiers Pharmacology*; Journal of Steroid Biochemistry and Molecular Biology*; Drug Design, Development and Therapy*Journal of Advanced Research*; Current Pharmaceutical Analysis*; Heliyon*; Research Journal of Biotechnology*; Current Nutrition & Food Science; Drug Metabolism and Drug Interactions; ISRN Biochemistry; BMC Research Notes; Austin Chromatography


    研究方向

    1生理活性物质的转运、代谢和调控疾病的机制研究

    2药物代谢酶和转运体研究

    3建立基因敲除及人源化大鼠代谢模型, 开展抗肿瘤药物代谢及其代谢相关的毒理学研究

    4利用分子生物学,体内体外以及动物模型等方法研究中药西药相互作用机理, 以及中药药理和毒理

    招生与培养

    开授课程

    1 简明药理学,本科生专业选修

    2 药理学,本科生专业选修

    3 药物研发基本原理,本科生专业选修

    4 药物代谢酶学,研究生专业选修

    科研项目

    主持国家自然科学基金(82274010)

    主持国家自然科学基金(81773808)

    主持国家自然科学基金(81301908)

    主持上海市自然科学基金(13ZR1412600)

    主持上海市科委实验动物创新基金(15140904700)

    主持上海市科委“科技创新行动计划”实验动物研究领域重点项目17140901000

    主持上海市科委“科技创新行动计划”科技合作项目(18430760400)

    主持上海市长宁区卫生健康委员会科研项目(2019CNECNUPI02)

    主持中央高校基本科研业务费专项资金项目(40500-20104-222370

    主持国家药品监督管理局药物代谢研究与评价重点实验室(DMRE-NMPA)开放基金

    主持华东师大创新创业实验室“药物质谱分析实验室”建设项目(44400-21301-512200

    主持华东师大创新创业课程建设基金(44400-23301-512200)

    参与国家自然科学基金重点项目(81830083

    参与上海市科委基金多项(11DZ2260300, 12XD1406100, 14DZ2270100


    学术成果

    个人简介

    王昕(https://www.x-mol.com/groups/wang_xin),香港中文大学医学院药理学博士,香港大学和美国得州大学医学院博士后,华东师范大学教授,博士生导师,荣获中国药理学会施维雅青年药理学家奖和刘昌孝人才奖励基金优秀青年科技工作者奖,主要研究方向为药物代谢及创新代谢模型构建。作为课题负责人承担国自然及省部级等课题13项,在国内外发表学术论文100余篇,其中以通讯作者或第一作者在国际著名学术期刊Nat Commun,Biochem Pharmacol,Pharmacol Res,Acta Pharm Sin B,Drug Metab Dispos,Toxicol Appl Pharmacol,Mol Pharmacol发表SCI论文68篇,申请发明专利13项获授权8项,主编英文学术专著2部,参编学术专著4部,担任中国药理学会药物代谢专业委员会委员/青委副主委,中国毒理学会青年委员,药物毒理与安全性评价专业委员会委员,药物代谢朝阳论坛委员,上海药物代谢专业委员会委员,药学学报中英文期刊青年编委,为46药理植物医学代谢及毒理学国际知名SCI学术期刊审稿,例如:Biochem Pharmcol, J Pharm Biomed AnalDiabetes Obes MetabJ Nat Prod等,多次荣获国际药理学知名期刊J Pharm Biomed Anal国际植物医学知名期刊Phytomedicine,J Ethnopharmacol及国际食品科学知名期刊J Funct Foods颁发的杰出贡献奖。


    指导学生获奖

    国家级

    2023年 硕士生付田田 荣获研究生国家奖学金

    2022年 硕士生徐媛 荣获研究生国家奖学金

    2021年 硕士生刘洁 荣获研究生国家奖学金

    2020年 本科生徐媛,罗函荣获第五届全国大学生生命科学创新创业大赛一等奖

    2019年 张远金荣获中国毒理学会药物毒理与安全性评价学术大会青年优秀论文奖

    2019年 硕士生程怡,尚旭阳获得研究生国家奖学金

    2018年 覃璇荣获博士研究生国家奖学金

    2018年 张远金荣获第十二届全国药物和化学异物代谢大会青年优秀论文奖

    2017年 硕士生唐朔文获得研究生国家奖学金

    2016年 博士生覃璇,陈昂分别荣获第二届药物代谢朝阳论坛---朝阳学子报告二,三等奖

    2016年 博士生鲁健获得中国药理学会第十四次全国学术大会优秀壁报奖

    2016年 硕士生赵军芳获得研究生国家奖学金

    2015年 硕士生陈昂,覃璇获得研究生国家奖学金

    2014年 硕士生汤玉,丁同贵获得研究生国家奖学金

    2013年 硕士生孙敏获得首届研究生国家奖学金

    省级

    2023年 张远金荣获第七届浦江DMPK论坛优秀青年学术报告奖

    2023年 徐媛获上海市优秀毕业生称号

    2019年 梁辰美子获上海市优秀毕业生称号

    2019年 罗函,徐媛荣获上海大学生创新创业训练计划项目基金

    2018年 鲁健荣获第五届浦江DMPK论坛优秀青年论文奖

    2017年 赵军芳获上海市优秀毕业生称号

    2015年 汤玉获上海市优秀毕业生称号

    2014年 孙敏获上海市优秀毕业生称号

    校级

    2023年 徐媛荣获第32届十佳女大学生称号

    2020年 尚旭阳,程怡荣获华东师范大学优秀毕业生称号

    2016年 张远金获华东师范大学优秀毕业生称号

    2016年 赵军芳获华东师范大学优秀学生称号

    2016年 硕士生周小静获华东师范大学研究生科研创新基金

    2015年 硕士生张远金获华东师范大学优秀研究生奖学金

    2015年 硕士生陈昂获华东师范大学研究生科研创新基金

    2014年 本科生张禾雨获华东师范大学本科生优秀毕业论文



    主编书籍

    Xin Wang (Editor),《Dextromethorphan: Pharmacology, Clinical Uses and Health Effects》,ISBN:978-1-63484-016-3,美国诺华科学出版社Nova Science Publishers, Inc. (2015)

    点击查看原图


    Xin Wang (Editor),《CRISPR: Advances in Research and Applications》,ISBN:978-1-53612-946-5,美国诺华科学出版社Nova Science Publishers, Inc. (2017)

    点击查看原图



    参编书籍

    1 《基础与临床中药毒理学》P377-386,香港商务出版社(2009)

    2 《Caffeine Consumption and Health》P33-50,美国诺华科学出版社Nova Science Publishers, Inc. (2012)

    3 《Advances in Chemistry Research: Volume 15》P133-142, 美国诺华科学出版社Nova Science Publishers, Inc. (2012)

    4 《Cytochrome P450 Enzymes: Biochemistry, Pharmacology and Health Implications》P51-86, 美国诺华科学出版社Nova Science Publishers, Inc. (2014)


    发表论文

    Zhang Y, Huang J, Huang S, Liu J, Deng L, Liang C, Guo Y, Yao B, Wang X*. Construction and characterization of a humanized SLCO1B1 rat model with its application in evaluating the uptake of different statins. Acta Pharmaceutica Sinica B 2024, https://doi.org/10.1016/j.apsb.2023.12.019 (APSB推荐论文设计构建OATP1B1人源化大鼠模型用于研究他汀类药物的摄取转运


    Liu J, Lu J, Yao B, Zhang Y, Huang S, Chen X, Shen Y, Wang X*. Construction of humanized CYP1A2 rats using CRISPR/CRISPR-associated protein 9 to promote drug metabolism and pharmacokinetic research. Drug Metabolism and Disposition 2024, 52(1): 56-62.



    Chen X, Lu N, Huang S, Zhang Y, Liu Z, Wang X*Assessment of doxorubicin toxicity using human cardiac organoids: A novel model for evaluating drug cardiotoxicity. Chemico-Biological Interactions 2023, 386: 110777.

    Lu J, Shang X, Yao B, Sun D, Liu J, Zhang Y, Wang H, Shi J, Chen H, Shi T, Liu M, Wang X*. The role of CYP1A1/2 in cholesterol ester accumulation provides a new perspective for the treatment of hypercholesterolemiaActa Pharmaceutica Sinica B 2023, 13(2): 648-661. doi: 10.1016/j.apsb.2022.08.005 (APSB推荐论文https://mp.weixin.qq.com/s/Iz3uOmKRPQSwmJAh9CxOoA 

    Zhang Y, Lu J, Huang S, Zhang Y, Liu J, Xu Y, Yao B, Wang X*CYP2J deficiency leads to cardiac injury and presents dual regulatory effects on cardiac function in rats. Toxicology and Applied Pharmacology 2023, 473: 116610.

     

    Zhang Y, Gao J, Xu Y, Liu J, Huang S, Li G, Yao B, Sun Z, Wang X*Investigation of cytochrome P450 inhibitory properties of deoxyshikonin, a bioactive compound from Lithospermum erythrorhizon Sieb. et Zucc. Phytotherapy Research 2023, doi: 10.1002/ptr.7664. 

    Liu J, Shang X, Yao B, Zhang Y, Huang S, Guo YWang X*. Design and construction of carboxylesterase 2c gene knockout rats by CRISPR/Cas9. Current Drug Metabolism 2023, 24(3): 190-199.

    Fu T, Yao B, Guo Y, Zhang Y, Huang S, Wang X*. Establishment of LC–MS/MS method for quantifying chlorpromazine metabolites with application to its metabolism in liver and placenta microsomes. Journal of Pharmaceutical and Biomedical Analysis 2023, 233: 115457.

     Liao J, Chen S, Hsiao S, Jiang Y, Yang Y, Zhang Y, Wang X, Lai Y, Bauer DE, Wu Y. Therapeutic adenine base editing of human hematopoietic stem cells. Nature Communications 2023, 14(1): 207.

    Liu J, Yao B, Gao L, Zhang Y, Huang S, Wang X*.  Emerging role of carboxylesterases in nonalcoholic fatty liver disease. Biochemical Pharmacology 2022, 205: 115250. doi: 10.1016/j.bcp.2022.115250


    Zhang Y, Gao L, Yao B, Huang S, Zhang Y, Liu J, Liu Z, Wang X*. Role of epoxyeicosatrienoic acids in cardiovascular diseases and cardiotoxicity of drugs. Life Sciences 2022, 310: 121122. doi: 10.1016/j.lfs.2022.121122


    Zhang Y, Zhang L, Xu P, Qin X, Wang P, Cheng Y, Yao B, Wang X*. Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure. Biochemical Pharmacology 2022, 202:115160.


    Xu Y, Lu J, Guo Y, Zhang Y, Liu J, Huang S, Zhang Y, Gao L*, Wang X*. Hypercholesterolemia reduces the expression and function of hepatic drug metabolizing enzymes and transporters in rats. Toxicology Letters 2022, 364:1-11. doi.org/10.1016/j.toxlet.2022.05.009

    Yu J, Chen X, Zhang Y, Cui X, Zhang Z, Guo W, Wang D, Huang S, Chen Y, Hu Y, Zhao C, Qiu J, Li Y, Meng M, Guo M, Shen F, Zhang M, Zhou B, Gu X, Wang J, Wang X*, Ma X*, Xu L*. Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents. Theranostics 2022; 12(3): 1187-1203. doi:10.7150/thno.63067

    Gao J, Zhang Y, Lei X, Xu Y, Sun Z, Wang X*Risk assessment of the inhibition of hydroxygenkwanin on human and rat cytochrome P450 by cocktail method. Toxicol In Vitro 2022, 79:105281. doi: 10.1016/j.tiv.2021.105281.

    Wang X, Fa J, Zhang Y, Huang S, Liu J, Gao J, Xing L, Liu Z, Wang X*. Evaluation of herbdrug interaction between Danshen and rivaroxaban in rat and human liver microsomes. Frontiers in Pharmacology 2022, 13: 950525.

    Fu B, Liao J, Chen S, Li W, Wang Q, Hu J, Yang F, Hsiao S, Jiang Y, Wang L, Chen F, Zhang Y, Wang X, Li D, Liu M, Wu Y. CRISPR-Cas9-mediated gene editing of the BCL11A enhancer for pediatric β00 transfusion-dependent β-thalassemia. Nature Medicine 2022, 28(8):1573-1580.

    Wang W, He J, Yang J, Zhang C, Cheng Z, Zhang Y, Zhang Q, Wang P, Tang S, Wang X, Liu M, Lu W, Zhang HK. Scaffold Hopping Strategy to Identify Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy. Journal of Medicinal Chemistry 2022, 65(11):7896-7917.

    Jin Y, Liu Q, Chen P, Zhao S, Jiang W, Wang F, Li P, Zhang Y, Lu W, Zhong TP, Ma X, Wang X, Gartland A, Wang N, Shah KM, Zhang H, Cao X, Yang L, Liu M, Luo J. A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration. Cell Discovery 2022, 8(1): 24.

    Xing Y, Guo W, Wu M, Xie J, Huang D, Hu P, Zhou M, Zhang L, Zhang Q, Wang P, Wang X, Wang G, Wu H, Zhou C, Chen Y, Liu M, Yi Z, Sun Z. An orally available small molecule BCL6 inhibitor effectively suppresses diffuse large B cell lymphoma cells growth in vitro and in vivo. Cancer Letters 2022, 529: 100-111. 

    Lu J, Liu J, Guo Y, Zhang Y, Xu Y, Wang X*.  CRISPR-Cas9: A method for establishing rat models of drug metabolism and pharmacokinetics. Acta Pharmaceutica Sinica B 2021, 11(10): 2973-2982. doi.org/10.1016/j.apsb.2021.01.007


    Xu Y, Lu J, Yao B, Zhang Y, Huang S, Liu J, Zhang Y, Guo Y, Wang X*. P-glycoprotein mediates the pharmacokinetic interaction of olanzapine with fluoxetine in rats.Toxicology and Applied Pharmacology 2021, 431: 115735. https://doi.org/10.1016/j.taap.2021.115735

    Liu J, Shang X, Huang S, Xu Y, Lu J, Zhang Y, Liu Z, Wang X*. Construction and characterization of CRISPR/Cas9 knockout rat model of carboxylesterase 2a gene. Molecular Pharmacology 2021, 100(5): 480-490. DOI: https://doi.org/10.1124/molpharm.121.000357 (Editor choice paper)


    Liu J, Cheng Y, Zhang Y, Huang S, Liu Z, Wang X*. Lactobacillus rhamnosus induces CYP3A and changes the pharmacokinetics of verapamil in rats. Toxicology Letters 2021, 352: 46-53. https://doi.org/10.1016/j.toxlet.2021.09.010 


    Qin X, Zhang Y, Lu J, Huang S, Liu Z, Wang X*. CYP3A deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats. Toxicology and Applied Pharmacology 2021, 429: 115703. doi.org/10.1016/j.taap.2021.115703

      



    Zhang Y, Huang S, Zhong W, Chen W, Yao B, Wang X*. 3D organoids derived from the small intestine: An emerging tool for drug transport research. Acta Pharmaceutica Sinica B 2021, 11(7): 1697-1707. doi.org/10.1016/j.apsb.2020.12.002


    Zhang Y, Huang S, Liu J, Wang X*. Construction and application of innovation gene-edited rats and intestinal 3D organoids models in drug metabolism and pharmacokinetics. Chinese Journal of Clinical Pharmacology and Therapeutics 2021, 26(8): 914-922. (Cover story)


    Huang S, Zhang Y, Zhang Y, Liu J, Liu Z, Wang X*. Establishment of LC-MS/MS method for determination of aloperine in rat plasma and its application in preclinical pharmacokinetics. Journal of Chromatography B 2021, 1173(2):122671. doi.org/10.1016/j.jchromb.2021.122671

    Sun D, Lu J, Zhang Y, Liu J, Liu Z, Yao B, Guo Y, Wang X*. Characterization of a novel CYP1A2 knockout rat model constructed by CRISPR/Cas9. Drug Metabolism and Disposition 2021, 49(8): 638-647.

    Chen A, Zhang Y, Sun D,  Xu Y, Guo Y, Wang X*. Investigation of the content differences of arachidonic acid metabolites in a mouse model of breast cancer by using LC–MS/MS. Journal of Pharmaceutical and Biomedical Analysis 2021, 194: 113763.

    Lu W, Yu W, He J, Liu W, Yang J, Lin X, Zhang Y, Wang X, Jiang W, Luo J, Zhang Q, Yang H, Peng S, Yi Z, Ren S, Chen J, Siwko S, Nussinov R, Cheng F, Zhang H, Liu M. Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer. EMBO Molecular Medicine 2021, 13(1): e12798.

    Lu J, Chen A, Ma X, Shang X, Zhang Y, Guo Y, Liu M, Wang X*. Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model. 


    Ma X, Shang X, Qin X, Lu J, Liu M, Wang X*. Characterization of organic anion transporting polypeptide 1b2 knockout rats generated by CRISPR/Cas9: A novel model for drug transport and hyperbilirubinemia disease. Acta Pharmaceutica Sinica B 2020, 10(5): 850-860. doi:10.1016/j.apsb.2019.11.007

    Luo H, Xu Y, Sun D, Cheng Y, Sun Z, Gao J, Zhang Y, Wang X*. Assessment of the inhibition risk of paris saponins, bioactive compounds from Paris polyphylla, on CYP and UGT enzymes via cocktail inhibition assays. Regulatory Toxicology and Pharmacology 2020, 113: 104637.doi:10.1016/j.yrtph.2020.104637


    Lu J, Shang X, Zhong W, Xu Y, Shi R, Wang X*. New insights of CYP1A in endogenous metabolism:a focus on single nucleotide polymorphisms and diseases. Acta Pharmaceutica Sinica B 2020, 10: 91-104. doi:10.1016/j.apsb.2019.11.016


    Yang JJ, Yu WW, Hu LL, Liu WJ, Lin XH, Wang W, Zhang Q, Wang PL, Tang SW, Wang X, Liu M, Lu W, Zhang HK. Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy. Journal of Medicinal Chemistry 2020, 63(2): 569-590. 

    Ma X, Qin X, Shang X, Liu M, Wang X*. Organic anion transport polypeptide 1b2 selectively affects the pharmacokinetic interaction between paclitaxel and sorafenib in rats. Biochemical Pharmacology 2019, 169:113612. doi:10.1016/j.bcp.2019.08.014

    点击查看原图

    Li Y, Meng Q, Yang M, Liu D, Hou X, Tang L, Wang X#, Lyu Y, Chen X, Liu K, Yu A, Zuo Z, Bi H. Current Trends in Drug Metabolism and Pharmacokinetics. Acta Pharmaceutica Sinica B 2019, 9: 1113-1144. doi:10.1016/j.apsb.2019.10.001


    点击查看原图


    Qin X, Wang X*. Role of vitamin D receptor in the regulation of CYP3A gene expression. Acta Pharmaceutica Sinica B 2019, 9: 1087-1098. doi:10.1016/j.apsb.2019.03.005



    Zhang L, Xu P, Cheng Y, Wang P, Ma X, Liu M, Wang X*, Xu F*. Diet-induced obese alters the expression and function of hepatic drug-metabolizing enzymes and transporters in rats. Biochemical Pharmacology 2019, 164: 368-376. doi:10.1016/j.bcp.2019.05.002


    Liang C, Zhao J, Lu J, Zhang Y, Ma X, Shang X, Li Y, Ma X, Liu M,‍ Wang X*. Development and characterization of MDR1 (Mdr1a/b) CRISPR/Cas9 knockout rat model. 

    Cheng Y, Tang S, Chen A, Zhang Y, Liu M, Wang X*. Evaluation of the inhibition risk of shikonin on human and rat UDP-glucuronosyltransferases (UGT) through the cocktail approach. Toxicology Letters 2019, 312: 214-221. doi: 10.1016/j.toxlet.2019.05.017


    Zhang L, Liang C, Xu P, Liu M, Xu F*, Wang X*. Characterization of in vitro Mrp2 transporter model based on intestinal organoids. Regulatory Toxicology and Pharmacology 2019, 108: 104449. doi:10.1016/j.yrtph.2019.104449


    点击查看原图


    Tang S, Ma X, Lu J, Zhang Y, Liu M, Wang X*. Preclinical toxicology and toxicokinetic evaluation of ailanthone, a natural product against castration-resistant prostate cancer, in mice. Fitoterapia 2019, 136: 104161. doi:10.1016/j.fitote.2019.04.016




    Li Y, He Y, Shao T, Pei H, Guo W, Mi D, Krimm I, Zhang Y, Wang P, Wang X, Liu M, Yi Z, Chen Y. Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin. Journal of Medicinal Chemistry 2019, 62(10):4949-4966. 

    Su L, Li J, Zhou Z, Huang D, Zhang Y, Pei H, Guo W, Wu H, Wang X, Liu M, Yang CG, Chen Y. Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents. European Journal of Medicinal Chemistry 2019, 162: 203-211. doi: 10.1016/j.ejmech.2018.11.016. 

    He Y, Peng S, Wang J, Chen H, Cong X, Chen A, Hu M, Qin M, Wu H, Gao S, Wang L, Wang X*, Yi Z*, Liu M*. Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nature Communications 2016, 7: 13122.

    Cancer: Antimalarial agent shows potential for prostate cancer treatment(Nature Communications)

    点击查看原图

    A drug used for malaria could stop prostate cancer tumours growing

    Prostate cancer NEWS: Deadly tumours could be treated with MALARIA drug


    Wang P, Qin X, Liu M, Wang X*. The burgeoning role of cytochrome P450-mediated vitamin D metabolites against colorectal cancer. Pharmacological Research 2018, 133: 9-20. doi:10.1016/j.phrs.2018.04.022


    点击查看原图








    Qin X, Wang X*Quantification of nucleotides and their sugar conjugates in biological samples: Purposes, instruments and applications. Journal of Pharmaceutical and Biomedical Analysis 2018, 158: 280-287. doi:10.1016/j.jpba.2018.06.013 (The invited review)

    Lu J, Liu D, Zhou X, Chen A, Jiang Z, Ye X, Liu M, Wang X*.Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme. Phytomedicine 2018, 39: 137-145. doi: 10.1016/j.phymed.2017.12.026







    Chen A, Zhou X, Cheng Y, Tang S, Liu M, Wang X*Design and optimization of the cocktail assay for rapid assessment of the activity of UGT enzymes in human and rat liver microsomes. Toxicology Letters 2018, 295: 379-389. doi: 10.1016/j.toxlet.2018.07.021

    Li J, Li L, Qin X, Degrace P,  Demizieux L, Limbu S, Wang X, Zhang M, Li D, Du Z. Inhibited carnitine synthesis causes systemic alteration of nutrient metabolism in zebrafish. Frontiers in Physiology 2018, 9: 509. doi:10.3389/fphys.2018.00509

    Zhang L, Zhao J, Liang C, Liu M, Xu F*Wang X*A novel biosensor based on intestinal 3D organoids for detecting the function of BCRP. Drug Delivery 2017, 24: 1453-1459. doi:10.1080/10717544.2017.1381199

    Tang S, Chen A, Zhou X, Zeng L, Liu M, Wang X*. Assessment of the inhibition risk of shikonin on cytochrome P450 via cocktail inhibition assay. Toxicology Letters 2017, 281: 74-83. doi: 10.1016/j.toxlet.2017.09.014

    点击查看原图














    Qin X, Lu J, Wang P, Xu P, Liu M, Wang X*Cytochrome P450 3A selectively affects the pharmacokinetic interaction between erlotinib and docetaxel in rats. Biochemical Pharmacology 2017, 143: 129-139. doi:10.1016/j.bcp.2017.07.013



    Lu J, Zhang Y, Sun M, Liu M, Wang X*. Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein. Phytomedicine 2017, 26: 1-10.

    点击查看原图


    Lu J, Shao Y, Qin X, Liu D, Chen A, Li D*, Liu M*Wang X*. CRISPR knockout rat cytochrome P450 3A1/2 model for advancing drug metabolism and pharmacokinetics research. Scientific Reports 2017, 7: 42922.

    点击查看原图

    Li JM, Li LY, Qin X, Ning LJ, Lu DL, Li DL, Zhang ML, Wang X*, Du ZY*. Systemic regulation of L-carnitine in nutritional metabolism in zebrafish, Danio rerio. Scientific Reports 2017, 7: 40815.

    Qin X, Chen A, Lu J, Zhang YJ, Liu MY, Wang X*. Evaluation of plasma stability and pharmacokinetics of parthenolide in rats with LC-MS/MS analysis. Acta Pharmaceutica Sinica 2017, 52: 609-614. doi:10.16438/j.0513-4870.2016-1006

    点击查看原图

    Wang X*, Tang Y, Lu J, Shao Y, Qin X, Li Y, Wang L, Li D, Liu M. Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9. Biochemical Pharmacology 2016, 105: 80-90.

    Qin X, Liu M, Wang X*. New insights into the androgen biotransformation in prostate cancer: a regulatory network among androgen, androgen receptors and UGTs. Pharmacological Research 2016, 106: 114-22.

    点击查看原图

    Zhao J, Zeng Z, Sun J, Zhang Y, Li D, Zhang X, Liu M, Wang X*. A Novel Model of P-Glycoprotein Inhibitor Screening Using Human Small Intestinal Organoids. Basic & Clinical Pharmacology & Toxicology 2017, 120: 250-255.

    点击查看原图

    Chen A, Zhou X, Tang S, Liu M, Wang X*. Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach.  Scientific Reports 2016, 6: 28482.

    点击查看原图

    Zhang Y, Zeng Z, Zhao J, Li D, Liu M, Wang X*Measurement of Rhodamine 123 in Three-Dimensional Organoids: A Novel Model for P-Glycoprotein Inhibitor Screening. Basic & Clinical Pharmacology & Toxicology 2016, 119: 349-352.

    点击查看原图

    Qin M, Peng S, Liu N, Hu M, He Y, Li G, Chen H, He Y, Chen A, Wang X, Liu M, Chen Y, Yi Z. LG308, a novel synthetic compound with anti-microtubule activity in prostate cancer cells, exerts effective antitumor activity. J Pharmacol Exp Ther 2015, 355: 473-483. 

    Lu J, Ding T, Qin X, Liu M, Wang X*. In vitro and in vivo evaluation of cucurbitacin E on rat hepatic CYP2C11 expression and activity using LC-MS/MS. Sci China Life Sci 2017, 60: 215-224. doi10.1007/s11427-015-4911-7. 

    Zheng C, Zhou W, Wang T, You P, Zhao Y, Yang Y, Wang X, Luo J, Chen Y, Liu M, Chen H. A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-Cells in Type 2 Diabetic Mice. PLoS One 2015 Jul 24;10(7): e0134051. doi: 10.1371/journal.pone.0134051.

    Chen A, Qin X, Lu J, Yi Z, Liu M, Wang X*. Development of a validated LC-MS/MS method for the determination of ailanthone in rat plasma with application to pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis 2015, 102: 514-518.

    点击查看原图

    Sun M, Tang Y, Ding T, Liu M, Wang X*. Investigation of cytochrome P450 inhibitory properties of maslinic acid, a bioactive compound from Olea europaea L., and its structure-activity relationship. Phytomedicine 2015, 22: 56-65.

    Ding T, Zhang Y, Chen A, Tang Y, Liu M, Wang X*. Effects of Cucurbitacin E, a Tetracyclic Triterpene Compound from Cucurbitaceae, on the Pharmacokinetics and Pharmacodynamics of Warfarin in Rats. Basic & Clinical Pharmacology & Toxicology 2015, 116: 385-389. DOI: 10.1111/bcpt.12329

    Yang F, Zhang T, Wu H, Yang Y, Liu N, Chen A, Li Q, Li J, Qin L, Jiang B, Wang X, Pang X, Yi Z, Liu M, Chen Y. Design and Optimization of Novel Hydroxamate-Based Histone Deacetylase Inhibitors of Bis-Substituted Aromatic Amides Bearing Potent Activities against Tumor Growth and Metastasis. Journal of Medicinal Chemistry 2014, 57: 9357-9369. DOI: 10.1021/jm5012148

    Chen A, Qin X, Tang Y, Liu M, Wang X*. Evaluation of enzyme inhibition kinetics in drug-drug interactions. Chemico-Biological Interactions 2014, 222: 133-134.

    Lu J, Qin X, Liu M, Wang X*. A note on CYP2J2-mediated terfenadine hydroxylation in human liver microsomes. Food and Chemical Toxicology 2014, 71: 284-285.

    Sun M, Tang Y, Ding T, Liu M, Wang X*. Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity. Fitoterapia 2014, 92: 1-8.

    Wang X*, Yeung JH. Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture. Phytomedicine 2012, 19: 348-354.

    Wang X*, Yeung JH. Inhibitory effect of tanshinones on rat CYP3A2 and CYP2C11 activity and its structure-activity relationship. Fitoterapia 2011, 82: 539-545.

    Wang X*, Yeung JH. Effects of Salvia miltiorrhiza extract on the liver CYP3A activity in humans and rats. Phytotherapy Research 2011, 25: 1653-1659.

    Wang X, Nanovskaya TN, Zhan Y, Abdel-Rahman SM, Hankins GD, Ahmed MS. Pharmacokinetics of metronidazole in pregnant patients with bacterial vaginosis. Journal of Maternal-Fetal and Neonatal Medicine 2011, 24: 444-448.

    Wang X*(Corresponding author), Yeung JH. Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats. Journal of Pharmacy and Pharmacology 2010, 62: 1077-1083.

    Wang X, Zhan Y, Rytting E, Patrikeeva S, Nanovskaya T, Clark S, et al. Pharmacokinetics of famotidine during pregnancy and postpartum. Journal of Clinical Pharmacology 2010, 50: 1076.

    Wang X, Cheung CM, Lee WY, Or PM, Yeung JH. Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro. Phytomedicine 2010, 17: 868-875.

    Wang X, Lee WY, Zhou X, Or PM, Yeung JH. A pharmacodynamic– pharmacokinetic (PD–PK) study on the effects of Danshen (Salvia miltiorrhiza) on midazolam, a model CYP3A probe substrate, in the rat. Phytomedicine 2010, 17: 876-883.

    Wang X, Lee WY, Or PM, Yeung JH. Pharmacokinetic interaction studies of tanshinones with tolbutamide, a model CYP2C11 probe substrate, using liver microsomes, primary hepatocytes and in vivo in the rat. Phytomedicine 2010, 17: 203-211.

    Wang X, Lee WY, Or PM, Yeung JH. Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates. Phytomedicine 2009, 16: 712-725.


    授权专利:

    1 发明人:王昕等。发明名称:一种检测肝微粒体中UGT酶活性的cocktail方法。专利号ZL201710045239.4, 授权日2020年7月14日,申请日2017年1月22日。

    2 发明人:王昕等。发明名称:人小肠3D类器官研究P-糖蛋白模型的构建方法和应用。专利号ZL201610345283.2, 授权日2020年1月7日,申请日2016年5月23日。

    3 发明人:王昕等。发明名称:Cyp基因敲除大鼠的培育方法及其肝微粒体的制备方法。专利号ZL201510131768.7, 授权日2019年9月26日,申请日2015年3月24日。

    4 发明人:王昕等。发明名称:一种检测3D类器官中P-gp介导Rh123转运的方法及应用。专利号ZL201510617275.4,授权日2018年8月24日,申请日2015年9月24日。

    5 发明人:王昕等。发明名称:用于检测转运的生物传感器及其应用。专利号ZL201810161920.X,授权日2021年4月9日,申请日2018年2月27日。

    发明人:王昕等。发明名称:一种Mdr1a/1b双基因敲除的方法及应用。专利号ZL201710771262.1,授权日2022年7月8日,申请日2017年8月31日。

    发明人:王昕等。Ces2基因敲除大鼠模型的构建方法和应用。专利号ZL202010533212.1

    发明人:王昕等。细胞色素P450酶人源化大鼠模型及其构建方法和应用。专利号ZL202010358608.7

    申请专利:

    1 发明人:王昕等。一种重组人源CYP3A4/CPR/cyt b5蛋白共转染共表达的方法。 申请号CN201410842611.0

    2 发明人:王昕等。一种小肠3D类器官研究BCRP介导药物转运模型的构建方法与应用。申请号CN201710320167.X

    3 发明人:王昕等。一种高效表达人源CYP2J2重组酶的方法和应用。申请号CN201710531480.8

    4 发明人:王昕等。一种Slco1b2基因敲除大鼠的培育方法及应用。申请号CN201811068044.2

    5 发明人:王昕等。一种利用3D类器官评价药物肠毒性的检测方法。申请号CN201910028168.6

    6 发明人:王昕等。一种滋养层类器官模型及其构建方法和应用。申请号CN202311486996.7


    欢迎青年才俊加入我们ECNU DMPK GROUP!

    本课题组一直从事生理活性物质的代谢转运及其调控疾病的机制研究,在国际上率先得到系列代谢酶及转运蛋白敲除大鼠,已取得多项国际领先的科研成果。课题组招收硕士,博士,同时招聘博士后,助理研究员和副研究员,欢迎青年才俊申请。





    荣誉及奖励

    第二十二届施维雅(SERVIER)青年药理学家奖(2018)

    第三届刘昌孝院士人才奖:优秀青年科技工作者奖(2017)

    第二十届中国药理学会青年药理学家(2016)

    《药学学报》中英文两刊优秀青年编委(2020)

    全国大学生生命科学创新创业大赛优秀指导教师一等奖(2020)

    华东师大研究生优秀毕业论文指导教师(2021)

    国际药理学知名期刊Journal of Ethnopharmacology 杰出贡献奖(2018)

    国际食品科学知名期刊Journal of Functional Foods 杰出贡献奖(2017)

    国际药学知名期刊Journal of Pharmaceutical and Biomedical Analysis 杰出贡献奖(2017,2016,2015)

    国际植物医学知名期刊Phytomedicine 杰出贡献奖(2016)