Yi-Hsuan Pan

2009 – 2011 

East China Normal University • School of Life Science • Postdoc • Laboratory of Molecular Biology and Evolution

2000 - 2005 

Institute of Biochemistry and Molecular Biology • National Yang-Ming University • Taipei, Taiwan • Master and Ph.D. • Molecular Biology and Protein Chemistry

1996 - 2000 

National Taiwan Ocean University•Keelung city • Bachelor • Aquaculture, Bioscience and Biotechnology

2018 - present–

East China Normal University • Associate Research Fellow • Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), Institute of Brain Functional Genomics, School of Life Sciences and the Collaborative Innovation Center for Brain Science

2011 – 2018

East China Normal University • School of Life Science • Associate Research Fellow • Laboratory of Molecular Biology and Evolution

Journal Referee: 

Antioxidants & Redox Signaling, 

Cryobiology, 

Frontiers in Microbiology, 

Journal of Proteomics, 

Frontiers in Genetics

Using multidisciplinary strategies, I study the molecular basis of autism and investigate ultra-long-acting blood sugar control mechanism of DMH-1. I also investigate the evolutionary mechanism of genes, populations, and mammalian hibernation.

Research directions:

1. Brain Development and Diseases

2. Molecular Ecology and Evolution  

3. Regulation of Blood Glucose Level in Type 2 Diabetes

Websites: 

https://www.researchgate.net/profile/Yi-Hsuan_Pan; 

http://orcid.org/0000-0001-5156-9887

Nutrition - 2013 English Demonstration Course, Shanghai (Undergraduate, 2021—2023 Elective course for liberal education)

Contemporary Ecology (Graduate, Major elective course)

Biochemistry and Molecular Biology (Graduate, basic, Major required course)

Scientific Writing (Graduate, Major required- or elective- course)

Advances in Modern Biology - Omics Research (Graduate, Major required course)

Research Progress and Medical Application of Hibernation (Graduate, Major elective course)

Psychobiotics, Brain function and diseases

Nan Wu, Yue Wang, Jing-Yan Jia, Yi-Hsuan Pan*, Xiao-Bing Yuan*. Association of CDH11 with Autism Spectrum Disorder Revealed by Matched-gene Co-expression Analysis and Mouse Behavioral Studies. Neuroscience Bulletin (2022) 38: 29-46. doi.org/10.1007/s12264-021-00770-0

Zhang, X., Yi-Hsuan Pan, Chen, Y., Pan, C., Ma, J., Yuan, C., Yu, G. and Ma, J*. The protease-sensitive N-terminal polybasic region of prion protein modulates its conversion to the pathogenic prion conformer. Journal of Biological Chemistry (2021) p.101344.

Yuting Wang^#, Guangyi Dai^#, Zhili Gu^#, Guopeng Liu^#, Ke Tang, Yi-Hsuan Pan, Yujie Chen, Xin Lin, Nan Wu, Haoshan Chen, Su Feng, Shou Qiu, Hongduo Sun, Qian Li, Chuan Xu, Yanan Mao, Yong Edward Zhang, Philipp Khaitovich, Yan-Ling Wang, Qunxiu Liu, Jing-Dong Jackie Han, Zhen Shao, Gang Wei, Chun Xu, Naihe Jing and Haipeng Li*. Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies. Cell Research (2020) 30:408-420. doi.org/10.1038/s41422-020-0308-7

Chenhua Pan, Junwei Yang, Xiangyi Zhang, Ying Chen, Shunxiong Wei, Guohua Yu, Yi-Hsuan Pan, Jiyan Ma*, Chonggang Yuan*. Oral ingestion of synthetically generated recombinant prion is sufficient to cause prion disease in wild-type mice. Pathogens (2020) 9 (8), 653. doi.org/10.3390/pathogens9080653.

Yi-Hsuan Pan, Wu Nan, Xiao-Bing Yuan*. Toward a better understanding of neuronal migration deficits in autism spectrum disorders. Front. Cell Dev. Biol (2019). doi:10.3389/fcell.2019.00205

Chunlei Wang, Yi-Hsuan Pan, Yue Wang, Gene Blatt and Xiao-Bing Yuan*. Segregated expressions of autism risk genes Cdh11 and Cdh9 in autism-relevant regions of developing cerebellum. Molecular Brain (2019). doi.org/10.1186/s13041-019-0461-4

Rui Zhu, Yi-Hsuan Pan, Lijie Sun, Tianhao Zhang, Caiyun Wang, Shuai Ye, Ning Yang, Tiantian Lu, Thomas Wisniewski, Suying Dang*, Wei Zhang*. ADAMTS18 deficiency affects neuronal morphogenesis and reduces the levels of depression-like behaviors in mice. Neuroscience (2019). doi.org/10.1016/j.neuroscience.2018.12.025

Molecular Ecology and Evolution

Wangjie Hu^#, Ziqian Hao^#, Pengyuan Du, Fabio Di Vincenzo, Giorgio Manzi, Jialong Cui, Yun-Xin Fu, Yi-Hsuan Pan*, Haipeng Li*. Genomic inference of a severe human bottleneck during the Early to Middle Pleistocene transition. Science. (2023) 381: 6661 doi: 10.1126/science.abq7487; https://www.science.org/stoken/author-tokens/ST-1403/full

Jianing Yang^#, Yingmin Cui^#, Dalang Yu^#, Guoqing Zhang^#, Ruifang Cao, Zhili Gu, Guangyi Dai, Xiaoxian Wu, Yunchao Ling, Chunyan Yi, Xiaoyu Sun, Bing Sun, Xin Lin, Yu Zhang, Guo-Ping Zhao*, Yixue Li*, Yi-Hsuan Pan*, Haipeng Li*. A Noncoding A-to-U Kozak Site Change Related to the High Transmissibility of Alpha, Delta, and Omicron VOCs. Molecular Biology and Evolution (2023) 40: 6 doi.org/10.1093/molbev/msad142

Yang-Yang Li^#, Qing-Yun Lv^#, Gun-Tao Zheng, Di Liu, Ji Ma, Gui-Mei He, Li-Biao Zhang, Shan Zheng, Hai-Peng Li*, Yi-Husan Pan*. Unexpected expression of heat-activated transient receptor potential (TRP) channels in winter torpid bats and cold-activated TRP channels in summer active bats. Zoological Research (2022) 43(1): 52-63. doi: 10.24272/j.issn.2095-8137.2021.209

Dalang Yu^#, Junwei Zhu^#, Jianing Yang^#, Yi-Hsuan Pan^#, Hailong Mu, Ruifang Cao, Bixia Tang, Guangya Duan, Zi-Qian Hao, Long Dai, Guo-Ping Zhao, Ya-Ping Zhang, Wenming Zhao, Guoqing Zhang*, Haipeng Li*.  Global cold-chain related SARS-CoV-2 transmission identified by pandemic-scale phylogenomics. Zoological Research (2022) 43 (5): 871. doi: 10.24272/j.issn.2095-8137.2022.238

Dalang Yu^#, Xiao Yang^#, Bixia Tang^#, Yi-Hsuan Pan^#, Jianing Yang^#, Junwei Zhu^#, Guangya Duan, Zi-Qian Hao, Hailong Mu, Long Dai, Wangjie Hu, Mochen Zhang, Ying Cui, Tong Jin, Cuiping Li, Lina Ma, Xiao Su, Guo-Qing Zhang*, Wenming Zhao*, Haipeng Li*. Coronavirus GenBrowser for monitoring the transmission and evolution of SARS-CoV-2. Briefings in Bioinformatics (2022). doi.org/10.1093/bib/bbab583

Ziqian Hao, Pengyuan Du, Yi-Husan Pan*, Haipeng Li*. Fine human genetic map based on UK10K data set. Human Genetics (2022). doi.org/10.1007/s00439-021-02415-8

Dalang Yu, Junwei Zhu, Jianing Yang, Yi-Hsuan Pan, Hailong Mu, Ruifang Cao, Bixia Tang, Guangya Duan, Zi-Qian Hao, Long Dai, Guo-Ping Zhao, Ya-Ping Zhang, Wenming Zhao*, Guoqing Zhang*, Haipeng Li*. Global Cold-Chain Related SARS-CoV-2 Transmission. (October 30, 2021) Available at SSRN: https://ssrn.com/abstract=3953300 or http://dx.doi.org/10.2139/ssrn.3953300

Guopeng Liu^#, Chunxiao Zhang^#, Yuting Wang^#, Guangyi Dai, Shu-Qun Liu, Wenshuai Wang, Yi-Hsuan Pan*, Jianping Ding*, and Haipeng Li*. New exon and accelerated evolution of placental gene Nrk occurred in the ancestral lineage of placental mammals. Placenta (2021) 114: 14-21. doi.org/10.1016/j.placenta.2021.08.048

Wenjie Huang^#, Chen-Chung Liao^#, Yijie Han, Junyan Lv, Ming Lei, Yangyang Li, Qingyun Lv, Dong Dong, Shuyi Zhang, Yi-Husan Pan*, Jian Luo*.Co-activation of Akt, Nrf2, and NF-κB signals under UPR_ER in torpid Myotis ricketti bats for survival. Communications Biology (2020). doi.org/10.1038/s42003-020-01378-2

H Sun, J Wang, Y Xing, Yi-Hsuan Pan, X Mao*. Gut transcriptomic changes during hibernation in the greater horseshoe bat (Rhinolophus ferrumequinum). Frontiers in Zoology (2020) 17, Article number: 21. doi.org/10.1186/s12983-020-00366-w.

Huiling Xue^#, Zhe Wang^#, Yongjie Hua, Shanshan Ke, Yao Wang, Junpeng Zhang, Yi-Hsuan Pan, Wenjie Huang, David M. Irwin, Shuyi Zhang*. Molecular signatures and functional analysis of beige adipocytes induced from in vivo intra-abdominal adipocytes. Science Advances (2018). doi: 10.1126/sciadv.aar5319

Di Liu, Shenghui Zheng, Guantao Zheng, Qingyun Lv, Bin Shen, Xinpu Yuan, Yi-Hsuan Pan*. Adaptation of the FK506 Binding Protein 1B to Hibernation in Bats. Cryobiology (2018). doi.org/10.1016/j.cryobiol.2018.07.004

Qiuyuan Yin^#, Yijian Zhang^#, Dong Dong, Ming Lei, Shuyi Zhang, Chen-Chung Liao*, Yi-Hsuan Pan*. Maintenance of neural activities in torpid Rhinolophus ferrumequinum bats revealed by 2D gel-based proteome analysis. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2017). doi.org/10.1016/jbbapap.2017.04.006

Dong Dong, Ming Lei, Panyu Hua,Yi-Hsuan Pan, Shuo Mu, Guantao Zheng, Erli Pang, Kui Lin, and Shuyi Zhang*. The Genomes of Two Bat Species with Long Constant Frequency Echolocation Calls. Molecular Biology and Evolution (2016). doi.10.1093/molbev/msw231

Qiuyuan Yin, Hanxiao Ge, Chen-Chong Liao, Di Liu, Shuyi Zhang*, and Yi-Hsuan Pan*. Antioxidant Defenses in the Brains of Bats during Hibernation. PLoS ONE (2016) (3): e0152135. doi: 10.1371/journal.pone. 0152135

Qiuyuan Yin, Lei Zhu, Di Liu, David M. Irwin, Shuyi Zhang*, and Yi-Hsuan Pan*. Molecular Evolution of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene Nrf2 in Old World Fruit Bats (Chiroptera: Pteropodidae). PLoS ONE (2016) 11(1): e0146274. doi:10.1371/journal. pone.0146274

Yijie Han, Guantao Zheng, Tianxiao Yang, Shuyi Zhang, Dong Dong, and Yi-Hsuan Pan*. Adaptation of Peroxisome Proliferator-activated Receptor alpha to Hibernation in Bats. BMC Evolutionary Biology (2015). doi:10.1186/s12862-015-0373-6

Yih-Huei Uena, Chen-Chung Liao, Jung-Chun Lin,Yi-Hsuan Pan, Yi-Chung Liu, You-Chia Chen, Wei-Jung Chen, Chih-Chun Tai, Kuan-Wei Lee, Yun-Ru Liu, Hung-TseLine, Ching-Yu Lin^*. Analysis of differentially expressed novel post-translational modifications of plasma apolipoprotein E in Taiwanese females with breast cancer. Journal of Proteomics (2015) 126: 252 262. doi.org/10.1016/j.jprot.2015.05.038

Ming Lei, Dong Dong*, Shuo Mu, Yi-Hsuan Pan, and Shuyi Zhang*. Comparison of brain transcriptomes between active and torpid episodes of the greater horseshoe bats (Rhinolophus ferrumequinum). PLoS ONE (2014). doi: 10.1371/journal.pone.0107746.

Yijian Zhang^#, Yi-Hsuan Pan^#, Qiuyuan Yin, Tianxiao Yang, Dong Dong, Chen-Chung Liao* and Shuyi Zhang*. Critical Roles of Mitochondria in Brain Activities of Torpid Myotis ricketti Bats Revealed by a Proteomic Approach. Journal of Proteomics (2014) 105 (13): 266-284.

Yijian Zhang, Tengteng Zhu, Lina Wang, Yi-Hsuan Pan* and Shuyi Zhang*. Homocysteine Homeostasis and Betaine-Homocysteinem S-methyltransferase Expression in the Brian of Hibernating Bats. PLoS ONE (2013). doi: 10.1371/journal.pone.0085632.

Yi-Hsuan Pan, Yijian Zhang, Jie Cui, Yang Liu, Bronwyn M. McAllan, Chen-Chung Liao^*, Shuyi Zhang^*. Adaptation of Phenylalanine and Tyrosine Catabolic Pathway to Hibernation in Bats. PLoS ONE (2013) doi.org/10.1371/journal.pone.0062039.

Lingjiang He^#‚ Yi-Hsuan Pan^#‚ Guimei He‚ Benfu Lin‚ Chen-Chung Liao‚ Xueguo Zuo‚ Lihong Yuan^*. Structural and functional studies of leptins from hibernating and non-hibernating bats. General and Comparative Endocrinology (2010) 168.

Jie Cui^#‚ Yi-Hsuan Pan^#‚ Yijian Zhang‚ Gareth Jones‚ Shuyi Zhang*. Progressive Pseudogenization: Vitamin C Synthesis and Its Loss in Bats. Molecular Biology and Evolution (2011) 28 (2):1025–103

Pan Y-H.‚ Liao C-C.‚ Duan K-J‚ Liang P-H‚ Yuan H-S.‚ Hu S-T‚ Chak K-F*. The critical roles of polyamines in regulating ColE7 production and restricting ColE7 uptake of the colicin producing Escherichia coli. Journal of Biological Chemistry (2006) 281(19):13083-13091.

Physiological functions of ADAMTS-18

N. Yang^# Q. Zhang^#, S. Ye, T. Lu, M. Sun, L. Wang, M. Wang, Yi-Hsuan Pan, S. Dang*, and W. Zhang*. Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice. Journal of Dental Research (2022) 101 (2), 226-234. doi.org/10.1177/00220345211029270

Xiaotian Lin^#, Caiyun Wang^#, Qi Zhang, Yi-Hsuan Pan, Suying Dang*, Wei Zhang*. ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice. Reproductive Biology (2021). doi.org/10.1016/j.repbio.2021.100537

Shuai Ye, Ning Yang, Tiantian Lu, Taojing Wu, Liya Wang, Yi-Hsuan Pan, Xiaohua Cao, Xiaobing Yuan, Thomas Wisniewski, Suying Dang*, Wei Zhang* ADAMTS18 Modulates the Development of Aortic Arch and Common Carotid Artery. iScience (2021). doi.org/10.1016/j.isci.2021.102672

Tiantian Lu, Xiaotian Lin,Yi-Hsuan Pan, NingYang, ShuaiYe, Qi Zhang, Caiyun Wang, Rui Zhu, Tianhao Zhang, Thomas M. Wisniewski, Zhongwei Cao, Bi-Sen Ding, Suying Dang*, WeiZhang*. ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation. iScience (2020). doi.org/10.1016/j.isci.2020.101472.

Tiantian Lu, Tianhao Zhang, Caiyun Wang, Ning Yang, Yi-Hsuan Pan, Suying Dang, Wei Zhang*. Adamts18 deficiency in zebrafish embryo causes defective trunk angiogenesis and caudal vein plexus formation. Biochemical and Biophysical Research Communications (2020). doi.org/10.1016/j.bbrc.2019.10.202

Rui Zhu, Yi-Hsuan Pan, Tiantian Lu, Suying Dang, Chen-Chung Liao and Wei Zhang*. Vascular Proteomics Reveals Critical Roles of ADAMTS18 in Stroke Associated with Imbalanced Level of Von Willebrand Factor Versus ADAMTS13. Blood (2018). doi.org/10.1182/blood-2018-99-110341

Rui Zhu, Mengting Cheng, Tiantian Lu, Ning Yang, Shuai Ye, Yi-Hsuan Pan, Tao Hong, Suying Dang, Wei Zhang*. A Disintegrin and Metalloproteinase with Thrombospondin Motifs 18 Deficiency Leads to Visceral Adiposity and Associated Metabolic Syndrome in Mice. The American Journal of Pathology (2017). doi.org/10.1016/j.ajpath.2017.10.020

科普词条创建

精神益生菌（百度百科）2019/08/22，创建者：潘逸萱（YHPJP)

https://baike.baidu.com/item/%E7%B2%BE%E7%A5%9E%E7%9B%8A%E7%94%9F%E8%8F%8C/23691919 

科普文章

新型冠状病毒源于自然而非实验室，科学网，2020/0212，作者：李海鹏，潘逸萱，赵方庆，苏枭

https://news.sciencenet.cn/htmlnews/2020/2/435662.shtm

科普视频

为何说人类曾险遭灭绝，湖南卫视，新闻大求真栏目 — 芒果TV，2023/09/19，华师大/潘逸萱。

https://www.mgtv.com/b/510426/19780429.html 

其它

校稿 应用分子生物学（ISBN 978-957-616-918-2, 2007），李昭鋐教授，艺轩图书出版社。

阳明大学博士班优良论文奖学金（2005）。

International Conference on polyamines Best Poster and Presentation Award (2004) awarded by Prof. Kazuei Igarashi et al.

阳明大学硕士班优良学术论文奖学金（2001）。

海洋大学水产养殖系书卷奖（1999）。