生命科学学院

学术成果

Brain Development and Diseases

Wei Shang, Shuangyi Xie, Wenbo Feng, Zhuangzhuang Li, Jingyan Jia, Xiaoxiao Cao, Yanting Shen, Jing Li, Haibo Shi, Yiran Gu, Shi- Jun Weng, Longnian Lin, Yi-Hsuan Pan*, Xiao-Bing Yuan*. A non-image-forming visual circuit mediates the innate fear of heights in male mice. Nature Communications (2024)15: 3746. DOI: 10.1038/s41467-024-48147-x

Nan Wu, Yue Wang, Jing-Yan Jia, Yi-Hsuan Pan*, Xiao-Bing Yuan*. Association of CDH11 with Autism Spectrum Disorder Revealed by Matched-gene Co-expression Analysis and Mouse Behavioral Studies. Neuroscience Bulletin (2022) 38: 29-46. DOI: 10.1007/s12264-021-00770-0

Zhang, X., Yi-Hsuan Pan, Chen, Y., Pan, C., Ma, J., Yuan, C., Yu, G. and Ma, J*. The protease-sensitive N-terminal polybasic region of prion protein modulates its conversion to the pathogenic prion conformer. Journal of Biological Chemistry (2021) 297:5 p.101344. DOI: 10.1016/j.jbc.2021.101344

Yuting Wang^#, Guangyi Dai^#, Zhili Gu^#, Guopeng Liu^#, Ke Tang, Yi-Hsuan Pan, Yujie Chen, Xin Lin, Nan Wu, Haoshan Chen, Su Feng, Shou Qiu, Hongduo Sun, Qian Li, Chuan Xu, Yanan Mao, Yong Edward Zhang, Philipp Khaitovich, Yan-Ling Wang, Qunxiu Liu, Jing-Dong Jackie Han, Zhen Shao, Gang Wei, Chun Xu, Naihe Jing and Haipeng Li*. Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies. Cell Research (2020) 30:408-420. DOI: 10.1038/s41422-020-0308-7

Chenhua Pan, Junwei Yang, Xiangyi Zhang, Ying Chen, Shunxiong Wei, Guohua Yu, Yi-Hsuan Pan, Jiyan Ma*, Chonggang Yuan*. Oral ingestion of synthetically generated recombinant prion is sufficient to cause prion disease in wild-type mice. Pathogens (2020) 9 (8), 653. DOI: 10.3390/pathogens9080653.

Yi-Hsuan Pan, Wu Nan, Xiao-Bing Yuan*. Toward a better understanding of neuronal migration deficits in autism spectrum disorders. Front. Cell Dev. Biol (2019). DOI: 10.3389/fcell.2019.00205

Chunlei Wang, Yi-Hsuan Pan, Yue Wang, Gene Blatt and Xiao-Bing Yuan*. Segregated expressions of autism risk genes Cdh11 and Cdh9 in autism-relevant regions of developing cerebellum. Molecular Brain (2019). DOI: 10.1186/s13041-019-0461-4

Rui Zhu, Yi-Hsuan Pan, Lijie Sun, Tianhao Zhang, Caiyun Wang, Shuai Ye, Ning Yang, Tiantian Lu, Thomas Wisniewski, Suying Dang*, Wei Zhang*. ADAMTS18 deficiency affects neuronal morphogenesis and reduces the levels of depression-like behaviors in mice. Neuroscience (2019). DOI: 10.1016/j.neuroscience.2018.12.025

Molecular Ecology and Evolution

Wangjie Hu^#, Ziqian Hao^#, Pengyuan Du, Fabio Di Vincenzo, Giorgio Manzi, Jialong Cui, Yun-Xin Fu, Yi-Hsuan Pan*, Haipeng Li*. Genomic inference of a severe human bottleneck during the Early to Middle Pleistocene transition. Science. (2023) 381: 6661 DOI: 10.1126/science.abq7487; https://www.science.org/stoken/author-tokens/ST-1403/full

Jianing Yang^#, Yingmin Cui^#, Dalang Yu^#, Guoqing Zhang^#, Ruifang Cao, Zhili Gu, Guangyi Dai, Xiaoxian Wu, Yunchao Ling, Chunyan Yi, Xiaoyu Sun, Bing Sun, Xin Lin, Yu Zhang, Guo-Ping Zhao*, Yixue Li*, Yi-Hsuan Pan*, Haipeng Li*. A Noncoding A-to-U Kozak Site Change Related to the High Transmissibility of Alpha, Delta, and Omicron VOCs. Molecular Biology and Evolution (2023) 40: 6 DOI: 10.1093/molbev/msad142

Yang-Yang Li^#, Qing-Yun Lv^#, Gun-Tao Zheng, Di Liu, Ji Ma, Gui-Mei He, Li-Biao Zhang, Shan Zheng, Hai-Peng Li*, Yi-Husan Pan*. Unexpected expression of heat-activated transient receptor potential (TRP) channels in winter torpid bats and cold-activated TRP channels in summer active bats. Zoological Research (2022) 43(1): 52-63. DOI: 10.24272/j.issn.2095-8137.2021.209

Dalang Yu^#, Junwei Zhu^#, Jianing Yang^#, Yi-Hsuan Pan^#, Hailong Mu, Ruifang Cao, Bixia Tang, Guangya Duan, Zi-Qian Hao, Long Dai, Guo-Ping Zhao, Ya-Ping Zhang, Wenming Zhao, Guoqing Zhang*, Haipeng Li*. Global cold-chain related SARS-CoV-2 transmission identified by pandemic-scale phylogenomics. Zoological Research (2022) 43 (5): 871. DOI: 10.24272/j.issn.2095-8137.2022.238

Dalang Yu^#, Xiao Yang^#, Bixia Tang^#, Yi-Hsuan Pan^#, Jianing Yang^#, Junwei Zhu^#, Guangya Duan, Zi-Qian Hao, Hailong Mu, Long Dai, Wangjie Hu, Mochen Zhang, Ying Cui, Tong Jin, Cuiping Li, Lina Ma, Xiao Su, Guo-Qing Zhang*, Wenming Zhao*, Haipeng Li*. Coronavirus GenBrowser for monitoring the transmission and evolution of SARS-CoV-2. Briefings in Bioinformatics (2022). DOI: 10.1093/bib/bbab583

Ziqian Hao, Pengyuan Du, Yi-Husan Pan*, Haipeng Li*. Fine human genetic map based on UK10K data set. Human Genetics (2022). DOI: 10.1007/s00439-021-02415-8

Guopeng Liu^#, Chunxiao Zhang^#, Yuting Wang^#, Guangyi Dai, Shu-Qun Liu, Wenshuai Wang, Yi-Hsuan Pan*, Jianping Ding*, and Haipeng Li*. New exon and accelerated evolution of placental gene Nrk occurred in the ancestral lineage of placental mammals. Placenta (2021) 114: 14-21. DOI: 10.1016/j.placenta.2021.08.048

Wenjie Huang^#, Chen-Chung Liao^#, Yijie Han, Junyan Lv, Ming Lei, Yangyang Li, Qingyun Lv, Dong Dong, Shuyi Zhang, Yi-Husan Pan*, Jian Luo*.Co-activation of Akt, Nrf2, and NF-κB signals under UPR_ER in torpid Myotis ricketti bats for survival. Communications Biology (2020). DOI: 10.1038/s42003-020-01378-2

H Sun, J Wang, Y Xing, Yi-Hsuan Pan, X Mao*. Gut transcriptomic changes during hibernation in the greater horseshoe bat (Rhinolophus ferrumequinum). Frontiers in Zoology (2020) 17, Article number: 21. DOI: 10.1186/s12983-020-00366-w

Huiling Xue^#, Zhe Wang^#, Yongjie Hua, Shanshan Ke, Yao Wang, Junpeng Zhang, Yi-Hsuan Pan, Wenjie Huang, David M. Irwin, Shuyi Zhang*. Molecular signatures and functional analysis of beige adipocytes induced from in vivo intra-abdominal adipocytes. Science Advances (2018). DOI: 10.1126/sciadv.aar5319

Di Liu, Shenghui Zheng, Guantao Zheng, Qingyun Lv, Bin Shen, Xinpu Yuan, Yi-Hsuan Pan*. Adaptation of the FK506 Binding Protein 1B to Hibernation in Bats. Cryobiology (2018). DOI: 10.1016/j.cryobiol.2018.07.004

Qiuyuan Yin^#, Yijian Zhang^#, Dong Dong, Ming Lei, Shuyi Zhang, Chen-Chung Liao*, Yi-Hsuan Pan*. Maintenance of neural activities in torpid Rhinolophus ferrumequinum bats revealed by 2D gel-based proteome analysis. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2017). DOI: 10.1016/jbbapap.2017.04.006

Dong Dong, Ming Lei, Panyu Hua,Yi-Hsuan Pan, Shuo Mu, Guantao Zheng, Erli Pang, Kui Lin, and Shuyi Zhang*. The Genomes of Two Bat Species with Long Constant Frequency Echolocation Calls. Molecular Biology and Evolution (2016). DOI: 10.1093/molbev/msw231

Qiuyuan Yin, Hanxiao Ge, Chen-Chong Liao, Di Liu, Shuyi Zhang*, and Yi-Hsuan Pan*. Antioxidant Defenses in the Brains of Bats during Hibernation. PLoS ONE (2016) (3): e0152135. DOI: 10.1371/journal.pone.0152135

Qiuyuan Yin, Lei Zhu, Di Liu, David M. Irwin, Shuyi Zhang*, and Yi-Hsuan Pan*. Molecular Evolution of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene Nrf2 in Old World Fruit Bats (Chiroptera: Pteropodidae). PLoS ONE (2016) 11(1): e0146274. DOI:10.1371/journal. pone.0146274

Yijie Han, Guantao Zheng, Tianxiao Yang, Shuyi Zhang, Dong Dong, and Yi-Hsuan Pan*. Adaptation of Peroxisome Proliferator-activated Receptor alpha to Hibernation in Bats. BMC Evolutionary Biology (2015). DOI: 10.1186/s12862-015-0373-6

Yih-Huei Uena, Chen-Chung Liao, Jung-Chun Lin,Yi-Hsuan Pan, Yi-Chung Liu, You-Chia Chen, Wei-Jung Chen, Chih-Chun Tai, Kuan-Wei Lee, Yun-Ru Liu, Hung-TseLine, Ching-Yu Lin^*. Analysis of differentially expressed novel post-translational modifications of plasma apolipoprotein E in Taiwanese females with breast cancer. Journal of Proteomics (2015) 126: 252 262. DOI: 10.1016/j.jprot.2015.05.038

Ming Lei, Dong Dong*, Shuo Mu, Yi-Hsuan Pan, and Shuyi Zhang*. Comparison of brain transcriptomes between active and torpid episodes of the greater horseshoe bats (Rhinolophus ferrumequinum). PLoS ONE (2014). DOI: 10.1371/journal.pone.0107746

Yijian Zhang^#, Yi-Hsuan Pan^#, Qiuyuan Yin, Tianxiao Yang, Dong Dong, Chen-Chung Liao* and Shuyi Zhang*. Critical Roles of Mitochondria in Brain Activities of Torpid Myotis ricketti Bats Revealed by a Proteomic Approach. Journal of Proteomics (2014) 105 (13): 266-284. DOI: 10.1016/j.jprot.2014.01.006

Yijian Zhang, Tengteng Zhu, Lina Wang, Yi-Hsuan Pan* and Shuyi Zhang*. Homocysteine Homeostasis and Betaine-Homocysteinem S-methyltransferase Expression in the Brian of Hibernating Bats. PLoS ONE (2013). DOI: 10.1371/journal.pone.0085632.

Yi-Hsuan Pan, Yijian Zhang, Jie Cui, Yang Liu, Bronwyn M. McAllan, Chen-Chung Liao^*, Shuyi Zhang^*. Adaptation of Phenylalanine and Tyrosine Catabolic Pathway to Hibernation in Bats. PLoS ONE (2013) DOI: 10.1371/journal.pone.0062039.

Lingjiang He^#‚ Yi-Hsuan Pan^#‚ Guimei He‚ Benfu Lin‚ Chen-Chung Liao‚ Xueguo Zuo‚ Lihong Yuan^*. Structural and functional studies of leptins from hibernating and non-hibernating bats. General and Comparative Endocrinology (2010) 168. DOI: 10.1016/j.ygcen.2010.04.001

Jie Cui^#‚ Yi-Hsuan Pan^#‚ Yijian Zhang‚ Gareth Jones‚ Shuyi Zhang*. Progressive Pseudogenization: Vitamin C Synthesis and Its Loss in Bats. Molecular Biology and Evolution (2011) 28 (2):1025–103. DOI: 10.1093/molbev/msq286

Yi-Hsuan Pan, Chen-Chung Liao, Chou-Chiang Kuo, Kow-Jen Duan, Po-Huang Liang, Hanna S. Yuan, Shiau-Ting Hu, Kin-Fu Chak The critical roles of polyamines in regulating ColE7 production and restricting ColE7 uptake of the colicin producing Escherichia coli. Journal of Biological Chemistry (2006) 281(19):13083-13091.DOI: 10.1074/jbc.M511365200

Physiological functions of ADAMTS-18

Liya Wang^#, Li He^#, Weijia Yi, Min Wang, Fangmin Xu, Hanlin Liu, Jiahui Nie, Yi-Hsuan Pan, Suying Dang*, Wei Zhang*. ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells. iScience, (2024), 27 (7): 1-19. DOI: 10.1016/j.isci.2024.110273

N. Yang^# Q. Zhang^#, S. Ye, T. Lu, M. Sun, L. Wang, M. Wang, Yi-Hsuan Pan, S. Dang*, and W. Zhang*. Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice. Journal of Dental Research (2022) 101 (2), 226-234. DOI: 10.1177/00220345211029270

Xiaotian Lin^#, Caiyun Wang^#, Qi Zhang, Yi-Hsuan Pan, Suying Dang*, Wei Zhang*. ADAMTS18 regulates vaginal opening through influencing the fusion of Mullerian duct and apoptosis of vaginal epithelial cells in mice. Reproductive Biology (2021). DOI: 10.1016/j.repbio.2021.100537

Shuai Ye, Ning Yang, Tiantian Lu, Taojing Wu, Liya Wang, Yi-Hsuan Pan, Xiaohua Cao, Xiaobing Yuan, Thomas Wisniewski, Suying Dang*, Wei Zhang* ADAMTS18 Modulates the Development of Aortic Arch and Common Carotid Artery. iScience (2021). DOI: 10.1016/j.isci.2021.102672

Tiantian Lu, Xiaotian Lin,Yi-Hsuan Pan, NingYang, ShuaiYe, Qi Zhang, Caiyun Wang, Rui Zhu, Tianhao Zhang, Thomas M. Wisniewski, Zhongwei Cao, Bi-Sen Ding, Suying Dang*, WeiZhang*. ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation. iScience (2020). DOI: 10.1016/j.isci.2020.101472

Tiantian Lu, Tianhao Zhang, Caiyun Wang, Ning Yang, Yi-Hsuan Pan, Suying Dang, Wei Zhang*. Adamts18 deficiency in zebrafish embryo causes defective trunk angiogenesis and caudal vein plexus formation. Biochemical and Biophysical Research Communications (2020). DOI: 10.1016/j.bbrc.2019.10.202

Rui Zhu, Yi-Hsuan Pan, Tiantian Lu, Suying Dang, Chen-Chung Liao and Wei Zhang*. Vascular Proteomics Reveals Critical Roles of ADAMTS18 in Stroke Associated with Imbalanced Level of Von Willebrand Factor Versus ADAMTS13. Blood (2018). DOI: 10.1182/blood-2018-99-110341

Rui Zhu, Mengting Cheng, Tiantian Lu, Ning Yang, Shuai Ye, Yi-Hsuan Pan, Tao Hong, Suying Dang, Wei Zhang*. A Disintegrin and Metalloproteinase with Thrombospondin Motifs 18 Deficiency Leads to Visceral Adiposity and Associated Metabolic Syndrome in Mice. The American Journal of Pathology (2017). DOI: 10.1016/j.ajpath.2017.10.020

科普词条创建

精神益生菌（百度百科）2019/08/22，创建者：潘逸萱（YHPJP）

科普文章

新型冠状病毒源于自然而非实验室，科学网，2020/0212，作者：李海鹏，潘逸萱，赵方庆，苏枭

科普视频

为何说人类曾险遭灭绝，湖南卫视，新闻大求真栏目 — 芒果TV，2023/09/19，华师大/潘逸萱。

其它

校稿应用分子生物学（ISBN 978-957-616-918-2, 2007），李昭鋐教授，艺轩图书出版社。

阳明大学博士班优良论文奖学金（2005）。

International Conference on polyamines Best Poster and Presentation Award (2004) awarded by Prof. Kazuei Igarashi et al.

阳明大学硕士班优良学术论文奖学金（2001）。

海洋大学水产养殖系书卷奖（1999）。

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