Laiyuping

    1997-2001   B.S.     East China Normal University, Shanghai, P.R. China

    2001-2006   Ph.D.   East China Normal University, Shanghai, P.R. China

    2005-2006   Ph.D.   Rocky Mountain Laboratories,National Institute of Allergy and Infectious Diseases,

                                    National Institutes of Health, U.S.A.

2005-2010     Postdoctoral Fellowship, Division of Dermatology, University of California-San Diego, San Diego

2010-present Professor of  Shanghai Key Laboratory of Regulatory Biology at School of Life Sciences, East China Normal University

Dr. Lai’s lab is interested in understanding immune regulations of keratinocytes during the development of inflammatory skin diseases, such as psoriasis, atopic dermatitis and acne. Fundamental basic science approaches using modern techniques of immunology, biochemistry and genetics are applied to dissect  how keratinocyte dysfunctions result in the pathogenesis of inflammatory skin diseases. Dr. Lai has published 40 papers in high profile journals including Nature Medicine, Immunity, Nature Communications, PNAS, and has received multiple awards including Top-Notch Young Professionals.

The Asian Society for Psoriasis              Director

Frontiers in Immunology-Inflammation   Associate editor

Skin Immunology, including:

1) Alternative splicing of cytokines/receptors and inflammatory skin diseases

2) Innate immune memory of keratinocytes and the relapse of inflammatory skin diseases

3) Skin commensals and immunematabolism

The introduction of Biomedicine

Innate immunity and skin health

National Natural Science Foundation:

1. 2021-2024 (82071785)

2. 2017-2020 (31670925)

3. 2015-2018 (31470878)  

4. 2013-2015 (31222021)   

5. 2012-2015 (31170867)

6. 2011-2013 (81072422)

Publications (* Corresponding author)：

1. Wang X, Lai Y*. Keratinocytes in the pathogenesis, phenotypic switch, and relapse of psoriasis. Eur J Immunol, 2024,54(5): e2250279.

2. Lin X, Lai Y*.  Scarring skin: Mechanisms and Therapies. Int J Mol Sci, 2024, 25(3): 1458.

3. Wang X, Lai Y*. When SLC46A2 delivers cargo into keratinocytes. Immunity,  2023, 56(5):897-900.

4. Ni X, Xu Y, Wang W, Kong B, Ouyang J, Chen J, Yan  M, Wu Y, Chen Q, Wang X, Li H, Gao X, Guo H, Cui L, Chen Z, Shi Y, Zhu R,  Li W, Shi T, Wang L-F, Huang J, Dong C, Lai Y*. IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifiers IL-36R-mediated skin inflammation. Nat Immunol.2022,23(11): 1577-1587.

5. Tian D & Lai Y*. The relapse of psoriasis: mechanisms and mysteries. JID Innov. 2022, 2(3) :100116.

6. Ni X  & Lai Y*. Crosstalk between keratinocytes and immune cells in inflammatory skin diseases. Explor Immunol. 2021, 1:418-431.

7. Ni X  & Lai Y*. Keratinocyte: a trigger or an executor of psoriasis? J Leukoc Biol. 2020, 108(2): 485-491.

8. Li D, Wang W, Wu  Y, Ma X, Zhou W, Lai Y*.   Lipopeptide 78 from Staphylococcus epidermidis activates β-catenin to inhibit skin inflammation. J Immunol, 2019, 202(4): 1219-1228.

9.  Jiang Z, Liu Y, Li C, Chang L, Wang W, Wang Z, Gao X, Ryffel B, Wu Y, Lai Y*. Interleukin-36γ induced by the TLR3-SLUG-VDR axis promotes wound healing via REG3A. J Invest Dermatol. 2017, 137（12）：2620-2629.

10. Lei H, Wang Y, Zhang T, Chang L, Wu Y, Lai Y*. TLR3 activation induces S100A7 to regulate keratinocyte differentiation after   skin injury. Sci China Life Sci. 2017, 60(2): 158-167.

11. Wu Y, Quan Y, Liu Y, Liu K, Li H, Jiang Z, Zhang T, Lei H, Radek KA, Li D, Wang Z, Lu J, Wang W, Ji S, Xia Z, Lai Y*. Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes. Nat Commun. 2016, 7:13393.

12. Lai Y & Dong C. Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases. Int Immunol. 2016, 28(4): 181-188.

13. Xia X, Li Z, Liu K, Wu Y, Jiang D*, Lai Y*. Staphylococcal LTA-induced miR-143 inhibits Propionibacterium acnes-mediated inflammatory response in  skin. J Invest Dermatol. 2016,136(3): 621-630.

14. Zhang M, Jiang Z, Li D, Jiang D,  Wu Y, Ren H, Peng H, Lai Y*.Oral antibiotic treatment induces skin microbiota dysbiosis and influences wound healing. Microb Ecol. 2015, 69(2): 415-421.

15. Li C, Li H, Jiang      Z, Zhang T, Wang Y, Li Z, Wu Y, Ji S, Xiao S, Ryffel B, Radek KA, Xia Z*, Lai Y*. Interleukin-33 increases      antibacterial defense by activation of inducible nitric oxide synthase in skin. PLoS Pathog. 2014, 10(2): e1003918.

16. Li D, Lei H, Li Z, Li H, Wang Y, Lai Y*. A novel lipopeptide from  skin commensal activates TLR2/CD36-p38 MAPK signaling to increase      antibacterial defense against bacterial infection. PLoS One. 2013, 8(3): e58288.

17. Lai Y*, Li D, Li C,Muhleisen B,Radek KA, Park HJ, Jiang Z, Li Z, Lei H, Quan Y, Zhang T, Wu Y, Kotol P, Morizane S, Hata TR, Iwatsuki K, Tang C, Gallo RL. The  antimicrobial protein REG3A regulates keratinocyte proliferation and  differentiation after skin injury. Immunity. Issue highlight.  2012, 37(1):74-84.

18. Lai  Y, Cogen AL, Radek KA, Park HJ,Macleod DT, Leichtle A, Ryan AF,  Di Nardo A, Gallo RL. Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections. J Invest Dermatol.2010, 130(9):2211-2221.

19. Lai Y, Gallo RL. Commensal skin bacteria as the probiotic of the cutaneous immune response. Expert Rev. Dermatol. Editorial.  2010, 5(3): 251-253.

20. Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu Z-R, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang C-M, Ryan AF, Gallo RL.  Commensal bacteria regulate TLR3-dependent inflammation after skin injury.Nat Med.Covey Story. 2009, 15(12): 1377-1382.

21. Lai Y, Gallo RL. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends  Immunol. Feature Review.  2009, 30(3): 131-141.

22. Lai Y, Gallo RL. Toll-like receptors in skin infections and inflammatory diseases. Infect Disord Drug Targets (Formerly 'Current Drug Targets - Infectious Disorders'). 2008, 8(3): 144-155.

23. Li M, Lai Y,Villaruz AE, Cha DJ, Sturdevant DE, Otto M. Gram-positive three-component antimicrobial peptide-sensing system. Proc Natl Acad Sci U S A. 2007, 104(22):9469-9474 (Co-first author).      

24. Lai Y, Villaruz AE, Li M., Cha DJ, Sturdevant DE, Otto M. The human anionic antimicrobial peptide dermcidin induces  proteolytic defence mechanisms in staphylococci. Mol Microbiol. 2007, 63(2):497-506.

25. Lai YP, Peng YF, Zuo Y, Li J, Huang J, Wang LF, Wu ZR.  Functional and structural characterization of recombinant dermcidin-1L, a human antimicrobial peptide. Biochem Biophy Res Commun. 2005, 328(1):243-250.      

26. Lai YP, Huang J, Wang LF, Li J, Wu ZR. A new approach to random mutagenesis in vitro. Biotechnol Bioeng. 2004, 86(6): 622-627.

27. Liu Q, Han M, Wu Z, Fu W, Ji J, Liang Q, Tan M, Zhai L, Gao J, Shi D, Jiang Q, Sun Z, Lai Y, Xu Q, Sun Y. DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding. Nat Aging.     2024, 4(5): 664-680.

28. Zhu Y, Wu Z, Yan W, Shao F, Ke B, Jiang X, Gao J, Guo W, Lai Y, Ma H, Chen D, Xu Q, Sun Y. Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis. EMBO Mol Med. 2022, 14(3): e14455.

29. Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, He HH, Lieberman J, Wu H, Chen X, Li J. TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell Death Differ. 2022. 29(2): 439-450.

30. Su Y, Huang J, Zhao X, Lu H, Wang W, Yang X, Shi Y, Wang X, Lai Y, Dong C. Interleukin-17 receptor D constitutes an    alternative receptor for interleukin-17A important in psoriasis-like skin inflammation. Sci Immunol. 2019, 4(36): eaau9657.

31. Han Z, Ren X, Huang Q, Shi T, Lai Y, Zhao YL. Lipopolysaccharides Inhibit REG3A Self-Aggregation on Gold Nanoparticles:    A Combined Study of Multivariate Analysis on Time-Resolved Localized Surface Plasmon Resonance Spectra and Molecular Modeling. Langmuir. 2019, 35(9): 3498-3506.

32. Xu M, Lu H, Lee YH, Wu Y, Liu K, Shi Y, An H, Zhang J, Wang X, Lai Y, Dong C. An interleukin-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation.Immunity. 2018, 48(4): 787-798.

33. Li C, Maillet I, Mackowiak C, Viala C, Di Padova F, Li M, Togbe D, Quesniaux V, Lai Y, Ryffel B. Experimental atopic dermatitis depends on IL-33R signaling via      MyD88 in dendritic cells. Cell Death Dis. 2017, 8(4): e2735.

34. Hu J, Quan Y, Lai Y, Zheng Z, Hu Z, Wang X, Dai T, Zhang Q, Cheng Y. A smart aminoclycoside hydrogel with tunable      gel degradation, on-demand drug release, and high antibacterial activity. J  Control Release. 2017, 10(247): 145-152.

35. Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J,  Liu Z, Liu J, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Su B, Li Q, Yang X, Yu J, Lai Y, Yu XZ, Zheng Y, Shen N, Chin YE, Wang H. NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis. Nat Commun. 2015, 3(6): 7652.

36. Hata TR, Afshar M, Miller J, Two AM, Kotol P, Jackson M, Alexandrescu DT, Kabigting F, Gerber M, Lai Y, Gallo RL.Etanercept decreases the innate immune wounding response in psoriasis. Exp Dermatol. 2013, 22(9): 599-601.

37. Wang Z, Lai Y, Bernard JJ, Macleod DT, Cogen AL, Moss B, Di Nardo A. Skin Mast Cells Protect Mice against Vaccinia Virus by Triggering Mast Cell Receptor S1PR2 and Releasing Antimicrobial Peptides. J Immunol. 2012, 188(1):345-357.

38. Leichtle A, Lai Y, Wollenberg B, Wasserman SI, Ryan AF. Innate signaling in otitis media: pathogenesis and recovery. Curr Allergy Asthma Rep. 2011, 11(1):78-84.

39. Wu YL, Huang J, Xu J, Liu J, Feng Z, Wang Y, Lai Y*, Wu ZR*. Addition of a cysteine to glucagon-like peptide-1 (GLP-1) conjugates GLP-1 to albumin in serum and prolongs GLP-1 action in vivo. Regul Pept. 2010, 164(2-3):83-89.

40. Feng Z, Lai Y, Ye H, Huang J, Xi XG, Wu Z. Poly (gamma,  L-glutamic acid)-cisplatin bioconjugate exhibits potent antitumor activity  with low toxicity: A comparative study with clinically used platinum derivatives. Cancer Sci.  2010, 101(11): 2476-2482.

41. Leichtle A, Hernandez M, Ebmeyer J, Yamasaki K, Lai Y, Radek K, Choung YH, Euteneuer S, Pak K, Gallo R, Wasserman SI, Ryan AF. CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice. J Immunol. 2010, 184(6): 3087-3097.

42. Cogen AL, Yamasaki K, Muto J, Sanchez KM,  Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. Staphylococcus epidermidis antimicrobial  delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus. PLoS One. 2010, 5(1): e8557.

43. Cogen AL, Yamasaki K, Sanchez KM, Dorschner      RA, Lai Y, Macleod DT, Torpey JW, Otto M, Nizet V, Kim JE, Gallo RL. Selective antimicrobial action is      provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin.J Invest Dermatol. 2010, 130(1): 192-200.

44. Li M, Rigby K, Lai Y, Nair V, Peschel A, Schittek B, Otto M. Staphylococcus aureus mutant screen reveals the interaction of human antimicrobial peptide dermcidin with membrane phospholipids. Antimicrob Agents Chemother. 2009, 53(10):4200-4210.

45. Di Nardo A, Yamasaki K, Dorschner RA, Lai Y, Gallo RL. Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin. J Immunol. 2008, 180(11):7565-7573.

46. Li M, Cha DJ, Lai Y,Villaruz AE, Sturdevant DE, Otto M. The antimicrobial peptide-sensing system aps of Staphylococcus aureus. Mol  Microbiol. 2007, 66(5): 1136-1147.

47. Yao Y, Vuong C, Kocianva S, Villaruz AE, Lai Y, Sturdevant DE, Otto M.  Characterization of the Staphylococcus   epidermidis accessory gene regulator response: quorum-sensing  regulation of resistance to innate host defense. J Infect Dis. 2006, 193(6):841-848.

48. 王梦珂、赖玉平*。组蛋白修饰在固有免疫记忆中的作用。生物学教学，2022，47（11）：2-5。

49. 林新晔、赖玉平*。病理性瘢痕的形成机制与治疗概述。生物学教学，2022，47（12）：2-5。

50. 吴叶林、全艳春、赖玉平*。角质形成细胞与T细胞的crosstalk诱发银屑病的研究现状及展望。生命科学， 2016， 28（2）：258-267

51. 蒋子威、李长伟、雷虎、全艳春、赖玉平*。胰岛再生源蛋白(Reg)在组织修复中的功能和调控机制。中国细胞生物学学报，2012，34（1）：1-10。

52. 李冬青、李之珩、李茜、赖玉平*。皮肤共生菌调节机体免疫应答的研究进展。中华皮肤科杂志，2012，45（3）：215-217。

53. 赖玉平、彭沂非、郁正艳、黄静、吴自荣。DCD-1L在毕赤酵母中的克隆和表达。中国生物工程杂志， 2004, 24（2）: 61-65。

Book chapter：

1. Lai Y& Dong C. Interleukin-17 family. In: Michael J.H. Ratcliffe (Editor in Chief), Encyclopedia of Immunobiology,  Vol. 2, pp.534-543. Oxford: Academic Press, London. ISBN: 978-0-08-092152-5. 2016

2. Lai Y. Keratinocytes: gatekeeper in innate defense (Chapter 5). In: Elia Ranzato (eds),  Keratinocytes: structure, molecular mechanisms and role in immunity, page 109-116. Nova Science Publishers, Inc.  New York. ISBN: 978-1-62618-798-6. 2013.   

Patent:

1. 赖玉平、孔柏达。细胞因子白介素-17D及其诱导的组蛋白乳酰化和乙酰化修饰在银屑病复发治疗中的应用。专利号及申请号：202410299098.9。

2. 赖玉平、林新晔、倪欣惠。IL-17D在疤痕预防和治疗中的应用。专利号及申请号：202210747679.8。

3. 赖玉平、徐艺、倪欣惠、孔柏达、王旺。炎症性皮肤疾病生物标志物DDX5和/或sIL-36R及其应用。专利号及申请号：202110117195.8。

4. 赖玉平、梁韵宁、蒋璐璐。REG3A-DGTM光敏水凝胶组合物及其诱导表皮再生修复的应用。专利号及申请号：202110486145.7。

5. 赖玉平、王旺、雷虎、吴雅伟。一种IL-36的可溶性受体sIL-36R及其应用。专利号及申请号：201910333393.0。

6. Dongqing Li, Hu Lei, Hongquan Li, Yuping Lai.      Anti-inflammatory lipopeptide and preparing method and application      thereof. US 10072051B2. 2018/9/11

7. 赖玉平、王玥、吴叶林。一种脂肽在制备抗黑色素瘤的药物中的应用。专利号：ZL201410370095.6，授权时间：2016/11/16。

8. 李冬青、雷虎、李红泉、赖玉平。一种脂肽及其衍生物、及其制备方法和应用。专利号：ZL      201210138021.0，授权时间：2016/01/13。

9. 李冬青、王玥、李红泉、赖玉平。一种抗炎症的脂肽及其制备方法和应用。专利号：ZL 201210254311.1，授权时间：2015/06/24。

10. 赖玉平、吴叶林、刘媛琪、全艳春、鲁纪龙、雷虎。胰再生源蛋白在制备促进过度炎症伤口愈合的药物中的应用。专利号：ZL 201410747546.3，授权时间：2020/08/25。

11. 赖玉平、吴自荣、黄静、王林发、左翼、李骏。一种高效表达重组人汗腺抗菌肽的基因工程菌及其构建方法和应用。专利号： ZL 200510023674.4 (已授权)。

12. Gallo RL, Nizet V,  Cogen A, Lai Y. Antimicrobial and anti-inflammatory therapies and compositions. U.S.A. Patent No. US2010/0166708A1.

13. Otto M, Li M, Lai  Y, Villaruz AE, Cha DJ, Sturdevant DE. Gram-positive three-component      antimicrobial peptide-sensing system. U.S.A. patent. Application  No.60/930,709.