生命科学学院

学术成果

发表论文(* 通讯作者)：

1. Wang X, Lai Y*. When SLC46A2 delivers cargo into keratinocytes. Immunity, 2023, 56(5):897-900.

2. Ni X, Xu Y, Wang W, Kong B, Ouyang J, Chen J, Yan M, Wu Y, Chen Q, Wang X, Li H, Gao X, Guo H, Cui L, Chen Z, Shi Y, Zhu R, Li W, Shi T, Wang L-F, Huang J, Dong C, Lai Y*. IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifiers IL-36R-mediated skin inflammation. Nat Immunol. 2022,23(11):1577-1587.

3. Tian D & Lai Y*. The relapse of psoriasis: mechanisms and mysteries. JID Innov. 2022, 2(3) :100116.

4. Ni X & Lai Y*. Crosstalk between keratinocytes and immune cells in inflammatory skin diseases. Explor Immunol. 2021,1:418-431.

5. Ni X & Lai Y*. Keratinocyte: a trigger or an executor of psoriasis? J Leukoc Biol. 2020, 108(2): 485-491.

6. Li D, Wang W, Wu Y, Ma X, Zhou W, Lai Y*. Lipopeptide 78 from Staphylococcus epidermidis activates β-catenin to inhibit skin inflammation. J Immunol, 2019, 202(4):1219-1228.

7. Jiang Z, Liu Y, Li C, Chang L, Wang W, Wang Z, Gao X, Ryffel B, Wu Y, Lai Y*. Interleukin-36γ induced by the TLR3-SLUG-VDR axis promotes wound healing via REG3A. J Invest Dermatol. 2017, 137(12): 2620-2629.

8. Lei H, Wang Y, Zhang T, Chang L, Wu Y, Lai Y*. TLR3 activation induces S100A7 to regulate keratinocyte differentiation after skin injury. Sci China Life Sci. 2017, 60(2): 158-167.

9. Wu Y, Quan Y, Liu Y, Liu K, Li H, Jiang Z, Zhang T, Lei H, Radek KA, Li D, Wang Z, Lu J, Wang W, Ji S, Xia Z, Lai Y*. Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes. Nat Commun. 2016, 7:13393.

10. Lai Y & Dong C. Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases. Int Immunol. 2016, 28(4): 181-188.

11. Xia X, Li Z, Liu K, Wu Y, Jiang D*, Lai Y*. Staphylococcal LTA-induced miR-143 inhibits Propionibacterium acnes-mediated inflammatory response in skin. J Invest Dermatol. 2016,136(3): 621-630.

12. Zhang M, Jiang Z, Li D, Jiang D, Wu Y, Ren H, Peng H, Lai Y*. Oral antibiotic treatment induces skin microbiota dysbiosis and influences wound healing. Microb Ecol. 2015, 69(2): 415-421.

13. Li C, Li H, Jiang Z, Zhang T, Wang Y, Li Z, Wu Y, Ji S, Xiao S, Ryffel B, Radek KA, Xia Z*, Lai Y*. Interleukin-33 increases antibacterial defense by activation of inducible nitric oxide synthase in skin. PLoS Pathog. 2014, 10(2): e1003918.

14. Li D, Lei H, Li Z, Li H, Wang Y, Lai Y*. A novel lipopeptide from skin commensal activates TLR2/CD36-p38 MAPK signaling to increase antibacterial defense against bacterial infection. PLoS One. 2013, 8(3): e58288.

15. Lai Y*, Li D, Li C,Muhleisen B,Radek KA, Park HJ, Jiang Z, Li Z, Lei H, Quan Y, Zhang T, Wu Y, Kotol P, Morizane S, Hata TR, Iwatsuki K, Tang C, Gallo RL. The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. Immunity. Issue highlight. 2012, 37(1):74-84.

16. Lai Y, Cogen AL, Radek KA, Park HJ,Macleod DT, Leichtle A, Ryan AF, Di Nardo A, Gallo RL. Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections. J Invest Dermatol.2010, 130(9):2211-2221.

17. Lai Y, Gallo RL. Commensal skin bacteria as the probiotic of the cutaneous immune response. Expert Rev. Dermatol. Editorial. 2010, 5(3): 251-253.

18. Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu Z-R, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang C-M, Ryan AF, Gallo RL. Commensal bacteria regulate TLR3-dependent inflammation after skin injury. Nat Med. Covey Story. 2009, 15(12): 1377-1382.

19. Lai Y, Gallo RL. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol. Feature Review. 2009, 30(3): 131-141.

20. Lai Y, Gallo RL. Toll-like receptors in skin infections and inflammatory diseases. Infect Disord Drug Targets (Formerly 'Current Drug Targets - Infectious Disorders'). 2008, 8(3): 144-155.

21. Li M, Lai Y,Villaruz AE, Cha DJ, Sturdevant DE, Otto M. Gram-positive three-component antimicrobial peptide-sensing system. Proc Natl Acad Sci U S A. 2007, 104(22):9469-9474 (Co-first author).

22. Lai Y, Villaruz AE, Li M., Cha DJ, Sturdevant DE, Otto M. The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci. Mol Microbiol. 2007, 63(2):497-506.

23. Lai YP, Peng YF, Zuo Y, Li J, Huang J, Wang LF, Wu ZR. Functional and structural characterization of recombinant dermcidin-1L, a human antimicrobial peptide. Biochem Biophy Res Commun. 2005, 328(1):243-250.

24. Lai YP, Huang J, Wang LF, Li J, Wu ZR. A new approach to random mutagenesis in vitro. Biotechnol Bioeng. 2004, 86(6): 622-627.

25. Zhu Y, Wu Z, Yan W, Shao F, Ke B, Jiang X, Gao J, Guo W, Lai Y, Ma H, Chen D, Xu Q, Sun Y. Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis. EMBO Mol Med. 2021, 14(3): e14455.

26. Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, He HH, Lieberman J, Wu H, Chen X, Li J. TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell Death Differ. 2021, 29(2): 439-450.

27. Su Y, Huang J, Zhao X, Lu H, Wang W, Yang X, Shi Y, Wang X, Lai Y, Dong C. Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation. Sci Immunol. 2019, 4(36): eaau9657.

28. Han Z, Ren X, Huang Q, Shi T, Lai Y, Zhao YL. Lipopolysaccharides Inhibit REG3A Self-Aggregation on Gold Nanoparticles: A Combined Study of Multivariate Analysis on Time-Resolved Localized Surface Plasmon Resonance Spectra and Molecular Modeling. Langmuir. 2019, 35(9): 3498-3506.

29. Xu M, Lu H, Lee YH, Wu Y, Liu K, Shi Y, An H, Zhang J, Wang X, Lai Y, Dong C. An interleukin-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation.Immunity. 2018, 48(4): 787-798.

30. Li C, Maillet I, Mackowiak C, Viala C, Di Padova F, Li M, Togbe D, Quesniaux V, Lai Y, Ryffel B. Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells. Cell Death Dis. 2017, 8(4): e2735.

31. Hu J, Quan Y, Lai Y, Zheng Z, Hu Z, Wang X, Dai T, Zhang Q, Cheng Y. A smart aminoclycoside hydrogel with tunable gel degradation, on-demand drug release, and high antibacterial activity. J Control Release. 2017, 10(247): 145-152.

32. Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, Liu Z, Liu J, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Su B, Li Q, Yang X, Yu J, Lai Y, Yu XZ, Zheng Y, Shen N, Chin YE, Wang H. NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis. Nat Commun. 2015, 3(6): 7652.

33. Hata TR, Afshar M, Miller J, Two AM, Kotol P, Jackson M, Alexandrescu DT, Kabigting F, Gerber M, Lai Y, Gallo RL. Etanercept decreases the innate immune wounding response in psoriasis. Exp Dermatol. 2013, 22(9): 599-601.

34. Wang Z, Lai Y, Bernard JJ, Macleod DT, Cogen AL, Moss B, Di Nardo A. Skin Mast Cells Protect Mice against Vaccinia Virus by Triggering Mast Cell Receptor S1PR2 and Releasing Antimicrobial Peptides. J Immunol. 2012, 188(1):345-357.

35. Leichtle A, Lai Y, Wollenberg B, Wasserman SI, Ryan AF. Innate signaling in otitis media: pathogenesis and recovery. Curr Allergy Asthma Rep. 2011,11(1):78-84.

36. Wu YL, Huang J, Xu J, Liu J, Feng Z, Wang Y, Lai Y*, Wu ZR*. Addition of a cysteine to glucagon-like peptide-1 (GLP-1) conjugates GLP-1 to albumin in serum and prolongs GLP-1 action in vivo. Regul Pept. 2010, 164(2-3):83-89.

37. Feng Z, Lai Y, Ye H, Huang J, Xi XG, Wu Z. Poly (gamma, L-glutamic acid)-cisplatin bioconjugate exhibits potent antitumor activity with low toxicity: A comparative study with clinically used platinum derivatives. Cancer Sci. 2010, 101(11): 2476-2482.

38. Leichtle A, Hernandez M, Ebmeyer J, Yamasaki K, Lai Y, Radek K, Choung YH, Euteneuer S, Pak K, Gallo R, Wasserman SI, Ryan AF. CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice. J Immunol. 2010, 184(6): 3087-3097.

39. Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus. PLoS One. 2010, 5(1): e8557.

40. Cogen AL, Yamasaki K, Sanchez KM, Dorschner RA, Lai Y, Macleod DT, Torpey JW, Otto M, Nizet V, Kim JE, Gallo RL. Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin.J Invest Dermatol. 2010, 130(1): 192-200.

41. Li M, Rigby K, Lai Y, Nair V, Peschel A, Schittek B, Otto M. Staphylococcus aureus mutant screen reveals the interaction of human antimicrobial peptide dermcidin with membrane phospholipids. Antimicrob Agents Chemother. 2009, 53(10):4200-4210.

42. Di Nardo A, Yamasaki K, Dorschner RA, Lai Y, Gallo RL. Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin. J Immunol. 2008, 180(11):7565-7573.

43. Li M, Cha DJ, Lai Y,Villaruz AE, Sturdevant DE, Otto M. The antimicrobial peptide-sensing system aps of Staphylococcus aureus. Mol Microbiol. 2007, 66(5): 1136-1147.

44. Yao Y, Vuong C, Kocianva S, Villaruz AE, Lai Y, Sturdevant DE, Otto M. Characterization of the Staphylococcus epidermidis accessory gene regulator response: quorum-sensing regulation of resistance to innate host defense. J Infect Dis. 2006,193(6):841-848.

专著

1. Lai Y& Dong C. Interleukin-17 family. In: Michael J.H. Ratcliffe (Editor in Chief), Encyclopedia of Immunobiology, Vol. 2, pp.534-543. Oxford: Academic Press, London. ISBN: 978-0-08-092152-5. 2016

2. Lai Y. Keratinocytes: gatekeeper in innate defense (Chapter 5). In: Elia Ranzato (eds), Keratinocytes: structure, molecular mechanisms and role in immunity, page 109-116. Nova Science Publishers, Inc. New York. ISBN: 978-1-62618-798-6. 2013

专利

1. Dongqing Li, Hu Lei, Hongquan Li, Yuping Lai. Anti-inflammatory lipopeptide and preparing method and application thereof. US 10072051B2. 2018/9/11

2. 赖玉平、王玥、吴叶林。一种脂肽在制备抗黑色素瘤的药物中的应用。专利号：ZL201410370095.6，授权时间：2016/11/16。

3. 李冬青、雷虎、李红泉、赖玉平。一种脂肽及其衍生物、及其制备方法和应用。专利号：ZL 201210138021.0，授权时间：2016/01/13。

4. 李冬青、王玥、李红泉、赖玉平。一种抗炎症的脂肽及其制备方法和应用。专利号：ZL 201210254311.1，授权时间：2015/06/24。

5. 赖玉平、吴叶林、刘媛琪、全艳春、鲁纪龙、雷虎。胰再生源蛋白在制备促进过度炎症伤口愈合的药物中的应用。专利号：ZL 201410747546.3，授权时间：2020/08/25。

6. 赖玉平、吴自荣、黄静、王林发、左翼、李骏。一种高效表达重组人汗腺抗菌肽的基因工程菌及其构建方法和应用。专利号： ZL 200510023674.4 。

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