赖玉平,华东师范大学与美国国家健康研究所过敏与感染性疾病研究所(NIH/NIAID)联合培养博士。2006-2010年在美国加州大学圣地亚哥分校医学院皮肤学系Richard L. Gallo实验室做博士后。2010年回到华东师范大学建立皮肤免疫学实验室,主要利用免疫学、生物化学、遗传学等技术系统研究皮肤微环境紊乱导致角质形成细胞免疫应答失衡,从而引发银屑病、特应性皮炎或糖尿病皮肤感染的调控机制以及炎症性皮肤疾病复发的免疫代谢机制。以第一作者或通讯作者在Nature Medicine、Immunity、Nature Communications、 PLoS Pathogens、PNAS等知名学术期刊发表SCI论文40篇,获得“万人计划”青年拔尖人才、国家自然科学基金委优秀青年、上海市“东方学者”、“曙光学者”、“启明星”、“巾帼建功标兵”等荣誉称号。目前主要担任The Asian Society for Psoriasis理事、Frontiers in Immunology-Inflammmation副主编、上海市免疫学会皮肤免疫学分会副主委、中华中医药学会免疫学分会青年副主委、Exploration of Immunology编委和Frontiers in Cell and Developmental Biology审稿编委。
社会兼职
2021-至今 中国免疫学学会皮肤学分会 委员
2021-至今 Frontiers in Immunology-Inflammation 副主编
2020-至今 The Asia Society for psoriasis理事
2020-至今 上海市免疫学会皮肤免疫学分会 副主委
2019-2023中华中医药学会免疫学分会青年副主委
2016-至今Frontiers in Cell and Developmental Biology审稿编委
Wang X, Lai Y*. Keratinocytes in the pathogenesis, phenotypic switch, and relapse of psoriasis. Eur J Immunol, 2024,54(5): e2250279.
Lin X, Lai Y*. Scarring skin: Mechanisms and Therapies. Int J Mol Sci, 2024, 25(3): 1458.
Wang X, Lai Y*. When SLC46A2 delivers cargo into keratinocytes. Immunity, 2023, 56(5):897-900.
Ni X, Xu Y, Wang W, Kong B, Ouyang J, Chen J, Yan M, Wu Y, Chen Q, Wang X, Li H, Gao X, Guo H, Cui L, Chen Z, Shi Y, Zhu R, Li W, Shi T, Wang L-F, Huang J, Dong C, Lai Y*. IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifiers IL-36R-mediated skin inflammation. Nat Immunol.2022,23(11): 1577-1587.
Tian D & Lai Y*. The relapse of psoriasis: mechanisms and mysteries. JID Innov. 2022, 2(3) :100116.
Ni X & Lai Y*. Crosstalk between keratinocytes and immune cells in inflammatory skin diseases. Explor Immunol. 2021, 1:418-431.
Ni X & Lai Y*. Keratinocyte: a trigger or an executor of psoriasis? J Leukoc Biol. 2020, 108(2): 485-491.
Li D, Wang W, Wu Y, Ma X, Zhou W, Lai Y*. Lipopeptide 78 from Staphylococcus epidermidis activates β-catenin to inhibit skin inflammation. J Immunol, 2019, 202(4): 1219-1228.
Jiang Z, Liu Y, Li C, Chang L, Wang W, Wang Z, Gao X, Ryffel B, Wu Y, Lai Y*. Interleukin-36γ induced by the TLR3-SLUG-VDR axis promotes wound healing via REG3A. J Invest Dermatol. 2017, 137(12):2620-2629.
Lei H, Wang Y, Zhang T, Chang L, Wu Y, Lai Y*. TLR3 activation induces S100A7 to regulate keratinocyte differentiation after skin injury. Sci China Life Sci. 2017, 60(2): 158-167.
Wu Y, Quan Y, Liu Y, Liu K, Li H, Jiang Z, Zhang T, Lei H, Radek KA, Li D, Wang Z, Lu J, Wang W, Ji S, Xia Z, Lai Y*. Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes. Nat Commun. 2016, 7:13393.
Lai Y & Dong C. Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases. Int Immunol. 2016, 28(4): 181-188.
Xia X, Li Z, Liu K, Wu Y, Jiang D*, Lai Y*. Staphylococcal LTA-induced miR-143 inhibits Propionibacterium acnes-mediated inflammatory response in skin. J Invest Dermatol. 2016,136(3): 621-630.
Zhang M, Jiang Z, Li D, Jiang D, Wu Y, Ren H, Peng H, Lai Y*.Oral antibiotic treatment induces skin microbiota dysbiosis and influences wound healing. Microb Ecol. 2015, 69(2): 415-421.
Li C, Li H, Jiang Z, Zhang T, Wang Y, Li Z, Wu Y, Ji S, Xiao S, Ryffel B, Radek KA, Xia Z*, Lai Y*. Interleukin-33 increases antibacterial defense by activation of inducible nitric oxide synthase in skin. PLoS Pathog. 2014, 10(2): e1003918.
Li D, Lei H, Li Z, Li H, Wang Y, Lai Y*. A novel lipopeptide from skin commensal activates TLR2/CD36-p38 MAPK signaling to increase antibacterial defense against bacterial infection. PLoS One. 2013, 8(3): e58288.
Lai Y*, Li D, Li C,Muhleisen B,Radek KA, Park HJ, Jiang Z, Li Z, Lei H, Quan Y, Zhang T, Wu Y, Kotol P, Morizane S, Hata TR, Iwatsuki K, Tang C, Gallo RL. The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. Immunity. Issue highlight. 2012, 37(1):74-84.
Lai Y, Cogen AL, Radek KA, Park HJ,Macleod DT, Leichtle A, Ryan AF, Di Nardo A, Gallo RL. Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections. J Invest Dermatol.2010, 130(9):2211-2221.
Lai Y, Gallo RL. Commensal skin bacteria as the probiotic of the cutaneous immune response. Expert Rev. Dermatol. Editorial. 2010, 5(3): 251-253.
Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu Z-R, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang C-M, Ryan AF, Gallo RL.Commensal bacteria regulate TLR3-dependent inflammation after skin injury.Nat Med.Covey Story. 2009, 15(12): 1377-1382.
Lai Y, Gallo RL. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol. Feature Review.2009, 30(3): 131-141.
Lai Y, Gallo RL. Toll-like receptors in skin infections and inflammatory diseases.Infect Disord Drug Targets (Formerly 'Current Drug Targets - Infectious Disorders'). 2008, 8(3): 144-155.
Li M, Lai Y,Villaruz AE, Cha DJ, Sturdevant DE, Otto M. Gram-positive three-component antimicrobial peptide-sensing system. Proc Natl Acad Sci U S A. 2007, 104(22):9469-9474 (Co-first author).
Lai Y, Villaruz AE, Li M., Cha DJ, Sturdevant DE, Otto M. The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci. Mol Microbiol. 2007, 63(2):497-506.
Lai YP, Peng YF, Zuo Y, Li J, Huang J, Wang LF, Wu ZR.Functional and structural characterization of recombinant dermcidin-1L, a human antimicrobial peptide. Biochem Biophy Res Commun. 2005, 328(1):243-250.
Lai YP, Huang J, Wang LF, Li J, Wu ZR. A new approach to random mutagenesis in vitro. Biotechnol Bioeng. 2004, 86(6): 622-627.
Liu Q, Han M, Wu Z, Fu W, Ji J, Liang Q, Tan M, Zhai L, Gao J, Shi D, Jiang Q, Sun Z, Lai Y, Xu Q, Sun Y. DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding. Nat Aging. 2024, 4(5): 664-680.
Zhu Y, Wu Z, Yan W, Shao F, Ke B, Jiang X, Gao J, Guo W, Lai Y, Ma H, Chen D, Xu Q, Sun Y. Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis. EMBO Mol Med. 2022, 14(3): e14455.
Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, He HH, Lieberman J, Wu H, Chen X, Li J. TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell Death Differ. 2022. 29(2): 439-450.
Su Y, Huang J, Zhao X, Lu H, Wang W, Yang X, Shi Y, Wang X, Lai Y, Dong C. Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation. Sci Immunol. 2019, 4(36): eaau9657.
Han Z, Ren X, Huang Q, Shi T, Lai Y, Zhao YL. Lipopolysaccharides Inhibit REG3A Self-Aggregation on Gold Nanoparticles: A Combined Study of Multivariate Analysis on Time-Resolved Localized Surface Plasmon Resonance Spectra and Molecular Modeling. Langmuir. 2019, 35(9): 3498-3506.
Xu M, Lu H, Lee YH, Wu Y, Liu K, Shi Y, An H, Zhang J, Wang X, Lai Y, Dong C. An interleukin-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation.Immunity. 2018, 48(4): 787-798.
Li C, Maillet I, Mackowiak C, Viala C, Di Padova F, Li M, Togbe D, Quesniaux V, Lai Y, Ryffel B. Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells. Cell Death Dis. 2017, 8(4): e2735.
Hu J, Quan Y, Lai Y, Zheng Z, Hu Z, Wang X, Dai T, Zhang Q, Cheng Y. A smart aminoclycoside hydrogel with tunable gel degradation, on-demand drug release, and high antibacterial activity. J Control Release. 2017, 10(247): 145-152.
Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, Liu Z, Liu J, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Su B, Li Q, Yang X, Yu J, Lai Y, Yu XZ, Zheng Y, Shen N, Chin YE, Wang H. NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis. Nat Commun. 2015, 3(6): 7652.
Hata TR, Afshar M, Miller J, Two AM, Kotol P, Jackson M, Alexandrescu DT, Kabigting F, Gerber M, Lai Y, Gallo RL.Etanercept decreases the innate immune wounding response in psoriasis. Exp Dermatol. 2013, 22(9): 599-601.
Wang Z, Lai Y, Bernard JJ, Macleod DT, Cogen AL, Moss B, Di Nardo A. Skin Mast Cells Protect Mice against Vaccinia Virus by Triggering Mast Cell Receptor S1PR2 and Releasing Antimicrobial Peptides. J Immunol. 2012, 188(1):345-357.
Leichtle A, Lai Y, Wollenberg B, Wasserman SI, Ryan AF. Innate signaling in otitis media: pathogenesis and recovery. Curr Allergy Asthma Rep. 2011, 11(1):78-84.
Wu YL, Huang J, Xu J, Liu J, Feng Z, Wang Y, Lai Y*, Wu ZR*. Addition of a cysteine to glucagon-like peptide-1 (GLP-1) conjugates GLP-1 to albumin in serum and prolongs GLP-1 action in vivo. Regul Pept. 2010, 164(2-3):83-89.
Feng Z, Lai Y, Ye H, Huang J, Xi XG, Wu Z. Poly (gamma, L-glutamic acid)-cisplatin bioconjugate exhibits potent antitumor activity with low toxicity: A comparative study with clinically used platinum derivatives. Cancer Sci. 2010, 101(11): 2476-2482.
Leichtle A, Hernandez M, Ebmeyer J, Yamasaki K, Lai Y, Radek K, Choung YH, Euteneuer S, Pak K, Gallo R, Wasserman SI, Ryan AF. CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice. J Immunol. 2010, 184(6): 3087-3097.
Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus. PLoS One. 2010, 5(1): e8557.
Cogen AL, Yamasaki K, Sanchez KM, Dorschner RA, Lai Y, Macleod DT, Torpey JW, Otto M, Nizet V, Kim JE, Gallo RL. Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin.J Invest Dermatol. 2010, 130(1): 192-200.
Li M, Rigby K, Lai Y, Nair V, Peschel A, Schittek B, Otto M. Staphylococcus aureus mutant screen reveals the interaction of human antimicrobial peptide dermcidin with membrane phospholipids. Antimicrob Agents Chemother. 2009, 53(10):4200-4210.
Di Nardo A, Yamasaki K, Dorschner RA, Lai Y, Gallo RL. Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin. J Immunol. 2008, 180(11):7565-7573.
Li M, Cha DJ, Lai Y,Villaruz AE, Sturdevant DE, Otto M. The antimicrobial peptide-sensing system aps of Staphylococcus aureus. Mol Microbiol. 2007, 66(5): 1136-1147.
Yao Y, Vuong C, Kocianva S, Villaruz AE, Lai Y, Sturdevant DE, Otto M. Characterization of the Staphylococcus epidermidis accessory gene regulator response: quorum-sensing regulation of resistance to innate host defense. J Infect Dis. 2006, 193(6):841-848.
Lai Y& Dong C. Interleukin-17 family. In: Michael J.H. Ratcliffe (Editor in Chief), Encyclopedia of Immunobiology, Vol. 2, pp.534-543. Oxford: Academic Press, London. ISBN: 978-0-08-092152-5. 2016
Lai Y. Keratinocytes: gatekeeper in innate defense (Chapter 5). In: Elia Ranzato (eds), Keratinocytes: structure, molecular mechanisms and role in immunity, page 109-116. Nova Science Publishers, Inc.New York. ISBN: 978-1-62618-798-6. 2013.
Gallo RL, Nizet V, Cogen A, Lai Y. Antimicrobial and anti-inflammatory therapies and compositions. U.S.A. Patent No. US2010/0166708A1.
Otto M, Li M, Lai Y, Villaruz AE, Cha DJ, Sturdevant DE. Gram-positive three-component antimicrobial peptide-sensing system. U.S.A. patent. Application No.60/930,709.
荣誉及奖励
2016.3上海市巾帼建功标兵
2014 上海市曙光学者
2013.8中组部万人计划“青年拔尖人才”支持计划
2011.11教育部新世纪优秀人才支持计划
2011.11上海市高校特聘教授(东方学者)
2011.4上海市青年科技启明星
2009.2美国Albert M. Kligman Travel Fellowship
2007.12上海市优秀博士论文
2006. 5美国Outstanding graduate research at the National Institutes of Health (NIH)
2005-2006美国Graduate Partnerships Program Fellowship (NIAID, NIH)