Lixiaotao

 

American Society for Endocrinology

American Association for the Advancement of Science

Our research mainly engaged in the protein metabolism, the mechanism of the tumor development, protein degradation of drug research.

1.      Liu S, Lai L, Zuo Q, Dai F, Wu L, Wang Y, Liu M, Yi Z, Xiao J, Li X*. PKA turnover by the REGγ-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis. J Mol Cell Cardiol. 2014 Feb 20; 72C: 28-38.

2.      Shi J, Wong J, Piesik P, Fung G, Zhang J, Jagdeo J, Li X, Jan E, Luo H. Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling. Autophagy. 2013 Aug 13;9 (10).

3.      Ali A,  Wang Z,  Ji L, Liu J, Li L, Yang Y, Wang Y, Zhou L,  Guo L, Wang H, Chen J, Caulin C, Myers JN, Fu J, Xiao J, Zhang B, Li X*. WT-p53/TGF-β signaling and mutant-p53 differentially regulates REGγ to target ubiquitin/ATP-independent REGγ-proteasome pathway during cancer progression. Nature Communication 2013 4:2667.

4.      Dong S, Jia C, Zhang S, Fan G, Xiao W, Shan P, Sun L, Li L, Zheng Y, Liu J, Li Y, Wei H, Hu C, Zhang W, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X* and Wang C* The REGγ Proteasome Regulates Hepatic Lipid Metabolism through Inhibition of Autophagy. Cell Metabolism 2013 Sep 3;18(3):380-91. 

5.      Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, Xu J, Liu J, Guo L, Li D, Li Z, Zuo D, Zhang Y, Liu J, Huang S, Jia C, Wang L, Wang Y, Xie Y, Luo J, Zhang B, Luo H, Donehower LA, Moses RE, Xiao J, O'Malley BW, Li X*. REGγ deficiency promotes premature aging via the casein kinase 1 pathway. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11005-10.

6.      Liu J, Wang Y, Li L, Zhou L, Wei H, Zhou Q, Liu J, Wang W, Ji L, Shan P, Wang Y, Yang Y, Jung SY, Zhang P, Wang C, Long W, Zhang B, Li X*. Site-specific acetylation of the proteasome activator REGγ directs its heptameric structure and functions. J Biol Chem. 2013 Jun 7;288(23):16567-78

7.      Redfern AD, Colley SM, Beveridge DJ, Ikeda N, Epis MR, Li X, Foulds CE, Stuart LM, Barker A, Russell VJ, Ramsay K, Kobelke SJ, Li X, Hatchell EC, Payne C, Giles KM, Messineo A, Gatignol A, Lanz RB, O'Malley BW, Leedman PJ. RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6536-41. 

8.      Jing He, Long Cui, Yu Zeng, Guangqiang Wang, Li X*. (2012).  REGgamma is associated with multiple oncogenic pathways in human cancers. BMC Cancer. Feb 23; 12(1):75.

9.      Qiao S, Murakami K, Zhao Q, Wang B, Seo H, Yamashita H, Li X, Iwamoto T, Ichihara M, Yoshino M. (2012). Mimosine-Induced Apoptosis in C6 Glioma Cells Requires the Release of Mitochondria-Derived Reactive Oxygen Species and p38, JNK Activation. Neurochem Res. Feb;37(2):417-27.

10.  Shen J, Zhang S, Li Y, Zhang W, Chen J, Zhang M, Wang T, Jiang L, Zou X, Wong J, Li X, Cui Y, Wang C. (2011). p14(ARF) inhibits the functions of adenovirus E1A oncoprotein. Biochem J. Mar 1;434(2):275-85.

11.  Wu Y, Wang L, Zhou P, Wang G, Li X*. (2011).  Regulation of REGg cellular distribution and function by SUMO modification. Cell Research.  2011 May; 21(5):807-16.

12.  Gao G, Wong J, Zhang J, Mao I, Shravah J, Wu Y, Xiao A, Li X*, Luo H. (2010). Proteasome Activator REGg Enhances Coxsackieviral Infection via Facilitating p53 Degradation. J. Virol. 84 (21): 11056-11066. 

13.  Liu J, Yu G., Zhao P., Wang C., Luo H., Long W., Wang Y., Zhao Y., Tsai M., O'Malley B.W. and Li X*. (2010).  REGγ modulates p53 activity by regulating its cellular localization. J. Cell Science. 123 (pt23): 4076-84.

14.  Tian M, Xiaoyi W, Li X, Guosheng R. (2009). Proteasomes reactivator REGgamma enchances oncogenicity of MDA-MB-231 cell line via promoting cell proliferation and inhibiting apoptosis. Cell Mol Biol (Noisy-le-grand). 55 Suppl:OL1121-31.

15.  Yu G, Zhao Y, He J, Mukherjee A, Mao CA, Li M, and Li X*. (2008). Comparative analysis of REGγ expression augurs functional implication. J. Mol. Cell. Biol. Aug; 2(4):192-8.

16.  Ivy Mao, Jian Liu, Li X*, Honglin Luo. (2008). REGg, A Proteasome Activator and Beyond? Cell and Mol Life Sci. Dec;65(24):3971-80.

17.  Li X, Larbi Amazit, Weiweng Long, David M. Lonard, John J. Monaco and O’Malley B.W. (2007). Proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol. Cell, 26,  831-842

18.  Li X., Lonard D., Jung S.Y., Malovannaya A., Feng Q., Qin J., Tsai S. Y., Tsai M-J., and O’Malley B.W. (2006).  The SRC-3/AIB1 coactivator is degraded in an ubiquitin- and ATP-independent manner by the REGgamm-proteasome  Cell. 124, 381-392.

19.  Verma S., Ismail A., Gao X., Fu G., Li X., O’Malley B. W., Nawaz Z. (2004).  Ubiquitin-conjugating enzyme, UBCH7 act as a coactivator for steroid hormone receptors. Mol. Cell. Biol. 24, 8716-26.

20.  Li X. Lonard D. M. and O’Malley B. W. (2004).  A Contemporary Understanding of Progesterone Receptor Function (Review). Mechanisms of Aging and Development. 125, 669-78.

21.  Auboeuf D., Dowhan D.H., Li X., Larkin K., Ko L., Berget S.M., O'Malley B.W. (2004). CoAA, a Nuclear Receptor Coactivator Protein at the Interface of Transcriptional Coactivation and RNA Splicing. Mol. Cell. Biol. 24, 442-53.

22.  Li X. and O'Malley B.W. Unfolding the action of progesterone receptors (minireview). (2003). J. Biol. Chem. 10, 39261-4.

23.  Li X., Wong J., Tsai S.Y., Tsai M.J., and O'Malley B.W. (2003). Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol. Cell. Biol. 23, 3763-73.

24.  Li X., Bhattacharya C., Maity S., Dayal S, and Klein W.H. (2002). Ectoderm Gene Activation in Sea Urchin Embryos Mediated by CCAAT Binding Factor CBF. Differentiation. 70, 109-19

25.  Angerer L.M., Oleksyn D. W., Levine A.M., Li X., Klein W.H. and Angerer R. (2001). Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes. Development. 128, 4393-404

26.  Yuh C., Li X., Davidson E.H., and Klein W.H. (2001). Correct Expression of Spec2a in the Sea Urchin Embryo Requires Both Otx and Other cis-Regulatory Elements. Dev. Biol. 232, 424-438

27.  Huang L., Li X., El-Hodiri H.M., Dayal S., Athula H.W., and Klein W.H. (2000). Involvement of Tcf/Lef in Establishing Cell Types along the Animal-Vegetal Axis of Sea Urchins. Dev. Genes Evol. 210, 73-81.

28.  Li X., Athula HW and Klein WH. (1999). Requirement of SpOtx in Cell Fate Decisions in the Sea Urchin Embryo and Possible Roles as a Mediator of beta-Catenin Signaling. Dev. Biol. 212, 425-439

29.  Klein W.H. and Li X. (1998). Function and Evolution of Otx Proteins. Biochem. Biophys. Res. Commun.  258, 22-34

30.  Li X., Chuang C.K., Mao C.A., Angerer L.M., and Klein WH. (1997). Two Otx proteins generated from alternative splicing of multiple transcripts of a single gene in Strongylocentrotus purppuratus.  Dev. Biol. 187, 253-266

31.  Chuang C.K., Athula H.W., Mao C.A., Li X. and Klein W.H. (1996). Transient Appearance of S. purpuratus Otx in Micromere Nuclei: Cytoplasmic Retention of SpOtx Mediated Through an alpha-Actinin SH3 Domain.  Dev. Genetics 19, 231-239

32.  Li X., Weinstock G.M. and Murray B.E. (1995).  Generation of Auxotrophic mutants of Enterococcus faecalis.  J. Bacteriol. 177, 6866-6873