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Yuting Guan

East China Normal University      

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  • About
  • Research Fields
  • Enrollment and Training
  • Course
  • Scientific Research
  • Academic Achievements
  • Honor

About

  • Department: School of Life Science
  • Graduate School: East China Normal University
  • Degree:
  • Academic Credentials:
  • PostCode: 200241
  • Tel:
  • Fax:
  • Email: ytguan@bio.ecnu.edu.cn
  • Office:
  • Address: 500 Dongchuan Rd, Shanghai, China

Education

September 2010 - June 2016 Doctoral Candidate, East China Normal University, Supervisors: Prof. Liu Mingyao, Prof. Li Dali 


September 2006 - June 2010 Undergraduate student Fujian Normal University


WorkExperience

March 2022 - Present  Researcher  East China Normal University 


February 2021 - February 2022  Research Assistant  Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 


April 2017 - January 2021  Postdoctoral Researcher, University of Pennsylvania, USA. Advisor: Katalin Susztak


Resume


 

Guan Yuting, Ph.D., is a researcher and doctoral supervisor at the School of Life Sciences, East China Normal University. She is a recipient of the Shanghai Oriental Scholar Program for Outstanding Young Scholars, the Shanghai Rising Star Program, and the Shanghai Pujiang Program. She received her bachelor's degree in Biotechnology from Fujian Normal University in 2010 and her Ph.D. in Biochemistry and Molecular Biology from East China Normal University in 2016. From 2017 to 2021, she conducted postdoctoral research at the University of Pennsylvania. In 2022, she was appointed to the School of Life Sciences at East China Normal University to engage in teaching and research. Over the years, through multi-omics and gene editing techniques, she has established a high-resolution dataset of expression quantitative trait loci (eQTL) in human kidney tissues and elucidated the functions of several chronic kidney disease susceptibility genes (DPEP1, CHMP1A, PPDPF). To date, she has published 15 papers as the first or corresponding author (including co-authors) in high-impact journals such as Nature Genetics, Nature Communications (2 papers), Nature Protocols, Science Advances, Journal of the American Society of Nephrology (3 papers), and EMBO Molecular Medicine. Her most highly cited paper has received 883 citations. She has led National Natural Science Foundation of China (NSFC) general and youth projects and participated in key research and development programs.

Other Appointments

Research Fields

1.Molecular mechanism of kidney injury
2.Develop gene therapies targeted to kidney


Enrollment and Training

Course

Scientific Research

Academic Achievements

 

1.        MUC20   alleviates kidney fibrosis by modulating pyroptosis through the MET/RAS/STING   axis. Theranostics 2026; 16(8):4374-4393.   doi:10.7150/thno.123986. (Corresponding author)

2.        PPDPF   preserves integrity of proximal tubule by modulating NMNATs activity in   chronic kidney diseases. Science Advances. 2025 Mar   21;11(12):eadr8648. doi: 10.1126/sciadv.adr8648. Epub 2025 Mar 19. （Corresponding   author）

Commented   by Science Advances (FOCUS)：DOI: 10.1126/sciadv.adw6815

3.        Long-read   sequencing of 945 Han individuals identifies novel structural variants   associated with phenotypic diversity and disease susceptibility. Nature   Communications. 2025 Feb 10;16(1):1494. doi:   10.1038/s41467-025-56661-9. （Corresponding author）

4.        Mitochondrial   SLC3A1 regulates sexual dimorphism in cystinuria. Genes &   Diseases. 2024 Nov 29;12(3):101472. doi:   10.1016/j.gendis.2024.101472. eCollection 2025 May. （Corresponding   author）

5.        Genetically   modified E. Coli secreting melanin (E. melanin) activates the astrocytic     PSAP-GPR37L1 pathway and mitigates the pathogenesis of   Parkinson’s disease. Journal of Nanobiotechnolog. 2024 Nov   10;22(1):690. doi: 10.1186/s12951-024-02955-x. （Corresponding author）

6.        A   single genetic locus controls both expression of DPEP1/CHMP1A and   kidney disease development via ferroptosis. Nature Communications.   2021 Aug 23;12(1):5078. （First author）

Commented   by Nature reviews nephrology (Research Highlight): DOI:   10.1038/s41581-021-00496-2

7.        Mapping   the genetic architecture of human traits to cell types in the kidney   identifies mechanisms of disease and potential treatments. Nature   Genetics. 2021 Sep;53(9):1322-1333. （First author）

Commented   by Kidney International (nephrology digest): DOI:   10.1016/j.kint.2021.10.026

Commented   by American journal of kidney disease (In the literature): DOI: 10.1053/j.ajkd.2021.11.002

8.        Dnmt3a and Dnmt3b-Decommissioned   Fetal Enhancers are Linked to Kidney Disease. Journal of the   American Society of Nephrology. 2020 Apr;31(4):765-782. （First   author）

9.        Functional   methylome analysis of human diabetic kidney disease. JCI Insight. 2019   Jun 6;4(11). （First author）

10.      DNMT1   in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and   Kidney Development. Journal of the American Society of Nephrology. 2019   Apr;30(4):594-609. （First author）

11.      Long-Range   Chromatin Interactions in the Kidney. Journal of the American   Society of Nephrology. 2019 Feb 13;30(3):367-369. （First   author）

12.      CRISPR/Cas9-mediated   somatic correction of a novel coagulator factor IX gene mutation ameliorates   hemophilia in mouse. EMBO Molecular Medicine. 2016 May   2;8(5):477-88. （First author）

Commented   by EMBO Molecular Medicine (news & views): DOI:   10.15252/emmm.201606325

13.      Large   genomic fragment deletion and functional gene cassette knock-in via Cas9   protein mediated genome editing in one-cell rodent embryos. Scientific   Report. 2015 Dec 1;5:17517. （First author）

14.      Repression   of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration   in Acute Inflammatory Bowel Disease Models. Journal of Immunology.   2015 Jul 1;195(1):339-46. （First author）

15.      CRISPR/Cas-mediated   genome editing in the rat via direct injection of one-cell embryos. Nature   Protocols. 2014 Oct;9(10):2493-512. （First author）

16.      Generation   of site-specific mutations in the rat genome via CRISPR/Cas9. Methods   in Enzymology. 2014;546:297-317. （First author）




Honor

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