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Yuting Guan

      

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  • Research Fields
  • Enrollment and Training
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  • Scientific Research
  • Academic Achievements
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About

  • Department: School of Life Science
  • Graduate School: East China Normal University
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  • Email: ytguan@bio.ecnu.edu.cn
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Education

WorkExperience

Resume


 

Dr. Yuting Guan received her Ph. D degree in 2016 from the East China Normal University (ECNU), Shanghai, China. Upon her completion of Ph.D training, shewas trained as a postdoctoral researcherin University of Pennsylvania, Philadelphia, PA, USA from 2017 to 2021. She joined School of Life Sciences, ECNU,and became a principal investigator in 2022.


Dr. Guan’s research mainly focuses on the molecular mechanism of chronic kidney disease and acute kidney injury through integration of GWAS, high-throughput sequencing and CRISPR/Cas9 technology, and the development of new gene therapies targeted to kidney. Dr. Guan published articles in high-impact journals, such asNat Genet and Nat Commun


Other Appointments

Research Fields

1.Molecular mechanism of kidney injury
2.Developmentofgene therapies targeted to kidney


Enrollment and Training

Course

Scientific Research

Academic Achievements

1.   PPDPF preserves integrity of proximal tubule by  modulating NMNATs activity in chronic kidney diseases. Science Advances. 2025 Mar 21;11(12):eadr8648. doi: 10.1126/sciadv.adr8648. Epub 2025 Mar 19. （Corresponding author）

2.   Long-read sequencing of 945 Han individuals identifies novel structural variants   associated with phenotypic diversity and disease susceptibility. Nature Communications. 2025 Feb 10;16(1):1494. doi: 10.1038/s41467-025-56661-9. （Corresponding author）

3.  Mitochondrial SLC3A1 regulates sexual dimorphism in cystinuria. Genes & Diseases. 2024 Nov 29;12(3):101472. doi: 10.1016/j.gendis.2024.101472. eCollection 2025 May. （Corresponding author）

4.        Genetically modified E. Coli secreting melanin (E. melanin) activates the astrocytic   PSAP-GPR37L1 pathway and mitigates the pathogenesis of Parkinson’s disease. Journal of Nanobiotechnology. 2024 Nov 10;22(1):690. doi: 10.1186/s12951-024-02955-x. （Corresponding author）

5.     A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis. Nature Communications. 2021 Aug 23;12(1):5078. （First author）

6.    Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments. Nature Genetics. 2021 Sep;53(9):1322-1333. （First author）

7.   Dnmt3a and Dnmt3b-Decommissioned Fetal Enhancers are Linked to Kidney Disease. Journal of the American Society of Nephrology. 2020 Apr;31(4):765-782. （First author）

8.       Functional methylome analysis of human diabetic kidney disease. JCI Insight. 2019 Jun 6;4(11). （First author）

9.  DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney  Development. Journal of the American Society of Nephrology. 2019 Apr;30(4):594-609. （First author）

10.     Long-Range Chromatin Interactions in the Kidney. Journal of the American Society of Nephrology. 2019 Feb 13;30(3):367-369. （First author）

11.   CRISPR/Cas9-mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse. EMBO Molecular Medicine. 2016 May 2;8(5):477-88. （First author）

12.  Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos. Scientific Report. 2015 Dec 1;5:17517. （First author）

13.  Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models. Journal of Immunology. 2015 Jul 1;195(1):339-46. （First author）

14.  CRISPR/Cas-mediated genome editing in the rat via direct  injection of one-cell embryos. Nature Protocols. 2014 Oct;9(10):2493-512. （First author）

15. Generation of site-specific mutations in the rat genome via CRISPR/Cas9. Methods in Enzymology. 2014;546:297-317. （First author）





Honor

10 Visits

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