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Yuting Guan

East China Normal University      

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  • About
  • Research Fields
  • Enrollment and Training
  • Course
  • Scientific Research
  • Academic Achievements
  • Honor

About

  • Department: School of Life Science
  • Graduate School: East China Normal University
  • Degree:
  • Academic Credentials:
  • PostCode: 200241
  • Tel:
  • Fax:
  • Email: ytguan@bio.ecnu.edu.cn
  • Office:
  • Address: 500 Dongchuan Rd, Shanghai, China

Education

September 2010 - June 2016 Doctoral Candidate, East China Normal University, Supervisors: Prof. Liu Mingyao, Prof. Li Dali 


September 2006 - June 2010 Undergraduate student Fujian Normal University


WorkExperience

March 2022 - Present  Researcher  East China Normal University 


February 2021 - February 2022  Research Assistant  Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine 


April 2017 - January 2021  Postdoctoral Researcher, University of Pennsylvania, USA. Advisor: Katalin Susztak


Resume


 

Guan Yuting, Ph.D., is a researcher and doctoral supervisor at the School of Life Sciences, East China Normal University. She is a recipient of the Shanghai Oriental Scholar Program for Outstanding Young Scholars, the Shanghai Rising Star Program, and the Shanghai Pujiang Program. She received her bachelor's degree in Biotechnology from Fujian Normal University in 2010 and her Ph.D. in Biochemistry and Molecular Biology from East China Normal University in 2016. From 2017 to 2021, she conducted postdoctoral research at the University of Pennsylvania. In 2022, she was appointed to the School of Life Sciences at East China Normal University to engage in teaching and research. Over the years, through multi-omics and gene editing techniques, she has established a high-resolution dataset of expression quantitative trait loci (eQTL) in human kidney tissues and elucidated the functions of several chronic kidney disease susceptibility genes (DPEP1, CHMP1A, PPDPF). To date, she has published 15 papers as the first or corresponding author (including co-authors) in high-impact journals such as Nature Genetics, Nature Communications (2 papers), Nature Protocols, Science Advances, Journal of the American Society of Nephrology (3 papers), and EMBO Molecular Medicine. Her most highly cited paper has received 883 citations. She has led National Natural Science Foundation of China (NSFC) general and youth projects and participated in key research and development programs.

Other Appointments

Research Fields

1.Molecular mechanism of kidney injury
2.Develop gene therapies targeted to kidney


Enrollment and Training

Course

Scientific Research

Academic Achievements

 

2026

1.       Maternal obesity induces macrophage to myofibroblast transition in kidneys of male offspring through a pathway driven by 20-hydroxyeicosatetraenoic acid. Nature Communications. 2026 May 14. doi: 10.1038/s41467-026-73237-3. (Last corresponding author)

2.       MUC20 alleviates kidney fibrosis by modulating pyroptosis through the MET/RAS/STING axis. Theranostics 2026; 16(8):4374-4393. doi:10.7150/thno.123986. （joint corresponding author）

 

2025

1.       PPDPF preserves integrity of proximal tubule by modulating NMNATs activity in chronic kidney diseases. Science Advances. 2025 Mar 21;11(12):eadr8648. doi: 10.1126/sciadv.adr8648. Epub 2025 Mar 19. （Last corresponding author）

Science Advances（FOCUS）：DOI: 10.1126/sciadv.adw6815

2.       Long-read sequencing of 945 Han individuals identifies novel structural variants associated with phenotypic diversity and disease susceptibility. Nature Communications. 2025 Feb 10;16(1):1494. doi: 10.1038/s41467-025-56661-9. （joint corresponding author）

3.       Mitochondrial SLC3A1 regulates sexual dimorphism in cystinuria. Genes & Diseases. 2024 Nov 29;12(3):101472. doi: 10.1016/j.gendis.2024.101472. eCollection 2025 May. （joint corresponding author）

 

2024

1.       Genetically modified E. Coli secreting melanin (E. melanin) activates the astrocytic PSAP-GPR37L1 pathway and mitigates the pathogenesis of Parkinson’s disease. Journal of Nanobiotechnology. 2024 Nov 10;22(1):690. doi: 10.1186/s12951-024-02955-x. （joint corresponding author）

 

2021

1.       A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis. Nature Communications. 2021 Aug 23;12(1):5078. （First Author）

a)       Nature reviews nephrology (Research Highlight）: DOI: 10.1038/s41581-021-00496-2

2.       Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments. Nature Genetics. 2021 Sep;53(9):1322-1333. （First Author）

a)       Kidney International（nephrology digest）：DOI: 10.1016/j.kint.2021.10.026

b)      American journal of kidney disease（In the literature）: DOI: 10.1053/j.ajkd.2021.11.002

 

2020

1.       Dnmt3a and Dnmt3b-Decommissioned Fetal Enhancers are Linked to Kidney Disease. Journal of the American Society of Nephrology. 2020 Apr;31(4):765-782. （First Author）


2019

1.       Functional methylome analysis of human diabetic kidney disease. JCI Insight. 2019 Jun 6;4(11). （First Author）

2.       DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development. Journal of the American Society of Nephrology. 2019 Apr;30(4):594-609. （First Author）

3.       Long-Range Chromatin Interactions in the Kidney. Journal of the American Society of Nephrology. 2019 Feb 13;30(3):367-369. （First Author）

 

2016及以前

1.       CRISPR/Cas9-mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse. EMBO Molecular Medicine. 2016 May 2;8(5):477-88. （First Author）

EMBO Molecular Medicine（news & views）: DOI: 10.15252/emmm.201606325

2.       Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos. Scientific Report. 2015 Dec 1;5:17517. （First Author）

3.       Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models. Journal of Immunology. 2015 Jul 1;195(1):339-46. （First Author）

4.       CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos. Nature Protocols. 2014 Oct;9(10):2493-512. （First Author）

5.       Generation of site-specific mutations in the rat genome via CRISPR/Cas9. Methods in Enzymology. 2014;546:297-317. （First Author）




Honor

10 Visits

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