个人资料
- 部门: 心理与认知科学学院
- 毕业院校: 华东师范大学
- 学位: 理学博士
- 学历: 博士
- 邮编: 200062
- 联系电话: 021-62235172
- 传真:
- 电子邮箱: dzyin@psy.ecnu.edu.cn
- 办公地址:
- 通讯地址: 上海市普陀区中山北路3663号老图书馆311室
教育经历
2012/9—2014/5,美国哥伦比亚大学,磁共振成像计算方法,博士联合培养 2011/9—2014/6,华东师范大学,无线电物理专业,博士 2009/9—2011/7,华东师范大学,无线电物理专业,硕士(硕博连读) 2005/9—2009/7,安庆师范学院,物理学专业,学士
工作经历
2019/10—至今, 华东师范大学心理与认知科学学院,紫江青年学者,研究员,博士生导师 2016/12—2019/9,中国科学院神经科学研究所(神经科学国家重点实验室),副研究员 2014/8—2016/11,中国科学院神经科学研究所(神经科学国家重点实验室),助理研究员
个人简介
尹大志,博士,现任华东师范大学心理与认知科学学院紫江青年学者,研究员,博士生导师。2014年6月毕业于华东师范大学物理系上海市磁共振重点实验室,获得理学博士学位。博士期间有两年在美国哥伦比亚大学精神病学系进行博士生联合培养(国家公派)。2014年8月至2019年9月,在中国科学院神经科学研究所脑影像中心依次担任助理研究员、副研究员。2017年入选“中国科学院青年创新促进会”,2018年获得“长三角神经科学青年科学家奖”和“赛诺菲-中国科学院上海生命科学研究院”优秀青年人才奖励基金,先后主持国家自然科学基金面上项目和青年项目,主要从事脑网络计算方法学及其在脑认知和脑疾病中的应用研究,相关研究成果以第一/通讯作者(含共同)已发表在Biological Psychiatry、Neurology、Journal of Neuroscience、NeuroImage等国际权威学术期刊上。
社会兼职
1. 中国康复医学会脑功能检测与调控康复专业委员会委员,2019.06-2023.06 2. 中国卫生信息与健康医疗大数据学会康复专业及信息化标准委员会委员,2019.03-2024.03
研究方向
研究领域:脑成像与认知神经科学 研究方向:认知控制与脑可塑性(网络神经科学) 1. 研究主题:认知与行为灵活性的神经基础、神经精神疾病的诊疗机制、自发(内在)和任务诱发脑活动组织规律、大脑可塑性。 2. 研究方法:多模态磁共振成像技术、认知训练、神经调控与干预、复杂网络、动态脑网络、复杂性。
招生与培养
招生和招聘信息(包括硕士研究生、博士研究生以及博士后) 1. 具有心理学、物理学、或计算机科学等理工科专业背景。 2. 对脑科学研究具有强烈的兴趣。 3. 为人诚实守信,勤奋刻苦,具有较好的数理基础和编程经验。
开授课程
《磁共振成像原理与技术》(本科生) 《专业报告与交流》(本科生) 《网络神经科学导论》(研究生) 《认知神经科学前沿》(研究生)
科研项目
国家自然科学基金面上项目(32271096),认知灵活性的脑动力学表征研究,2023/1-2026/12,54万元,主持。
科技创新2030重大项目,“中国学龄儿童脑智发育队列研究”子课题(2021ZD0200535),情绪与社会技能发展的脑网络基础及分化机制,2021/8-2026/7,参与。 上海市脑功能基因组学重点实验室主任基金,2022/6-2023/6,12万元,主持。 中国科学院青年创新促进会(中科院青年人才项目), 2018/1-2021/12,80万元,主持。 国家自然科学基金青年项目(31600869),静息态功能连接模式的动态重配及其应用研究,2017/1-2019/12,20万元,主持。 中国科学院上海生命科学研究院优秀青年人才领域前沿项目(2014KIP206),一种联合多模态磁共振成像方法预测脑中风患者手功能转归,2014/10-2016/9,15万元,主持。 科技部重点研发计划(2017YFC1310400),甲基苯丙胺依赖诊断与复发预警客观指标和干预新技术体系的研发,2017/1-2020/12,785万元,项目骨干。 国家自然科学基金委重大仪器装备研制项目(81527901),基于超声辐射力的深部脑刺激与神经调控仪器研制,2016/1-2020/12,7366万,项目骨干。 国家自然科学基金委面上项目(81771477),注意缺陷多动障碍儿童执行功能缺陷的优化干预及脑影像学变化的机制研究,2018/1-2021/12,70万元,参与。 国家自然科学基金委面上项目(81671307),亚甲蓝PI3K/AKT信号通路中保护慢性脑低灌注致神经血管单元损伤中的作用,2017/1-2020/12,57 万元,参与。 国家自然科学基金委面上项目(81471651),康复治疗对脑卒中后不同阶段运动功能恢复作用机制的静息态功能磁共振成像研究,2015/1-2018/12,72 万元,参与。
学术成果
Peer-Reviewed Articles(#First Author, *Corresponding Author) Zhao W#, Su K#, Zhu H, Kaiser M, Fan M, Zou Y, Li T, Yin D*. Activity flow under the manipulation of cognitive load and training. NeuroImage. 2024; 297:120761. Su K, Huang Z, Li Q, Fan M, Li T, Yin D*. Dissociable functional responses along the posterior-anterior gradient of the frontal and parietal cortices revealed by parametric working memory and training. Brain Structure and Function. 2024; online published. Yu Q#, Yin D#, Kaiser M, Xu G, Guo M, Liu F, Li J, Fan M. Pathway-specific mediation effect between structure, function, and motor impairment after subcortical stroke. Neurology. 2023;100:e616-e626. [Commentary by Bhaskar Roy & Randolph S. Marshall, New Insight in Causal Pathways Following Subcortical Stroke: From Correlation to Causation. Neurology. 2023;100:271-272] Zhu H, Huang Z, Yang Y, Su K, Fan M, Zou Y, Li T, Yin D*. Activity flow mapping over probabilistic functional connectivity. Human Brain Mapping. 2023;44:341–361. Lu J, Donner R, Yin D, Guan S, Zou Y. Partial event coincidence analysis for distinguishing direct and indirect coupling in functional network construction. Chaos. 2022, 32:063134. Fang F, Gong Y, Luo Q, Ge R, Kang M, Ma M, Zhang L, Mu D, Yin D*, Wang Y*. Cognitive Dysfunction in Type 2 Diabetes Is Not a One-Way Process: Evidence From a Longitudinal Brain Connectivity Study. Frontiers in Endocrinology. 2022, 13:874538. Li D, Liu C, Huang Z, Li H, Xu Q, Zhou B, Hu C, Zhang Y, Wang Y, Nie J, Qiao Z*, Yin D*, Xu X*. Common and distinct disruptions of cortical surface morphology between ASD children with and without SHANK3 deficiency. Frontiers in Neuroscience. 2021, 15:751364. Yin D*, Wang X, Zhang X, Yu Q, Wei Y, Cai Q, Fan M*, Li L*. Dissociable plasticity of visual-motor system in functional specialization and flexibility in expert table tennis players. Brain Structure and Function. 2021; 226:1973-1990. Yin D*, Kaiser, M*. Understanding Neural Flexibility from a Multifaceted Definition. NeuroImage. 2021; 235:118027. Feng L#, Yin D#, Wang X, Xu Y, Xiang Y, Teng F, Pan Y, Zhang X, Su J, Wang Z, Jin L. Brain connectivity abnormalities and treatment-induced restorations in patients with cervical dystonia. European Journal of Neurology. 2021; 28:1537–1547. Lv Q, Lv Q, Yin D, Zhang C, Sun B, Voon V, Wang Z. Neuroanatomical Substrates and Predictors of Response to Capsulotomy in Intractable Obsessive-Compulsive Disorder. Biological psychiatry: Cognitive neuroscience and neuroimaging. 2021; 6:29–38. Su H, Liu Y, Yin D, Chen T, Li X, Zhong N, Jiang H, Wang J, Du J, Xiao K, Xu D, Zeljic K, Wang Z, Zhao M. Neuroplastic changes in resting-state functional connectivity after rTMS intervention for methamphetamine craving. Neuropharmacology. 2020; 175:108177. Yin D, Chen X, Zeljic K, Zhan Y, Shen X, Yan G, and Wang Z. A Graph Representation of Functional Diversity of Brain Regions. Brain and Behavior. 2019; e01358. Fang F, Lai M, Huang J, Kang M, Ma M, Li K, Lian J, Wang Z, Yin D*, Wang Y*. Compensatory Hippocampal Connectivity in Young Adults with Early-Stage Type 2 Diabetes. The Journal of Clinical Endocrinology & Metabolism. 2019; 104:3025–3038. Yin D, Zhang Z, Wang Z, Zeljic K, Lv Q, Cai D, Wang Y, Wang Z. Brain Map of Intrinsic Functional Flexibility in Anesthetized Monkeys and Awake Humans. Frontiers in Neuroscience. 2019, 13:174. Li HF#, Yang L#, Yin D#, Chen WJ, Liu GL, Ni W, Wang N, Yu W, Wu ZY, Wang Z. Associations between neuroanatomical abnormality and motor symptoms in paroxysmal kinesigenic dyskinesia. Parkinsonism & Related Disorders. 2019; 62:134-140. Yin D#, Zhang C#, Lv Q, Chen X, Zeljic K, Gong H, Zhan S, Jin H, Wang Z, Sun B. Dissociable Frontostriatal Connectivity: Mechanism and Predictor of the Clinical Efficacy of Capsulotomy in Obsessive-Compulsive Disorder. Biological Psychiatry. 2018; 84:926-936. [Commentary by Hoexter MQ, Are we ready for individualized target planning of ablative procedures in intractable obsessive-compulsive disorder? Biological Psychiatry, 2018, 84(12): e85-e87] Zhao Z, Wu J, Fan M, Yin D, Tang C, Gong J, Xu G, Gao X, Yu Q, Yang H, Sun L, Jia J. Altered intra- and inter-network functional coupling of resting-state networks associated with motor dysfunction in stroke. Human Brain Mapping. 2018; 39:3388-3397. Zhao Z, Tang C, Yin D, Wu J, Gong J, Sun L, Jia J, Xu D, Fan M. Frequency-specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function. Human Brain Mapping. 2018; 39:4373-4384. Zou Y, Zhao Z, Yin D, Fan M, Small M, Liu Z, Hilgetag CC, Kurths J. Brain anomaly networks uncover heterogeneous functional reorganization patterns after stroke. Neuroimage Clinical. 2018; 20:523-530. Peng W, Mao L, Yin D, Sun W, Wang H, Zhang Q, Wang J, Chen C, Zeng M, Ding J, Wang X. Functional network changes in the hippocampus contribute to depressive symptoms in epilepsy. Seizure. 2018; 60:16-22. Fang F, Zhan Y, Zhuo Y, Yin D, Li K, Wang Y. Brain atrophy in middle-aged subjects with Type 2 diabetes mellitus, with and without microvascular complications. Journal of Diabetes. 2018; 10:625-632. Song Y, Li W, Meng S, Zhou W, Su B, Tang L, Zhao Y, Wu X, Yin D, Fan M, Zhou C. Dual integrin alphavbeta 3 and NRP-1-Targeting Paramagnetic Liposome for Tumor Early Detection in Magnetic Resonance Imaging. Nanoscale Research Letters. 2018; 13:380. Yin D#, Liu W#, Zeljic K, Lv Q, Wang Z, You M, Men W, Fan M, Cheng W, Wang Z. Failure in Cognitive Suppression of Negative Affect in Adolescents with Generalized Anxiety Disorder. Scientific Reports. 2017; 7:6583. Wen Z, Cheng , Yin D, Sun S, Wang Z, Yu S, Zhang Y, Qiu Z, Du Y. Identification of the Genetic Cause for Childhood Disintegrative Disorder by Whole-Exome Sequencing. Neuroscience Bulletin. 2017; 33:251-254. Yin D, Liu W, Zeljic K, Wang Z, Lv Q, Fan M, Cheng W, Wang Z. Dissociable Changes of Frontal and Parietal Cortices in Inherent Functional Flexibility across the Human Life Span. Journal of Neuroscience. 2016; 36(39):10060 –10074. Zheng X, Sun L, Yin D, Jia J, Zhao Z, Jiang Y, Wang X, Wu J, Gong J, Fan M. The plasticity of intrinsic functional connectivity patterns associated with rehabilitation intervention in chronic stroke patients. Neuroradiology. 2016; 58:417-427. Zhao Z, Wang X, Fan M, Yin D, Sun L, Jia J, Tang C, Zheng X, Jiang Y, Wu J, Gong J. Altered Effective Connectivity of the Primary Motor Cortex in Stroke: A Resting-State fMRI Study with Granger Causality Analysis. PLoS One. 2016; 11:e0166210. Yan C, Su L, Wang Y, Xu T, Yin D, Fan M, Deng C, Hu Y, Wang Z, Cheung E, Lim K, Chan R. Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex. Scientific Reports. 2016; 6:29079. Yan C, Wang Y, Su L, Xu T, Yin D, Fan M, Deng C, Wang Z, Lui S, Cheung E, Chan R. Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy. Psychiatry Research: Neuroimaging. 2016; 254:127-136. Liu W#, Yin D#, Cheng W, Fan M, You M, Men W, Zang L, Shi D, Zhang F. Abnormal Functional Connectivity of the Amygdala-Based Network in Resting-State fMRI in Adolescents with Generalized Anxiety Disorder. Medical Science Monitor. 2015; 21: 459-467. Jiang Y, Yin D, Xu D, Men W, Cao R, Li B, Fan M. Investigating microbleeding in cerebral ischemia rats using susceptibility-weighted imaging. Magnetic Resonance Imaging. 2015; 33:102-109. Wang Y, Yan C, Yin D, Fan M, Cheung E, Pantelis C, Chan RC. Neurobiological changes of schizotypy: evidence from both volume-based morphometric analysis and resting-state functional connectivity. Schizophrenia Bulletin. 2015; 41 Suppl 2:S444-454. Yin D, Song F, Xu D, Sun L, Men W, Zang L, Yan X, Fan M. Altered topological properties of the cortical motor-related network in patients with subcortical stroke revealed by graph theoretical analysis. Human Brain Mapping. 2014; 35:3343–3359. He X, Liu W, Li X, Li Q, Liu F, Rauh VA, Yin D, Bansal R, Duan Y, Kangarlu A, Peterson BS, Xu D. Automated assessment of the quality of diffusion tensor imaging data using color cast of color-encoded fractional anisotropy images. Magnetic Resonance Imaging. 2014;32:446-456. Guo W, Li D, Zhu J, Wei X, Men W, Yin D, Fan M, Xu Y. A magnetic nanoparticle stabilized gas containing emulsion for multimodal imaging and triggered drug release. Pharmaceutical Research. 2014; 31:1477–1484. Lin Z, Tao J, Gao Y, Yin D, Chen A, Chen L. Analysis of central mechanism of cognitive training on cognitive impairment after stroke: Resting-state functional magnetic resonance imaging study. Journal of International Medical Research. 2014; 42(3) 659–668. Yin D, Yan X, Fan M, Hu Y, Men W, Sun L, Song F. Secondary degeneration detected by combining voxel-based morphometry and tract-based spatial statistics in subcortical strokes with different outcomes in hand function. American Journal of Neuroradiology. 2013; 34:1341-1347. Yin D#, Luo Y#, Song F, Xu D, Peterson BS, Sun L, Men W, Yan X, Fan M. Functional reorganization associated with outcome in hand function after stroke revealed by regional homogeneity. Neuroradiology. 2013; 55:761-770. Dai H, Yin D, Hu C, Morelli JN, Hu S, Yan X, Xu D. Whole-brain voxel-based analysis of diffusion tensor mri parameters in patients with primary open angle glaucoma and correlation with clinical glaucoma stage. Neuroradiology. 2013; 55:233-243. Sun L, Yin D, Zhu Y, Fan M, Zang L, Wu Y, Jia J, Bai Y, Zhu B, Hu Y. Cortical reorganization after motor imagery training in chronic stroke patients with severe motor impairment: A longitudinal fmri study. Neuroradiology. 2013; 55:913-925. Dai H, Morelli JN, Ai F, Yin D, Hu C, Xu D, Li Y. Resting-state functional mri: Functional connectivity analysis of the visual cortex in primary open-angle glaucoma patients. Human Brain Mapping. 2013; 34:2455-2463. Yan X, Zhou M, Ying L, Yin D, Fan M, Yang G, Zhou Y, Song F, Xu D. Evaluation of optimized b-value sampling schemas for diffusion kurtosis imaging with an application to stroke patient data. Computerized Medical Imaging and Graphics. 2013; 37:272-280. Men W, Falk D, Sun T, Chen W, Li J, Yin D, Zang L, Fan M. The corpus callosum of albert einstein's brain: Another clue to his high intelligence? Brain. 2013. doi:10.1093/brain/awt252. Yin D, Song F, Xu D, Peterson BS, Sun L, Men W, Yan X, Fan M. Patterns in cortical connectivity for determining outcomes in hand function after subcortical stroke. PLoS One. 2012; 7:e52727. Song F#, Zhang F#, Yin D#, Hu Y, Fan M, Ni H, Nan X, Cui X, Zhou C, Huang C, Zhao Q, Ma L, Xu Y, Xia Q. Diffusion tensor imaging for predicting hand motor outcome in chronic stroke patients. Journal of International Medical Research. 2012; 40:126-133.
郭苗,徐国军,余秋蓉,王鹤玮,尹大志,孙莉敏,宁瑞鹏,刘凡,范明霞,脑卒中后运动功能障碍与连接半球间同位脑区的胼胝体结构损伤相关,磁共振成像,2022年第6期28-35 詹爽,余秋蓉,尹大志,王鹤玮,徐国军,王雪飞,郭苗,孙长慧,朱秉,孙莉敏,范明霞,脑卒中后手运动相关脑区正负网络连接的变化:一项静息态fMRI 的研究,磁共振成像,2021年第6期44-50 王雪飞,尹大志,李琳,徐国军,余秋蓉,詹爽,郭苗,张小友,范明霞,太极拳学习过程中的静息态脑功能活动局部一致性研究,磁共振成像,2021年第6期51-56 魏彧,余秋蓉,尹大志,王鹤玮,孙莉敏,徐国军,詹爽,王雪飞,郭苗,刘凡,范明霞,基于健康人皮质脊髓束模板分析脑卒中皮质脊髓束损伤,磁共振成像,2021年第7期39-45 邵方方,尹大志,贾杰,赵智勇,王想敏,郑晓慧,宋凡,范明霞,孙莉敏,皮质下脑卒中对运动想象有关脑区功能连接的影响,中国康复医学杂志,2016年第2期133-139。 王想敏,赵智勇,尹大志,孙莉敏,郑晓慧,贾杰,范明霞,脑卒中静息态下脑活动异常的比率低频振幅,磁共振成像,2016年第7卷第6期401-406。 孙莉敏,吴毅,尹大志,范明霞,臧丽丽,胡永善,健康成人在手部主动、被动和想象握拳运动时脑区激活特点的功能性磁共振成像研究,中华物理医学与康复杂志,2016年第2期126-131。 孙莉敏,吴毅,尹大志,范明霞,臧丽丽,胡永善,朱秉,徐一鸣,运动想象训练促进脑卒中患者上肢运动功能恢复的功能磁共振研究,中国康复医学杂志,2015年第12期 1217-1222。 范亮艳,范晓芳,罗位超,吴功航,严 序,尹大志,吕 岳,朱君明,徐冬溶,艺术设计中创造性思维的fMRI 研究:一项基于智能 CAD 的探索,心理学报,2014年第46卷第4期。 宋凡,尹大志,胡永善,范明霞,倪欢欢,崔晓,基于体素的形态学测量分析脑卒中后残障手的机制,中国康复医学杂志,2013年第28卷第7期。 尤美娜,程文红,门卫伟,范明霞,刘文敬,尹大志,青少年广泛性焦虑障碍患者静息态功能磁共振成像研究,临床精神医学杂志,2012年第22 卷第5 期。
荣誉及奖励
2018年获“长三角神经科学青年科学家奖” 2018年获“赛诺菲-中国科学院上海生命科学研究院”优秀青年人才奖励基金 2017年入选“中国科学院青年创新促进会” 2013年获博士研究生“国家奖学金” 2012年获国家留学基金委国家公派博士生联合培养资助
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