孙磊

Ø 2025.11 — 至今         华东师范大学，药学院

Ø 2022.08 — 2025.08  加州大学圣地亚哥分校，化学与纳米工程系，博士后，导师：张良方教授

                             （美国医学与生物工程院院士，美国国家发明家科学院院士）

Ø 2021.01 — 2022.08   华东师范大学，化学与分子工程学院，博士后，导师：闫志强研究员、余家会

                               研究员

孙磊，药学院博士生导师，紫江青年学者。主要从事AI赋能的仿生纳米药物递送系统与生物载体药物递送技术研究，聚焦细胞膜仿生纳米平台及细胞/工程化微生物（细菌、微藻）与病毒等载体的构建与工程化，面向肿瘤与耐药微生物感染等重大疾病的检测、预防与治疗应用与转化。以第一作者/共同第一作者在 Nature Communications、Science Advances、Advanced Materials、Journal of the American Chemical Society、Angewandte Chemie International Edition、ACS Nano 等国际高水平期刊发表论文15篇。主持国自然基金项目等5项，中国发明专利授权6项。

Society for Biomaterials（SFB，美国生物材料学会）2026 年会评审专家

1.  AI赋能的生物药物递送系统研究

2. 基于核酸纳米药物的基因疗法和细胞免疫疗法

3. 新型工程化微生物（细菌/微藻及病毒等）载体药物研究

基金项目:

  国家自然科学基金青年科学基金项目，2023.01-2025.12，No. 82204307.（主持, 结题）

  中国博士后科学基金第 69 批面上资助二等，2021.9-2022.9，NO. 2021M691040.（主持，结题）

  中国博士后科学基金第 3 批特别资助（站前），2021.9-2022.9，NO. 2021TQ0111.（主持，结题）

  南京大学研究生科研创新基金，2018.12-2020.12，NO. 2018CL12.（主持，结题）

  国家大学生创新创业培养计划，2017.8-2019.8，NO. G201710284147.（主持，结题）

  国家自然科学基金面上项目，2024.1-2027.12，NO. 82373813.（参与, 在研）

  国家自然科学基金青年科学基金项目，2024.1-2026.12，8230131683.（参与, 在研）

代表性文章

1. Sun L; Yu Y; Zhang JA; Shen WT; Feng K; Bai D; Zhou Z; Gao W*; Zhang L*; Controlled dimerization of cellular nanodiscs via click chemistry to enhance immune compatibility, Journal of the American Chemical Society, 2025, 147(33): 30136–30145. (IF = 15.7, 一区Top)

2. Sun L; Feng K; Bai D; Yu Y; Shen WT; Zhang JA; Fang RH; Gao W*; Zhang L*; Hepatic endoplasmic reticulum-derived nanodiscs for broadspectrum drug detoxification, Biomaterials, 2025, 318: 123188. (IF = 12.9, 一区Top)

3. Sun L; Feng K; Zhang JA; Shen WT; Gao W*; Zhang L*; Pharmacological mechanisms of cellular nanoparticles in biological neutralization, Annual Review of Pharmacology and Toxicology, 2025. (IF = 13.1, 一区Top, 顶级综述期刊)

4. Feng K⁺; Sun L⁺; Zhou Z; Zhang JA; Fang RH*; Gao W*; Zhang L*; Macrophagemimicking nanodiscs for treating systemic infections caused by methicillinresistant Staphylococcus aureus, Science Advances, 2025, 11(27): eadw7511. (IF = 12.5, 一区Top)

5. Sun L; Wang D; Feng K; Zhang JA; Gao W; Zhang L*; Cell membranecoated nanoparticles for targeting carcinogenic bacteria, Advanced Drug Delivery Reviews, 2024, 209: 115320. (IF = 17.6, 一区Top, 顶级综述期刊)

6. Sun L; Yu Y; Peng Y; Wang D; Wang S; Noh I; Fang RH*; Gao W*; Zhang L*; Platelet membranederived nanodiscs for neutralization of endogenous autoantibodies and exogenous virulence factors, Small, 2024, 2308327. (IF = 12.1, 一区Top)

7. Sun L⁺; Wang D⁺; Noh I⁺; Fang RH; Gao W*; Zhang L*; Synthesis of erythrocyte nanodiscs for bacterial toxin neutralization, Angewandte Chemie International Edition, 2023, 62(21): e202301566. (IF = 16.9, 一区Top)

8. Sun L; Zhang J; Zhou JE; Wang J; Wang Z; Luo S; Wang Y; Zhu S; Yang F; Tang J; Lu W; Wang Y; Yu L; Yan Z*; Monitoring the in vivo siRNA release from lipid nanoparticles based on the fluorescence resonance energy transfer principle, Asian Journal of Pharmaceutical Sciences, 2023, 18(1): 100769 (IF = 11.9, 一区Top)

9. Sun L; Zhou JE; Luo T; Wang J; Kang L; Wan Y; Luo S; Wang Z; Zhou Z; Zhu J; Yu J; Yu L; Yan Z*. Nanoengineered neutrophils as cellular sonosensitizer for visual sonodynamic therapy of malignant tumors, Advanced Materials, 2022, 34(15): 2109969. (IF = 26.8, 一区Top)

10. Sun L; Xu Y; Zhang X; Gao Y; Chen J; Zhou A; Lu Q; Wang Z; Shao K*; Wu H*; Ning X*. MSCs functionalized sonodynamic treatment for improving therapeutic efficacy and compliance of orthotopic oral cancer, Advanced Materials, 2020, 32(48): e2005295. (IF = 26.8, 一区Top)

11. Sun L; Xu Y; Gao Y; Huang X; Feng S; Chen J; Wang X; Guo L; Li M; Meng X; Zhang J; Ge J; An X; Ding D; Luo Y; Zhang Y*; Jiang Q*; Ning X*. Synergistic amplification of oxidative stressmediated antitumor activity via liposoma dichloroacetic acid and MOFFe2+, Small, 2019, 15(24): e1901156. (IF = 12.1, 一区Top)

12. Li Z⁺; Guo Z⁺; Zhang F⁺; Sun L⁺; Luan H; Fang Z; Dedrick JL; Zhang Y; Tang C; Zhu A; Yu Y; Ding S; Wang D; Chang AY; Yin L; Russell LM; Gao W; Fang RH; Zhang L*; Wang J*; Inhalable biohybrid microrobots: a noninvasive approach for lung treatment, Nature Communications, 2025, 16(1): 666. (IF = 15.7, 一区Top)

13. Nandhakumar P; Sun L⁺; Li Z; Cheung C; Nguyen L; Ding S; Gao W; Zhang L*; Wang J*; Biomimetic cell membrane layers for the detection of insulin and glucagon, Analytical Chemistry, 2024, 96(49): 19812–19821. (IF = 6.7, 一区Top)

14. Zhou JE; Sun L⁺; Liu L; Jia Y; Han Y; Shao J; Wang J; Wang Y; Yu L; Yan Z*; Hepatic macrophage targeted siRNA lipid nanoparticles treat nonalcoholic steatohepatitis, Journal of Controlled Release, 2022, 343: 175–186. (IF = 11.5, 一区Top)

15. Zhou JE; Sun L⁺; Jia Y; Wang Z; Luo T; Tan J; Fang X; Zhu H; Wang J; Yu L; Yan Z*; Lipid nanoparticles produce chimeric antigen receptor T cells with interleukin6 knockdown in vivo, Journal of Controlled Release, 2022, 350: 298–307. (IF = 11.5, 一区Top)

授权发明专利