程孝龙

1）2013.09 - 2018.01, 中国海洋大学，工学博士

 （2015.09 - 2017.10, 乔治华盛顿大学，国家公派联合培养）

2）2010.09 - 2013.06, 中国海洋大学，工学硕士

3）2006.09 - 2010.06, 中国海洋大学，理学学士

1）2026.01 至今，华东师范大学药学院，副研究员

2）2023.08 - 2026.01, Life Edit Therapeutics, Scientist II Computational Biology

3）2019.09 - 2023.08, Children's National Hospital, 博士后

4）2018.02 - 2019.09, UT Health San Antonio, 博士后

程孝龙，华东师范大学药学院副研究员，博士生导师。长期从事人工智能与功能基因组学交叉学科研究，包括表观遗传学、基因编辑、蛋白质优化等领域。共发表SCI论文13篇，其中以第一作者或者共同第一作者在Nature Biomedical Engineering、Nature Communications、Genome Medicine、Nucleic Acids Research等期刊发表论文8篇，申请并授权国家发明专利2项。

1）基因编辑系统评估与优化

2）AI蛋白质设计与优化

# 为第一或共同第一作者

1. Song, B., Liu, D., Dai, W., McMyn, N. F., Wang, Q., Yang, D., Cheng, X., ... & Li, W. (2025). Decoding heterogeneous single-cell perturbation responses. Nature Cell Biology, 1-12.

2. Li, Z.#, Li, Z.#, Cheng, X.#, Wang, S., Wang, X., Ma, S., ... & Fei, T. (2024). Intrinsic targeting of host RNA by Cas13 constrains its utility. Nature Biomedical Engineering, 8(2), 177-192.

3. Wang, X.#, Cheng, X.#, Li, Z., Ma, S., Zhang, H., Chen, Z., ... & Fei, T. (2024). A comprehensive benchmark for multiple highly efficient base editors with broad targeting scope. bioRxiv, 2024-12.

4. Cheng, X.#, Li, Z.#, Shan, R., Li, Z., Wang, S., Zhao, W., ... & Li, W. (2023). Modeling CRISPR-Cas13d ontarget and off-target effects using machine learning approaches. Nature Communications, 14(1), 752.

5. Wang, X., Su, S., Zhu, Y., Cheng, X., Cheng, C., Chen, L., ... & Zhang, J. (2023). Metabolic Reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell-derived CAR-macrophages in solid tumors. Nature Communications, 14(1), 5778.

6. Li, Z., Yao, Y., Cheng, X., Li, W., & Fei, T. (2021). An in silico drug repositioning workflow for host-based antivirals. STAR protocols, 2(3), 100653.

7. Li, Z.#, Yao, Y.#, Cheng, X.#, Chen, Q., Zhao, W., Ma, S., ... & Fei, T. (2021). A computational framework of host-based drug repositioning for broad-spectrum antivirals against RNA viruses. IScience, 24(3).

8. Cui, Y.#, Cheng, X.#, Chen, Q., Song, B., Chiu, A., Gao, Y., ... & Li, W. (2021). CRISP-view: a database of functional genetic screens spanning multiple phenotypes. Nucleic Acids Research, 49(D1), D848-D854.

9. Zhou, Y.#, Cheng, X.#, Yang, Y., Li, T., Li, J., Huang, T. H. M., ... & Jin, V. X. (2020). Modeling and analysis of Hi-C data by HiSIF identifies characteristic promoter-distal loops. Genome Medicine, 12, 1-13.

10. Yang, L., Zhu, Y., Yu, H., Cheng, X., Chen, S., Chu, Y., ... & Li, W. (2020). scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens. Genome Biology, 21, 1-14.

11. Chen, Z., Wu, D., Thomas-Ahner, J. M., Lu, C., Zhao, P., Zhang, Q., Cheng, X., ... & Wang, Q. (2018). Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13. Proceedings of the National Academy of Sciences, 115(26), 6810-6815. 

12. Cheng, X.#, & Jin, V. X. (2018). An introduction to integrative genomics and systems medicine in cancer. Genes, 9(1), 37.

13. Tang, B.#, Cheng, X.#, Xi, Y., Chen, Z., Zhou, Y., & Jin, V. X. (2017). Advances in genomic profiling and analysis of 3D chromatin structure and interaction. Genes, 8(9), 223.

14. Cheng, X.#, Ji, T., Wang, G., & Ji, G. (2016). Correlation analysis of X-band sea clutter in complex domain. Journal of Ocean University of China, 15, 613-618.