陈示洁

2011年9月-2016年6月  中科院上海药物研究所，药物设计，博士                                                                           

2007年9月-2011年6月  南京大学，生命科学学院理科基地班，学士  

2024年09月-     至今        华东师范大学药学院，研究员，博士生导师

2018年09月-2024年08月  中国科学院上海药物研究所，化学生物学研究中心，副研究员

2016年07月-2018年08月  中国科学院上海药物研究所，药物发现与设计中心，博士后，

研究员，博士生导师，紫江青年学者。通过建立多学科交叉的药物化学生物学平台，长期针对新靶标开展化合物高通量筛选方法开发、先导化合物发现、靶标确证及功能机制研究，相关研究成果以第一或通讯作者身份（含共同）在Cancer Cell、Nucleic Acids Res、Nat Commun、Cancer Res、Mol cancer、Signal Transduct Target Ther、Theranostics、J Med Chem等杂志发表SCI论文25篇，申请专利5项，其中2项已授权，1项已完成转化。承担国家级省部级项目7项，获得中科院青促会、赛诺菲优秀青年人才基金奖励。

1.     化合物高通量筛选新技术开发及应用

2.     新靶标先导化合物发现及候选药物开发

3.     新靶标化学干预及功能机制研究

1.     国家自然科学基金面上项目，82473893，2025.01-2028.12，主持

2.     中科院青年促进会会员基金，2022279，2022.03-2026.03，主持

3.     上海市自然科学基金面上项目，21ZR1474700，2021.07-2024.06，主持

4.     国家自然科学基金青年科学基金项目，81703415，2018.01-2020.12，主持

5.     上海市青年科技英才扬帆计划项目，17YF1423100，2017.05-2020.04，主持

部分代表性论文（^(#)第一作者；^(*)通讯作者）

1.    Senhao Xiao^(#), Siqi Guo, Jie Han, Yanli Sun, Mingchen Wang, Yantao Chen, Xueyu Fang, Feng Yang, Yajuan Mu, Liang Zhang, Yiluan Ding, Naixia Zhang, Hualiang Jiang, Kaixian Chen, Kehao Zhao, Cheng Luo and Shijie Chen^(*), High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/ RNA methyltransferases and demethylases,Nucleic Acids Res, 2022, 50(2):e9  （IF=16.6）

2.     Liangliang Wang^(#), Xiaoyang Dou^(#), Shijie Chen^(#), Xianbin Yu, Xiaona Huang, Linda Zhang, Yantao Chen, Jiaai Wang, Kaiting Yang, Jason Bugno,Sean Pitroda, Xingchen Ding, Andras Piffko, Wei Si, Chao Chen, Hualiang Jiang, Bing Zhou, Steven J. Chmura,Cheng Luo^(*), Hua Laura Liang^(*), Chuan He^(*), Ralph R Weichselbaum^(*), YTHDF2 inhibition potentiates radiotherapy antitumor efficacy, Cancer Cell, 2023, 41(7):1294-1308. （IF=48.8）

3.   Yang Wang(#), Wenjie Yuan(#), Siqi Guo(#), Qiqi Li, Xiaomei Chen, Cheng Li, Qianying Liu, Lei Sun, Zhenguo Chen, Zhenghong Yuan, Cheng Luo, Shijie Chen(*), Shuping Tong, Michael Nassal, Yu-Mei Wen, Yongxiang Wang(*),A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments,Nat Commun,2022, 13(1):4614. （IF=14.7）

4.    Cai Linyan^(#), Chen Shijie^(#), Xiao senhao^(#), Sun Qinjuan, Ding Chenhong, Zheng Bainan, Zhu Xinyan, Liu Shuqing, Yang Feng, Yang Yaxi, Zhou Bing, Luo Cheng, Zhang Xin^(*), Xie Weifen^(*), Targeting p300/CBP attenuates hepatocellular carcinoma progression through epigenetic regulation of metabolism, Cancer Res, 2021, 81(4):860-872. （IF=12.5）

5.  Hui Qian^(#), Chenhong Ding^(#), Fang Liu^(#), Shijie Chen^(#), Chenkai Huang, Mengchao Xiao, Xialu Hong, Mingchen Wang, Fangzhi Yan, Kai Ding, Yalu Cui, Bainan Zheng, Jin Ding, Cheng Luo^(*), Xin Zhang^(*)and Weifen Xie^(*), SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors, Signal Transduct Target Ther, 2024, 9(1):96. （IF=40.8）

6.     Ding Chenhong^(#), Yin Chuan^(#), Chen Shijie^(#), Wen Liangzhi, Ding Kai, Lei Shujuan, Liu Jinpei, Wang Jian, Chen Kaixian, Jiang Hualiang, Zhang Xin, Luo Cheng^(*), Xie Weifen^(*), The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1.Mol Cancer, 2018, 17(1):63-76. （IF=27.7）

7.   Zheng Bainan^(#), Ding Chenhong^(#), Chen Shijie^(#), Zhu Kongkai , Shao Jingwei, Feng Jifeng, Xu Wenping, Cai Lingyan, Zhu Changpeng, Duan Wenhu , Ding Jin , Zhang Xin^(*), Luo Cheng^(*), Xie Weifen^(*),Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α.Theranostics,2019, 9(9):2606-2617. （IF=12.4）

8.    Yu Mingcheng^(#), Yang Feng^(#), Ding Xiaoyu^(#), Sun Nannan, Jiang Zhengyuan, Huang Yafei, Yan Yurong, Zhu Chen, Xie Qiong, Chen Zhifeng, Guo Siqi, Jiang Hualiang, Chen Kaixian, Luo Cheng, Luo Xiaomin^(*), Chen Shijie^(*), Wang Yonghui^(*), Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with “short” and“long” inverse agonists. Acta Pharmacol Sin,2021, 42(9):1524-1534. （IF=6.9）

9.     Yu Cao^(#), Bin Wu^(#), Ying Xu^(#), Mingchen Wang, Xinyu Wu, Xiaochen Liang, Jin Lin, Zhihai Li, Hua Lin^(*), Cheng Luo^(*), Shijie Chen^(*),  Discovery of GPX4 inhibitors through FP-based high-throughput screening, Eur J Med Chem, 2024, 265:116044. （IF=6.0）

10.  Siqi Guo^(#), Tongguan Jia^(#), Xiaoming Xu, Feng Yang, Senhao Xiao, Zeng Hou, Hesong Xu, Shuyuan Ma, Xiao Liu, Cheng Luo, Hualiang Jiang^(*), Hua Chen^(*), Shijie Chen^(*), Design, synthesis of novel benzimidazole derivatives as ENL inhibitors suppressing leukemia cells viability via downregulating the expression of MYC,Eur J Med Chem, 2023, 248:115093. （IF=6.0）

11.  Feng Yuxin^(#), Xiao Senhao^(#), Chen Yantao, Jiang Hao, Liu Na, Luo Cheng, Chen Shijie^(*), Chen Hua^(*), Design, synthesis and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as BRD4 inhibitors.Eur J Med Chem, 2018, 152:264-273. （IF=6.0）2018.5.25:

12.  Chen Shijie^(#), Wang Yulan^(#), Zhou Wen^(#), Li Shanshan, Peng Jianlong, Shi Zhe, Hu Junchi, Liu Yu-Chih, Ding Hong, Lin Yijyun, Li Linjuan, Cheng Sufang, Liu Jingqiu, Lu Tao, Jiang Hualiang, Liu Bo^(*), Zheng Mingyue^(*), Luo Cheng^(*),Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening,  J Med Chem, 2014, 57(21):9028-9041.（IF=6.8）

13.  Chen Shijie^(#), Li Linjuan^(#), Chen Yantao^(#), Hu Junchi, Liu Jingqiu, Liu Yu-Chih, Liu Rongfeng, Zhang Yuanyuan, Meng Fanwang, Zhu Kongkai, Lu Junyan, Zheng Mingyue, Chen Kaixian, Zhang Jin, Jiang Hualiang^(*), Yao Zhiyi ^(*),Luo Cheng^(*), Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays.J Chem Inf Model,2016, 56(3):527-534. （IF=5.6）

14.  Xiaocheng Liang^(#), Yu Cao^(#), Zhe Duan^(#), Mingcheng Wang, Naixia Zhang, Yiluan Ding, Cheng Luo,Na Lu^(*),Shijie Chen^(*), Discovery of New Small Molecule Inhibitors of the BPTF Bromodomain,Bioorg Chem, 2023, 134: 106453. （IF=4.5）

15.  Debing Pu^(#), Siqi Guo^(#), Dongxuan Ni^(#), Jing Lin, Junbo Gao, Xiaoning Li, Ruihan Zhang, Xiaoli Li, Cheng Luo,Shijie Chen^(*)and Weilie Xiao^(*), Spiroarborin, an ent-Clerodane Homodimer from Callicarpa arborea as an Inhibitor of the Eleven-Nineteen Leukemia (ENL) Protein by Targeting the YEATS Domain, J Nat Prod, 2022, 85(2):317-326.（IF=3.3）

16.  Ye Fei^(#), Kong Xiangqian^(#), Zhang Hao, Liu Yan, Shao Zhiyuan, Jin Jia, Cai Yi, Zhang Rukang, Li Linjuan, Zhang Yang W, Liu Yu-Chi, Zhang Chenhua, Xie Wenbing, Yu Kunqian, Ding Hong, Zhao Kehao,Chen Shijie^(*),Jiang Hualiang, Baylin Stephen B^(*), Luo Cheng^(*), Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA methyltransferase-1 (DNMT1). ACS Chem Biol, 2018, 13(3):772-781. （IF=3.5）

1.     赛诺菲优秀青年人才奖励基金

2.     第二届MEGA(Mega Engineering Grants and Awards) 镁伽工程奖--科学项目奖