张晓燕

张晓燕,华东师范大学医学与健康研究院教授、博士生导师。致力于研究核受体在水盐代谢调控、肝脏糖脂代谢调节及重大代谢疾病（高血压、脂肪肝和糖尿病肾病）发病中的作用和机制。主持国家自然科学基金优秀青年科学基金项目和面上项目，参与科技部重点研发计划、国家自然科学基金委重大项目等。在Proc Natl Acad Sci、Nature Communications、J Am Soc Nephrol等国际知名杂志上发表论文60余篇。担任《生理学报》副主编、《医学生理学》（第四版）规划教材编委。担任Frontiers in Physiology - Renal Physiology and Pathophysiology section副主编。担任AJP-Endocrinology and Metabolism、Journal of Diabetes、scientific reports等国内外期刊的审稿人。担任中国生理学会肾脏生理专业委员会委员、中国生理学会整合生理专业委员会委员、中国生理学会青年工作委员会委员、中国生物化学与分子生物学会代谢专业分会委员。

1. Su W, Huang SZ, Gao M, Kong XM, Gustafsson JA, Xu SJ, Wang B, Zheng F, Chen LH, Wang NP, Guan YF, Zhang XY*. Liver X Receptor β (LXRβ) Increases AQP2 Protein Level via a Post-transcriptional Mechanism in Renal Collecting Ducts. Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F619-F628.

2. Wen Su†, Jun Peng†, Chun-jiong Wang, Sha Li, Yu-bing Dai, Hu Xu, Min Gao, Xiong-zhong Ruan, Jan-Åke Gustafsson, You-fei Guan, Xiao-yan Zhang*. Liver X receptor α induces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c. Am J Physiol Endocrinology and Metabolism. 2017 Apr 1;312(4):E357-E367.

3. Xiaoyan Zhang#, Sha Li#, Yunfeng Zhou#, Wen Su, Xiongzhong Ruan, Bing Wang, Feng Zheng, Margaret Warner, Jan-Åke Gustafsson. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. Proc Natl Acad Sci. 2017 Mar 21;114(12):3181-3185.

4. Zhou Y, Yu J, Liu J, Cao R, Su W, Li S, Ye S, Zhu C, Zhang X, Xu H, Chen H, Zhang X*, Guan Y*. Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice. Biochim Biophys Acta. 2018 Mar;1864(3):860-870.

5. Zhang X, Yang W, Wang J, Meng Y, Guan Y, Yang J. FAM3 gene family: a promising therapeutical target for NAFLD and type 2 diabetes. Metabolism. 2018 Apr;81:71-82.

6. Sujuan Xua, Shizheng Huang, Zhilin Luan, Tingyue Chen, Yuanyi Wei, Miaomiao Xing, Yaqing Li, Chunxiu Du, Bing Wanga, Feng Zheng, Nanping Wang, Youfei Guan, Jan-Åke Gustafssond, and Xiaoyan Zhang*. Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress. Proc Natl Acad Sci U S A . 2018 May 22;115(21):5600-5605.

7.Xu H, Du S, Fang B, Li C, Jia X, Zheng S, Wang S, Li Q, Su W, Wang N, Zheng F, Chen L, Zhang X, Gustafsson JÅ, Guan Y. VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. Proc Natl Acad Sci U S A .2019 Apr 23;116(17):8457-8462.

8. Hu Xu#, Bingying Fang#, Shengnan Du#, Sailun Wang, Qingwei Li, Xiao Jia, Chengzhen Bao, Lan Ye, Xue Sui, Lei Qian, Zhilin Luan, Guangrui Yang, Feng Zheng, Nanping Wang, Lihong Chen*, Xiaoyan Zhang*, and Youfei Guan*. Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis. JCI Insight. 2020 Jul 9;5(13):e138505.

9. Gulzar Alam, Zhilin Luan, Aneesa Gul, Heyuan Lu, Yunfeng Zhou, Xiaoxiao Huo, Yaqing Li, Chunxiu Du, Zhaokang Luo, Haibo Zhang, Hu Xu, Feng Zheng, Youfei Guan*, Xiaoyan Zhang*. Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells. Pflugers Arch.2020 Nov;472(11):1631-1641.

10. Zhilin Luan , Yuanyi Wei , Xiaoxiao Huo , Xiaowan Sun , Cong Zhang , Wenhua Ming , Zhaokang Luo, Chunxiu Du , Yaqing Li 2, Hu Xu , Heyuan Lu , Feng Zheng , Youfei Guan*, Xiaoyan Zhang*. Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice. Biochim Biophys Acta Mol Basis Dis. 2021 Mar 1;1867(3):165996.

11. Luan ZL, Ming WH, Sun XW, Zhang C, Zhou Y, Zheng F, Yang YL, Guan YF*, Zhang XY*. A naturally occurring FXR agonist, alisol B 23-acetate, protects against renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2021 Nov 1;321(5):F617-F628.

12.  Luan Z, Wei Y, Huo X, Sun X, Zhang C, Ming W, Luo Z, Du C, Li Y, Xu H, Lu H, Zheng F, Guan Y*, Zhang X*. Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice. Biochim Biophys Acta Mol Basis Dis. 2021 Mar 1;1867(3):165996.

13. Zhang HB, Su W, Xu H, Zhang XY*, Guan YF*. HSD17B13: A Potential Therapeutic Target for NAFLD. Front Mol Biosci. 2022 Jan 7;8:824776.

14.Yaqing Li#, Rong Cao#, Tingting Gu, Cong Cao, Tingyue Chen, Youfei Guan*, Xiaoyan Zhang*. PPARβ/δ Augments IL-1β-Induced COX-2 Expression and PGE2 Biosynthesis in Human Mesangial Cells via the Activation of SIRT1. Metabolites. 2022 Jun 27;12(7):595;

15.Wen Su , Sijin Wu, Yongliang Yang , Yanlin Guo  5 , Haibo Zhang , Jie Su , Lei Chen , Zhuo Mao, Rongfeng Lan , Rong Cao , Chunjiong Wang , Hu Xu , Cong Zhang , Sha Li , Min Gao , Xiaocong Chen , Zhiyou Zheng , Bing Wang , Yi'ao Liu , Zuojun Liu , Zimei Wang , Baohua Liu , Xinmin Fan , Xiaoyan Zhang* , Youfei Guan*. Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice. Nat Commun. 2022 Nov 2;13(1):6577;

16.Chunxiu Du, Hu Xu, Cong Cao, Jiahui Cao, Yufei Zhang, Cong Zhang, Rongfang Qiao, Wenhua Ming , Yaqing Li, Huiwen Ren, Xiaohui Cui, Zhilin Luan, Youfei Guan*, Xiaoyan Zhang*. Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosis. Elife. 2023 Feb 1;12:e80647;

17.Shen-Ming Huang, Meng-Yao Xiong , Lei Liu , Jianqiang Mu, Ming-Wei Wang, Ying-Li Jia , Kui Cai, Lu Tie , Chao Zhang, Sheng Cao, Xin Wen, Jia-Le Wang, Sheng-Chao Guo, Yu Li, Chang-Xiu Qu, Qing-Tao He , Bo-Yang Cai, Chenyang Xue, Shiyi Gan, Yihe Xie, Xin Cong, Zhao Yang , Wei Kong, Shuo Li, Zijian Li, Peng Xiao, Fan Yang , Xiao Yu, You-Fei Guan, Xiaoyan Zhang, Zhongmin Liu, Bao-Xue Yang, Yang Du, and Jin-Peng Sun. Single hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc Natl Acad Sci U S A. 2023 July 21;120 (30) e2216329120.