物理与电子科学学院

About

Department: 物理与电子科学学院
Gender: male
Post: Head of Bio-NMR Lab
Graduate School: Stockholm University, Sweden
Degree: Ph.D.
Academic Credentials: Professor

Tel: 00862162234229
Email: xzhao@phy.ecnu.edu.cn
Office: B419, Optics Building
Address: 500 Dongchuan Road, Minhang District
PostCode: 200241
Fax: 00862162234229

Education

04.1998 – 03.2003	Doctoral Degree in Physical Chemistry
	Supervisor: Professor Malcolm. H. Levitt Subject: Solid-state NMR theory and application Place: Department of Physical Chemistry, Stockholm University, Sweden; Department of Chemistry, Southampton University, UK. Title of the thesis: Symmetry-based heteronuclearrecoupling in solid-state NMR.
09.1989 – 07.1992	Doctoral Degree in Nuclear Chemistry and Chemical Engineering
	Supervisor: Professors Dexi Wang and Zhangji Lin Subject: Actinide Environmental Chemistry Place: Department of Radiochemistry, China Institute of Atomic Energy, Beijing, China. Title of the thesis: Study of migration behaviour of actinides and fission products in the geosphere.
09.1986 – 07.1989	Master Degree in Nuclear Chemistry and Chemical Engineering
	Supervisor: Professors Fangding Wang and Jingru Guo Subject: Nuclear Chemistry Place: Department of Radiochemistry, China Institute of Atomic Energy, Beijing, China. Title of the thesis: Study of spontaneous fission of ²⁵²Cf.
09.1982 – 07.1986	Bachelor Degree
	Subject: Radiochemistry Place: Department of Modern Physics, Lan Zhou University, Lan Zhou, China

WorkExperience

09.2008 – present	Professor, Department of Physics, East China Normal University
01.2006 – 08.2008	Associate Professor, Foreign PI Lab, Institute for Protein Research, Osaka University, Japan
04.2003 – 12.2005	Senior research associate, Department of Biochemistry, University of Oxford, UK Technique Manager, National Biological Solid-state NMR facility, Rutherford Appleton Lab, Oxford, UK
04.1998 – 03.2003	Doktorand, Department of Physical Chemistry, University of Stockholm, Sweden
01.1996 – 03.1998	Vice-chairman of the Science and Technology Committee, Department of Radiochemistry, China Institute of Atomic Energy, China
09.1995 – 03.1998	Senior research staff scientist in actinide environmental chemistry, Department of Radiochemistry, China Institute of Atomic Energy, China
08.1992 – 08.1995	Research staff scientist in actinide environmental chemistry, Department of Radiochemistry, China Institute of Atomic Energy, China
09.1989 – 07.1992	Research assistant in actinide environmental chemistry, Department of Radiochemistry, China Institute of Atomic Energy, China

Resume

Other Appointments

Research Fields

Structure and function of the dual-chromophore microbial rhodopsins and optogenetic applications.
New biological solid-state NMR methods.
MD simulations of the dual-chromophore microbial rhodopsins
Expression of the dual-chromophore microbial rhodopsins in the native environment.

Enrollment and Training

Course

Protein NMR (postgraduate course)
Biological solid-state NMR (postgraduate course)
Advances of biological solid-state NMR on membrane protein structure biology (undergraduate course)

Scientific

Academic Achievements

Selected publications:

1.王铭, 陈思瑾, and 赵欣. (2020) W182在细菌视紫红质光循环中的分子作用机制研究. 基因组学与应用生物学已录用

2.孟馨茹, 董欣怡, and 赵欣. (2020) 正电性氨基酸残基K129 对细菌视紫红质光循环动力学的影响. 基因组学与应用生物学已录用

3.董欣怡, 丁小燕, 孙超, 崔浩琳, and 赵欣. (2020) W86F/W86A突变对细菌视紫红质光循环影响的差异性研究. 基因组学与应用生物学已录用

4.Dong, X., Ding, X., Sun, C., Cui, H., and Zhao, X. (2019) Different effects of W86A and W86F mutations on the bacteriorhodopsin photocycle. Genomics and Applied Biology Accepted

5.Ding, X., Sun, C., Cui, H., Chen, S., Dong, X., Meng, X., Wang, M., Yang, Y., Liu, W., Mi, Q., He, X., Watts, A., and Zhao, X. (2019) Photocycle and Abnormal Activity of the Dual Chromophore Proton Pump Archaerhodopsin-4 with and Without the Second Chromophore. Biophys. J. 116, 127a

6.杨雅楠, 孙超, 崔浩琳, and 赵欣. (2019) M145F/F146M突变对光受体蛋白细菌视紫红质和古紫质4光循环的影响. 中国生物工程杂志 31, 21-30

7.Sun, C., Ding, X., Cui, H., Yang, Y., Chen, S., Watts, A., and Zhao, X. (2018) In Situ Study of the Function of Bacterioruberin in the Dual-Chromophore Photoreceptor Archaerhodopsin-4. Angew. Chem. Int. Ed. 57, 8937-8941

8.Ding, X., Sun, C., Cui, H., Chen, S., Gao, Y., Yang, Y., Wang, J., He, X., Iuga, D., Tian, F., Watts, A., and Zhao, X. (2018) Functional roles of tyrosine 185 during the bacteriorhodopsin photocycle as revealed by in situ spectroscopic studies. Biochim. Biophys. Acta 1859, 1006-1014

9.郜玉娇, 孙超, 王娟, and 赵欣. (2018) Y186F突变对光受体蛋白古紫质-4质子传输和能量转换的影响. 基因组学与应用生物学 37, 1-7

10.Peng, B., Ding, X.-Y., Sun, C., Yang, Y.-N., Gao, Y.-J., and Zhao, X. (2017) The chain order of binary unsaturated lipid bilayers modulated by aromatic-residue-containing peptides: an ATR-FTIR spectroscopy study. RSC Advances 7, 29386-29394

11.王娟, 郜玉娇, 孙超, and 赵欣. (2017) D97N突变对光受体蛋白古紫质4质子泵和能量转换效率的影响. 中国生物工程杂志 37, 23-30

12.Peng, B., Ding, X.-Y., Sun, C., Liu, W., Zhang, J. Z. H., and Zhao, X. (2016) The effect of POPC acyl chains packing by aromatic amino acid methyl esters investigated by ATR-FTIR combined with QM calculations. RSC Advances 6, 45569-45577

13.Ding, X., Wang, H., Peng, B., Cui, H., Gao, Y., Iuga, D., Judge, P. J., Li, G., Watts, A., and Zhao, X. (2016) Mediation mechanism of tyrosine 185 on the retinal isomerization equilibrium and the proton release channel in the seven-transmembrane receptor bacteriorhodopsin. Biochim. Biophys. Acta 1857, 1786-1795

14.Cao, Z., Ding, X., Peng, B., Zhao, Y., Ding, J., Watts, A., and Zhao, X. (2015) Novel expression and characterization of a light driven proton pump archaerhodopsin 4 in a Halobacterium salinarum strain. Biochim. Biophys. Acta 1847, 390-398

15.Ding, X., Zhao, X., and Watts, A. (2013) G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy. Biochem. J. 450, 443-457

16.Watts, A., Straus, S. K., Grage, S. L., Kamihira, M., Lam, Y. H., and Zhao, X. (2004) Membrane protein structure determination using solid-state NMR. in Methods in Molecular Biology: Protein NMR Techniques (Downing, A. K. ed.), Humana Press Inc., Totowa, NJ. pp 403-473

17.Carravetta, M., Zhao, X., Johannessen, O. G., Lai, W. C., Verhoeven, M. A., Bovee-Geurts, P. H. M., Verdegem, P. J. E., Kiihne, S., Luthman, H., de Groot, H. J. M., deGrip, W. J., Lugtenburg, J., and Levitt, M. H. (2004) Protein-induced bonding perturbation of the rhodopsin chromophore detected by double-quantum solid-state NMR. Journal of the American Chemical Society 126, 3948-3953

18.Zhao, X., Sudmeier, J. L., Bachovchin, W. W., and Levitt, M. H. (2001) Measurement of NH bond lengths by fast magic-angle spinning solid-state NMR spectroscopy: A new method for the quantification of hydrogen bonds. Journal of the American Chemical Society 123, 11097-11098

19.Zhao, X., Eden, M., and Levitt, M. H. (2001) Recoupling of heteronuclear dipolar interactions in solid-state NMR using symmetry-based pulse sequences. Chem. Phys. Lett. 342, 353-361

20.Carravetta, M., Eden, M., Zhao, X., Brinkmann, A., and Levitt, M. H. (2000) Symmetry principles for the design of radiofrequency pulse sequences in the nuclear magnetic resonance of rotating solids. Chem. Phys. Lett. 321, 205-215

教师个人主页

Xin Zhao

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