张翠玲

2009.9-2014.6 武汉大学，分析化学，硕博连读，获得理学博士学位

2024.1至今      华东师范大学 化学与分子工程学院，教授

2022.12-2023.12 悉尼科技大学     访问学者

2018.1-2023.12  华东师范大学 化学与分子工程学院，副教授

2014.7-2017.12  华东师范大学 化学与分子工程学院，晨晖学者

    主要从事功能性近红外量子点探针、稀土上转换纳米探针的合成及光学性能研究；荧光传感器与细胞成像研究；循环肿瘤细胞、外泌体等液体活检标志物、生物活性分子、离子、蛋白质分析及检测研究，为癌症、炎症等相关疾病提供早期诊断、预后监测。

工作经历

  2024.1至今      华东师范大学 化学与分子工程学院，教授

  2022.12-2023.12 悉尼科技大学     访问学者

  2018.1-2023.12  华东师范大学 化学与分子工程学院，副教授

  2014.7-2017.12  华东师范大学 化学与分子工程学院，晨晖学者

学习经历

  2009.09-2014.06  武汉大学，分析化学，硕博连读，获得理学博士学位

获奖情况

  2016.03  荣获湖北省优秀博士学位论文

  2012.11 荣获教育部学术新人奖

《分析科学与分析技术实验》

《生化分析》

国家自然科学基金-面上基金（22274054）

国家自然科学基金-面上基金（21974050）

国家自然科学基金-青年基金（21605050）

上海市自然科学基金（20ZR1418000）

上海市自然科学基金（15ZR1411600）

主持项目：

国家自然科学基金-面上基金（22274054）

国家自然科学基金-面上基金（21974050）

国家自然科学基金-青年基金（21605050）

上海市自然科学基金（15ZR1411600）

代表性论文：

32.    Miaomiao Xiang+, Yuelin Jiang+, Jiajia Zhou, Guochen Bao, Xianzhu Luo, Le Zhang, Dayong Jin, Yuezhong Xian,* and Cuiling Zhang,* NIR Light-Controlled DNA Nanodevice for Amplified mRNA Imaging and Precise Gene Therapy. Nano Today, 2024, 102110.

31.    Xianzhu Luo, Cuiling Zhang*, Chenyang Yue, Yuelin Jiang, Fei Yang, Yuezhong Xian* Near-infrared light-activated nanoprobe for simultaneous detection of hydrogen polysulfide and sulfur dioxide in myocardial ischemia-reperfusion injury. Chem. Sci. 2023, 14, 14129.

30.     Xinyu Hu, Shasha Cheng, Xianzhu Luo, Yuezhong Xian,* and Cuiling Zhang* Polymerase-Driven Logic Signal Amplification for the Detection of Small Extracellular Vesicle Surface Proteins and the Identification of Breast Cancer. Anal. Chem.,2023,95, 10330−10336

29.  Xianzhu Luo, Cuiling Zhang*, Zihang Yu, Shihui Wen, Yuezhong Xian*, Recent advances in responsive lanthanide-doped luminescence nanoprobes in the near-infrared-II window. Trends Anal. Chem. 2023,169, 117368.

28.  Fang Yuan, Cuiling Zhang, * Xianzhu Luo, Shasha Cheng, Yingxin Zhu and Yuezhong Xian. An erythrocyte membrane-camouflaged fluorescent covalent organic framework for starving/nitric oxide/immunotherapy of triple-negative breast cancer. Chem. Sci. 2023, DOI: 10.1039/d3sc02022c.

27.   Yingxin Zhu, Xianzhu Luo, Zihang Yu, Shihui Wen, Guochen Bao, Le Zhang, Cuiling Zhang*, Yuezhong Xian.^∗Dye-sensitized rare-earth-doped nanoprobe for simultaneously enhanced NIR-II imaging and precise treatment of bacterial infection. Acta Biomater. 2023, 170, 532–542.

26.   Yujing Kong, Fang Yuan, Fei Yang, Cuiling Zhang *, Yuezhong Xian * Cell-Membrane-Anchored Upconversion Nanoprobe for Near-Infrared Light Triggered Cell–Cell Interactions Kong, Anal.  Chem., 2022, 94, 12024–12032. 

25.  Ding Caiping; Cheng Shasha; Yuan Fang; Cuiling Zhang *; Yuezhong Xian* Ratiometrically pH-Insensitive Upconversion Nanoprobe: Toward Simultaneously Quantifying Organellar Calcium and Chloride and Understanding the Interaction of the Two Ions in Lysosome Function Anal. Chem., 2022, 94, 10813-10823. 

24.    Jia You, Fang Yuan, Shasha Cheng, Qianqian Kong, Yuelin Jiang, Xianzhu Luo, Yuezhong Xian* Zhang Cuiling* AIEgen-Based sp2 Carbon-Conjugated Covalent Organic Frameworks with High Stability and Emission for Activatable Imaging and Ferroptosis in Target Tumor Cells. Chem. Mater., 2022, 34, 7078-7089. 

23. Shasha Cheng, Qianqian Kong, Xinyu Hu, Cuiling Zhang,* Yuezhong Xian*An Ultrasensitive Strand Displacement Signal Amplification-Assisted Synchronous Fluorescence Assay for Surface Proteins of Small Extracellular Vesicle Analysis and Cancer Identification Anal. Chem., 2022, 94, 1085-1091. 

22.   Mingqiang Ye, Yujing Kong, Cuiling Zhang*, Yifei Lv, Shasha Cheng, Dongyan Hou, and Yuezhong Xian*. Near-Infrared Light Controllable DNA Walker Driven by Endogenous Adenosine Triphosphate for in Situ Spatiotemporal Imaging of Intracellular MicroRNA. ACS Nano 2021, 15, 9, 14253–14262. 

21.   Fang Yuan, Yujing Kong, Jia You, Cuiling Zhang*, and Yuezhong Xian*. Rational Synthesis of Imine-Linked Fluorescent Covalent Organic Frameworks with Different pKa for pH Sensing In Vitro and In Vivo. ACS Appl. Mater. Interfaces 2021, https://doi.org/10.1021/acsami.1c14690. 

20.   Xiuli Wang, Shasha Cheng, Xinjun Wang, Liran Wei, Qianqian Kong, Mingqiang Ye, Xianzhu Luo, Jiao Xu, Cuiling Zhang,* and Yuezhong Xian*. pH-Sensitive Dye-Based Nanobioplatform for Colorimetric Detection of Heterogeneous Circulating Tumor Cells. ACS Sens. 2021, 6, 1925−1932.

19. Caiping Ding, Cuiling Zhang,* Shasha Cheng, and Yuezhong Xian*, Multivalent Aptamer Functionalized Ag₂S Nanodots/HybridCell Membrane-Coated Magnetic Nanobioprobe forthe Ultrasensitive Isolation and Detection of Circulating Tumor Cells, Adv.         Funct.   Mater. 2020, 1909781.

18. Yi You, Shasha Cheng, Li Zhang, Yingxin Zhu, Cuiling Zhang*, Yuezhong Xian*, Rational Modulation of the Luminescence of Upconversion Nanomaterials with Phycocyanin for the Sensing and Imaging of Myeloperoxidase during an Inflammatory Process. Anal. Chem. 2020, DOI: 10.1021/acs.analchem.9b05468.

17. Xiuli Wang, Xinjun Wang, Shasha Cheng, Mingqiang Ye,  Cuiling Zhang,* and Yuezhong Xian*, Near-infrared Light Switched MoS₂ Nanoflakes@ Gelatin Bioplatform for Capture, Detection and Non-destructive Release of Circulating Tumor Cells. Anal. Chem. 2020, 92, 3111-3117

16. Caiping Ding, Shasha Cheng,  Cuiling Zhang*, Youran Xiong, Mingqiang Ye, Yuezhong Xian*. Ratiometric upconversion luminescence nanoprobe with near-infrared Ag₂S nanodots as the energy acceptor for sensing and imaging of pH in vivo. Anal. Chem.2019, 91, 7181-7188.

15. Fangfang Wang, Cuiling Zhang*, Xuetong Qu, Shasha Cheng, Yuezhong Xian*.Cationic cyanine chromophore-assembled upconversion nanoparticles for sensing and imaging H2S in  living  cells and zebrafish. Biosens. Bioelectron. 2019, 126, 96–101.

14. Caiping Ding, Cuiling Zhang,* Xueyang Yin, Xuanyu Cao, Meifang Cai, and Yuezhong Xian*, Near-Infrared Fluorescent Ag2S Nanodot-Based Signal Amplification for Efficient Detection of Circulating Tumor Cells. Anal. Chem. 2018, 90, 6702−6709.

13. Huaping Li, Huifang Liu, Jidong Zhang, Yuxiao Cheng, Cuiling Zhang *, Xinyu Fei, and Yuezhong Xian*. Platinum Nanoparticle Encapsulated Metal–Organic Frameworks for Colorimetric Measurement and Facile Removal of Mercury(II). ACS Appl. Mater. Interfaces 2017, DOI 10.1021/acsami.7b13695.

12. Caiping Ding, Xuanyu Cao, Cuiling Zhang,* Tangrong He, Nan Hua and Yuezhong Xian*. Rare Earth Ions Enhanced Near Infrared Fluorescence of Ag2S Quantum Dots for the Detection of Fluoride Ions in Living Cells. Nanoscale. 2017, 9, 14031-14038.

11. Cuiling Zhang, Shiming Zhang, Yinghan Yan, Fei Xia, Anni Huang, and Yuezhong Xian*. Highly Fluorescent Polyimide Covalent Organic Nanosheets as Sensing Probes for the Detection of 2,4,6-Trinitrophenol. ACS Appl. Mater. Interfaces 2017, 9, 13415−13421

10. Fangfang Wang, Cuiling Zhang*, Qin Xue, Huaping Li, Yuezhong Xian*. Label-free Upconversion Nanoparticles-based Fluorescent Probes for Sequential Sensing of Cu2+, Pyrophosphate and Alkaline Phosphatase Activity. Biosens. Bioelectron., 2017, 95, 21–26.

9. Wei Gu, Xueyu Pei, Yuxiao Cheng, Cuiling Zhang,* Jidong Zhang, Yinghan Yan, Caiping Ding, and Yuezhong Xian*. Black Phosphorus Quantum Dots as the Ratiometric Fluorescence Probe for Trace Mercury Ion Detection Based on Inner Filter Effect. ACS Sensors 2017, 2, 576−582

8. Yinghan Yan, Cuiling Zhang*, Wei Gu, Caiping Ding, Xinchang Li, and Yuezhong Xian*. Facile Synthesis of Water-Soluble WS₂ Quantum Dots for Turn-On Fluorescent Measurement of Lipoic Acid. J. Phys. Chem. C, 2016, 120, 12170–12177.

7. Wei Gu, Yinghan Yan, Cuiling Zhang*, Caiping Ding, and Yuezhong Xian*. One-Step synthesis of water-soluble MoS₂ quantum dots via a hydrothermal method as a fluorescent probe  for hyaluronidase detection. ACS Appl. Mater. Interfaces, 2016, 8, 11272–11279.

6. Cuiling Zhang, Ji Yan, Chen Liu，Xinghu Ji* and Zhike He*. One-pot Synthesis of DNA-CdTe: Zn²⁺ Nanocrystrals Using Na₂TeO₃ as Te source. ACS Appl. Mater. Interfaces, 2014, 6 (5), 3189–3194.

5. Yuan Zhang†, Xianliang Ke†, Zhenhua Zheng, Cuiling Zhang, Zhenfeng Zhang, Fuxian Zhang, Qinxue Hu, Zhike He, Hanzhong Wang*. Encapsulating Quantum Dots into Enveloped Virus in Living Cells for Tracking Virus Infection. ACS Nano, 2013, 7, 3896-3904.

4. Cuiling Zhang, Xinghu Ji, Yuan Zhang, Guohua Zhou, Xianliang Ke, Hanzhong Wang, Philip Tinnefeld, Zhike He*. One-Pot Synthesized Aptamer-Functionalized CdTe: Zn²⁺ Quantum Dots for Tumor Targeted Fluorescence Imaging in Vitro and in Vivo. Anal. Chem., 2013, 85, 5843-5849.

3. Cuiling Zhang†, Ding Gao†, Guohua Zhou, Lu Chen, Xian-an Zhang, Zongqiang Cui*, and Zhike He*. Label-Free Homogeneous Immunosensor Based on FRET for the Detection of Virus Antibody in Serum. Chem. Asian J., 2012, 7, 1764-1767.

2. Cuiling Zhang, Jing Xu, Shiming Zhang, Xinghu Ji, Zhike He*. One-Pot Synthesized DNA-CdTe Quantum Dots Applied in a Biosensor for the Detection of Sequence-Specific Oligonucleotides. Chem. Eur. J., 2012, 18, 8296-8300.

1. Cuiling Zhang, Yunxia Yuan, Shiming Zhang, Yuhui Wang, Zhihong Liu*. Biosensing Platform Based on Fluorescence Resonance Energy Transfer from Upconverting Nanocrystals to Graphene  Oxide. Angew. Chem. Int. Ed., 2011, 50, 6851-6854.

  2016.03 荣获湖北省优秀博士学位论文

  2012.11 荣获教育部学术新人奖