个人简介
俞磊教授现为华东师范大学紫江学者，生物医学工程与技术研究所所长，美国犹他大学化学制药与制药系和生物工程系客座副教授。主要研究方向为靶向药物传递系统、基因治疗和细胞治疗领域。早期在被誉为世界基因治疗之父的TheodoreFriedman指导下，进行病毒载体用于遗传疾病、癌症、心血管疾病、神经性病变、传染性疾病的基因治疗和细胞治疗中转基因技术的研究。随后在被世界生物高分子药物载体先驱Sun WangKim课题组工作，并成功申请到美国NIH的基金资助。2004在美国成立公司继续进行肿瘤靶向治疗和细胞免疫治疗技术的临床转化和产品开发。2012年全职回国加入华东师范大学，与全国著名的血液科开展多中心临床实验合作，目前已开展了200多例CAR-T治疗血液肿瘤临床案例研究，在难治复发急性B淋巴细胞白血病的治疗中取得了86%以上完全缓解的疗效。近年来在Theranostics，Journal of Controlled Release，Bioconjugate Chemistry，Molecular Pharmaceutics等杂志发表SCI论文30余篇。
承担项目
1.师资队伍建设经费，2013.1-2018.12，华东师范大学，14300-120215-10296，200万元，在研，主持 2.华东师范大学生物医药工程和技术研究所-凯利泰临床医学和生物医药工程联合研究所（室）横向合作经费，2015.1-2016.12，上海凯利泰医疗科技股份有限公司，48303190，180万元，已结题，主持 3.上海市自然科学基金项目，15ZR1430200，肿瘤穿透长循环紫杉醇pH敏感胶束递药系统的研究，2015/01-2017/12－31,10万元，已结题，主持 4.上海市科技型中小企业技术创新资金，1402H234200，T细胞（CART）靶向免疫治疗恶性脑胶质瘤的临床研究，2014/07-2016/06,30万元，已结题，主持 5.国家863项目，44032780，基因传递肺癌治疗的载体研发，2005年，100万，已结题，主持 6.美国国立卫生研究院，RO1 HL65477-01，功能性和具有靶向的高分子基因载体，2000年，170万美金，已结题，主持
发表文章
(1)Jia Z#, Gong Y#, Pi Y, Liu X, Gao L,Kang L, Wang J, Yang F, Tang J, Lu W, Li Q, Zhang W, Yan Z*, Yu L*. pPB Peptide-MediatedsiRNA-Loaded Stable Nucleic Acid Lipid Nanoparticles on Targeting Therapy ofHepatic Fibrosis. Mol Pharm, 2018, 15(1): 53-62. (2)Gao L, Yu J, Liu Y, Zhou J, Sun L, Wang J, Zhu J, Peng H, LuW, Yu L, Yan Z*, Wang Y*. Tumor-penetrating Peptide Conjugated and DoxorubicinLoaded T1-T2 Dual Mode MRI Contrast Agents Nanoparticles for TumorTheranostics[J]. Theranostics, 2018, 7(20):4984-5000. (3)Yu J#, Sun L#, Zhou J, Gao L, Nan L,Zhao S, Peng T, Han L, Wang J, Lu W, Zhang L, Wang Y, Yan Z*, Yu L*. Self-Assembled Tumor PenetratingPeptide Modified Poly (L-gamma-glutamylglutamine)-Paclitaxel NanoparticlesBased on Hydrophobic Interaction for Treatment of Glioblastoma. Bioconjug Chem,2017, 28(11):2823-2831 (4)Gao L, Wang H, Nan L, Peng T, Sun L, Zhou J, Xiao Y, Wang J,Sun J, Lu W, Zhang L, Yan Z*, Yu L, Wang Y*. Erythrocyte Membrane-Wrapped pHSensitive Polymeric Nanoparticles for Non-Small Cell Lung Cancer Therapy[J].Bioconjug Chem, 2017, 28(10):2591-2598 (5)Luo Z, Yan Z, Jin K, Pang Q, Jiang T, Lu H, Liu X, Pang Z*, Yu L*, Jiang X. Precise glioblastomatargeting by AS1411 aptamer-functionalized poly (l-gamma-glutamylglutamine)-paclitaxelnanoconjugates. J Colloid Interface Sci, 2017, 490: 783-796. (6)Luo Z, Jin K, Pang Q, Shen S, Yan Z, Jiang T, Zhu X, Yu L*, Pang Z*, Jiang X. On-Demand DrugRelease from Dual-Targeting Small Nanoparticles Triggered by High-IntensityFocused Ultrasound Enhanced Glioblastoma-Targeting Therapy. ACS Appl MaterInterfaces, 2017, 9(37): 31612-31625. (7)Fan M, Li M, Gao L, Geng S, Wang J, Wang Y, Yan Z*, Yu L*. Chimeric antigen receptors foradoptive T cell therapy in acute myeloid leukaemia. J Hematol Oncol, 2017,10(1): 151. (8)Zhou JE#, Yu J#, Gao L, Sun L, Peng T,Wang J, Zhu J, Lu W, Zhang L, Yan Z*, YuL*. iNGR-Modified Liposomes for Tumor Vascular Targeting and Tumor TissuePenetrating Delivery in the Treatment of Glioblastoma. Mol Pharm, 2017, 14(5):1811-1820. (9)Gao L, Han L, Ding X, Xu J, Wang J, Zhu J, Lu W, Sun J, Yu L,Yan Z*, Wang, Y*. An Effective Intracellular Delivery System of MonoclonalAntibody for Treatment of Tumor: Erythrocyte Membrane-coated Self-associatedAntibody Nanoparticles[J]. Nanotechnology, 2017, 28(33):335101. (10)Gao L, Gao L, Fan M, Li Q, Jin J, Wang J, Lu W, Yu L, Yan Z*,Wang Y*. Hydrotropic polymer-based paclitaxel-loaded self-assemblednanoparticles: preparation and biological evaluation[J]. Rsc Advances, 2017,7(53): 33248-33256. (11)Gao L, Zhou J, Yu J, Li Q, Liu X, Sun L, Peng T, Wang J, ZhuJ, Sun J*, Lu W, Yu L, Yan Z*, Wang Y*. A Novel Gd-DTPA-conjugatedPoly(L-gamma-glutamyl-glutamine)-paclitaxel Polymeric Delivery System for TumorTheranostics[J]. Sci Rep, 2017, 7(1): 3799. (12)T Peng, K Liu, L Gao, J Chen, J Wang, Y Liu, Y Wang, Z Yan*,L Yu*, Poly (l-γ-glutamylglutamine) Polymer Enhances Doxorubicin Accumulationin Multidrug Resistant Breast Cancer Cells, Molecules, 2016, 21(6): E720 (13)Y. Pi, J. Zhou, J. Wang, J. Zhong, L. Zhang, Y. Wang, L. Yu*,Z. Yan*, Strategies of Overcoming the Physiological Barriers for Tumor-TargetedNano-Sized Drug Delivery Systems, Curr Pharm Des, 2015, 21(42): 6236-45 (14)Yanjie Bao, Yi Jin, Padmanabh Chivukula,Jun Zhang, Yun Liu, Jian Liu, Jean-Pierre Clamme, Ram I. Mahato, Dominic Ng,Wenbin Ying, Yiting Wang, and Lei Yu*. Effect of PEGylation on Biodistribution and GeneSilencing of siRNA/Lipid Nanoparticle Complexes. Pharmaceutical Research, 2013,30(2):342-51 (15)Yang D, Liu X, Jiang X, Liu Y, Ying W,Wang H, Bai H, Taylor WD, Wang Y, Clamme JP, Co E, Chivukula P, TsangKY, Jin Y,Yu L*. Effect of molecular weight of PGG-paclitaxel conjugateson in vitro and in vivo efficacy. J Control Release. 2012, 161(1):124-31 (16)Yang D, Van S, Shu Y, Liu X, Ge Y, JiangX, Jin Y, Yu L*. Synthesis, characterization, and in vivo efficacyevaluation of PGG-docetaxel conjugate for potential cancer chemotherapy. Int JNanomedicine, 2012, 7:581-9 (17)Liu C, Zhao G, Liu J, Ma N, Chivukula P,Perelman L, Okada K, Chen Z, Gough D, YuL*. Novel biodegradable lipid nano complexfor siRNA delivery significantly improving the chemosensitivity of human coloncancer stem cells to paclitaxel. J Control Release, 2009, 140(3):277-83
申请或授权发明专利
(1) 俞磊，王华，张磊涛，南丽娟，肖晔，闫志强，王镜，王依婷，朱建中，用于抗肿瘤药物递送的小分子材料及制备方法和应用，2017.12.6，中国，ZL201610124031.7。已授权 (2) 王依婷，肖晔，南丽娟，赵潇，王镜，俞磊，朱建中，董素珍，闫志强，用于抗肿瘤药物递送的酸敏感高分子载体及制备方法和应用，2017.1.25，ZL201510051159。已授权 (3) 俞磊，赵潇，肖晔，王镜，董素珍，闫志强，王依婷，朱建中，彭辉，用于生物成像和脑胶质瘤靶向的纳米粒子及制备方法和应用，2018.1.15，ZL201510032689.0。已授权 (4) 王依婷, 高礼鹏, 余静, 刘秧, 周靖娥, 孙磊, 闫志强, 王镜, 朱建中, 俞磊 . 一种肿瘤靶向多功能纳米递药系统及制备方法和用途. 申请号：201710038827.5. 申请日：2017-1-19. (5) 王依婷, 汉琳, 范明雪, 张金芳, 刘秧, 闫志强, 王镜, 朱建中, 俞磊 . 一种多功能高分子纳米粒及制备方法和应用. 申请号：201710146044.9. 申请日：2017-3-13. (6) 俞磊, 孙磊, 周靖娥, 彭婷, 李奇龙, 南立娟, 高礼鹏, 闫志强, 王镜, 朱建中 . 一种物理包裹的肿瘤靶向纳米递药系统及制备方法和应用. 申请号：201710136815.6. 申请日：2017-3-9. (7) 俞磊, 罗子淼, 庞志清, 金恺, 庞强, 闫志强, 王镜, 朱建中, 王依婷 . HIFU控释的脑胶质瘤靶向纳米递药系统及其制备方法和用途. 申请号：201710187799.3. 申请日：2017-3-27. (8) 王依婷, 赵世民, 王昊, 彭婷, 贾宗翔, 余静, 闫志强, 王镜, 朱建中, 俞磊 . 用于难溶性药物递送的助溶高分子载体材料及制备方法和应用. 申请号：201710522869.6. 申请日：2017-6-30. (9) 俞磊，李奇龙，周靖娥，高礼鹏，余静，孙磊，闫志强，王镜，朱建中，王依婷. 一种光聚合水凝胶局部药物递送系统及制备方法和应用. 申请号：201610935556.9. 申请日：2016-11-01. (10) 王依婷，高礼鹏，周靖娥，余静，彭婷，李奇龙，闫志强，王镜，朱建中，俞磊. 多功能高分子前药纳米递药系统及制备方法和用途. 申请号：201610917771.6. 申请日：2016-10-21. (11) 俞磊，周靖娥，余静，高礼鹏，彭婷，孙磊，闫志强，王镜，朱建中，王依婷. 一种肿瘤靶向递药的脂质体递药系统及制备方法和应用. 申请号：201610621956.2. 申请日：2016-08-01. (12) 俞磊，罗子淼，庞志清，闫志强，王镜，朱建中，王依婷. 一种脑胶质瘤靶向递药系统及其制备方法和用途. 申请号：201610630904.1. 申请日：2016-08-04. (13) 俞磊，高猎防，彭婷，王昊，南丽娟，孙磊，闫志强，王一婷，王镜，朱建中. 一种用于抗肿瘤药物递送的助溶高分子载体及制备方法. 申请号：201610149027.6. 申请日：2016-03-16. (14) 王依婷，皮玉芳，刘雪莹，贾宗翔，祁伟，王镜，朱建中，闫志强，俞磊. 靶向肝星状细胞的siRNA脂质纳米囊泡及应用. 申请号：201610159833.1. 申请日：2016-03-21. (15) 王依婷，丁晓铃，汉琳，孙磊，闫志强，朱建中，王镜，俞磊. 用于抗体药物递送的红细胞膜包裹的抗体纳米粒子及制备方法. 申请号：201610148434.5. 申请日：2016-03-16. (16) 俞磊，南丽娟，王依婷，肖晔，王华，高猎防，闫志强，王镜，朱建中. 红细胞膜包裹的酸敏感高分子前药纳米递药系统的制备方法及用途. 申请号：201610040717.8. 申请日：2016-01-21. (17) 俞磊，赵潇，肖晔，王镜，董素珍，闫志强，王依婷，朱建中，彭辉. 用于生物成像和脑胶质瘤靶向的纳米粒子及制备方法和应用. 申请号：201510032689.0. 申请日：2015-01-22. (18) Sang Van, Sanjib Kumar Das, Gang Zhao, LeiYu: Method of preparing polyglutamate conjugates. Nitto DenkoApr, 15 2010:US 20100093935 (2 citation) (19) Sang Van, Jiadong Zhou, Xiaoli Fu, LeiYu: Biodegradable polyacetals for in vivo polynucleotide delivery. NittoDenko Sep, 14 2010: US 7794696 (1 citation) (20) Gang Zhao, Xiaoli Fu, Lei Yu:Biodegradable cationic polymers. Nitto Denko Aug, 19 2010: US 20100210715 (1citation) (21) Sang Van, Yasunobu Tanaka, Lei Yu:Polymer coating of cells. Nitto Denko Mar, 9 2010: US 7674452 (1 citation) (22) Lei Yu, Gang Zhao,Sang Van, Fu Chen: Drug carriers. Nitto Denko Feb, 4 2010: US 20100028416 (1citation) (23) Yoshiro Niitsu, Lei Yu, JianLiu, Gang Zhao, Nianchun Ma, Sang Van: Drug carriers. Nitto Denko Aug, 232011:US 8003621 (24) Sang Van, Yucheng Song, Xinghe Wang, Zheng Hou, Zhongling Feng, Gang Zhao, Lei Yu: Wetted wall cyclone system andmethods. Nitto Denko Jun, 19 2012: US 8202352 (25) Sang Van, Yasunobu Tanaka, Lei Yu:Polymer coating of cells. Nitto Denko Jul, 10 2012: US 8216558 (26) Lei Yu, Kenji Matsumoto,Shouping Ji, Fusheng Du: Solid surface for biomolecule delivery andhigh-throughput assay. Nitto Denko Jun, 5 2012: US 8192989 (27) Lei Yu, Gang Zhao,Sang Van, Sanjib Kumar Das, Fu Chen, Yi Jin, Xiaoli Fu: Multi-functional drugcarriers. Nitto Denko Jul, 26 2012: US 20120189554 (28) Padmanabh Chivukula, Jian Liu, Akinobu Soma, Keisaku Okada, Sang Van, JuliaZhu, Nianchun Ma, Chen-Chang Lee, Fu Chen, LeiYu: Nucleic acid delivery compounds. Nitto Denko May, 3 2012: US20120107264 (29) Padmanabh Chivakula, Jian Liu, Sang Van, Akinobu Soma, Keisaku Okada, Lei Yu, Nianchun Ma: Nucleic aciddelivery compounds. Nitto Denko Apr, 19 2012: US 20120093762 (30) Padmanabh Chivukula, Jian Liu, Akinobu Soma, Keisaku Okada, Sang Van,Chen-Chang Lee, Lei Yu: Nucleic aciddelivery compounds. Nitto Denko Apr, 19 2012: US 20120094924 (31) Lei Yu, Hai Wang, KwokYin Tsang, Yi Jin, Sang Van: End-capped polymers. Nitto Denko Mar, 1 2012: US20120052015 (32) Yoshiro Niitsu, Lei Yu, JianLiu, Gang Zhao, Nianchun Ma, Sang Van: Drug carriers. Nitto Denko Oct, 202011:US 20110257249 (33) Mohammad Ahmadian, Wendy Taylor, Sang Van, Lei Yu: Carbohydrate-polyamino acid-drug conjugates. Nitto DenkoSep, 15 2011: US 20110224148 (34) Xiaomei Jin, Lei Yu, HirokazuTakahashi, Yasunobu Tanaka, Yoshiro Niitsu, Elena Feinstein, SharonAvkin-Nachum, Hagar Kalinski, Igor Mett, Shai Erlich, Elizabeth C Squiers:Modulation of hsp47 expression. Nitto Denko Technical Jul, 21 2011: US20110178157 (35) Zheng Hou, Jian Liu, Lei Yu:Multi-valent guanidinium compounds for enhancing molecular translocation acrosscellular membranes and epithelial tissues. Nitto Denko Jun, 29 2010: US 7745392 (36) Gang Zhao, Lei Yu, Jian Liu,Chieko Kitaura, Xinghe Wang, Chris Castello: Guanidinium delivery carriers.Nitto Denko Jun, 24 2010: US 20100160210 (37) Gang Zhao, Chieko Kitaura, Jian Liu, LeiYu: Peptide nucleic acid based guanidinium compounds. Nitto DenkoJun, 242010: US 20100160239 (38) Gang Zhao, Chieko Kitaura, Jian Liu, LeiYu: Peptide nucleic acid based guanidinium compounds. Nitto DenkoApr, 202010: US 7700565 (39) Gang Zhao, Xiaoli Fu, Lei Yu:Biodegradable cationic polymers. Nitto Denko Apr, 20 2010: US 7700542 (40) Yasunobu Tanaka, Gang Zhao, Lei Yu:Biodegradable cationic polymers. Nitto Denko Apr, 20 2010: US 7700541 Gang Zhao, Lei Yu, Jian Liu, Chieko Kitaura,Xinghe Wang, Chris Castello: Guanidinium delivery carriers. Nitto Denko Mar, 302010: US 7687603
团队合影
课题组邀请世界著名CART细胞治疗专家Stephan Grupp教授来访 |
