徐志爱

2001年9月－2006年12月，中国科学院长春应用化学研究所，博士

2018年1月－至今：华东师范大学 教授

2012年5月－2017.12：华东师范大学 副教授

2009年6月－2012年4月：助教授，东北大学，日本 (Tohoku University, Japan)。 

2007年6月－2009年5月：日本学术振兴会（JSPS）博士后研究员，东北大学，日本 (Tohoku University, Japan)。

研究方向

生物大分子的组装及在生物分析中的应用

荧光探针的合成和生物分析应用

癌症和神经退行性疾病等相关分析检测与治疗

分析化学与分析技术I

分析化学与分析技术I实验

分析化学与分析技术II实验

国家自然科学基金面上项目 2021-2024

国家自然科学基金面上项目 2017-2020

国家自然科学基金青年项目 2014-2016

代表性研究论文：

[1] Y. Dang, L. Ruan, Y. Tian, Z. Xu,* and W. Zhang,* Nitric Oxide Prodrug Delivery and Release Monitoring Based on Galactose-Modified Multifunctional Nanoprobe. Anal. Chem. 2021,  93, 7625−7634. 

[2] L. Lei, Z. Zou, J. Liu, Z. Xu,* Y. Fu, Y. Tian and W. Zhang* Multifunctional peptide-assembled micelles for simultaneously reducing amyloid-β and reactive oxygen species, Chemical Science, 2021, 2021, 12, 6449-6457.

[3] F. Zhou, J. Gao, Z. Xu, * T. Li, A. Gao, F. Sun, F. Wang, W. Wang, Y. Geng, F. Zhang, Z.P. Xu, H. Yu*. Overcoming immune resistance by sequential prodrug nanovesicles for promoting chemoimmunotherapy of cancer. Nano Today, 2021, 36, 101025.

[4] L. Lei, M. Li, S. Wu, Z. Xu, * P. Geng, Y. Tian, Y. Fu, and W. Zhang *, Non-invasive In-situ Ratiometric Imaging of Biometals Based on Self-Assembling Peptide Nanoribbon. Anal. Chem. 2020, 92, 5838-5845. 

[5] Y. Lai, Y. Zhu, Z. Xu,* X. Hu, M. Saeed, H. Yu, X. Chen, J. Liu, W. Zhang*, Engineering Versatile Nanoparticles for Near-Infrared Light-Tunable Drug Release and Photothermal Degradation of Amyloid β. Adv. Funct. Mater. 2020, 30, 1908473.

[6] Yijing Dang, Fengyang Wang, Lingling Li, Yi Lai, Zhiai Xu, * Zhi Xiong, Ao Zhang, Yang Tian, Chunyong Ding,* and Wen Zhang* Activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice. Chem. Commun. 2020, 56, 707-710.

[7] Y. Lai, Z. Xu,* X. Hu, L. Lei, L. Li, L. Dong, H. Yu,* W. Zhang*. Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor. Small 2019, 1904397.

[8] L. Lei, R. Geng, Z. Xu,* Y. Dang, X. Hu, L. Li, P. Geng, Y. Tian, W. Zhang*. Glycopeptide Nanofiber Platform for Ab-Sialic Acid Interaction Analysis and Highly Sensitive Detection of Ab. Anal. Chem. 2019, 91, 8129-8136.

[9] R. Geng, D. Lu, Y. Lai, S. Wu, Z. Xu* and W. Zhang*, Peptide nanotube for carbon dioxide chemisorption with regeneration properties and water compatibility. Chem. Commun. 2019, 55, 3797-3800.

[10] L. Lei, Z. Xu*, X. Hu, Y. Lai, J. Xu, B. Hou, Y. Wang, H. Yu*, Y. Tian, W. Zhang*. Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging-Guided Treatment of Metastatic Melanoma. Small 2019, 15(22), 1900157.

[11] F. Wang, S. Yu, Z. Xu, * L. Li, Y. Dang, X. Xu, Y. Luo, Z. Cheng, H. Yu, W. Zhang, A. Zhang, and C. Ding*. Acid-Promoted D-A-D Type Far-Red Fluorescent Probe with High Photostability for Lysosomal Nitric Oxide Imaging, Anal. Chem. 2018, 90 (13), 7953-7962.

[12] F. Lin, Y. Zhou, Q. Li, X. Zhou, Y. Shao,^* B. Habermeyer, H. Wang, X. Shi, and Z. Xu,^* Prototropically Allosteric Probe for Superbly Selective DNA Analysis, Anal. Chem. 2017, 89 (17), 9299–9306.

[13] C. Feng, F. Wang, Y. Dang, Z. Xu, ^* H. Yu, and W. Zhang. A Self-Assembled Ratiometric Polymeric Nanoprobe for Highly Selective Fluorescence Detection of Hydrogen Peroxide, Langmuir, 2017, 33, 3287–3295.

[14] Y. Hu, F. Lin, T. Wu, Y. Zhou, Q. Li, Y. Shao,^* Z. Xu, ^* DNA Duplex Engineering for Enantioselective Fluorescent Sensor, Anal. Chem., 2017, 89, 2181-2185.

[15] L. Lu, C. Feng, J. Xu, F. Wang, H. Yu, Z. Xu, ^* W. Zhang, Hydrophobic-carbon-dot-based dual-emission micelle for ratiometric fluorescence biosensing and imaging of Cu2+ in liver cells, Biosensors and Bioelectronics, 2017, 92, 101-108.

[16] F. Wang, † Q. Sun, † B. Feng, Z. Xu, ^* J. Zhang, J. Xu, L. Lu, H. Yu, M. Wang, Y. Li and W. Zhang*, Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer, Adv. Healthc. Mater., 2016, 5, 2227–2236.

[17] J. Zhang, J. Liu, Y. Zhu, Z. Xu, ^* J. Xu, T. Wang, H. Yu and W. Zhang^*, Photodynamic micelles for amyloid β degradation and aggregation inhibition, Chem. Commun., 2016, 52, 12044-12047.

[18] Y. Wang, L. Lu, H.Peng, J. Xu, F. Wang, R. Qi, Z. Xu* and W. Zhang*, Multi-doped carbon dots with ratiometric pH sensing properties for monitoring enzyme catalytic reactions. Chem. Commun., 2016, 52, 9247-9250.

[19] L. Zhu, J. Zhang, F. Wang, Y. Wang, L. Lu, C. Feng, Z. Xu*, W. Zhang*. Selective amyloid β oligomer assay based on abasic site-containing molecular beacon and enzyme-free amplification, Biosensors and Bioelectronics, 2016, 78, 206-212.

[20] Y. Wang, Q. Sun, L. Zhu, J. Zhang, F. Wang, L. Lu, H. Yu, Z. Xu* and W. Zhang*. Triplex molecular beacons for sensitive recognition of melamine based on abasic-site-containing DNA and fluorescent silver nanoclusters. Chem. Commun., 2015, 51, 7958-7961.

[21] B. Lin, D. Lu, Y. Fu, Q. Sun, K. Liu, Z. Xu* and W. Zhang*. Label-free Colorimetric Protein Assay and Logic Gates Design Based on the Self-assembly of Hemin-Graphene Hybrid Nanosheet.  Langmuir, 2014, 30(8), 2144-251.

[22] Y. An, Y. Fu, D. Lu, Y. Wang, W. Bi, Z. Xu,* S. Dong, S. Zhang, C. Wang and W. Zhang*. A TiO2-Au–polymer hybrid system for the photoelectrochemical immunoassay of SirT1. J. Mater. Chem. B, 2014, 2, 1644-1652.