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肖元晶

职称: 副教授

直属机构: 化学与分子工程学院

学科:

10 访问

相关教师

个人资料

  • 部门: 化学与分子工程学院
  • 性别:
  • 专业技术职务: 副教授
  • 毕业院校: 武汉大学
  • 学位: 博士
  • 学历: 研究生
  • 联系电话: 021-54345471
  • 电子邮箱: yjxiao@chem.ecnu.edu.cn
  • 办公地址: 华东师大闵行校区化学楼523
  • 通讯地址: 上海市闵行区东川路500号华东师范大学化学与分子工程学院
  • 邮编: 200241
  • 传真: 54345471

教育经历

1993.09-1997.07 湖北大学化学与材料科学学院 理学学士

1997.09-2002.07 武汉大学化学与分子科学学院 理学博士



工作经历

2002.09-至今    华东师范大学化学与分子工程学院

2011.10-2012.10 美国加州大学圣巴巴拉分校访问学者

                


个人简介

社会兼职

Journal of Heterocyclics (ISSN 2639-6734),编委

研究方向

基础理论研究方向:

高选择性现代有机合成反应设计,多样性导向有机合成方法学研究, 新型催化剂的设计与开发,新型含氟砌块的设计与转化研究,不对称催化。先后参与多项上海市科委重大基础研究项目及国家自然科学基金项目。

应用化学研究方向:药物及中间体的合成工艺开发


招生与培养

开授课程

主讲本科生专业必修课:有机化学(II), 有机化学实验

辅导本科生参加上海市及全国师范类化学实验竞赛

科研项目

国家自然科学基金项目:新型手性非血红素模拟酶及其分子氧活化的不对称催化作用,21871093,64万,201901-2022.12,已结题。

上海市科委科技项目:基于含氟共轭烯炔的有机合成反应设计13ZR1412900, 10万,2013.07-2016.06,已结题。

上海市科委科技项目:基于含氟共轭烯炔的有机合成反应设计17ZR1408800, 20万,2017.05-2020.04已结题。

上海市科委科技项目:新型手性亚磺酰胺吡啶-氮杂卡宾钳式配体的合成及其在不对称催化反应中的应用,20ZR1417600, 20万,2020.07-2023.06,已结题 

企业合作项目:2-庚酮的合成工艺开发,7.5万,已结题。

企业合作项目:纳米氮化钛及纳米钨酸铯粉体材料研制,20万,在研。

学术成果

代表性论文:

31. Zongxiang Yu, Jintong Li, Yuxuan Cao, Tingwei Dong, and Yuanjing Xiao*3‑Trifluoromethyl Pyrrole Synthesis Based on β‑CF3‑1,3-Enynamides. J. Org. Chem. 2023, 88, 15501.


30. Juan Feng,   Jiayi Shi,   Lan Wei,  Mingqing Liu,  Zhiming Li, * Yuanjing Xiao* and Junliang Zhang*Palladium/PC-Phos-Catalyzed Asymmetric Heck/Tsuji-Trost Reactions of Amino-Tethered 1,3-Cyclohexadiene with Aryl and Alkenyl Halides. Angew.  Chem.  Int.  Ed., 2022, 61,10.1002/anie.202215407.



29. QinZeng,  Xinyu Huang, Mingqing Liu, Zongxiang Yu, and Yuanjing Xiao*Synthesis of Trifluoromethylated 4H-Pyran and 4H-Thiopyran via Divergent Reaction of β-CF3-1,3-Enynes with β-Ketothioamides.Org. Lett., 2022, 24, 8186−8191.


28.  LanWei, Shiteng Ding, Mingqing Liu, Zongxiang Yu, and Yuanjing XiaoSynthesis of Trifluoromethylated Pyrazolidines, Pyrazolines and Pyrazoles via Divergent Reaction of β-CF3-1,3-Enynes with Hydrazines. Org. Lett.2021,  23, 7718−7723.



27. Anjing Hu, Zhan-Ming Zhang, Yuanjing Xiao*, Junliang ZhangStereoselective Synthesis of Chiral Sulfinamide Monophosphine Ligands (Ming-Phos)(S, Rs)-M. Org. Synth., 2020, 97, 262-273.



26. Yi Wu, Yuanjing Xiao*, Junliang Zhang* BCl3 Mediated Borylative Cyclization of 2-(1-alkynyl)-2-alken-1-ones. 

Chin. J. Org. Chem. 2020, 40. cjoc202005025.R1.



25. HuayuChengXiaofanZhou, AnjingHu, ShitengDing, YimoWang, Yuanjing Xiao*Junliang ZhangThioether-Functionalized Trifluoromethyl-alkynes, 1, 3-Dienes and Allenes: Divergent Synthesis from Reaction of 2-Trifluoromethyl-1, 3-Conjugated Enynes with Sulfur Nucleophiles. RSC Adv., 2018, 8, 34088–34093.


24.  Qin Zeng, Li Zhang,Yuanjing Xiao* and Junliang Zhang* Divergent Access to N-Hydroxypyrroles and Isoxazoles via Gold(I)- or Brønsted Acid- Catalysed Regioselective Cyclization of N-(2-trifluoromethyl-3-Alkynyl) Oximes. Org. Biomol. Chem., 201816,1375-1380。



23. Chaoqian Huang, Yu Zeng, Huayu Cheng, Anjing Hu, Lu Liu, Yuanjing Xiao, * and Junliang Zhang*A One-Pot Construction of Halogenated Trifluoromethylated Pyrroles through NXS (X =Br, I) Triggered Cascade. Org. Lett.201719, 4968-4971.



22. Yu Zeng,Chaoqian Huang, Peiyun Ni, Lu Liu,Yuanjing Xiao*and Junliang Zhang* Silver-Catalyzed Double Hydrocarbonation of 2-Trifluorometh- yl-1,3-Conjugated Enynes with 1,3-Dicarbonyl Compounds: Synthesis of Ring-Trifluoromethylated Cyclopentene. Adv. Synth. Catal. 2017, 359, 3555-3559.  




21. Jieru Yang, Xiaofan Zhou, Yu Zeng, Chaoqian Huang, Yuanjing Xiao* and  Junliang Zhang*Divergent Synthesis from Reactions of 2-Trifluoromethyl-1,3-Conjugated EnyneswithN-Acetylated 2-Aminomalonates.

Org. Biomol. Chem., 201715, 2253-2258.


20. Xiaofan Zhou, Chaoqian Huang, Yu Zeng, Jiarui Xiong, Yuanjing Xiao and Junliang Zhang, Silver-Catalysed Tandem Hydroamination and Cyclization of 2-Trifluoromethyl-1,3-Enynes with Primary Amines:A Modular Entry to 4-Trifluoromethyl-3-Pyrrolines. Chem. Commun.,2017, 53, 1084-1087.



19. Bing Xu, Zhan-Ming Zhang, Shan Xu, Bing Liu, Yuanjing Xiao and Junliang Zhang* Copper(I)/Ming-Phos-Catalyzed Asymmetric Intermolecular [3+2] Cycloaddition of Azomethine Ylides with a-Trifluoromethyl a, b-Unsaturated Esters. ACS Catal. 2017, 7, 210−214.




18. Jieru Yang, Xiaofan Zhou, Yu Zeng, Chaoqian Huang, Yuanjing Xiao* and Junliang Zhang*Synthesis of 2-fluoro-2-pyrrolines via tandem reaction of α-trifluoromethyl-α,β-unsaturatedcarbonyl compounds with N-tosylated2-aminomalonates. Chem.Commun., 2016, 52, 4922.




17. Yanqing Zhang, Yuanjing Xiao* and Junliang Zhang*. Gold(I)-Catalyzed Stereospecific [4+3] Cycloaddition Reaction of Optically Active 1-(1-alkynyl)cyclopropyl Ketone with Nitrones: A Modular Entry to Enantioriched 5,7-Fused Bicyclicfuro[3,4-d]-[1,2]oxazepines. Synthesis, 2016, 48, 512(Feature Article).



16. Peng Chen, Xiao Su, Wei Zhou,Yuanjing Xiao* and Junliang Zhang*. Novel Chiral Sulfinamide Phosphines : Valuable Precursors to Chiral β-Aminophosphines. Tetrahedron,2016, 72, 2700.



15. Jieru Yang, Ao Mao, Zhenting Yue, Wenxuan Zhu, Xuewei Luo, Chuwei Zhu,Yuanjing Xiao* and Junliang Zhang* A simple base-mediated synthesis of diverse functionalized ring-fluorinated 4H-pyran via double direct C-F substitutionsChem.Commun,2015, 51, 8326.


14. Ziqi Tian, Yuanjing Xiao, Xianggai Yuan, Zuliang Chen, Junliang Zhang* and Jing Ma*. Control of Chemoselectivity by Coordinated Water and Relative Size of Ligands to Metal Cations of Lewis Acid Catalysts for Cycloaddition of an Oxirane Derivative to an Aldehyde: Theoretical and Experimental Study. Organometallics. 2014, 33, 1715.



13. Li Zhang, Qin Zeng, Ao Mao, Ziang Wu, Tian Luo, Yuanjing Xiao* and Junliang Zhang*. NIS-mediated oxidative cyclization of N-(2-trifluoromethyl-3-alkynyl)hydroxylamines:a facile access to 4-trifluoromethyl-5-acylisoxazoles.Org.Biomol. Chem.2014, 12, 8942.



12.Qin Zeng, Li Zhang, Jieru Yang, Bing Xu, Yuanjing Xiao* and Junliang Zhang*. Pyrroles versus Cyclic Nitrones: Catalyst-Controlled Divergent Cyclization of N-(2-perfluoroalkyl-3-alkynyl) hydroxylamines. Chem. Commun. 2014, 504203.



11.Junqing Zhang, Yuanjing Xiao and Junliang Zhang*. Nickel-Catalyzed Annulation of Donor–Acceptor Oxiranes with Imines: Diastereoselective Access to Highly Substituted 2,4-trans- Oxazolidines. Adv. Synth. Catal.2013, 355, 2793.



10. Zuliang Chen, Yuanjing Xiao and Junliang Zhang* . Reaction of Two Differently Functionalized Oxiranes with Nickel Perchlorate :A Modular Entry to Highly Substituted 1,3-Dioxolanes. Eur. J. Org. Chem.2013, 4748.



9.Yuanjing Xiao and Liming Zhang*. Synthesis of Bicyclic Imidazoles via [2 + 3] Cycloaddition between Nitriles and Regioselectively Generated α-Imino Gold Carbene Intermediates.Org. Lett., 2012, 14 (17), 4662.



8. Ze-Yi Yan,Yuanjing Xiao and Liming Zhang*. Gold-Catalyzed One-Step Construction of 2,3-Dihydro-1H-Pyrrolizines with an Electron-Withdrawing group in the 5-position: A Formal Synthesis of 7-Methoxymitosene. Angew. Chem. Int. Ed. 2012, 51, 8624.



7. Yuanjing Xiao‚ Junliang Zhang*. Tetrasubstituted Allenes by Pd0-Catalyzed Three-Component Tandem Michael Addition / Cross-Coupling Reaction.Chem. Commun. 201046‚ 752.



6. Yuanjing Xiao‚ Junliang Zhang*. Pd(II)-Catalyzed Domino Reaction of 2-(1-Alkynyl)-2-alken-1-ones with Nucleophiles: Scope‚ Mechanism and Synthetic Application in the Synthesis of 3‚4-Fused Bicyclic Tetrasubstituted Furans. Adv. Synth. Catal. 2009351‚ 617.


5.Yuanjing Xiao‚ Junliang Zhang*. Furan versus 4H-Pyran: Catalyst-Controlled Regiodivergent Tandem Michael Addition/Cyclization Reaction of 2-(1-Alkynyl)-2-alken-1-ones with 1‚3-Dicarbonyl Compounds. Chem. Commun. 2009‚ 3594.



4.Yanqing Zhang‚ Zuliang Chen‚ Yuanjing Xiao‚ Junliang Zhang*. RhI-Catalyzed Regio- and Stereospecific Carbonylation of 1-(1-Alkynyl)cyclopropyl Ketones: A Modular Entry to Highly Substituted 5‚6-Dihydrocyclopenta[c]furan-4-ones. Chem. Eur. J. 200915‚ 5208.



3. Wenbo Li‚ Yuanjing Xiao‚ Junliang Zhang*. Alkynyl Group as Activating Group: Base-Catalyzed Diastereo-selective Domino Reactions of Electron-Deficient Enynes. Adv. Synth. Catal. 2009351‚ 3083.


2. Yuanjing Xiao‚ Junliang Zhang*. Tetrasubstituted Furans by a Pd(II)-Catalyzed Three-Component Michael Addition /Cyclization /Cross-Coupling Reaction. Angew. Chem. Int. Ed. 200847‚ 1903.


1. Xiuzhao Yu‚Hongjun Ren‚Yuanjing Xiao‚ Junliang Zhang*. Efficient Assembly of Allenes‚ 1‚3-Dienes‚ and 4H-Pyrans by Catalytic Regioselective Nucleophilic Addition to Electron-Deficient 1‚3-Conjugated Enynes. Chem. Eur. J. 200814‚ 8481.


撰写专著

(1) Junliang Zhang‚ Yuanjing Xiao "Cyclization of cyclopropane and cyclopropnene-contaninng compounds" in "Handbook of Cyclization Reactions"(Eds. Shengming Ma)‚ Willey-VCH‚ 2009, Volume 2‚ 733-813.


(2) Yuanjing Xiao and Junliang Zhang*Au- and Pt-Catalyzed C–H Activation/ Functionalizations for the Synthesis of Heterocycles in Transition Metal-Catalyzed Heterocycle Synthesis via C-H Activation (Xiaofeng Wu, Ed), Wiley-VCH, 2016. pp 359-402.


授权专利:

9.卤代三氟甲基吡咯衍生物及其制备方法和应用,专利授权号:201710716742.8

8. 1-三氟甲基-四取代环戊烯衍生物及其制备方法和应用,专利授权号:201710404108.0

7. 一种3,5-二氯苯胺的合成方法,专利授权号:201611235021.7

6. 一种4-三氟甲基-2,4-二取代-2,5-二氢吡咯衍生物及其制备方法和应用,专利授权号:201610894495.6

5. 5-氟多取代二氢吡咯衍生物及其制备方法,专利授权号:201610070648.5

42-氟多取代4H-吡喃衍生物及其制备方法,专利授权号:201510047442.6

3. 4-多氟烷基-4,5-二取代异噁唑衍生物及其制备方法,专利授权号:201410246937.7

2. 一种含多氟烷基五元环状硝酮衍生物及其制备方法,专利授权号:201410005088.6

1. 4-多氟烷基-2,4-二取代吡咯衍生物及其制备方法,专利授权号:201410004756.3


主持科研项目:

(1)2013上海市自然科学基金:基于含氟共轭烯炔的有机合成反应设计,10万(项目号:13ZR1412900)执行年限:2013.7-2016.7;

(2)承担教育部创新团队子课题项目 25万

(3)2017上海市自然科学基金:基于2-三氟甲基-1,3-共轭烯炔的有机合成反应设计,20万(项目号:17ZR1408800)执行年限:2017.5-2020.4。

(4)2018 国家自然科学基金:新型手性非血红素模拟酶及其分子氧活化的不对称催化作用,64万(项目号:21871093)执行年限:2019.1-2022.12。




荣誉及奖励

华东师范大学自然科学奖二等奖

2018年度上海大学生实验竞赛优秀指导教师奖