马明亮

2005/09 - 2008/06，华东师范大学，生理学，博士，导师：文珂、赵康

2002/09 - 2005/06，山东大学，化学，硕士，导师：胡清萍、赵康

1998/09 - 2002/06，山东大学，化学，学士，导师：胡清萍

2011/08 - 至今，华东师范大学，副研究员

2015/08 - 2017/08，江苏省南通市如东县科技局，副局长（挂职）  

2013/03 - 2014/03，美国亚利桑那大学，药学院，访问学者

2008/07 - 2011/07，华东师范大学，助理研究员

主要从事1）抗肿瘤药物的研发、新型功能材料的研发和应用；2）重要药物及其中间体的绿色合成工艺研究。目前已经在J. Am. Chem. Soc., J. Med. Chem., Chem. Commun., J. Mater. Chem. B, Eur. J. Med. Chem., Bioorg. Med. Chem., CrystEngComm, Dalton Trans., Oncotarget 等期刊上发表SCI论文30余篇，授权专利2件。

1）抗肿瘤新药的研发；

2）功能分子材料的研发与应用;

3）绿色工艺研究。

主讲研究生课程：《高等药物化学》、《药物合成工艺学》；

本科生课程：《药物化学》、《有机化学》、《有机化学实验》、《有机化学实验II》等。

一、纵向项目：  

6、国家自然科学基金（面上项目），NSFC:21572067，2016/01-2019/12，直接经费65.0万元，主持。

5、上海市2014年度“科技创新行动计划”生物医药领域科技支撑项目，14431902700，2014/07-2017/09，40.0万  元，（主要参与人，排名第二）。

4、国家自然科学基金（青年项目），NSFC:21002031，2011/01-2013/12，19.0万元，主持。

3、国家自然科学基金（面上项目），NSFC:21071053，2011/01-2013/12，33.0万元，（主要参与人，排名第 二）。

2、上海市自然科学基金，10ZR1409700，2010/4-2012/3，10.0万元，（主要参与人，排名第二）。

1、2009年度华东师范大学科研创新基金，2010/1/1-2011/12/31，15.0万元，主持。

二、横向项目：

10、DNP等小分子与BSA/OVA/HSA蛋白偶联工艺的开发与制备，2022/11/07-2024/12/31，40万主持。

9、分子靶向NEK2抑制剂新药研发框架协议，2021/12/10-2024/12/10，60万，主持。

8、铸件去污表面活性剂的应用研究 ，2020/10/08-2021/10/31，10万，主持。

7、高效生物除臭菌种以及VOCs销毁低温催化剂优化开发项目，2020/08/01-2022/06/30，100万，主持。

6、CAS12a的发酵工艺优化及蛋白制备，2020/09/01-2021/08/31，20万，主持。

5、“氟聚酰亚胺”工艺技术研究开发，2020/07/01-2021/12/31，10万，主持。

4、CAS13a的发酵工艺优化及蛋白制备，2020/03/01-2020/12/31，20万，主持。

3、阿尔兹海默病Tau蛋白近红外荧光探针的设计及PROTAC技术的运用，2019/12/01-2022/03/31，5万，主持，精细化工国家重点实验室（大连理工大学）。

2、专利权转让合同，2018/12/01-2038/12/01，28.4万（合同金额1000万），主持。

1、姜黄素化合物库研制，合作研究，美国左治亚医学院，项目起止时间：2009/5 -2011/4 ；项目金额：4万美元，主要参与人，排名第二。

发表部分论文： 

37. Chuchu Li^#, Yuqiao Han^#, Zhengyang Wang, Yanan Yu, Chen Wang, Ziwei Ren, Yanzhi Guo, Tong Zhu, XuWen Li*, Suzhen Dong*, Mingliang Ma*, Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b]pyridazine derivatives as potent PI3K/mTOR dual inhibitors, European Journal of Medicinal Chemistry,247 (2023), 115030. https://doi.org/10.1016/j.ejmech.2022.115030

36. Mifang†, Yeying Wang†, Xinai Han†, Yibiao Liu, Mingliang Ma* and Lingyan Zhang*, Multifunctional Polydopamine-Based Nanoparticles for Dual-Mode Imaging Guided Targeted Therapy of Lupus Nephritis, Pharmaceutics, 2022, 14, 1988. https://doi.org/10.3390/pharmaceutics14101988

35. Haili Wang, Chuchu Li, Xiaoqing Liu*, Mingliang Ma*, Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase, Bioorganic & Medicinal Chemistry, 61 (2022),  116707. https://doi.org/10.1016/j.bmc.2022.116707

34. Shanshan Lu, Yiwei Li, Qiang Shen, Wanli Zhang, Xiaofan Gu, Mingliang Ma, Yiming Li, Liuqiang Zhang, Xuan Liu* & Xiongwen Zhang, Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia, Journal of Cachexia, Sarcopenia and Muscle, 2021; 12: 779–795. DOI: 10.1002/jcsm.12710

33. Chun Zhang, Chao Zhang, Jie Tang, Shengqing*, Mingliang Ma*, and Jie Wu*, Synthesis of γ-Keto Sulfones through a Three-Component Reaction of Cyclopropanols, DABCO · (SO₂)₂ and Alkyl Halides, Adv. Synth. Catal., 2021, 363, 3109– 3114. https://doi.org/10.1002/adsc.202100066

32. Shuting Wang^#, Shulei Zhu^#, Yawen Tanzeng, Yuexing Zhang, Chuchu Li, Mingliang Ma^* and Wei Lu, Design, Synthesis, and Evaluation of Near-Infrared Fluorescent Molecules Based on 4H-1-Benzopyran Core, Molecules, 2021, 26, 6986. https://doi.org/10.3390/molecules26226986

31. YuqiaoHan^#, ziwei Ren^#, YixinWu, YunzhongChen, ZhenmeiCui, TongZhu, MingliangMa*, YijieDu*, SuzhenDong*, Pharmacological activation of the p53 pathway by a new compound CYZ2017 exerts anti-tumor effects, Biochemical and Biophysical Research Communications, 533 (2020) 1069-1075. https://doi.org/10.1016/j.bbrc.2020.09.122

30. Haili Wang^#, Yunzhong Chen^#, Xiaofan Gu, Jianbei Xi, ZiweiRen, Shuting Wang, Yanhong Duan, Hongyu Li, TongZhua, Yijie Du,* Xiongwen Zhang* Mingliang Ma*, Design, synthesis, and structure activity relationship (SAR) studies of novel imidazo[1,2-a] pyridine derivatives as Nek2 inhibitors, Bioorganic & Medicinal Chemistry, 28 (2020) 115775. https://doi.org/10.1016/j.bmc.2020.115775

29. Zelin Lai^#, Lingling Gu^#, Lu Yu^#, Huifen Chen, Zhenhua Yu, Cheng Zhang, Xiaoqing Xu, Mutian Zhang, Min Zhang, Mingliang Ma*, Zheng Zhao* and Jun Zhang*, Delta opioid peptide [d‑Ala2, d‑Leu5] enkephalin confers neuroprotection by activating delta opioid receptor‑AMPK‑autophagy axis against global ischemia,Cell & Bioscience., 2020, 10:79.  doi.org/10.1186/s13578-020-00441-z

28. Ya’nan Yu^#, Yuqiao Han^#, Fupo Zhang, Zhenmei Gao, Tong Zhu, Suzhen Dong*, Mingliang Ma*, Design, Synthesis, and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors, J. Med. Chem., 2020. 63(6), 3028-3046. doi.org/10.1021/acs.jmedchem.9b01736

27. ShuleiZhu, XumengYu, YangHe, Mingliang Ma*, Wei Lu*, Synthesis and fluorescent studies of a low molecular weight rotor for living cancer cell imaging, Dyes and Pigments, 178, 2020, 108353. doi.org/10.1016/j.dyepig.2020.108353

26. Shulei Zhu, Yalei Li, Yushu Huang, Minmin Zhang, Xiaofan Gu,  Yang He,  Hongchun Liu, Mingliang Ma*, Wei Lu*, Optimized HSP90 mediated fluorescent probes for cancer-specific bioimaging,  J. Mater. Chem. B, 2020, 8(9), 1878. DOI: 10.1039/c9tb02505g

25.JiajunSheng,Ya'nanYu, XinWang,YuQian, Liwu Fu, Yun Zhao, Mingliang Ma*, Wenhao Hu*, Synthesis of Paclitaxel Side Chain via Multi-Component Reaction and Its Application to the Synthesis of Paclitaxel Analogues, Chinese Journal of Organic Chemistry, 2019, 39(2): 377-389.

24. Jiajun Sheng, Huan Chang, Yu Qian, Mingliang Ma*, Wenhao Hu*, A convenient one-pot approach to Paclitaxel (Taxol) side chainvia1,3-dipolar cycloaddition of carbonyl ylides and N-benzoylbenzyl imines, Tetrahedron Letters, 2018, 59(22), 2141-2144.

23. Jian-Bei Xi^#, Yan-Fen Fang^#, Brendan Frett^#, Meng-Li Zhu, Tong Zhu, Yan-Nan Kong, Feng-Jie Guan, Yun Zhao,  Xiong-Wen Zhang*, Hong-yu Li*, Mingliang Ma*, Wenhao Hu*, Structure-based design and synthesis of imidazo[1, 2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities, Eur. J. Med. Chem., 2017, 126, 1083-1106.

22. Xin Wang, Suzhen Dong, Dengke Feng, Yazhou Chen, Mingliang Ma*, Wenhao Hu*, Synthesis and biological activity evaluation of dolastatin 10 analogues with N-terminal modifications, Tetrahedron, 2017, 73(16), 2255-2266.

21. Xin Wang, Mingliang Ma, Alavala Gopi Krishna Reddy, Wenhao Hu*, An efficient stereoselective synthesis of six stereoisomers of 3, 4-diaminocyclohexane carboxamide as key intermediates forthe synthesis of factor Xa inhibitors, Tetrahedron, 2017, 73(11), 1381-1388.

20. Jian-Bei Xi, Ming-Liang Ma, Wenhao Hu*, Rh2(OAc)4 and InCl3 co-catalyzed diastereoselective trapping of carbamate ammonium ylides with aldehydes for the synthesis of  β-hydroxyl-α-amino acid derivatives, Tetrahedron, 2016, 72(5), 579-583.

19. Yanfen Fang^#, Yannan Kong^#, Jianbei Xi^#, Mengli Zhu, Tong Zhu, Tongtong Jiang, Brendan Frett, Wenhao Hu, Hong-yu Li*, Mingliang Ma*, Xiongwen Zhang*, Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity, Oncotarget., 2016, 7(48), 79327-79341.

18. M.-L. Ma, M. Li, .J-J. Gou, T.-Y. Ruan, H.-Sh. Jin, L.-H. Zhang, L.-Ch. Wu, X.-Y. Li, Y.-H. Hu, K. Wen*, Z. Zhao*, Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor, Bioorganic & Medicinal Chemistry, 2014, 22(21), 6117–6123.

17. W.-B. Hu, H.-M. Yang, W.-J. Hu, M.-L. Ma,* X.-L. Zhao, X.-Q. Mi, Yahu A. Liu, J.-Sh. Li,* B. Jiang*, K. Wen*, A pillar[5]arene and crown ether fused bicyclic host: synthesis, guest discrimination and simultaneous binding of two guests with different shapes, sizes and electronic constitutions, Chem. Commun., 2014, 50(72), 10460-10463.

16. Brendan F., Robert V. B., M.-L. Ma, W.-H. Hu, H.-Y. Han, and H.-Y. Li*, Therapeutic Melting Pot of Never in Mitosis Gene A Related Kinase 2 (Nek2): A Perspective on Nek2 as an Oncology Target and Recent Advancements in Nek2 Small Molecule Inhibition, J. Med. Chem., 2014, 57(14), 5835−5844.

15. Bo Tang, Hong-Mei Yang, Wen-Jing Hu, Ming-Liang Ma,* Yahu A. Liu, Jiu- Sheng Li,* Biao Jiang*, and Ke Wen*, 1,8-Dioxyanthracene-Derived Crown Ethers: Synthesis, Complexation with Paraquat and Assembly of a Tetracationic Cyclophane-Crown Ether Based [2]Catenane, Eur. J. Org. Chem., 2014, 31, 6925- 6934

14. W.-J. Hu, L.-Q. Liu, M.-L. Ma,* X.-L. Zhao, Y.-A. Liu, X.-Q. Mi, B. Jiang*, and K. Wen*, A Trigonal Prismatic Ligand in the Metal- Mediated Self-Assembly of One- and Two-Dimensional Metallosupramolecular Polymers, Inorg. Chem., 2013, 52(16), 9309-9319.

13. X.-Y. Li, Chun Hu, M.-L. Ma,* Yahu A. Liu, X.-Q. Mi, B. Jiang*, K. Wen,* Xylyl derived oxacalixcrowns: Synthesis and crystal structure, Chinese Chemical Letters, 2013, 24(4), 279-282.

12. L. Wang, L.-X. Zheng, M.-L. Ma*, X.-L. Zhao, Y.-A. Liu, X.-Q. Mi, B. Jiang*, and K. Wen*, Trigonal prismatic bicyclocalixaromatics, synthesis and Structures, Supramol. Chem., 2013, 25(7), 409-415.

11. L.-W. Kong, M.-L. Ma,* X.-L. Zhao, Y.-H. Liu, X.Q. Mi, B. Jiang*, and K. Wen*, Tetraamido-oxacalix[4]arene Derivatives: Synthesis, Structures and Supramolecular Assemblies, Chin. J. Chem., 2013, 31(5), 684-688.

10. W.-J. Hu, L.-Q. Liu, M.-L. Ma*, X.-L. Zhao, Y.-A. Liu, X.-Q. Mi, B. Jiang*, K. Wen*, m-Terphenyl-3,3''-dioxo-derived oxacalixaromatics: synthesis, structure, and solvent encapsulation in the solid state, Tetrahedron, 2013, 69(19), 3934-3941.

09. W.-J. Hu, X.-L. Zhao, M.-L. Ma,* F. Guo, X.-Q. Mi, B. Jiang*, and K. Wen*, Synthesis, Structure and Conformation of Terphenylene-Derived Oxacalixaromatics, Eur. J. Org.Chem., 2012, 1448-1454.

08. W.-J. Hu, M.-L. Ma*, X.-L. Zhao, F. Guo, X.-Q. Mi, B. Jiang*, and K. Wen*, Synthesis, structure, and conformation of terphenylene-derived azacalix[4]aromatics, Tetrahedron, 2012, 68 (30), 6071-6078.

07. X.-Y. Li, K.-Y. Yu, X.-L. Zhao, M.-L. Ma*, F. Guo, X.-Q. Mi, B. Jiang*, and K. Wen*, Carboxylic acid-derived oxacalix[2]arene[2]pyrazine self-assembles into unprecedented diamondoid networks, CrystEngComm, 2012, 14(23), 7869–7871.

06. L.-W. Kong, M.-L. Ma, L.-C. Wu, X.-L. Zhao, F. Guo, B. Jiang*, and K. Wen*, Carboxylic acid functionalized ortho-linked oxacalix[2]benzene[2]pyrazine: synthesis, structure, hydrogen bond and metal directed self-assembly, Dalton Trans., 2012, 41(18), 5625.

05. M.-L. Ma, X.-Y. Li, X.-L. Zhao, F. Guo, B. Jiang*, and K. Wen*, Silver-mediated self-assembly of metallosupramolecular networks based on pyrimidine containing oxacalix[n]-aromatics, CrystEngComm, 2011, 13(6), 1752–1754.

04. Ma Mingliang, Kong Lingwei, Li Xiaoyan, Jin Haishan, Zhao Xiaoli, and Wen Ke*, Synthesis and Supramolecular Assemblies of Tripodal 1,3,5-Tris(phenoxymethyl)-2,4,6-triethylbenzene Analogues, Chin. J. Chem., 2011, 29(7), 1503-1510

03.胡聪，马明亮，李晓燕，胡文敬，赵小莉，文珂*，具有三角架结构的丙二酸、β-二酮和吡唑衍生物的合成、结构及超分子自组装，高等化学学报，2011，32(9)，2145-2151。

02. X.-Y. Li, L.-Q. Liu, M.-L. Ma, X.-L. Zhao and K. Wen*, Coordination-driven self-assembly of discrete and polymeric copper(II) and dicopper(II) supramolecular structures based on oxacalix[2]benzene[2]pyrazines,Dalton Trans., 2010, 39(37), 8646-8651.

01. M.-L. Ma, X.-Y. Li, K. Wen,* Coordination-Driven Self-Assembly of a Discrete Molecular Cage and an Infinite Chain of Coordination Cages Based onortho-Linked Oxacalix[2]benzene[2] pyrazine and Oxacalix[2]arene[2]pyrazine, J. Am. Chem. Soc., 2009, 131(24), 8330-8339.

授权专利：

3.  马明亮，于雅楠，韩宇桥，王海莉，章富坡，董素珍；作为PI3K/mTOR激酶调节剂芳杂环化合物及其制备方法和应用；ZL201811579392.6。

2.  胡文浩，席间备，马明亮，吕思莹，王文科，章雄文，方艳芬；一种咪唑并吡啶骨架结构的新化合物的合成及应用；ZL201410181135.2。

1. 胡文浩，常欢，许海群，黄海峰，马明亮；一种环戊基嘧啶并吡咯类化合物的合成方法；ZL201510800951.1。

1. 第六届中国侨届贡献（创新团队）奖（2016）；

2. 2017-2018年度华东师范大学“实验室工作先进个人”。