刘智超

2015.09-2019.06  华东师范大学，博士，分析化学  导师：田阳 教授

2013.09-2015.06  南昌大学，硕士(提前毕业)，化学  导师：邱建丁 教授

2009.09-2013.06  南昌大学，本科，材料物理

2021.12 — 至今 华东师范大学，专任副研究员、紫江青年研究员

2019.07-2021.11 华东师范大学，博士后 导师：田阳 教授

活体拉曼分析

基于框架核酸的生物传感与成像

荧光生物传感与成像

2025-2028年 国家自然科学基金-面上项目

2024-2027年 上海市农业科技人才培育项目-春蕾项目

2023-2024年 精密光谱科学与技术国家重点实验室-开放课题

2023-2024年 教育部高校优秀青年团队项目-子课题

2021-2023年 国家自然科学基金-青年项目

29. Sihan Zhang, Yuxiao Mei, Jiaqi Liu, Zhichao Liu*, Yang Tian*.Alkyne-tagged SERS nanoprobe for understanding Cu⁺ and Cu²⁺ conversion in cuproptosis processes. Nat. Commun., 2024, 15, 3246.

28. Zhichao Liu, Zhonghui Zhang, Yuandong Liu, Yuxiao Mei, Enduo Feng, Yangyi Liu, Tingting Zheng, Jinquan Chen, Sanjun Zhang, Yang Tian*.Raman fiber photometry for understanding mitochondrial superoxide burst and extracellular calcium ion influx upon acute hypoxia in the brain of freely moving animals. Angew. Chem. Int. Ed., 2022, 61, e202111630.

27. Zhonghui Zhang, Zhichao Liu*, Peicong Wu, Xinhua Guo*, Xiao Luo, Youjun Yang, Jinquan Chen, Yang Tian*, A high-density Raman photometry for tracking and quantifying of AchE activity in the brain of freely moving animals with network. Adv. Sci., 2023, 10, 2301004.

26. Mengyu Liang, Zhichao Liu*, Zhonghui Zhang, Yuxiao Mei, Yang Tian*. Two-photon ratiometric fluorescent probe for real-time imaging and quantification of NO in neural stem cells during activation regulation. Chem. Sci., 2022, 13, 4303-4312.

25. Zhichao Liu, Hao Pei, Limin Zhang, Yang Tian*. Mitochondria-targeted DNA nanoprobe for real-time imaging and simultaneous quantification of Ca²⁺ and pH in neurons. ACS Nano, 2018, 12, 12357-12368. Back cover work.

24. Zhichao Liu^†, Ying Zhu ^†, Liming Zhang ^†, Weiping Jiang ^†, Yawei Liu ^†, Qiaowei Tang, Xiaoqing Cai, Jiang Li, Lihua Wang, Changlu Tao, Xianzhen Yin, Xiaowei Li, Shangguo Hou, Dawei Jiang, Kai Liu, Xin Zhou*, Hongjie Zhang*, Maili Liu*, Chunhai Fan* & Yang Tian*. Structural and functional imaging of brains. Sci. China Chem., 2023, 66, 324–366.

23. Zhonghui Zhang, Zhichao Liu*, Yang Tian*. A DNA-based FLIM reporter for simultaneous quantification of lysosomal pH and Ca²⁺ during autophagy regulation. iScience, 2020, 23, 101344.

22. Zhichao Liu, Yang Tian*. Recent advances in development of devices and probes for sensing and imaging in the brain. Sci. China Chem., 2021, 64, 915-931.

21. Zhichao Liu, Xia Jing, Sanjun Zhang, Yang Tian*. A copper nanocluster-based fluorescent probe for real-time imaging and ratiometric biosensing of calcium ion in neurons. Anal. Chem., 2019, 91, 2488−2497.

20. Zhichao Liu, Shengnan Wang, Wanying Li, Yang Tian*. Bioimaging and biosensing of ferrous ion in neurons and HepG2 cells upon oxidative stress. Anal. Chem., 2018, 90, 2816-2825.

19. Zhichao Liu, Peicong Wu, Yaoyao Yin and Yang Tian*.A ratiometric fluorescent DNA nanoprobe for cerebral adenosine triphosphate assay. Chem. Commun., 2019, 55, 9955-9958.

18. Zhichao Liu, Li Zhang, Wei Song, Ruping Liang, Jianding Qiu*. Cu nanoclusters-based ratiometric fluorescence probe for ratiometric and visualization detection of copper ions. Anal. Chim. Acta, 2015, 895, 95-103.

17. Zhichao Liu, Li Zhang, Yunmei Zhang, Ruping Liang, Jianding Qiu*. Exonuclease III-assisted recycling amplification detection of hepatitis B virus DNA by DNA-scaffolded silver nanoclusters probe. Sens. Actuators B: Chem., 2014, 205, 219-226.

16. Yanyu Dai, ^#Zhichao Liu, ^# Yunfeng Bai, Zezhong Chen, Feng Feng*. Highly fluorescent sulfur, nitrogen, oxygen co-doped carbon dots for label-free detection of pyrophosphate and alkaline phosphatase activity. RSC Advances, 2018, 8, 42246-42252. (^#contributed equally).

15. Yuandong Liu, Zhichao Liu, Yi Zhou*, Yang Tian*. Implantable Electrochemical Sensors for Brain Research, JACS Au 2023, 3, 1572-1582.

14. Sihang Zhang, Zhichao Liu, Zhonghui Zhang, Weikang Wang, Yang Tian*, High-density optophysiology for recording intracellular and extracellular signals across the brain of free-moving animals. Angew. Chem. Int. Ed., 2023, 62: e202301382.

13. Zhiwen Gong, Zhichao Liu, Zhonghui Zhang, Yuxiao Mei, Yang Tian*. A highly stable two-photon ratiometric fluorescence probe for real-time biosensing and imaging of nitric oxide in brain tissues and larval zebrafish. CCS Chem., 2022, 4, 2020-2030.

12. YuandongLiu, Zhichao Liu, Fan Zhao, Yang Tian*. Long-term tracking and dynamically quantifying of reversible changes of extracellular Ca²⁺ in multiple brain regions of freely moving animals. Angew. Chem. Int. Ed., 2021, 60, 14429-14437.

11. Jiaqi Liu, Zhichao Liu, Weikang Wang, Yang Tian*. Real-time tracking and sensing of Cu⁺ and Cu²⁺ with a single SERS probe in the live brain: toward understanding why copper ions were increased upon ischemia. Angew. Chem. Int. Ed., 2021, 60, 21351-21359.

10. Yuandong Liu, Zhichao Liu, Yang Tian. Real-time tracking of electrical signals and an accurate quantification of chemical signals with long-term stability in the live brain. Acc. Chem. Res., 2022, 16328-16332

9. Chuanping Zhang, Zhichao Liu, Limin Zhang, Anwei Zhu, Fumin Liao, Jingjing Wan, Jian Zhou, and Yang Tian*. A robust Au-C≡C functionalized surface: Toward real-time mapping and accurate quantification of Fe²⁺ in the brains of live AD mouse models. Angew. Chem. Int. Ed., 2020, 59, 20499-20507.

8. Lihong Ge, Zhichao Liu, Yang Tian*. A novel two-photon ratiometric fluorescent probe for imaging and sensing of BACE1 in different regions of AD mouse brain. Chem. Sci., 2020, 11, 2215-2224.

7. Wanying Li, Zhichao Liu, Bingqing Fang, Ming Jin,* and Yang Tian*. Two-Photon Fluorescent Zn²⁺ Probe for Ratiometric Imaging and Biosensing of Zn²⁺ in Living Cells and Larval Zebrafish. Biosens. Bioelectron., 2020, 148: 111666.

6. Jian Zhang, Jing Chen, Yufei Lu, Yan Yang, Weize Chen, Bo Shen, Jiachang Hu, Ping Jia, Sujuan Xu, Yiqin Shi, Yichun Ning, Jialin Wang, Yi Fang, Shuan Zhao, Yang Li, Yan Dai, Xiaoyan Zhang, Meng Xiang, Yang Tian, Zhichao Liu, Nana Song,* and Xiaoqiang Ding*. TWIK-related acid-sensitive K⁺ channel 2 promotes renal fibrosis by inducing cell-cycle arrest. iScience, 2022, 25: 105620. 

5. Chen Huang, Pei-Yi Sun, Yiming Jiang, Yuandong Liu, Zhichao Liu, Shao-Ling Han, Bao-Shan Wang, Yong-Xin Huang, An-Ran Ren, Jian-Fei Lu, Qin Jiang, Ying Li, Michael X. Zhu, Zhirong Yao, Yang Tian, Xin Qi*, Wei-Guang Li* & Tian-Le Xu*. Sensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice. Nat. Commun., 2024, 15: 5288.

4. Zhou Wu, Mengmeng Liu, Zhichao Liu, Yang Tian. Real-time imaging and simultaneous quantification of mitochondrial H₂O₂ and ATP in neurons with a single two-photon fluorescence-lifetime-based probe. J. Am. Chem. Soc., 2020, 142, 7532-7541.

3. Yuxiao Mei, Qi-Wei Zhang, Qingyi Gu, Zhichao Liu, Xiao He*, Yang Tian*. Pillar [5] arene-based fluorescent sensor array for biosensing of intracellular multi-neurotransmitters through host-guest recognitions. J. Am. Chem. Soc., 2022, 144, 2351-2359.

2. Lan Kuang, Shuping Cao, Li Zhang, Qiuhong Li, Zhichao Liu, Ruping Liang, Jianding Qiu*. A novel nanosensor composed of aptamer bio-dots and gold nanoparticles for determination of thrombin with multiple signals. Biosens. Bioelectron., 2016, 85, 798-806.

1. Qiuhong Li, Li Zhang, Jianmei Bai, Zhichao Liu, Ruping Liang, Jianding Qiu*. Preparation of novel fluorescent DNA bio-dots and their application for biothiols and glutathione reductase activity detection. Biosens. Bioelectron., 2015, 74, 886-894.

上海市农业科技人才培育“春蕾项目”

上海市超级博士后激励计划

华东师范大学优秀毕业生

江西省优秀硕士学位论文