刘媛媛

2015.9-11         北京大学余志祥教授课题组，短期访学

2009-2014        上海交通大学，博士（导师：张万斌 教授）

2012-2013        日本东北大学，亚洲校园计划（导师：Prof. Ilya Gridnev, Prof. Masahiro Terada）

2012. 1-3          日本东京大学，Global COE项目（导师：Prof. Makoto Fujita）

2005-2009        上海交通大学，本科

2017.12至今    华东师范大学，副教授

2014-2017      华东师范大学，讲师，晨晖学者

2015.3-2017.9  化学与分子工程学院 科研秘书

有机合成方法学

不对称催化反应设计及应用

理论计算化学及NMR对有机反应机理的探索研究

《有机化学及实验》  生科院菁英班大一

《手性合成》      研究生课程

国家自然科学基金-面上项目（21871088，2019.01.01-2022.12.31）主持

国家自然科学基金-青年科学基金项目（21502052，2016.01.01-2018.12.31）主持

上海市2016年度“晨光计划”项目（16CG22，2017.1-2018.12) 主持

发表论文：

[19]  Shan Xu, Zhan-Ming Zhang, Bing Xu, Bing Liu, Yuanyuan Liu,* and Junliang Zhang*, “Enantioselective Regiodivergent Synthesis of Chiral Pyrrolidines with Two Quaternary Stereocenters via Ligand-Controlled Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloadditions”, J. Am. Chem. Soc. 2018, 140, 2272−2283.

[18]    Shenhuan Li,‡ Yuanyuan Liu,‡ Ben Huang, Tao Zhou, Hongmei Tao, Yuanjing Xiao, Lu Liu,* and Junliang Zhang*, “Phosphine-Catalyzed Asymmetric Intermolecular Cross-Vinylogous Rauhut−Currier Reactions of Vinyl Ketones with para-Quinone Methides”, ACS Catal. 2017, 7, 2805−2809.

[17]    Bing Liu, Zhan-Ming Zhang, Bing Xu, Shan Xu, Hai-Hong Wu, Yuanyuan Liu* and Junliang Zhang*, “Cu(I)-Catalyzed Michael Addition of Ketiminoesters to β-Trifluoromethyl, β,β-Disubstituted Enones: A Rapid Access to 1-Pyrrolines Bearing a Quaternary All-Cabon Stereocenter”, Org. Chem. Front., 2017, 4, 1772–1776.

[16]  Yuanyuan Liu, Wenbo Li and Junliang Zhang*, “Chiral ligands designed in China”, Natl. Sci. Rev.2017, 4, 326-358.

[15] Yanzhao Wang, Yuanyuan Liu, Kun Li, Guoqiang Yang*, and Wanbin Zhang* Adv. Synth. Catal. 2017, 359, 1933-1941.

[14]     Liu, Yuanyuan* and Zhang, Wanbin* “Development of Cu-Catalyzed Asymmetric Addition of Boron to Olefin”, Chin. J. Org. Chem. 2016, 36, 2249-2271.

[13]     Xingcan Cheng, Yuanyuan Zhou, Fangfang Zhang, Kai Zhu, Yuanyuan Liu, and Yanzhong Li*, “Base-Promoted Tandem Reaction Involving Insertion into Carbon–Carbon σ-Bonds: Synthesis of Xanthone and Chromone Derivatives”, Chem. Eur. J. 2016, 22, 12655–12659.

[12]     Fangfang Zhang, Zhengchen Qin, Lingkai Kong, Yulei Zhao, Yuanyuan Liu, and Yanzhong Li*, “Metal/Benzoyl Peroxide (BPO)-Controlled Chemoselective Cycloisomerization of (o‑Alkynyl)phenyl Enaminones: Synthesis of α‑Naphthylamines and Indeno[1,2‑c]pyrrolones”, Org. Lett. 2016, 18, 5150−5153.

[11]     Lingkai Kong, Yushang Shao, Yanli Li, Yuanyuan Liu,* and Yanzhong Li*, “LDA-Promoted Synthesis of 3‑Amino Furans by Selective Lithiation of Enaminones”, J. Org. Chem. 2015, 80, 12641−12645.

[10]     Lingkai Kong, Yuanyuan Zhou, He Huang, Yang Yang, Yuanyuan Liu,* and Yanzhong Li*, “Copper-Catalyzed Synthesis of Substituted Quinolines via C−N Coupling/Condensation from ortho-Acylanilines and Alkenyl Iodides”, J. Org. Chem. 2015, 80, 1275−1278.

[9]     Yulei Zhao, Fangfang Zhang, Wenjun Yao, Chengyu Wang, Yuanyuan Liu,* Yanzhong Li*, “Base-Promoted Approach to Highly Functionalized Conjugated Dienes through Enamine Migration”, Eur. J. Org. Chem. 2015, 7984–7991.

[8]     Yuanyuan Liu, Ilya D. Gridnev,* and Wanbin Zhang*, “Mechanism of Asymmetric Hydrogenation of Exocyclic α,β-Unsaturated Carbonyl Compounds with Ir/BiphPHOX Catalyst: NMR and DFT Study”, Angew. Chem. Int. Ed. 2014, 53, 1901-1905.

[7]     Ilya D. Gridnev,* Yuanyuan Liu, and Tsuneo Imamoto*, “Mechanism of Asymmetric Hydrogenation of β-         Dehydroamino Acids Catalyzed by Rhodium Complexes. Large-Scale Experimental and Computational Study”, ACS Catal., 2014, 4, 203-219.

[6]     Ilya D. Gridnev,* Christina Kohrt, and Yuanyuan Liu, “Direct Experimental and Computational Evidence for the Dihydride Pathway in TangPHOS-Rh Catalysed Asymmetric Hydrogenation”, Dalton Trans. 2014, 43, 1785-1790.

[5]     Yuanyuan Liu, Wanbin Zhang*, “Iridium-Catalyzed Asymmetric Hydrogenation of a-Alkylidene Succinimides”, Angew. Chem. Int. Ed. 2013, 52, 2203-2206; highlighted by Mark Lautens and Harald Weinstabl in SYNFACTS 2013, 9, 0506; 《有机化学》亮点介绍：Chin. J. Org. Chem. 2013, 33, 868.

[4]     Kun Li, Guoqiang Yang, ‍‍Yuanyuan Liu‍‍, Wanbin Zhang*, “Chiral Polymetallic Catalysts and their Application in Asymmetric Catalysis”, Chin. J. Org. Chem. 2013, 33, 749-759. (review)

[3]     Yuanyuan Liu, Dongmei Yao, Kun Li, Fengtao Tian, Fang Xie, Wanbin Zhang*, “Iridium-Catalyzed Asymmetric Hydrogenation of 3-Substituted Unsaturated Oxindoles to Prepare Chiral C3-Mono Substituted Oxindoles”, Tetrahedron 2011, 67, 8445-8450.

[2]     Yuanyuan Liu, Guoqiang Yang, Dongmei Yao, Fengtao Tian, Wanbin Zhang*, “Convenient Synthesis of Tropos Phosphine-Oxazoline Ligands”, Sci. China Chem.2011, 54, 87-94.（邀稿）

[1]     Fengtao Tian, Dongmei Yao, Yuanyuan Liu, Fang Xie, Wanbin Zhang*, “Iridium-Catalyzed Highly Enantioselective Hydrogenation of Exocyclic α,β-Unsaturated Carbonyl Compounds”, Adv. Synth. Catal. 2010, 352, 1841-1845; highlighted by Hisashi Yamamoto in SYNFACTS 2011, 1, 0064.

授权专利：

[1]  专利名称：轴不安定联苯类膦-噁唑啉手性配体的合成方法；专利号：ZL2010 1 0523714.2

[2]  专利名称：用铱手性催化剂不对称氢化3-亚烯基取代吲哚酮的方法；专利号：ZL 2011 1 0229873.6

[3]  专利名称：C-3位取代的手性琥珀酰亚胺及其制备方法；中国发明专利申请号: 201210520729.2

2017  主讲课程《有机化学及实验（生物菁英班）》，获得“2017年度华东师范大学在线教平台优质课程建设项目”

          的资助支持。

2016  上海市研究生优秀成果（学位论文）

2014  上海市普通高等学校优秀毕业生