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2009.09-2013.06  华东理工大学  制药工程  工学学士

2013.09-2018.06  华东理工大学  药药学学  医学博士 （导师：杨有军 教授）

2018.06-2021.08 华东师范大学 化学与分子工程学院 博士后      （导师：钱旭红 院士）

2021.09-至今1  华东师范大学 化学与分子工程学院 紫江青年研究员 （博导、硕导）

研究主要面向耐药菌感染、脑缺血再灌注损伤、癌症等疾病，立足荧光染料母核，通过分子机制创新，开发疾病预防、诊断和治疗的分子工具。以第一/通讯作者在SCI收录的学术期刊上发表论文15篇，包括Nat. Commun, JACS, Anal. Chem., Chem. Commun., CCS Chem., Sci. China. Chem., Free Radical Biol. Chem., Sens. Actuators B Chem.等。申请国家发明专利2项，主持国家自然科学基金青年项目、中国博士后科学基金特别资助和面上项目。

Smart Molecules 青年编委

生物氧化还原的化学精准调控与染料药物化学

1，设计开发新型抗氧化分子机制，用于缺血再灌注损伤的治疗。

2，构建结构多样性“呫吨染料分子库”，用于高效抗耐药菌化合物的筛选发现。

3，创制新型光响应活性氧供体及分子荧光探针，理解生物氧化还原化学机制，绘制生物氧化还原网络。

《分析化学实验Ⅱ》

《光学分析与成像》

2021.09-2028.01   华东师范大学“紫江青年”科研启动经费，在研，主持。

2020.01-2022.12   国家自然科学基金青年科学基金项目，已结题，主持。

             基于结构多样性罗丹明染料库的抗耐药菌活性先导筛选发现及性质改造

2020.08-2021.08   中国博士后科学基金第13批特别资助（站中），已结题，主持。

             活性氧的精准光控释放及在氧化还原生物学中的应用  

2019.05-2021.05   中国博士后科学基金第65批面上资助，已结题，主持。

             新型荧光增强型光控一氧化碳供体的设计开发

23. Xiao Luo^‡*, Zhonghui Zhang^‡, Jie Wang^‡, Xueli Wang, Yani Zhang, Jinquan Chen, Guangbo Ge, Wen Yang*, Xuhong Qian*, Yang Tian*, Youjun Yang*. Acyl-Caged Rhodamines: Photo-Controlled and Self-Calibrated Generation of Acetyl Radical for Neural Function Recovery in Early AD Mouse. Chem. Sci. 2023, 14, 11689.

22. Jinyan Zhang, Liwei Liu, Zhen Dong, Xicun Lu, Wenxuan Hong, Jin Liu, Xiaoyi Zou, Jinfeng Gao, Hao Jiang, Xiaolei Sun, Kai Hu, Youjun Yang, Junbo Ge, Xiao Luo*, Aijun Sun*. An ischemic area-targeting, peroxynitrite-responsive, biomimetic carbon monoxide nanogenerator for preventing myocardial ischemia-reperfusion injury. Bioact. Mater. 2023, 28, 480–494.

21. Yinghua Guo, Lei Yin, Xuhong Qian, Youjun Yang*, Xiao Luo*. PET/d-PET (PdP) Pairing for the Design of Dual-Channel Probes. Anal. Chem. 2023, 95, 9722–9728.

20. Shuhuai Shen, Youjun Yang, Xiao Luo*, Xuhong Qian. Hill‑type pH probes. Anal. Bioanal. Chem. 2023, 415, 3693-3702.

19. Zhenzhen Lin, Fang Hu, Gang He*, Youjun Yang, Yujun Liao, Xiao Luo*, Xu-Dong Wang*. Highly Photostable and pH- Sensitive Nanosensors. Chemosensors 2022, 10, 354.

18. Linfeng Xing^#, Bin Wang^#, Jin Li^#, Xinjian Guo, Xicun Lu, Xiaohua Chen, Haitao Sun, Zhenrong Sun, Xiao Luo*, Suhua Qi*, Xuhong Qian*, Youjun Yang*. A Fluorogenic ONOO^--Triggered Carbon Monoxide Donor for Mitigating Brain Ischemic Damage. J. Am. Chem. Soc. 2022, 144, 2114-2119.

17. Yansheng Xiao, Yunxia Huang, Zhenhua Zeng, Xiao Luo*, Xuhong Qian, Youjun Yang*. “Harnessing Thorpe–Ingold Dialkylation to Access High-Hill-Percentage pH Probes.” J. Org. Chem. 2022, 87, 85-93.

16. Yang Yu, Xiaodong Zhang, Yan Dong, Xiao Luo*, Xuhong Qian, Youjun Yang*. “Fusing the Nagano’s and the Anslyn’s chemistry for lyso-specifc NO detection.” Sens. Actuators B Chem. 2021, 346, 130562.

15. Fang Hu, Yunxia Huang, Yansheng Xiao, Yanchun Li, Xiao Luo*, Xuhong Qian, Youjun Yang*. “A dual-channel Hill-type small-molecule pH probe.” Anal. Methods 2021, 13, 3012–3016.

14. Jin Li, Mengmeng Zhang, Lu Yang, Yubing Han, Xiao Luo*, Xuhong Qian*, YoujunYang*. “‘Xanthene’ is a premium bridging group for xanthenoid dyes.” Chin. Chem. Lett. 2021, 32, 3865-3869.

13. Rui Yan^#, Xiao Luo^#, Jinfeng Zhou, Ping Wang, Youjun Yang*, Xuhong Qian, Yueling Liu*. “Biodegradable ion-selective nanosensors with p-diethylaminophenol functionalized rhodamine as chromoionophore for metal ions measurements.” Sens. Actuators B Chem. 2021, 336, 129672

12. Yansheng Xiao, Yanchun Li, Fang Hu, Kang-nan Wang, Zong-wan Mao, Xiao Luo*, Zhenglong Sun*, Xuhong Qian, Youjun Yang*. “A nucleolus-targeting Hill-type pH probe.” Sens. Actuators B Chem. 2021, 335, 129712.

11. Xiu Xu^#, Meiling Sun^#, Xiao Luo^#, Ziqian Zhang, Lin Su, Lingfei Cui, Zhihui Zhu, Xicun Lu, Rui Wang, Feng Han*, Xuhong Qian, Youjun Yang*. “One-electron reduction triggered nitric oxide release for ischemia-reperfusion protection”. Free Radical Biol. Med. 2021, 164, 13-19.

10. Yansheng Xiao, Fang Hu, Xiao Luo*, Mingming Zhao, Zhenglong Sun*, Xuhong Qian*, Youjun Yang*. “Modulating the pKa Values of Hill-Type pH Probes for Biorelevant Acidic pH Range”. ACS Appl. Bio Mater. 2020, 4, 2097-2103.

9. Ziqian Zhang, Xiao Luo, Youjun Yang*. “From Spontaneous to Photo-triggered and Photo-calibrated Nitric Oxide Donors”. Isr. J. Chem. 2021, 61, 159-168.

8. Kai Xin^#, Xinxing Li^#, Yinghua Guo^#, Youhuan Zhong^#, Jungang Wang, Haotian Yang, Jie Zhao, Chunlei Guo, Yunxia Huang, Zuhai Lei, Yi-Lun Ying, Xiao Luo*, Haolu Wang, Xuhong Qian, Wen Yang*, Xiaowen Liang*, Youjun Yang*. “A Mono-Chromophoric Approach to Succinct Ratiometric Fluorescent Probes without Probe-Product Crosstalk.” CCS Chem. 2020, 2, 2307–2315.

7. Xiao Luo, Yan Chen, Yanchun Li, Zhenglong Sun*, Weihong Zhu*, Xuhong Qian*, Youjun Yang*, “Structurally-thrifty and visible-absorbing fluorophores.” Spectrochimica Acta Part A 2021, 245, 118907

6. Luyan Gu^#, Lujia Zhang^#, Xiao Luo*, Ying Zheng, Zhiwei Ye, Meng Lv, Jinquan Chen, Chunlai Chen*, Yi Xiao, Weihong Zhu, Xuhong Qian, Youjun Yang*. “The Mechano Donor-Acceptor Coupling (MDAC) Approach for Uni-directional Multi-State Fluorochromism.” Sci China: Chem. 2020, 64, 253-262.

5. Xiao Luo, Youjun Yang*, Xuhong Qian*. “Recent progresses on the development of thioxo-naphthalimides.” Chin. Chem. Lett. 2020, 31, 2877-2883.

4. Xiao Luo, Luyan Gu, Xuhong Qian, Youjun Yang*. “Molecular probe design via the ‘covalent-assembly’ principle.” Chem. Commun. 2020, 56, 9067-9078.

3. Xiao Luo, Jin Li, Jie Zhao, Luyan Gu, Xuhong Qian*, Youjun Yang*. “A General Approach to the Design of High-Performance Near-Infrared (NIR) D-p-A Type Fluorescent Dyes.” Chin. Chem. Lett. 2019, 30, 839-846.

2. Xiao Luo^#, Liujia Qian^#, Yansheng Xiao, Yao Tang, Yang Zhao, Xia Wang, Luyan Gu, Zuhai Lei, Jianming Bao, Jiahui Wu, Tingting He, Fupin Hu, Jing Zheng, Honglin Li, Weiping Zhu, Lei Shao, Xiaojing Dong, Daijie Chen*, Xuhong Qian*, Youjun Yang*. “A Diversity-Oriented Rhodamine Library for Wide-Spectrum Bactericidal Agents with Low Inducible Resistance against Resistant Pathogens.” Nat. Commun. 2019, 10, 258.

1. Xiao Luo, Haotian Yang, Haolu Wang, Zhiwei Ye, Zhongneng Zhou, Luyan Gu, Jinquan Chen, Yi Xiao, Xiaowen Liang*, Xuhong Qian, Youjun Yang*. “Highly Sensitive Hill-Type Small-Molecule pH Probe That Recognizes the Reversed pH Gradient of Cancer Cells.” Anal. Chem. 2018, 90, 5803–5809.