吕伟 教授

1988.7-1992.7 大连理工大学 化工学院 工学学士

1992.9-1995.7 大连理工大学 化工学院 工学硕士

1995.9-1998.7 中国科学院上海药物研究所 理学博士

1998.8-1999.8 威斯康星大学 药学院 研究助理

1999.9-2001.12 中国科学院上海药物研究所 副研究员 课题组长

2002.1-2005.6 中国科学院上海药物研究所 研究员 课题组长

2005.7-至今 华东师范大学 研究员

  2025年研究生招生专业：药学，生物与医药工程

  招生单位：药学院

      实验室招收相关专业的博士后及研究助理

研究组成员介绍：

吕伟教授：

   从事抗肿瘤药物研究，目前研究方向主要集中于新型药物递释系统，包括抗体药物偶联物（ADC）给药体系、多肽药物偶联物、微型药物药物偶联物给药体系。基于研究组发明的Linker-Payload的技术平台，设计开发的新型抗体偶联药物已有3个品种进入临床I和II期研究；三类新型的抗体偶联药物系统在合作公司进行转化中。已发表研究论文170多篇，获得发明专利授权30多项。2006年入选教育部新世纪人才计划，2001年入选上海市科技启明星计划。

https://orcid.org/0000-0003-3041-9200

课题组成员：

 金嵇煜 副研究员

 朱书雷 药学院 副教授

    丁梦园  博士后 

     姜星 博士后 

组内活动：    

2023年6月 课题组大连-烟台研学

2024年9月 教师节

药物递释系统

新一代抗体偶联药物

抗肿瘤药物

主持的科研项目

在研项目：

在研各类项目7项，实验室研究经费充足。

已结题项目：

1.  学科交叉推进项目，新型抗体药物偶联物候选新药的确立和研发，202001-202112

2.  中科院干旱植物重点实验室开放课题，含苯硼酸的一枝蒿酮酸的设计合成及抗病毒活性研究，201801-202012

3.  精细化工国家重点实验开放课题，类药性近红外染料的设计及其在药物传递中的应用，201601-201812

4.  新疆特有药用资源利用实验室开放课题，难溶性天然药物的靶向给药系统研究，201511-201611

5.  国家自然科学基金项目，81172936，基于结构多样性合成策略进行天然产物结构改造及抗肿瘤药物发现，201201-201512

6.  华东师范大学科研创新基金，基于天然产物结构多样性合成策略进行抗肿瘤药物发现，200911-201112

7.  上海市科委重点公关项目，054319902，新型抗肿瘤药物的研究和开发，200511-200712

8.  国家自然科学基金项目，30572232，新型磷酸酯酶cdc25抑制剂研究，200601-200812

9.  教育部新世纪优秀人才项目，200701-200912

10.上海市科委重点公关项目，044319216，一类新药拓扑异构酶I抑制剂chimmitecan的临床前研究，200410-2006.12

11.国家863课题，2003AA2Z3531，喜树碱类抗肿瘤靶向前药的研究，200304-200512

12.中国科学院重要方向课题，KSCX2-3-07-02，以磷酸酶cdc25为靶点发展新型抗肿瘤药物，2001-2003

13.上海市科技启明星项目，01QB14047，拓扑异构酶抑制剂类抗肿瘤药物的研究，200108

14.国家自然科学基金项目，20002005，丹参二帖邻醌类抗肿瘤化合物的研究，200101-200312

15.企业合作和科技成果转化项目总计30项。

完整论文：

https://orcid.org/0000-0003-3041-9200

近期论文：

1.     FZ-AD005, a Novel DLL3-Targeted Antibody–Drug Conjugate with Topoisomerase I Inhibitor, Shows Potent Antitumor Activity in Preclinical Models, Molecular Cancer Therapeutics, (2024) 23 (10): 1367–1377

2.     Synthesis, and biological evaluation of EGFR/HER2‑NAMPT conjugates for tumor treatment, Molecular Diversity (2024) 28:2617–2636

3.     Synthesis and evaluation of homocamptothecin antibody-drug conjugates for cancer treatment，European Journal of Medicinal Chemistry, 2024, 279, 116899

4.     Enhancing SN38 prodrug delivery using a self-immolative linker and endogenous albumin transport，Journal of Controlled Release, 2024, 369, 622-629

5.     Synthesis and biological evaluation of novel quaternary ammonium antibody drug conjugates based on camptothecin derivatives, PLoS ONE, 2023, 18(12): e0292871

6.     Development of HSP90 inhibitors-SN38 conjugates for cancer treatment, Bioorganic Chemistry137 (2023) 106582

7.     Design and synthesis of multivalent drug delivery system with CA IX inhibitors as ligands, Bioorganic & Medicinal Chemistry93 (2023) 117456

8.     Design, synthesis, and biological evaluation of BRD4 degraders, Bioorganic & Medicinal Chemistry78 (2023) 117134

9.     Design, synthesis, and biological evaluation of 4‑(1H‑1,2,3‑triazol‑1‑yl) benzamides as HSP90 inhibitors, Molecular Diversity (2023) 27:239–248

代表性论文

1.     Enhancing SN38 prodrug delivery using a self-immolative linker and endogenous albumin transport，Journal of Controlled Release，2024, 369, 622-629

2.     SN38-based albumin-binding prodrug for efficient targeted cancer chemotherapy, Journal of Controlled Release, 2021, 339, 297-306

3.     Design, synthesis and biological evaluation of HSP90 inhibitor SN38 conjugates for targeted drug accumulation, Journal of Medicinal Chemistry, 2020, 53, 5421-5441

4.     Chimmitecan, a novel 9-substituted camptothecin, improved anticancer pharmacologic profiles in vitro and in vivo, Clinic Cancer Research,2007, 13, 1298-1237.

5.     Synthesis and anti-hepatitis B virus activity of novel benzimidazole derivatives, Journal of Medicinal Chemistry, 2006, 49, 4790-4794.

6.     Design, Synthesis, and Biological Evaluation of New Cathepsin B-Sensitive Camptothecin Nanoparticles Equipped with a Novel Multifuctional Linker, Bioconjugate Chemistry, 2016, 27(5), 1267-1275

7.     Carbamoylmannose enhances the tumor targeting ability of supramolecular nanoparticles formed through host–guest complexation of a pair of homopolymers, Journal of Materials Chemistry B, 2017, 5, 83

8.     Optimized HSP90 mediated fluorescent probes for cancer-specific bioimaging, Journal of Materials Chemistry B, 2020, 8, 1878—1896

9.     Camptothecin derivative-loaded poly(caprolactone-co-lactide)-b-PEG-b-poly(caprolactone-co-lactide) nanoparticles and their biodistribution in mice, Journal of Controlled Release, 2004, 96, 135-148

10.   Design, synthesis, and biological evaluation of Wee1 kinase degraders, European Journal of Medicinal Chemistry, 2022, 243, 114786

11.   A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo, European Journal of Medicinal Chemistry, 2021, 226, 113851

12.   Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities, European Journal of Medicinal Chemistry, 2019, 176, 419-430

13.   Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR, European Journal of Medicinal Chemistry, 2018, 158, 428-441

14.   Design and synthesis of aryloxypropanolamine as β3-adrenergic receptor antagonist in cancer and lipolysis, European Journal of Medicinal Chemistry, 2018, 150, 757-770

15.   Synthesis and biological evaluation of hypoxia-activated prodrugs of SN-38, European Journal of Medicinal Chemistry, 2017, 132, 135-141

16.   10-Boronic acid substituted camptothecin as prodrug of SN-38, European Journal of Medicinal Chemistry, 2016, 116, 84-89

17.   Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors, European Journal of Medicinal Chemistry, 2015, 95, 127-135

18.   Synthesis and biological evaluation of novel 1,6-diaryl pyridin-2(1H)-one analogs, European Journal of Medicinal Chemistry, 2013, 613-620

19.   Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents, European Journal of Medicinal Chemistry, 2013, 63, 746-757

20.   Synthesis and biological evaluation of new homocamptothecin analogs, European Journal of Medicinal Chemistry, 2012, 54, 281-286

21.   Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives, European Journal of Medicinal Chemistry, 2011, 46, 417-422

22.   Identification of 1-isopropylsulfonyl-2-amine benzimidazoles as a new class of inhibitors of hepatitis B virus, European Journal of Medicinal Chemistry, 2007, 42, 1358-1364

23.   Total Synthesis of Camptothecin and SN-38, The Journal of Organic Chemistry, 2012, 77(1), 713-717

24.   Synthesis and Biological Evaluation of Paclitaxel and Camptothecin Prodrugs on the Basis of 2-Nitroimidazole, ACS Medicinal Chemistry Letters, 2017, 8 (7), 762–765

25.   A water-soluble probe with p-hydroxybenzyl quaternary ammonium linker for selective imaging in senescent cells, Analytica Chimica Acta, 2020, 133, 99-108

26.   Synthesis and fluorescent studies of a low molecular weight rotor for living cancer cell imaging, Dyes and Pigments, 178 (2020) 108353

27.   An HSP90 inhibitor based fluorescent probe for selective tumor targeting, Dyes and Pigments, 196 (2021) 109783

28.   Design, Synthesis, and Biological Evaluation of Cathepsin B Cleavage Albumin-binding SN38 Prodrug in Breast Cancer, Bioorganic Chemistry, 2024,

29.   Development of HSP90 inhibitors-SN38 conjugates for cancer treatment, Bioorganic Chemistry, 137 (2023) 106582

30.   A Novel Multifunctional 2-Nitroimidazole-based Bioreductive Linker and its Application in Hypoxia-Activated Prodrugs, Bioorganic Chemistry, 101 (2020) 103975

31.   Design and Synthesis of Multivalent Drug Delivery System with CA IX Inhibitors as Ligands, Bioorganic & Medicinal Chemistry, 93 (2023) 117456

32.   Design, synthesis, and biological evaluation of BRD4 degraders, Bioorganic & Medicinal Chemistry, 78 (2023) 117134

33.   The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells, Bioorganic & Medicinal Chemistry, 28 (2020) 115639

34.   Enhanced cellular uptake efficiency of DCM probes or SN38 conjugating with phenylboronic acids, Bioorganic & Medicinal Chemistry, 28 (2020) 115377

35.   Synthesis and biological evaluation of paclitaxel and vorinostat co-prodrugs for overcoming drug resistance in cancer therapy in vitro, Bioorganic & Medicinal Chemistry, 27 (2019) 1405-1413

36.   A series of camptothecin prodrugs exhibit HDAC inhibition activity, Bioorganic & Medicinal Chemistry, 26 (2018) 4706-4715

37.   Design, Synthesis and Biological Evaluation of Novel Homocamptothecin Analogues as Potent Antitumor Agents, Bioorganic & Medicinal Chemistry, 23 (2015) 1950-1962

38.   The discovery of colchicine-SAHA hybrids as a new class of antitumor agents, Bioorganic & Medicinal Chemistry, 21 (2013) 3240-3244

39.   The Discovery and Optimization of Novel Dual Inhibitors of Topoisomerase II and Histone Deacetylase, Bioorganic & Medicinal Chemistry, 21 (2013) 6981-6995

40.   Design and Synthesis of Novel Benzimidazole Derivatives as Inhibitors of Hepatitis B Virus, Bioorganic & Medicinal Chemistry, 18 (2010) 5048-5055

41.   Synthesis and biological evaluation of bis and monocarbonate prodrugs of 10-hydroxycamptothecins, Bioorganic & Medicinal Chemistry, 12 (2004) 4003-4008

42.   Synthesis and antitumor activity of 7-ethyl-9-alkyl derivatives of camptothecin, Bioorganic & Medicinal Chemistry Letters, 2005, 15 (8), 2003-2006.

43.   Synthesis and Antitumor Activity of The Hexacyclic Camptothecin Derivatives, Bioorganic & Medicinal Chemistry Letters, 2005, 15, 3233-3236.

44.   Synthesis of Mitirone Analogues as Inhibitors of Cdc25 Phosphatases, Bioorganic & Medicinal Chemistry Letters, 2006, 16, 1905-1908.

45.   Synthesis and Biological Evaluation of Piperamide Analogues as HDAC Inhibitors, Bioorganic & Medicinal Chemistry Letters, 2011, 21, 4844-4846

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