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  • 个人概况
  • 研究方向
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  • 科研项目
  • 学术成果
  • 荣誉及奖励
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胡连瑞

职称：

直属机构： 化学与分子工程学院

学科：

10 访问

相关教师

个人资料

  • 部门： 化学与分子工程学院
  • 性别： 男
  • 专业技术职务： 青年研究员
  • 毕业院校： 中国科学院化学研究所
  • 学位： 博士
  • 学历： 博士
  • 联系电话：
  • 电子邮箱： lrhu@chem.ecnu.edu.cn
  • 办公地址： 上海市中山北路3663号华东师范大学化学馆A316
  • 通讯地址： 上海市中山北路3663号华东师范大学化学馆A316
  • 邮编： 200062
  • 传真：

教育经历

2006.9—2010.6   西华大学，学士，导师：刘治国 教授

2012.9—2017.7   中国科学院化学研究所，博士，导师：陈辉 研究员


工作经历

2010.6—2011.6  康龙化成(北京)新药技术有限公司，助理研究员

2011.6—2012.6  上海睿智化学研究有限公司，助理研究员

2017.7—2019.1   西华大学，讲师(硕士生导师)

2019.1—2020.1   德国哥廷根大学，博士后，导师： Lutz Ackermann 教授

2020.4—2022.4   香港科技大学，博士后，导师： 唐本忠 院士

2022.7—至今     华东师范大学，青年研究员(博士生导师)

个人简介

社会兼职

研究方向

1.超分子自组装、发光机理机制理论计算及实验表征研究；2.聚集诱导发光机理机制及实验表征研究；3.高精度理论计算研究；4.过渡金属催化的有机反应机理


欢迎具有理论与计算化学、有机化学、发光材料相关背景的学生报考！诚聘具有理论与计算化学、有机化学、发光材料相关的博士后，待遇从优！

招生与培养

开授课程

综合化学实验

计算化学导论


科研项目

教育部“春晖计划”合作科研项目（191655，主持）：具有抗炎活性Tedarene B衍生物的设计合成研究

四川省应用基础研究计划项目（2019YJ0471，主持）：3d过渡金属Fe催化C-C偶联反应的机理研究及新催化体系的优化设计(自由探索型)

国家自然科学基金青年基金（22103062，主持）：光敏色素光响应机理的理论研究

华东师范大学“紫江青年”科研启动经费（主持）

上海市“浦江人才”计划（22PJ1402800，主持）：超分子催化有机反应机理及理性设计策略研究

2023年度上海市分子智造前沿科学研究基地子项目（主持）

学术成果

1.    Chen, X.#; Zhang, S.#; Jiang, Y.#; He, G.; Zhang, M.; Wang, J.; Deng, Z.; Wang, H.; Lam, J. W. Y.*; Hu, L. R.*; Tang, B. Z.* “Turning Non‐emissive Schiff Bases into Aggregate Emitters.” Angew. Chem. Int. Ed. 2024, e02402175. (Impact Factor 16.823, Co-corresponding Author)

2.    Zeng, Q.-W.; Hu, L. R.*; Niu, Y.; Wang, D.; Kang, Y.; Jia, H.; Dou, W.-T.*; Xu, L.* “Metal–organic cages for gas adsorption and separation.” Chem. Commun. 2024, 10.1039/D3CC05935A. (Impact Factor 6.065, Co-corresponding Author)

3.    Zeng, Z.-Y.; Zhao, X.; Huang, J.; Zhu, J.; Jin, T.; Hu, L. R.*; Dou, W.-T.*; Xu, L.*“Anthracene-Functionalized Metallacage with Fluorescence Response Behavior to Anions.” Synlett2024, 35, 130–134. (Impact Factor 2.000, Co-corresponding Author)

4.    Jia, P.-P.; Hu, L. R.*; Dou, W.-Tao; Xu, X.-D.; Sun, H.; Peng, Z.-Y.; Zhang, D.-Y.; Yang, H.-B.; Xu, L.* “An Efficient Hierarchical Self-Assembly Approach to Construct Structurally Diverse Two-Step Sequential Energy-Transfer Artificial Light-Harvesting Systems.” J. Mater. Chem. C, 2023, 11, 6607–15. (Impact Factor 6.400, Co-corresponding Author)

5.    Dou, W.-T.; Yang, C.-Y.; Hu, L. R.; Song, B.; Jin, T.; Jia, P.-P.; Ji, X.; Zheng, F.; Yang, H.-B.; Xu, L.* “Metallacages and Covalent Cages for Biological Imaging and Therapeutics.”ACS Materials Lett.2023, 5, 1061–1082. (Impact Factor 11.400, Third Author Author)

6.    Zhang, D. Y.; Zheng, Y. H.; Jiang, Y.; Li, W.-J.; Wang, X.-Q.; Hu, L. R.*; Wang, W.*; Yang, H.-B.* “Seeing is Believing: Directly Imaging Contractions of Artificial Molecular Muscles by Platinum Atom Markers.”CCS Chemistry 2023, 1–27. DOI: 10.31635/ccschem.023.202303611. (Impact Factor 11.200, Co-corresponding Author)

7.     Mei, F.; Lin, H.; Hu, L. R.*; Dou, W.-T.*; Yang, H.-B.; Xu, L.* “Homogeneous, Heterogeneous, and Enzyme Catalysis in Microfluidics Droplets.” Smart Molecules.2023, 1, e20220001. (Co-corresponding Author)

8.    Lin, H. Y.; Zhou, L. Y.; Mei, F.; Dou, W. T.; Hu, L. R.; Yang, H. B.; Xu. L.* “Highly Efficient Self-Assembly of Metallacages and Their Supramolecular Catalysis Behaviors in Microdroplets.” Angew. Chem. Int. Ed.2023, 62, e202301900. (Impact Factor 16.823, Fifth Author)

9.    Qin, Y.; Ling, Q. H.; Wang, Y. T.; Hu, Y. X.; Hu, L. R.; Zhao, X.; Wang, D.; Yang, H. B.; Xu, L.; Tang, B. Z. “Construction of Covalent Organic Cages with Aggregation‐Induced Emission Characteristics from Metallacages for Mimicking Light‐Harvesting Antenna.” Angew. Chem. Int. Ed.2023, 62, e202308210. (Impact Factor 16.823, Fifth Author)

10.  Xie, H.; Bi, Z.; Yin, J.; Li, Z.; Hu, L. R.; Zhang, C.; Zhang, J.; Lam, J. W. Y.; Zhang, P.; Kwok, R. T. K.*; Li, K.*; Tang, B. Z.* “Design of One-for-All near-Infrared Aggregation-Induced Emission Nanoaggregates for Boosting Theranostic Efficacy.” ACS Nano2023, 17, 4591-600. (Impact Factor 17.100, Fifth Author)

11.  Xie, H.; Zhang, C.; Li, T.; Hu, L. R.; Zhang, J.; Guo, H.; Liu, Z.; Peng, D.; Li, Z.; Wu, W.; Gao, J.; Bi, Z.; Wang, J.; Zhang, P.; Kwok, R. T. K.; Lam, J. W. Y.; Guo, Z.; Xi, L.*; Li, K.*; Tang, B. Z.* “Fast Delivery of Multifunctional Nir-Ii Theranostic Nanoaggregates Enabled by the Photoinduced Thermoacoustic Process.” Adv. Sci.2023, 10, e2301104. (Impact Factor 15.100, Fourth Author)

12.  Zhao, J.; Yang, C.-Y.; Hu, L. R.*; Xu, L.; Dou, W.-T.* “Cage-based sensors for circular dichroism analysis”Dalton Trans., 2023, 52, 15303–15312. (Impact Factor 4.569, Co-corresponding Author)

13.  Jiang, X. L.; Liu, Q.; Wei, K. F.; Zhang, T. T.; Ma, G.; Zhu, X. H.; Ru, G. X.*; Liu, L.*; Hu, L. R.*; Shen, W. B.* “Copper-catalyzed alkyne oxidation/Buchner-type ring-expansion to access benzo[6,7]azepino[2,3-b]quinolines and pyridine-based diones”Commun. Chem. 2023, 6, 35. (Impact Factor 6.065, Co-corresponding Author)

14.  Liu, X.; Zhang, C.; Hu, L. R.; Wang, J.; Li, K.; Feng, H.-T.; Lam, J. W. Y.; He, B.; Tang, B. Z. “On Water” Effect for Green Click Reaction: Spontaneous Polymerization of Activated Alkyne with “Inert” Aromatic Amine in Aqueous Media. CCS Chem. 2023, 5, 385-396. (Impact Factor 11.200, Third Author)

15.  Li, W.-J.; Xu, W.-T.; Wang, X.-Q.*; Jiang, Y.; Zhu, Y.; Zhang, D.-Y.; Xu, X.-Q.; Hu, L. R.; Wang, W.*; Yang, H.-B.* Photoresponsive Rotaxane-Branched Dendrimers: From Nanoscale Dimension Modulation to Macroscopic Soft Actuators. J. Am. Chem. Soc.2023, 145, 14498–14509. (Impact Factor 14.612, Eighth Author)

16.  Wang, M.; You, F.-Y.; Gao, M.; Chen, Z.-Y.; Chu, L.-Y.; Hu, L. R.*; Zhu, J.; Ma, J.-B.* “Direct Conversion of N2 and O2 to Nitric Oxide at Room Temperature Initiated by Double Aromaticity in the Y2BO+ Cation.” J. Phys. Chem. Lett. 2022, 13, 10697-10704. (Impact Factor 6.888, Co-corresponding Author)

17.  He, L.; Chen, T.; Zhang, Y.; Hu, L. R.; Wang, T.*; Han, R.; He, J.-L.; Luo, W.; Liu, Z.-G., Deng, J. N.; Chen, M. J.* “Imide-DOPO derivative endows epoxy resin with excellent flame retardancy and fluorescence without losing glass transition temperature.” Compos. B. Eng. 2022. 230, 109553. (Impact Factor 9.078, Fourth Author)

18.  Wang, Z.; Zou, X.; Xie, Y.; Zhang, H.; Hu, L. R.; Chan, C. S. C.; Zhang, R.; Guo, J.; Kwok, R. T. K.; Lam, J. W. Y., L.; Williams, I. D.; Zeng, Z.; Wong, K. S.; Sherrill, C. D.; Ye, R.;* Tang, B. Z.* “A Nonconjugated Radical Polymer with Stable Red Luminescence in Solid State.” Mater. Horiz.2022, 9, 2564-2571. (Impact Factor 15.717, Fifth Author)

19.  Xu, C.; Zou, H.; Hu, L. R.;Shen, H.; Sung, H. H. Y.; Feng, H.; Kwok, R. T. K.; Lam, J. W. Y.; Zheng, L.; Tang, B. Z. A Photoactivatable AIEgen for Selective Imaging and Killing of Estrogen Receptor-Positive Cells. ACS Materials Lett. 2022, 4, 1831-1839. (Impact Factor 11.170, Third Author)

20.  Zhang, J.; Alam, P.; Zhang, S.; Shen, H.; Hu, L. R.; Sung, H.-Y.; Williams, I. D.; Sun, J.; Lam, J. W. Y., L.;* Zhang, H.;* Tang, B. Z.* “Secondary Through-space Interactions Facilitated Single-molecule White-light Emission from Clusteroluminogens” Nat. Commun. 2022,13, 3492. (Impact Factor 14.919, Second Author)

21.  He, X.#; Xie, H.#; Hu, L. R.#; Liu, P.; Xu, C.; He, W.; Du, W.; Zhang, S.; Xing, H.; Liu, X.; Park, H.; Cheung, T. S.; Li, M.; Kwok, R. T. K.; Lam, J. W. Y., L.; Lu, J.; Tang, B. Z.* “A versatile AIE fluorogen with selective reactivity to primary amines for monitoring amination, protein labeling, and mitochondrial staining” Aggregate 2022, e239. (Impact Factor 18.800, Co-first Author)

22.  Liu, J.; Zhang, H.;* Hu, L. R.; Wang, J.; Lam, J. W. Y.; Blancafort, L.;* Tang, B. Z.* “Through-Space Interaction: What, Where and How?” J. Am. Chem. Soc. 2022, 144, 7901–7910. (Impact Factor 14.612, Third Author)

23.  Wu, Q.; Liu, J.; Li, Y.; Lee, M. S.; Hu, L. R.; Zhou, P.; Wang, D.; Tang, B. Z.* “Janus luminogens with bended intramolecular charge transfer: Toward molecular transistor and brain imaging” Matter,2021, 4, 3286–3300. (Impact Factor 15.589, Fifth Author)

24.  Xie, H. L.; Li, Z.; Gong, J. Y.; Hu, L. R.; Alam, P.; Ji, X. F.; Hu, Y. B.; Chau, J. H. C.; Lam, J. W. Y., Kwok, R. T. K.; Tang, B. Z.* “Photo-triggered Aggregation-Induced Emission and Direct Generation of 4D Soft Patterns.” Adv. Mat.2021. 33, 2105113 (Impact Factor 30.849, Fourth Author)

25.  Ye, J.; Liao, Y.; Huang, H.; Liu, Y.; Fang, D.-M.; Wang, M.*; Hu, L. R.*; Liao, J.*“Halogenated Salt Assisted Cu-Catalyzed Asymmetric 1,4-Borylstannation of 1,3-Enynes: Enantioselective Synthesis of Allenylstannes”Chem. Sci.2021, 12, 3032-3038. (Impact Factor 9.969, Co-corresponding Author)

26.  Wang, M.; Chu, L.-Y.; Li, Z.-Y.; Messinis, A. M.; Ding, Y.-Q.; Hu, L. R.*; Ma, J.-B.*“ Dinitrogen and Carbon Dioxide Activation to Form C–N Bonds at Room Temperature: A New Mechanism Revealed by Experimental and Theoretical Studies”J. Phys. Chem. Lett. 2021, 12, 3490–3496. (Impact Factor 6.710, Co-corresponding Author)

27.  Zhang, J.; Hu, L. R.; Zhang, K.; Liu, J.; Li, X.; Wang, H.; Wang, Z.; Sung, H.-Y.; Williams, I. D.; Zeng, Z.; Wu, J, L.; Zhang, H.;* Tang, B. Z.* “How to Manipulate Through-Space Conjugation and Clusterolumi-nescence of Simple AIEgens with Isolated Phenyl Rings?” J. Am. Chem. Soc. 2021. 143, 9565–9574. (Impact Factor 14.612, Second Author)

28.  Messinis, A. M.; Finger, L. H.; Hu, L. R.; Ackermann, L.* “Allenes for Versatile Iron-Catalyzed C–H Activation by Weak O-Coordination: Mechanistic Insights by Kinetics, Intermediate Isolation, and Computation” J. Am. Chem. Soc.2020, 142, 13102–13111. (Impact Factor 14.612, Third Author)

29.  Rogge, T.; Oliveira, J. C. A.; Kuniyil, R.; Hu, L. R.; Ackermann, L.* “Reactivity-Controlling Factors in Carboxylate-Assisted C–H Activation under 4d and 3d Transition Metal Catalysis” Acs Catal.2020, 10, 10551–10558. (Impact Factor 12.350, Fourth Author)

30.  Liao, Y.; Yin, X. M.; Wang, X. H.; Yu, W. Z.; Fang, D. M.; Hu, L. R.*; Wang M.*; Liao J.* “Enantioselective Synthesis of Multisubstituted Allenes by Cooperative Cu/Pd-Catalyzed 1,4-Arylboration of 1,3-Enynes”Angew. Chem. Int. Ed. 2019, 59, 1176–1180. (Impact Factor 16.823, Co-corresponding Author)

31.  Zhao, Y.; Cui, J. T.; Wang, M.; Valdivielso, D. Y.; Fielicke, A.*; Hu, L. R.*; Cheng, X; Liu, Q. Y.; Li, Z. Y.; He, S. G.; Ma, J. B.*; “Dinitrogen Fixation and Reduction by Ta3N3H0,1− Cluster Anions at Room Temperature: Hydrogen-Assisted Enhancement of Reactivity” J. Am. Chem. Soc. 2019, 141, 12592–12600. (Impact Factor 14.612, Co-corresponding Author)

32.  Zhang S.-K.; Struwe J.; Hu, L. R.; Ackermann, L.* “Nickellaelectro‐Catalyzed C–H Alkoxylation with Secondary Alcohols: Oxidation‐Induced Reductive Elimination at Nickel(III)” Angew. Chem. Int. Ed. 2019, 59, 3178–3183. (Impact Factor 12.959, Third Author)

33.  Wang, X. H., Wang, B., Yin, X. M., Yu, W. Z., Liao, Y., Ye, J. l., Wang, M., Hu, L. R., Liao, J.* “Palladium-Catalyzed Enantioselective Thiocarbonylation of Styrenes”Angew. Chem. Int. Ed. 2019, 58, 12264–12270. (Impact Factor 12.959, Eighth Author)

34.  Hu, L. R.; Chen, H.* “Comparative computational study on C-C/C-N/C-Br Bond Formations in RhIII-catalyzed C-H bond functionalizations: stepwise versus concerted mechanisms” J. Organomet. Chem.2018, 864, 105–109. (Impact Factor 2.304, First Author)

35.  Hu, L. R.; Chen, H.* “What Factors Control the Reactivity of Cobalt-Imido Complexes in C-H Bond Activation via Hydrogen Abstraction?” Acs Catal.2017, 7, 285–292. (Impact Factor 13.700, First Author)

36.  Hu, L. R.; Chen, H.* “Substrate-Dependent Two-State Reactivity in Iron-Catalyzed Alkene [2+2] Cycloaddition Reactions” J. Am. Chem. Soc.2017, 139, 15564–15567. (Impact Factor 16.383, First Author)

37.  Hu, L. R.; Chen, K.; Chen, H.* “Modeling σ-Bond Activations by Nickel(0) Beyond Common Approximations: How Accurately Can We Describe Closed-Shell Oxidative Addition Reactions Mediated by Low-Valent Late 3d Transition Metal?” J. Chem. Theory Comput.2017, 13, 4841–4853. (Impact Factor 5.011, First Author)

38.  Liu, J.#; Hu, L. R.#; Wang, L.; Chen, H.*; Deng, L.* “An Iron(II) Ylide Complex as A Masked Open-Shell Iron Alkylidene Species in Its Alkylidene-Transfer Reactions with Alkenes” J. Am. Chem. Soc.2017, 139, 3876–3888. (Impact Factor 14.612, Co-first Author)

39.  Kumar, P.; Lee, Y. M.; Hu, L. R.; Chen, J.; Park, Y. J.; Yao, J.; Chen, H.*; Karlin, K. D.*; Nam, W.* “Factors That Control the Reactivity of Cobalt(III)-Nitrosyl Complexes in Nitric Oxide Transfer and Dioxygenation Reactions: A Combined Experimental and Theoretical Investigation” J. Am. Chem. Soc.2016, 138, 7753–7762. (Impact Factor 14.612, Third Author)

40.  Sun, Y.; Tang, H.; Chen, K.;Hu, L. R.; Yao, J.; Shaik, S.; Chen, H.* “Two-State Reactivity in Low-Valent Iron-Mediated C−H Activation and the Implications for Other First-Row Transition Metals” J. Am. Chem. Soc.2016, 138, 3715–3730. (Impact Factor 14.612, Fourth Author)

41.  Wang, C.; Zhao, C. Y.; Hu, L. R.; Chen, H.* “Evidences toward Establishing Mechanism of Cyanobacterial Aldehyde-Deformylating Oxygenase: Asymmetric Aldehyde Activation by Symmetric Diiron Cofactor” J. Phys. Chem. Lett., 2016, 7, 4427–4432. (Impact Factor 6.710, Third Author)

42.  Lu, S. J.; Hu, L. R.; Xu, X. L.; Xu, H. G.; Chen, H.*; Zheng, W.* “Transition from exohedral to endohedral structures of AuGen (n = 2–12) clusters: photoelectron spectroscopy and ab initio calculations” Phys. Chem. Chem. Phys.2016, 18, 20321–20329. (Impact Factor 3.430, Second Author)

43.  Liu, Q.-Y.; Hu, L. R.; Chen, H.*; He, S.-G.* “Photoelectron Imaging Spectroscopy of ZrO− Diatomic Anion” Chinese J. Chem. Phys.2015, 28, 452. (Impact Factor 1.067, Second Author)

44.  Li, Z.-Y.; Hu, L. R.; Liu, Q.-Y.; Ning, C.-G.; Chen, H.*; He, S.-G.*; Yao, J. N. “C-H Bond Activation by Early Transition Metal Carbide Cluster Anion MoC3−” Chem. Eur. J.2015, 21, 17748–17756. (Impact Factor 4.857, Second Author)

45.  Liu, Q.-Y.; Hu, L. R.; Li, Z.-Y.; Ning, C.-G.; Ma, J.-B.; Chen, H.*; He, S.-G.* “Photoelectron Imaging Spectroscopy of MoC− and NbN− Diatomic Anions: A Comparative Study” J. Chem. Phys.2015, 142, 164301. (Impact Factor 2.991, Second Author)

46.  Sun, Y. Y.; Hu, L. R.; Chen, H.* “Comparative Assessment of DFT Performances in Ru- and Rh-Promoted σ-Bond Activations” J. Chem. Theory Comput.2015, 11, 1428–1438. (Impact Factor 5.011, Second Author)

47.  Liu, Y. B.; Hu, L. R.; Chen, H.*; Du, H. F.* “An Alkene-Promoted Borane-Catalyzed Highly Stereoselective Hydrogenation of Alkynes to Z- and E-Alkenes” Chem. Eur. J.2015, 21, 3495–3501. (Impact Factor 4.857, Second Author)

48.  Wang, L.#; Hu, L. R.#; Zhang, H. Z.; Chen, H.*; Deng, L.* “Three-Coordinate Iron(IV) Bisimido Complexes with Aminocarbene Ligation: Synthesis, Structure and Reactivity” J. Am. Chem. Soc.2015, 137, 14196–14207. (Impact Factor 14.612, Co-first Author)

49.  Hu, L. R.; Chen, H.* “Assessment of DFT Methods for Computing Activation Energies of W/Mo-Mediated Reactions” J. Chem. Theory Comput.2015, 11, 4601–4614. (Impact Factor 5.011, First Author)

荣誉及奖励

2014年 中国科学院大学三好学生

2015年 中国科学院化学所青年科学奖优秀奖

2016年 中国科学院化学所瑞华泰奖

2018年 西华大学青年学者后备人才

2022年 华东师范大学紫江青年学者

2022年 上海市“浦江人才”计划

2023年 上海市海外高层次人才引进计划

2024年 上海市高等教育人才揽蓄计划