张思宇

2010.09 – 2015.07        中国科学院生态环境研究中心，环境科学，理学博士，导师：朱永官院士

2006.09 – 2010.07        南京农业大学，农业资源与环境，农学学士

2020.11至今                华东师范大学，研究员（紫江青年）

2017.08-2020.10         美国佐治亚理工学院，博士后

2015.07-2017.07         北京师范大学，博士后

课题组：微生物组学与生态系统健康（MEH Lab）

研究领域：生态系统微生物组学、微生物与污染物互作机制、胁迫环境下的微生物响应机制

Environmental Microbiology, Applied Microbiology and Biotechnology 等期刊审稿人

中国土壤学会青年工作委员会 创新委员

中国土壤学会土壤生物和生化专业委员会 青年委员

课题组：微生物组学与生态系统健康（MEH Lab）

研究领域：生态系统微生物组学、微生物与污染物互作机制、胁迫环境下的微生物响应机制

研究兴趣：

1. 微生物与砷的相互作用机制

砷胁迫环境中微生物多样性及功能适应性特征；微生物驱动的砷生物地球化学循环过程，以及砷与其他元素，如碳、氮等的耦合过程。

2. 微生物响应城市化进程的生态学机制及其环境健康风险

城市化进程中，生态系统不同环境介质（水、土、气、叶）中微生物多样性及功能适应性特征；基于微生物组学技术、机器学习模型等解析及预测新型污染物ARGs和潜在病原微生物的环境健康风险。  

3. 建立并优化环境微生物组的高通量识别及功能解析方法

构建基于高通量测序短序列精准识别功能基因，如抗生素抗性基因、砷代谢基因的ROCker模型；建立基于宏组学数据长序列的共存功能基因解析方法。

欢迎微生物生态、环境微生物、生物信息学专业的学生报考硕士、博士研究生~

课题组现招聘博士后（要求有宏基因组学、宏转录组学数据分析相关背景）~

• 本科生：

• 《生态学研究方法与实验设计II》（专业必修课）

• 《微生物组学与生态系统健康》（专业选修课）

• 《走进微生物组：人与自然和谐共处的新视角》（通识教育课程-模块课程：理性、科学与发展）

• 研究生：

• 《微生物组学分析》

华东师范大学“紫江青年学者”启动项目，2021-2026，主持。

国家自然科学基金青年项目，2022.01-2024.12，主持。

国家自然科学基金面上项目，2023.01-2026.12，主持。

国家重点研发计划青年科学家项目，2022.10-2025.09，项目骨干。

学术成果发表在Nature Microbiology, Proceedings of the National Academy of Sciences, Nature Communications, The ISME Journal, Environmental Microbiology, Environmental Science & Technology, Applied and Environmental Microbiology 等期刊，其中：

代表性论文：

Zi-Teng Liu, Rui-Ao Ma, Dong Zhu, Konstantinos T. Konstantinidis, Yong-Guan Zhu, Si-Yu Zhang*. Organic fertilization co-selects genetically linked antibiotic and metal(loid) resistance genes in global soil microbiome. Nature Communications. 2024. 15:5168.

A-Xiang Gao, Chuan Chen, Zi-Yu Gao, Zhi-Qiang Zhai, Peng Wang, Si-Yu Zhang*, Fang-Jie Zhao*. Soil redox status governs within-field spatial variation in microbial arsenic methylation and rice straighthead disease. The ISME Journal. 2024. 18 (1): wrae057. （共同通讯）

Xin-Di Zhao, Zi-Yu Gao, Jingjing Peng, Konstantinos T. Konstantinidis, Si-Yu Zhang*. Various microbial taxa couple arsenic transformation to nitrogen and carbon cycling in paddy soils. Microbiome. 2024. 12: 238.

Zi-Yu Gao, Xin-Di Zhao, Chuan Chen, Fang-Jie Zhao, and Si-Yu Zhang*. Paddy Soil Flooding and Nonflooding Affect the Transcriptional Activity of Arsenic Methylation and Demethylation Communities. Environmental Science & Technology. 2025. 59 (7): 3548−3561.

Si-Yu Zhang, Zi-Teng Liu, Xin-Di Zhao, Zi-Yu Gao, Ouyuan Jiang, Jie Li, Xiaoming Li, Andreas Kappler, Jianming Xu, and Xianjin Tang*. Lignin and Peptide Promote the Abundance and Activity of Arsenic Methylation Microbes in Paddy Soils. Environmental Science & Technology. 2025. 59 (5): 2541-2553.

其他论文：

Rui-Ao Ma, Yi-Hui Ding, Shifa Zhong, Ting-Ting Jing, Xuechu Chen, and Si-Yu Zhang*. A machine learning approach to predict phyllosphere resistome abundance across urbanization gradients. Environment International. 2025. 202: 109655.

Yihui Ding, Rui-Ao Ma, Ran Zhang, Hongwei Zhang, Jian Zhang, Shaopeng Li, Si-Yu Zhang*. Increased antibiotic resistance gene abundance linked to intensive bacterial competition in the phyllosphere across an elevational gradient. Environmental Microbiology Reports. 2024. 16 (6): e70042.

Ou-Yuan Jiang#, Si-Yu Zhang#, Xin-Di Zhao, Zi-Teng Liu, Andreas Kappler, Jian-Ming Xu, Xian-Jin Tang*. Arsenic Reduces Methane Emissions from Paddy Soils: Insights from Continental Investigation and Laboratory Incubations. Environmental Science & Technology. 2024. 58 (40): 17685-17694. 

Si-Yu Zhang#, Brittany J. Suttner#, Luis M. Rodriguez-R#, Luis H. Orellana, Roth E. Conrad, Fang Liu, Jessica L. Rowell, Hattie E. Webb, Amanda J. Williams-Newkirk, Andrew Huang, Konstantinos T. Konstantinidis. ROCker models for reliable detection and typing of short read sequences carrying β-lactamases. mSystems. 2022. 7 (3): e01281-21.

Si-Yu Zhang*, Xiao Xiao, Song-Can Chen, Yong-Guan Zhu, Guo-Xin Sun, and Konstantinos T. Konstantinidis*. High Arsenic Levels Increase Activity Rather than Diversity or Abundance of Arsenic Metabolism Genes in Paddy Soils. Applied and Environmental Microbiology. 2021. 87 (20): e01383-21.

Si-Yu Zhang, Despina Tsementzi, Janet K. Hatt, Aaron Bivins, Nikunj Khelurkar, Joe Brown, Sachchida Nand Tripathi, Konstantinos T. Konstantinidis. Intensive allochthonous inputs along the Ganges River and their effect on microbial community composition and dynamics. Environmental Microbiology. 2019. 21 (1): 182-196. (Top downloaded paper 2018-2019 in Environmental Microbiology)

Si-Yu Zhang, Jian-Qiang Su, Guo-Xin Sun, Yunfeng Yang, Yi Zhao, Junjun Ding, Yong-Shan Chen, Yu Shen, Guibing Zhu, Christopher Rensing, Yong-Guan Zhu. Land scale biogeography of arsenic biotransformation genes in estuarine wetland. Environmental Microbiology. 2017. 19 (6): 2468-2482.

Si-Yu Zhang, Paul N. Williams, Jinming Luo, Y.-G. Zhu. Microbial mediated arsenic biotransformation in wetlands. Frontiers of Environmental Science & Engineering. 2017. 722 (25): 555-563.

Si-Yu Zhang, Fang-Jie Zhao, Guoxin Sun, Jianqiang Su, Xiaoru Wang, Hu Li, Yong-Guan Zhu. Diversity and abundance of arsenic biotransformation genes in Chinese paddy soils. Environmental Science & Technology. 2015. 49 (7): 4138-4146.

Siyu Zhang, Dan Wang, Yihua Wang, Henrik Hasman, Frank M. Aarestrup, Hend A. Alwathnani, Yong-Guan Zhu, Christoper Rensing. Genome sequences of copper resistant and sensitive Enterococcus faecalis strain isolated from copper-fed pigs in Denmark. Standards in Genomic Sciences. 2015. 10 (35): 1-10.

Siyu Zhang, Christopher Rensing, Yong-Guan Zhu. Cyanobacteria–mediated arsenic redox dynamics is regulated by phosphate in aquatic environment. Environmental Science & Technology. 2014. 48 (2): 994-1000.

Si-Yu Zhang, Guoxin Sun, Xixiang Yin, Christopher Rensing, Yong-Guan Zhu. Biomethylation and volatilization of arsenic by the marine microalgae Ostreococcus tauri. Chemosphere. 2013. 93 (1): 47-53.

Song-Can Chen, Guo-Xin Sun, Yu Yan, Konstantinos T Konstantinidis, Si-Yu Zhang, Ye Deng, Xiao-Min Li, Hui-Ling Cui, Florin Musat, Denny Popp, Barry P Rosen, Yong-Guan Zhu. The Great Oxidation Event expanded the genetic repertoire of arsenic metabolism and cycling. Proceedings of the National Academy of Sciences. 2020. 117 (19): 10414–10421.

Yong-Guan Zhu, Yi Zhao, Bing Li, Chu-Long Huang, Si-Yu Zhang, Shen Yu, Yong-Shan Chen, Tong Zhang, Michael R Gillings, Jian-Qiang Su. Continental-scale pollution of estuarines with antibiotic resistance genes. Nature Microbiology. 2017. 2: 1-7.(高被引论文)

Song-Can Chen, Guo-Xin Sun, Barry P Rosen, Si-Yu Zhang, Ye Deng, Bo-Kai Zhu, Christopher Rensing, Yong-Guan Zhu. Recurrent horizontal transfer of arsenite methyltransferase genes facilitated adaptation of life to arsenic. Scientific Reports. 2017. 7(1).

Ke-Qing Xiao, Li-Guan Li, Li-Ping Ma, Si-Yu Zhang, Peng Bao, Tong Zhang, Yong-Guan Zhu. Metagenomic analysis revealed highly diverse microbial arsenic metabolism genes in paddy soils with low-arsenic content. Environmental Pollution. 2016. 211: 1-8.

Xiuli Hao, Freya L. Lüthje, Yanan Qin, Sylvia Franke McDevitt, Nataliya Lutay, Jon Hobman, Karishma Asiani, Fernando C. Soncini, Nadezhda German, Si-Yu Zhang, Yong-Guan Zhu and Christopher Rensing. Survival in amoeba-a major selection pressure on the presence of bacterial copper and zinc resistance determinants? Identification of a ‘copper pathogenicity island’. Applied Microbiology and Biotechnology. 2015. 99 (14): 5817 – 5824.

2021     中国生态学学会青年人才托举工程（2021-2023年）项目C类被托举人

2022     上海市领军人才（青年）

2024     第九届中国土壤学会优秀青年学者奖