王雪力

2016.9 - 2021.6  华东师范大学精密光谱科学与技术国家重点实验室 （博士）

2020.1 - 2020.7  美国俄亥俄州立大学 化学与生物化学系 （访问学者）

2023.7 - 至今     华东师范大学精密光谱科学与技术国家重点实验室 （专职副研究员）

2021.6 - 2023.6 华东师范大学精密光谱科学与技术国家重点实验室 （博士后）

   2021年7月作为专职副研究员加入陈缙泉团队，主要研究方向为超快光谱与分子激发态动力学，并聚焦于先进超快光谱系统的开发以及基于超快光谱技术解析生物大分子体系中的光物理与光化学特性。在先进超快光谱系统开发方面，作为主要成员参与搭建国际首台时间分辨的圆偏振发光光谱系统和国内首台飞秒时间分辨的圆二色吸收光谱系统。在解析大分子体系中的光物理与光化学特性方面，利用宽带时间分辨的瞬态吸收光谱、荧光上转换光谱以及时间分辨的圆偏振光谱技术解析了系列生物分子的激发态动力学特性，主要包括成功揭示了 DNA 双链体系中电荷转移三重态的超快生成机制、药物分子敏化 DNA 光损伤的超快动力学弛豫机制、超分子锁烃分子圆偏振发光机制等。相关成果以第一、共一、共同通讯作者身份在 J. Am. Chem. Soc.、Angew. Chem. Int. Ed.（2篇）、Nat.  Commun.、Adv. Mater.、J. Phys. Chem. Lett.、J. Phys. Chem. B、J. Chem. Phys.、Phys. Chem. Chem. Phys.、Chem. Eur. J.等国际知名期刊上发表论文 18 篇。此外，积极参与交叉学科合作，推进超快光谱技术在药学、生物学、环境学等多学科领域的应用，以合作作者身份在 J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Chem、Nat. Commun.、Chem. Sci.等高水平期刊上发表论文 20 余篇。主持国家自然科学基金委青年科学基金项目一项，上海市“科技创新行动计划”自然科学基金项目面上项目一项、上海市博士后日常经费项目一项，参与国家自然科学基金委重大研究计划项目一项。

研究兴趣：

激发态超快动力学，生物光子学，DNA损伤与修复，飞秒时间分辨的圆二色吸收光谱

4.上海市“科技创新行动计划”自然科学基金项目面上项目，24ZR1419500，基于宽带时间分辨光谱技术的靶向药物-DNA复合体系激发态动力学研究，主持

3.国家自然科学基金青年科学基金项目，2240030023，基于飞秒圆二色吸收光谱对褐黄癌菌素V敏化DNA光损伤反应的超快动力学研究，主持

2.国家自然科学基金重大研究计划重点项目，92156024，基于飞秒圆二色光谱和飞秒圆偏振发光光谱对手性传递机制和规律的研究，参与

1.国家自然科学基金面上项目，21873030，化学修饰核酸分子电子激发态动力学特性的研究，参与

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47. Han, Y.; Yang, X.; Wang, X.; Mao, H.; Huang, K.; Pan, H.; Liu, M.; Duan, P.*; Chen, J.* Real-Time  Observation of Ultrafast Concerted Dynamics between Energy and  Chirality Transfer by Femtosecond Time-Resolved Circular Polarization  Luminescence Spectroscopy.  J. Am. Chem. Soc. 2025, doi.org/10.1021/jacs.5c00695

46. Martinez Fernandez, L.#; Wu, P.#; Bao, L.#; Wang, X.; Wu, P.; Zhang, R.; Wang, W.; Yang, H.; Chen, J.*; Improta, R.*On the nature of the triplet electronic states of naphthalene dimers. Chem. Sci. 2025, doi.org/10.1039/D4SC07982E.

45. Bao，L.; Zhang, R.;Yuan, X. ; Wang, X.; Wu, P.; Wang, X.; Chen, J.; Zhu, A.*; Yang, H.; Wang, W.* Rigidly Locked Pyrene Excimers in Planar Chiral Pyrenophanes for Intense and Stable Circularly Polarized Photoluminescence and Electrochemiluminescence. Angew. Chem. Int. Ed. 2025, e202500472.

44. Chen，Z.; Qin, C.*; Wang, X.; Pan, H.; Chen, J.* Ultrafast Intersystem Crossing in Naturally Occurring Plant Pigments 5-Hydroxyflavones under Direct UV Excitation.J. Phys. Chem. Lett. 2025, 16, 1184-1190

43. Wang, X.#;Zhou, J.#, Wang, M.#, Wang, Y. Shen, Z.; Sun, H.; Hu, Z.*; Luo, X.*; Yang, Y.*; Chen. J.* Proximal Oblique-Packing of Heptamethine Cyanines through Spiro-Connection Boosts Triplet State Generation in Near-Infrared Angew. Chem. Int. Ed. 2025, e202425422.

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42.Chen, J. # ; Chen, F # ; Wang, X.#; Zhuang, H.; Guo, M.; Wang, L.; Xie, J.; Zhang, L.;  Liu, H.; Shi, Y.; Zhou, J.; Mao, X.; Lv, M.; Jiang, X.; Chen, J.*; Liu, Y.*; Jin, D.*; Bu,  W.*, Ultra-fast photoelectron transfer in bimetallic porphyrin optoelectrode for single neuron modulation. Nat. Commun. 2024, 15,10241.（共同一作）

41. Zhang, X.; Liu, M.; Hu, Y.; Wang, X.#; Wei, R.; Yao, C.; Shi, C.; Qiu, Y.; Yang, T.; Luo, X.; Chen, J.*; Sun, W.*; Chen, H.*; Qian, X.*; Yang, Y.*, Albumin-Chaperoned Deep-NIR Triarylmethane Dyes for High-Contrast In Vivo Imaging and Photothermal Therapy Adv. Mater. 2024, 2411515（共同一作）

40.Wang, X.#; Wu, P.#; Wang, Y.#; Cui, T.; Jia, M.; He, X.; Wang, W.; Pan, H.; Sun, Z.; Yang, H.; Chen, J.*; Unraveling the Origin of Multichannel Circularly Polarized Luminescence in a Pyrene-Functionalized Topologically Chiral [2]Catenane. Angew. Chem. Int. Ed. 2024, e202407929.（Front Cover paper）

39. Cui, T; Jia, M*; Wu, P; Hu, K; Wang, X. ; Zhang, S; Pan, H; Chen, J*; Development and Application of Ultrafast Circular Dichroism Spectroscopy Techniques CHINESE J. CHEM. PHYS.  DOI: 10.1063/1674-0068/cjcp2403041

38. Hu, K; He, X* ; Jin, P;Wang, X.; Pan, H.; Chen, J.*, Unravelling the Competition between Internal Conversion and Intersystem Crossing in Twisted molecule 9-Phenylacridine by Femtosecond Time-resolved Spectroscopy. ChemPhotoChem 2024,e202400108

37. Chen, Z.; Wang, X.*; Jia, M.; He, X.; Pan, H.; Chen, J.*, Ribose and Deoxyribose Group Alter Excited-State Dynamics of 5-Azacytosine in Solution. Photochem. Photobiol. 2024,100, 291-297

36. Zhou, J.; Wang, X.*; Jia , M.; He, X.; Pan, H.; Chen, J.* Ultrafast Spectroscopy Study of DNA Photophysics after Proflavine Intercalation. J. Chem. Phys. 2024, 160, 124305

35.Jin, P.; Wang, X.* ; Jia , M .; He, X.; Pan, H.; Chen, J. *, Ultrafast and Multichannel Generation of Triplet State in DNA Intercalated Gilvocarcin V for Enhanced Photo Addition Reaction . J. Phys. Chem. Lett. 2024, 15, 2765-2771

34. Wang, X.# ; Martinez Fernandez, L.# ; Zhang, Y.; Wu, P.; Kohler, B.*；Improta, R. *； Chen, J. *, Ultrafast Formation of a Delocalized Triplet Excited State in an Epigenetically Modified DNA Duplex under Direct UV Excitation J. Am. Chem. Soc. 2024, 146, 1839 1848. 

33. Chen, J.; Liu, Y.; Chen, F.;  Guo, M.; Zhou, J.; Fu, P.; Zhang, X.; Wang, X.; Wang, H.; Hua, W.;  Chen, J.; Hu, J.; Mao, Y.*; Jin, D.*; Bu, W.*; Non-Faradaic optoelectrodes for safe electrical neuromodulation. Nat. Commun. 2024, 15, 405

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32. Wu, P.;  Wang, X.*; Pan, H.; Chen, J.*; Wavelength dependent excited state dynamics observed in canonical pyrimidine nucleosides . J . Photochem. Photobio.2023, 1(8), 100211.

31. Luo, X.*;  Zhang, Z.*;  Wang, J.; Wang, X.; Zhang, Y.; Chen, J.  Ge, G.; Yang,W.*;  Qian, X.*; Tian, Y.*; Yang, Y.*; Acyl-Caged Rhodamines: Photo-Controlled and Self-Calibrated Generation of Acetyl Radical for Neural Function Recovery in Early AD Mouse. Chem. Sci. 2023,14,11689-11698

30. Jin, P.; Wang, J.; Wang, X.; Jia, M.; Pan, H.; Mei, Y.*; Chen, J.*, Tracking the Early Stage of Triplet-Induced Photodamage in a DNA Dimer and Oligomer Containing 5-Methylcytosine J. Phys. Chem. B 2023, 127 (31), 6878-6886.

29. Han, Y.; Wang, X.* ; He, X.; Jia , M.; Pan, H.; Chen, J.* Excited State Kinetics ofBenzo[a]pyrene Is Affected by Oxygen and DNA . Molecules 2023, 28, 5269

28.Wang, M.; Wang, X.; Wei, R.; Zhang, Y.; Chen, J.; Luo, X,; Qian, X.; Yang, Y.; Symmetry-breaking  charge-transfer enables turn-on fluorescence sensing in the shortwave  infrared spectral region for in vivo vasculature redox homeostasis  Sensor Actuat B-chem 2023，394,134382

27. Wang, D.; Wang, X.* ; Jin , P ; Zhou , Y ; Jia , M .; Pan, H.; Sun, Z. Chen, J.*, Distinct doorway states lead to triplet excited state generation in epigenetic RNA nucleosides Phys. Chem. Chem. Phys. 2023, 25,15153--15161.

26. Wei, R.; Dong, Y.; Wang, X.; Li J.; Lei Z., Hu, Z.; Chen, J., Sun, H., Chen, H., Luo, H., Qian, H.; Yang, Y. Rigid and Photostable Shortwave Infrared Fluorophore (EC7)Absorbing/Emitting beyond 1200 nm for High-Contrast Multiplexed Imaging  J. Am. Chem. Soc. 2023, 145 (22), 12013-12022.

25.  Jin, X.; Guo, S.; Wang, X.;  Cong, Y.;  Chen, J.*;  Zhang, Z.*; Su, J.;  Qu, D.; Tian, H.*, Sequential Multistep Excited-State Structural Transformations in N,N′-Diphenyl-dihydrodibenzo[a,c]phenazine Fluorophores. Angew. Chem. Int. Ed. 2023, 6(29), e202305572. 

24. Han, Y.; Jia, Y.*; Wang, X.; Chen, Z.; Jin, P.; Jia, M.; Pan, H.; Sun, Z.; Chen, J.*, Ultrafast excited state dynamics of two non-emissive flavonoids that undergo excited state intramolecular proton transfer in solution. Chem. Phys. Lett. 2023, 811, 140189.

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23. Zhou, J.; Jia, Y.*; Wang, X.; Jia, M.; Pan, H.; Sun, Z.; Chen, J.*, Excited-State Dynamics of Proflavine after Intercalation into DNA Duplex. Molecules 2022, 27 (23), 8157.

22. Li, X.; Wang, X.*; Lv, M.; Zhou, Z.; Pan, H.; Chen, J.*, Direct observation of singlet ππ∗ and nπ* equilibrium state in 2-amino-1,3,5-triazine solution. Chinese J. Chem. Phys. 2022, 35, 747-753.

21. Wu, P.; Wang, X.; Pan, H.; Chen, J.*, Direct Observation of Excitation Wavelength-Dependent Ultrafast Intersystem Crossing in Cytosine Nucleoside Solution. J. Phys. Chem. B 2022, 126 (40), 7975-7980.

20. Chen, L.; Jiang, X.; Lv, M.; Wang, X.; Zhao, P.; Zhang, M.; Lv, G.; Wu, J.; Liu, Y.; Yang, Y.*; Chen, J.*; Bu, W.*, Reductive-damage-induced intracellular maladaptation for cancer electronic interference therapy. Chem 2022, 8 (3), 866-879.

19. Wang, D.; Wang, X.*; Jiang, Y.; Cao, S.; Jin, P.; Pan, H.; Sun, H.; Sun, Z.; Chen, J.*, Excited State Dynamics of Methylated Guanosine Derivatives Revealed by Femtosecond Time-resolved Spectroscopy. Photochem. Photobiol. 2022, 98,1008-1016.

18. Jin, P.;Wang, X.*; Pan, H.; Chen, J.*, One order of magnitude increase of triplet state lifetime observed in deprotonated form selenium substituted uracil. Phys. Chem. Chem. Phys. 2022, 24, 875-882.

17. Tan, H.; Zhou, H.; Zhao, Y.; Wang, X.; He, X.; Chen, J.; Zhang, K.*; Antoine, R.*; Zhang, S.*; Tian, Y., Regulation of Silver Nanoclusters with 4 Orders of Magnitude Variation of Fluorescence Lifetimes with Solvent-Induced Noncovalent Interaction. J. Phys. Chem. C 2022, 126 , 5198-5205.

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16. Lv, M.; Wang, X.; Pan, H.; Chen, J.*, Direct Observation of Ultrafast Access to a Solvent-Independent Singlet–Triplet Equilibrium State in Acridone Solutions. J. Phys. Chem. B 2021, 125 , 13291-13297.

15. Lv, M.; Wang, X.; Wang, D.; Li, X.; Liu, Y.; Pan, H.; Zhang, S.; Xu, J.; Chen, J.*, Unravelling the role of charge transfer state during ultrafast intersystem crossing in compact organic chromophores. Phys. Chem. Chem. Phys. 2021. 25455-25466.

14. 王雪力，潘海峰，陈缙泉* 表观遗传修饰核酸碱基的超快激发态动力学研究《物理学进展》 2021, 41, 199-208

13. Wang, X.; Martinez-Fernandez, L.; Zhang, Y.; Zhang K.; Improta, R.*；Kohler, B.*；Xu, J.; Chen, J.*, Solvent-dependent Stabilization of a Charge Transfer State is the Key to Ultrafast Triplet State Formation in an Epigenetic DNA Nucleoside. Chem. Eur. J. 2021, 42 , 10932-10940.

12. Zhang, K.; Wang, F.; Jiang, Y.; Wang, X.; Pan, H.; Sun, Z.; Sun, H.; Xu, J.; Chen, J.*, New Insights about the Photostability of DNA/RNA Bases: Triplet nπ* State Leads to Effective Intersystem Crossing in Pyrimidinones. J. Phys. Chem. B 2021，125, 2042-2049.

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11. Xu, R.; Hu, Z.; Wang, X.; Liu, Y.; Zhou, Z.; Xu, J.; Sun, Z.; Sun, H.; Chen, J.*, Intramolecular Charge Transfer in 5-Halogen Cytidines Revealed by Femtosecond Time-Resolved Spectroscopy. J. Phys. Chem. B 2020, 124 , 2560-2567.

10. Liu, Y.; Chen, Z.; Wang, X.; Cao, S.; Xu, J.; Jimenez, R.*; Chen, J.*, Ultrafast spectroscopy of biliverdin dimethyl ester in solution: pathways of excited-state depopulation. Phys. Chem. Chem. Phys. 2020, 22, 19903-19912.

9. Li, W.; Wang, X. Q.; Wang, W.; Hu, Z.; Ke, Y.; Jiang, H.; He, C.; Wang, X.; Hu, Y.; Jia, P.; Yin, P.; Chen, J.; Sun, H.; Sun, Z.; Xu, L.*;Yang, H. *, Dynamic Artificial Light-Harvesting Systems Based on Rotaxane Dendrimers. Giant 2020, 100020.

8. Fu, L.; Wang, Z.; Liu, Y.; Wang, X.; Xu, R.; Liu, W.*; Chen, J.*; Xu, J., Observation of triplet nπ* state in ultrafast intersystem crossing of 6-azathymine. J. Photochem. Photobiol. A: Chem. 2020, 396, 112491.

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7. Wang, X.; Yu, Y.; Zhou, Z.; Liu, Y.; Yang, Y.; Xu, J.; Chen, J.*, Ultrafast Intersystem Crossing in Epigenetic DNA Nucleoside 2′-Deoxy-5-formylcytidine. J. Phys. Chem. B 2019, 123 , 5782-5790.

6. Zhou, Z.; Wang, X.; Chen, J.*; Xu, J., Direct Observation of Intramolecular Charge Transfer State in Epigenetic Nucleobase N6-methyladenine. Phys. Chem. Chem. Phys. 2019, 21, 6878-6885.

5.  Zhou, Z.; Hu, Z.; Zhang, X.; Jia, M.; Wang, X.; Su, H.; Sun, H.; Chen, J.*; Xu, J., pH Controlled Intersystem Crossing and Singlet Oxygen Generation of 8-Azaadenine in Aqueous Solution. ChemPhysChem 2019, 20 , 757-765.

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4. Wang,X.; Zhou, Z.; Tang, Y.; Chen, J.*; Zhong, D.; Xu, J., Excited State Decay Pathways of 2'-deoxy-5-Methylcytidine and Deoxycytidine Revisited in Solution: A Comprehensive Kinetic Study by Femtosecond Transient Absorption. J. Phys. Chem. B 2018, 122, 7027-7037.

3. He, H.; Liu, Y.; Zhou, Z.; Guo, C.; Wang, H. Y.; Wang, Z.; Wang, X.; Zhang, Z.; Wu, F. G.; Wang, H.;Chen, D.; Yang, D.; Liang, X.*; Chen, J.*; Zhou, S.*; Liang, X*; Qian, X.; Yang, Y.*,  A Photo-Triggered and Photo-Calibrated Nitric Oxide Donor: Rational Design, Spectral Characterizations, and Biological Applications. Free Radical Biology & Medicine 2018, 123, 1-7.

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2. Lei, Z.; Yue, P.; Wang, X.; Li, X.; Li, Y.; He, H.; Luo, X.; Meng, X.*; Chen, J.*; Qian, X.,Yang, Y.*, TPZ, a bright centrosymmetric two-photon scaffold for bioimaging. Chem. Commun. 2017, 10938.

1. Zhou, Z.; Zhou, X.; Wang, X.; Jiang, B.*; Li, Y.*; Chen, J.*; Xu, J., Ultrafast Excited-State Dynamics of Cytosine Aza-Derivative and Analogues. J. Phys. Chem. A 2017, 121 , 2780-2789.