张季平

1984.9-1988.7   华东师范大学生物学系本科生，1988年7月获学士学位。

1988.9-1991.7   华东师范大学生物学系生理学硕士生，1991年7月获硕士学位。

1996.9-1999.7   华东师范大学与美国密苏里大学生物学系生理学专业联合培养博士生，1999年7月获博士学位。

1997.12- 1999.2  美国密苏里大学生物学系，访问研究学者。

1991.7-1996.8   湖北大学生命科学系，助教、讲师。

1999.7- 2000.10  华东师范大学生物学系博士后。

2000.11-2004.12  美国加州大学Irvine分校解剖与神经生物学系博士后。

2005.3-现在      华东师范大学生命科学学院教授, 博士生导师。

    从事听觉神经生物学研究。用神经电生理学、行为学、分子生物学等方法，研究在复杂声环境下脑对听觉信息的编码机制、环境和经验依赖的听觉功能发育及可塑性的神经与分子机制、以及听觉学习行为。

    入选2005年度上海市曙光学者、2006年度上海市科委浦江人才计划、 2007年度教育部新世纪优秀人才支持计划。

    获得2014年度教育部自然科学二等奖（排名第二）、2018年度上海市自然科学三等奖（排名第三）。

    主讲的《神经生物学》（双语）入选国家双语教学示范课程。

上海市生物物理学会理事

听觉神经生物学

 主要研究：1）复杂声环境下脑对听觉信息的处理机制； 2）听觉功能的发育； 3）环境和经验影响听觉功能可塑性的行为表现、神经和分子机制。

《神经生物学》（双语）（本科生）

《脑科学研究进展》（本科生）

《神经生物学》（研究生）

曾主持多项国家自然科学基金项目，以及教育部新世纪优秀人才支持计划、上海市曙光人才计划、上海市浦江人才计划、上海市自然科学基金等项目。

在国内外核心期刊发表研究论文50余篇‚ 参加《听觉科学概论》专著的编写。

近期发表的研究论文

1. Liu J., Huang X., Zhang J., Unilateral conductive hearing loss disrupts the developmental refinement of binaurla processing in the rat primary auditory cortex, Frontiers in Neuroscience, 2021,15:762337, doi: 10.3389/fnins.2021.762337.

2. Wang X., Liu, J., Zhang J., Chronic unilateral hearing loss disrupts neural tuning to sound-source azimuth in the rat primary auditory cortex, Frontiers in Neuroscience, 2019,13:477,doi: 10.3389/fnins.2019.00477.

3. Wang,F., Liu J., Zhang J., Early postnatal noise exposure degrades the stimulus-specific adapation of neurons in the rat auditory cortex in adulthood, Neuroscience, 2019, 404:1-13.

4. Gao F., Chen L., Zhang J., Nonuniform impacts of forward suppression on neural responses to preferred stimuli and nonpreferred stimuli in the rat auditory cortex,European Journal of Neuroscience, 2018, 47(11): 1320-1338.

5.  Lu Q., Jiang C., Zhang J., Encoding of sound envelope transients in the auditory cortex of juvenile rats and adult rats, International journal of  developmental neuroscience, 2016, 48:50-57.

6. Jiang C., Xu X., Yu L., Xu J., Zhang J., Environmental enrichment rescues thedegraded auditory temporal resolution of cortical neurons induced by early noise exposure, Eur. J. Neurosci., 2015, 42 (5):2144-2154.

7.  Zhao Y., Xu X., He J., Xu J., Zhang J., Age-related changes in neural gap detection thresholds in the rat auditory cortex, Eur. J. Neurosci., 2015, 41(3): 285-292.

8. Xu J., Sun X., Zhou X, Zhang J., Yu L., The cortical distribution of multisensory neurons was modulated by multisensory experience, Neuroscience, 2014, 272:1-9.

9. Peng Y., Xing P., He J., Sun X., Zhang J.,The impact of preceding noise on the frequency tuning of rat auditory cortex neurons, BMC Neurosci, 2012, 13:70.

10. Guo F., Zhang J., Zhu X., Cai R., Zhou X., Sun X., Auditory discrimination training rescues developmentally degraded directional selectivity and restores mature expression of GABA(A) and AMPA receptor subunits in rat auditory cortex, Behav Brain Res, 2012, 229(2):301-307.

11. Pan Y., Zhang J., Cai R., Zhou X., Sun X., Developmentally degraded directional selectivity of the auditory cortex can be restored by auditory discrimination training in adults, Behav Brain Res, 2011, 225(2):596-602.

12.Peng Y.‚ Sun X.‚ Zhang J. ‚ Contextual modulation of frequency tuning of neurons in the rat auditory cortex‚ Neuroscience‚2010‚ 169:1403-1413.

13. Cai R.‚  Zhou X.‚ Guo  F.‚ Xu  J.‚ Zhang J.‚ Sun X.‚ Maintenance of enriched environment-induced changes of auditory spatial sensitivity and expression of GABA(A)‚ NMDA‚ and AMPA receptor subunits in rat auditory cortex‚ Neurobiology of Learning and Memory‚ 2010‚ 94(4):452-460.

14. Cui Y.‚Cai R.‚ Zhang J.‚ Pan Y.‚ Sun X.‚Early APV chronic blocked alters experience-dependent plasticity of auditory spatial representation in rat auditory cortical neurons‚ Neuroscience Letters‚ 2010‚ 478:119-123

15.  Xu J.‚ Yu L.‚ Zhang J.‚ Cai R.‚Sun X.‚ Early continuous white noise exposure alters l-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunit glutamate receptor 2 and gamma-aminobutyric acid type a receptor subunit beta3 protein expression in rat auditory cortex‚ Journal of Neuroscience Research‚ 2010‚ 88(3):614-619.

16. Xu J.‚Yu L.‚Cai R.‚ Zhang J.‚ Sun X.‚Early Continuous White Noise Exposure Alters Auditory Spatial Sensitivity and Expression of GAD65 and GABAA Receptor Subunits in Rat Auditory Cortex‚  Cerebral Cortex‚ 2010‚20(4):804-812

17.  Zhang J.‚ Nakamoto K.T.‚ Kitzes L.M‚ Responses of Neurons in the Cat Primary Auditory Cortex to Sequential Sounds. Neuroscience‚ 2009‚ 161:578-588.

18.Xu J.‚ Yu L.‚ Cai R.‚ Zhang J.‚ Sun X.‚ Early auditory enrichment with music enhances auditory discrimination learning and alters NR2B protein expression in rat auditory cortex. Behavioural Brain Research‚ 2009‚196:49-54.

19.  Cui Y.‚ Zhang J‚ Cai R.‚ Sun‚ X.‚ Early auditory experience-induced composition/ratio changes of NMDA receptor subunit expression and effects of APV chronic blockade in rat auditory cortex‚ Journal of Neuroscience Research‚ 2009‚ 87：1123-1134.

20.  Cai R.‚ Guo F.‚ Zhang J.‚ Xu J.‚ Cui Y.‚ Sun X.‚ Environmental enrichment improves behavioral performance and auditory spatial representation of primary auditory cortical neurons in rat. Neurobiology of learning and memory‚ 2009‚ 91: 366–376.

21.  Gao F.‚ Zhang J.‚ Sun X.‚ Chen L.‚ The effect of postnatal exposure to noise on sound level processing by auditory cortex neurons of rats in adulthood‚ Physiology & Behavior‚ 2009‚ 97:369-373.

22.  Zhang H.‚ Cai R.‚ Zhang J.‚ Pan Y.‚ Sun X.‚Environmental enrichment enhances directional selectivity of primary auditory cortical neurons in rats‚ Neuroscience Letters‚ 2009‚ 463(2): 162-165.

23.  Zhang J.‚ Chen L.‚ Gao F.‚ Pu Q.‚ Sun‚ X.‚ Noise exposure at young age impairs auditory object exploration behavior of rats in adulthood‚ Physiology & Behavior‚ 2008‚95(1-2):229-234.

24.   Lu J., Cui Y., Mao Y., Cai R., Zhang J., Sun X.‚ Early auditory deprivation alters the expression of NMDA receptor subunit NR1 mRNA in the rat auditory cortex‚ Journal of Neuroscience Research‚ 2008‚ 86:1290-1296

25.  Xu F.‚ Cai R.‚ Xu J.‚ Zhang J.‚ Sun X.‚ Early music exposure modifies GluR2 protein expression in rat auditory cortex and anterior cingulate cortex‚ Neurosci Lett.‚2007‚ 420(2):179-183.

26.   Nakamoto K.T.‚ Zhang J.‚ Kitzes L.M.‚ Temporal nonlinearity during recovery from sequential inhibition by neurons in the cat primary auditory cortex.Journal of Neurophysiology. 2006 Mar; 95(3):1897-1907.

27.  Mao Y.‚ Zang S.‚ Zhang J.‚ Sun X.‚ Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex. Brain Research. 2006 Feb; 1073-1074:131-138.

28.  Bi C.‚ Cui Y.‚ Mao Y.‚ Dong S.‚ Zhang J.‚ Sun X.‚ The effect of early auditory deprivation on the age-dependent expression pattern of NR2B mRNA in rat auditory cortex. Brain Research. 2006 Sep;1110(1):30-38

29.   Zhang J.‚ Nakamoto K. T.‚ and Kitzes L.M.‚ Modulation of level response area and stimulus selectivity of neurons in cat primary auditory cortex‚ Journal of Neurophysiology 2005 Oct; 94(4):2263-2274.

30.    Zhang J.‚ Nakamoto K.T.‚ and Kitzes L.M.‚ Binaural interaction revisited in the cat primary auditory cortex.Journal of Neurophysiology 2004 Jan; 91(1): 101-117.

31.   Nakamoto K.T.‚ Zhang J.‚ and Kitzes L.M.‚ Response patterns along an isofrequency contour in cat primary auditory cortex (AI) to stimuli varying in average and interaural levels. Journal of Neurophysiology‚ 2004 Jan; 91(1): 118-135.

32.    Jen P. ‚ Sun X.‚ Chen Q. ‚ Zhang J.‚ Zhou X.‚ Corticofugal modulation of midbrain auditory sensitivity in the bat‚ 2004‚ in Thomas J‚ Moss C‚ Vater M (eds)‚ Echolocation in Bats and Dolphines‚ Chicago: University of Chicago Press‚ pp. 196-200.

33.  Jen P.‚ Zhou X., Zhang J.‚ Chen Q.‚ Sun X.‚ Brief and short-term corticofugal modulation of acoustic signal processing in the bat midbrain. Hearing Research. 2002‚168(1-2):196-207.

34   Zhang .JP.‚ Sun X.D.‚ Jen P.H.S.Corticofugal modulation of frequency tuning of inferior collicular neurons in big brown bat‚ Eptesicus fuscus  CHINESE SCIENCE BULLETIN‚ 2001‚ 46 (10): 836-839.

35.   Zhang J.P.‚ Jen P.H.S.‚ Sun X.D.‚Direction-dependent corticofugal modulation of frequency-tuning curves of inferior collicular neurons in the big brown bat‚ Eptesicus fuscus.Journal of Comparative Physiology [A]. 2000‚186(10):913-922.

36.   Jen P.H.-S.‚ Zhang J.P.‚ The role of GABAergic inhibition on direction-dependent sharpening of frequency tuning in bat inferior collicular neurons. Brain Res. 2000‚ 862(1-2):127-137.

37.   Jen P.H.-S. and Zhang J.P.‚ Corticofugal regulation of excitatory and inhibitory frequency tuning curves of bat inferior collicular neurons.Brain Research‚1999‚ 841:184-188. 

38. 彭垠婷, 蒲青, 孙心德, 张季平, 弱背景噪声对大鼠听皮层神经元频率调谐的影响, 生物化学与生物物理进展, 2012, 39(11):1082-1088.

39. 高菲‚孙心德‚张季平‚双耳条件下超前声对人分辨滞后声强度的影响‚生物化学与生物物理进展‚2011‚38(2):142-150。

40. 孙海艳‚孙心德‚张季平‚大鼠初级听皮层神经元对声音空间信息的编码‚生物化学与生物物理进展‚2009‚ 36(8): 1041~1048

41. 张墨‚孙心德‚张季平‚背景噪声对人感知声音时间信息的影响‚生物物理学报‚2008‚24(3):203-210..

42.  韩琳琳‚杨文伟‚张皓‚张季平‚孙心德‚小鼠听皮层对下丘神经元方位敏感性的调控‚生物物理学报‚ 2008‚24（1）：6-14.

43. Yang W.W.‚ Zhou X.M.‚ Zhang J.P.‚ SUN X.D.  Modulation of frequency receptive field plasticity in rat auditory cortical neurons by electrical stimulation of medial prefrontal cortex‚Acta Physiologica Sinica‚ 2007‚ 59 (6): 784-790 .

44.   高菲‚蒲青‚陈良‚李相尧‚ 孙心德‚张季平‚ 大鼠胎儿期噪声暴露对成年后听觉目标探索行为的影响。动物学杂志‚ 2007‚42(5): 20-26.

45.   张季平‚孙心德‚  脑对双耳听觉信息整合的神经机制‚ 华东师范大学学报自然科学版‚(特约综述)‚ 2007‚ (6):1-11‚36.

46.   谭江秀‚王放‚杨文伟‚张季平‚孙心德‚大鼠生后发育过程中听皮层神经元特征频率的可塑性‚生物化学与生物物理进展‚2007‚34(4)：431-438.

47   李相尧‚李玲‚张季平‚孙心德‚大鼠听-视整合的行为学表征‚第二军医大学学报‚ 2007 28(5): 480-483.

48.   王放‚杨文伟‚谭江秀‚彭垠婷‚张季平‚孙心德‚ 经验改变大鼠听皮层神经元的特征频率生物化学与生物物理进展‚2006‚ 33(8):754-759.

49   俞黎平‚王晓艳‚李相尧‚张季平‚孙心德‚ 大鼠皮层听-视多感觉神经元和听-视信息整合‚ 生物化学与生物物理进展‚2006‚ 33(7):677-684.

50   王晓艳‚俞黎平‚李相尧‚张季平‚孙心德‚幼年大鼠皮层听-视多感觉神经元和听-视信息整合‚动物学杂志‚2006‚ 41(4):33-40.

51.  吴秀梅‚张凌‚ 许兢宏‚ 徐凤‚ 杨文伟‚ 张季平‚ 孙心德‚ 生后早期听觉剥夺、经验改变大鼠听皮层NMDA受体NR2B蛋白表达‚生物化学与生物物理进展‚2006‚ 33(10):1-5.

52.   张季平‚ Jen P.H.-S.‚孙心德‚ 大棕蝠下丘听神经元频率调谐的方向敏感性‚生物物理学报‚2000‚16(1):81-88.

53.   张季平‚孙心德‚詹喜平‚杨弘彦‚电刺激大马蹄蝠听皮层对下丘神经元听觉敏感性的影响‚生物物理学报‚1999‚15(1): 98-103.

54.  詹喜平‚张季平‚孙心德‚声诱导鼠耳蝠脑干听觉神经系统Fos的表达‚中国神经科学杂志‚1999‚15(3):181-185.

参与编写的专著：

编写《听觉科学概论》的第十章“外侧丘系和听觉中脑下丘”与第十七章“声源定位”‚2005年由中国科技出版社出版。主编：王坚；副主编：蒋涛‚曾凡钢。

获得2014年度教育部自然科学二等奖（排名第二）、2018年度上海市自然科学三等奖（排名第三）。

  主讲的《神经生物学》（双语）课程入选国家双语教学示范课程。

入选2005年度上海市曙光学者、2006年度上海市科委浦江人才计划、 2007年度教育部新世纪优秀人才支持计划。