叶希韵

上海细胞生物学会理事，上海市普陀区营养学会副理事长

主要研究方向：

（1）皮肤细胞的损伤与修复；

（2）皮肤抗衰、防皱、防晒、美白化妆品的研发；

（3）促毛发生长药物筛选及机制研究；

（4）影响黑色素生成的天然活性成分筛选与机制研究。

开授课程：

（1）细胞工程

（2）现代生物学大实验

（3）普通生物学（细胞部分）

近几年主持和参与的主要科研项目：

（1）主持国家自然科学基金委面上项目：Gpr48在皮肤鳞状细胞癌发生中的功能及机制；项目编号：81272226；立项部门：国家自然科学基金委

（2）主持上海市科委基础重点项目：Gpr48/Lgr4在皮肤癌发病中的作用及机制研究；项目编号：13JC1405102；立项部门：上海市科委

（3）参与科技部973项目：孤儿GPCR在发育和正常生理功能中的作用；项目编号：44201472；立项部门：科技部

（4）参与科技部973项目：干细胞向生殖细胞诱导分化的调控机理及应用性研究；项目编号：44201133；立项部门：科技部 

（5）主持企业研发项目：可用于化妆品的生发防脱活性成分及组方开发；项目编号：11300-412312-18129；立项单位：莱博药妆技术（上海）股份有限公司；

（6）主持企业研发项目：可用于化妆品的乌发活性成分及组方开发；项目编号：11300-412312-18190；立项单位：莱博药妆技术（上海）股份有限公司

科研成果：

主持研究的科研项目转化为产品2个：沙棘血脂康片；山楂生物饮料“开胃香”。

参与研发的产品有：金嗓子喉宝、康丽娜抗衰美容化妆品、怡心饮料、王氏悦心茶等。

主持国家、上海市、企业等科研项目30余项，参与科技部973项目2项，发表国内外学术论文60余篇。

授权专利：

1. 中药单体及其组合物在防晒美白抗衰老化妆品中的应用。发明人：叶希韵；周艳卿；*****。专利号：CN201611169734.8。

2.氮-(4-氯-2,5-二甲氧基苯基)-5-异丙基-2-甲氧基苯磺酰胺在促进毛发生长的应用，发明人：叶希韵；任小林；张叶；刘连喜。专利号：CN201410545572.8。

3.一种芳香基噻唑类化合物及其类似物、用途及其制备方法，发明人：陈益华；叶希韵；*****；李国亮；何云东；周文波。专利号：ZL201110415182.5

近几年主要发表的论文（﹡为通讯作者）：

1. Xiaolin Ren, Weili Xia, Peng Xu, Hongyang Shen, Xing Dai, Mingyao Liu, Yuling Shi,Xiyun Ye*, Yongyan Dang. Lgr4 deletion delays the hair cycle and inhibits the activation of hair follicle stem cells. Journal of Investigative Dermatology, 2020, 140(9):1706-1712.

2. Wu J,Li X,Li D,Ren X,Li Y,Herter EK,Qian M,Toma MA,Wintler AM,Sérézal IG,Rollman O,Ståhle M,Wikstrom JD, Ye X*,Landén NX. MicroRNA-34 Family Enhances Wound Inflammation by Targeting LGR4. Journal of Investigative Dermatology, 2020, 140(2):465-476.

3. Ting Fu,Bowen Chai,Yuling Shi,Yongyan Dang,Xiyun Ye*. Fargesin inhibits melanin synthesis in murine malignant and immortalized melanocytes by regulating PKACREB and P38MAPK signaling pathways. Journal of Dermatological Science, 2019,94:213–219.

4. Qin Y, Qin X, Xu P, Zhi Y, Xia W, Dang Y, Gu J, Ye X*. Potential role of S100A8 in skin rejuvenation with the 1064-nm Q-switched Nd:YAG laser. Lasers Med Sci 2018; 33(3):581-588. 

5. Peng Xu, Yongyan Dang, Luyang Wang, Xia Liu, Xiaolin Ren, Jun Gu, Mingyao Liu, Xing Dai, Xiyun Ye*. Lgr4 is crucial for skin carcinogenesis by regulating MEK/ ERK and Wnt/β-catenin signaling pathways. Cancer Letters, 2016, 383: 161-170.

6. Xiaolin Ren, Yuling Shi, Di Zhao, Mengyu Xu, Xiaolong Li, Yongyan Dang, Xiyun Ye*.Naringin protects ultraviolet B-induced skin damage by regulating p38 MAPK signal pathway. Journal of Dermatological Science,2016, 82(2):106–114.

7. Xiaolin Ren, Minggai Ge, Xiaofeng Qin, Peng Xu, Pingya Zhu, Yongyan Dang, Jun Gu, Xiyun Ye*. S100a8/NF-κB signal pathway is involved in the 800-nm diode laser-induced skin collagen remodeling. Lasers in Medical Science，2016, 31:673–678.

8. Pingya Zhu, Weihan Yin, Mengran Wang, Yongyan Dang,Xiyun Ye*. Andrographolide suppresses melanin synthesis through Akt/GSK3β/β-catenin signal pathway.Journal of Dermatological Science, 2015, 79:74-83.

9. Yimiao Zhai, Yongyan Dang, Wenke Gao, Ye Zhang, Peng Xu, Jun Gu andXiyun Ye*.P38 and JNK signal pathways are involved in the regulation of phlorizin against UVB-induced skin damage. Experimental Dermatology，2015,24(4):275-279.

10. Di Zhao, Yuling Shi, Yongyan Dang, Yimiao Zhai,Xiyun Ye*. Daidzein stimulates collagen synthesis by activating the TGF-β/smad signal pathway. Australasian Journal of Dermatology, 2015,56,e7–e14.

11. Yongyan Dang, Bei Liu, Peng Xu, Pingya Zhu, Yimiao Zhai, Mingyao Liu,Xiyun Ye*. Gpr48 Deficiency Induces Polycystic Kidney Lesions and Renal Fibrosis in Mice by Activating Wnt Signal Pathway. PLoS ONE, 2014, 9(3): e89835-89844.

12. Guoliang Li, Yundong He, Wenbo Zhou, Peng Wang, Yong Zhang, Weiguang Tong, Haigang Wu, Mingyao Liu,Xiyun Ye*, and Yihua Chen. Identification, synthesis and photo-protection evaluation of aryl thiazole derivatives as a novel series of sunscreens. HETEROCYCLES, 2014, 89(2): 453-464.

13. Xiaoyun C heng, Wenke G ao, Yongyan Dang, Xia Liu, Yujuan Li, Xu Peng,Xiyun Ye*. Both ERK/MAPK and TGF-Beta/Smad Signaling Pathways Play a Role i n the Kidney Fibrosis of Diabetic Mice Accelerated by Blood Glucose Fluctuation. Journal of Diabetes Research, 2013:1-8.

14.  X. Ye*, X. Cheng, L. Liu, D. Zhao and Y. Dang. Blood glucosefluctuation affects skin collagen metabolism in the diabetic mouse by inhibiting the mitogen-activated protein kinase and Smad pathways. Clinical and Experimental Dermatology, 2013, 38(5):530–537.

15. YD. He, YT. Liu, QX. Lin, J. Zhu, Y. Zhang, LY. Wang, X L. Ren,XY.Ye﹡. Polydatin suppresses ultraviolet B-induced cycooxygenase-2 expression in vitro and in vivo via reduced production of reactive oxygen species. British Journal of Dermatology, 2012, 167: 941-944.

16. Xiyun Ye*,LuyangWang, Yongyan Dang, Bei Liu,DiZhao. Investigation of the 1064nm Q-Switched Nd:YAG Laser on Collagen Expression in an Animal Model.Photomedicine and laser surgery, 2012, 30(10):604-609.

17. Zhao C,Wang Y,Su Y,Zhang H,Ding L,Yan X,Zhao D,Shao N,Ye X*,Cheng Y. Inclusion complexes of isoflavones with two commercially available dendrimers: solubility, stability, structures, release behaviors, and biocompatibility. International Journal of Pharmaceutics，2011，15; 421(2):301-309.

18. Yongyan Dang, Bei Liu, Lianxi Liu ,Xiyun Ye*, Xinling Bi, Yong Zhang, Jun Gu. The 800-nm diode laser irradiation induces skin collagen synthesis by stimulating TGF-β/Smad signaling pathway，Lasers in Medical Science，2011，26（6）：837-843.

19. Yujing Weng，Yongyan Dang,Xiyun Ye*, Ning Liu, Zaichao Zhang, Qiushi Ren. Investigation of several non-ablative lasers irradiation on primary cultured skin fibroblasts,Clinical and Experimental Dermatology, 2011，36（6）：655-660.

20. Yongyan Dang，Xiyun Ye *，Yujing Weng，Zhi Tong，Qiushi Ren. Effects of the 532 nm and 1064 nm Q-switched Nd:YAG lasers on collagen turnover of cultured human skinfibroblasts : A comparative study. LasersMedical Science, 2010, 25:719-726.

21. XiyunYe *, Zhi Tong, Yongyan Dang, Qian Tu, Yujing Weng, Jiang Liu, Zaichao Zhang. Effects of blood glucose fluctuation on skin biophysical properties, structure and antioxidant status in an animal model. Clinical and Experimental Dermatology, 2010, 35(1):78-82.

22. 叶希韵 *. 紫外线致皮肤光老化研究进展. 生物学教学，2015, 40（11）：2-5.

23. 叶希韵 *，朱萍亚. 黑色素的合成与美白产品的研究进展. 华东师范大学学报（自然科学版），2016, 2016（2）：1-8.

24. 叶希韵 *,涂皘,童智,翁宇静,王耀发.葡萄糖浓度波动损伤牛血管内皮细胞的机制.中华心血管杂志, 2010, 38(3): 264-267.

25. 党永岩,叶希韵 *,申杰.葡萄糖浓度波动对人肝L02细胞损伤的实验研究.华东师范大学学报(自然科学版), 2010, 150(5): 142-148.

26.张再超,叶希韵 *,徐敏华,王耀发.葛根黄酮降血糖防治糖尿病并发症的实验研究.华东师范大学学报(自然科学版), 2010, 150(2): 77-81.

出版著作：

1. 编著出版科普图书一本：《细胞——生命活动的摇篮》，获上海科普创作出版专项资金资助，国家“十五”规划重点图书，由少年儿童出版社2006.1出版。该套科普图书获第15届上海市中小学幼儿园优秀图书评选二等奖；2006年上海市优秀科普作品（书籍）；2006科学文化与科学普及优秀图书年度推荐活动中活动丛书奖；第四届吴大猷科学普及著作奖创作类金签奖。

2. 参编《细胞生物学实验》教材一本，2011年高教出版社出版。