尹剑丽

2013.9-2019.6   华东师范大学  生物化学与分子生物学专业（博士）    

2009.9-2013.6   绍兴文理学院  科学教育专业（本科）

2019.7-2020.7     复星医药上海精缮生物科技有限公司   研发科学家

2020.8-2024.12   华东师范大学生物学流动站   博士后

2025.1-至今         华东师范大学生命科学学院  副研究员

聚焦于前沿合成生物学技术，致力于真核生物遗传控制学工具的开发与应用。核心研究通过对酵母及哺乳动物细胞进行基因线路的理性设计与重构，实现对细胞行为的精准编程，使其能够智能感知并响应外源指令或内部的生理病理信号（如代谢异常、肿瘤微环境）。研究最终目标是将这些前沿工具转化为实际应用，具体包括：构建基于酵母模型的代谢疾病动态干预平台，以及开发用于癌症精准治疗的下一代智能溶瘤病毒等新型疗法。

1. 临床药物麝香酮调控基因回路的设计、构建及其用于非酒精性脂肪性肝炎的基因治疗研究 【国家自然青年科学基金项目】30万元，主持，在研

2. 代谢标志物高性能合成生物荧光传感系统创建与应用 【“合成生物学”重点专项2024年度项目】90万元，研发骨干，在研

3. 哺乳动物细胞的大规模基因线路设计技术 【国家重点研发项目】，150万元，研发骨干

1. Jianli Yin,  Xiaoding Ma, Lingfeng Hu,  and Haifeng Ye. Translating synthetic gene circuits  into the clinic: Challenges, opportunities,  and future directions. Cell Systems, 2025. 16(12): p. 101425.

2. Yang Zhou†, Yu Wei†, Jianli Yin†et. al. A rapid and efficient red-light-activated Cre recombinase system for genome engineering in mammalian cells and transgenic mice. Nucleic Acids Res, 2025. 53(15).

3. Jianli Yin^†, Hang Wan^†, Deqiang Kong, Xingwan Liu, Ying Guan, Jiali Wu, Yang Zhou, Xiaoding Ma, Chunbo Lou, Haifeng Ye and Ningzi Guan. A digital CRISPR/dCas9-based gene remodeling biocomputer programmed by dietary compounds in mammals. Cell Systems, 2024. 15(10): 941-955. 

4. Jianli Yin, Linfeng Yang, Lisha Mou, Kaili Dong, Jian Jiang, Shuai Xue, Ying Xu, Xinyi Wang, Ying Lu, Haifeng Ye. A green tea-triggered genetic control system for treating diabetes in mice and monkeys. Science Translational Medicine, 2019 Oct 23;11(515):eaav8826.  封面文章

5. Xiaoding Ma^†, Jianli Yin^†, Longliang Qiao Hang Wan Xingwan Liu, Yang Zhou, Jiali Wu, Lingxue Niu, Min Wu, Xinyi Wang, and Haifeng Ye. A programmable targeted protein degradation platform for versatile applications in mammalian cells and mice. Molecular Cell, 2024. 84(8): 1585-1600 

6. Linfeng Yang, Jianli Yin, Jiali Wu, Longliang Qiao, Evan M. Zhao, Fengfeng Cai, Haifeng Ye. Engineering genetic devices for in vivo control of therapeutic T cell activity triggered by the dietary molecule resveratrol. Proceedings of the National Academy of Sciences, 2021. 118(34) 

7. Shuai Xue, Jianli Yin, Jiawei Shao, Yuanhuan Yu, Linfeng Yang, Yidan Wang, Mingqi Xie, Martin Fussenegger, Haifeng Ye. A synthetic-biology-inspired therapeutic strategy for targeting and treating hepatogenous diabetes. Molecular Therapy, 2017 Feb 1;25(2):443-455.

8. Xin Wu, Yuanhuan Yu, Meiyan Wang, Di Dai, Jianli Yin, Wenjing Liu, Deqiang Kong, Shasha Tang, Meiyao Meng, Tian Gao, Yuanjin Zhang, Yang Zhou, Ningzi Guan, Shangang Zhao & Haifeng Ye. AAV-delivered muscone-induced transgene system for treating chronic diseases in mice via inhalation. Nature Communication, 2024. 15(1): 1122. 

9. Deqiang Kong, Yang Zhou, Yu Wei, Xinyi Wang, Qin Huang, Xianyun Gao, Hang Wan, Mengyao Liu, Liping Kang, Guiling Yu, Jianli Yin, Ningzi Guan & Haifeng Ye. Exploring plant-derived phytochrome chaperone proteins for light-switchable transcriptional regulation in mammals. Nature Communication, 2024. 15(1): 4894.

10. Xinyi Wang, Kaili Dong, Deqiang Kong, Yang Zhou, Jianli Yin, Fengfeng Cai, Meiyan Wang, Haifeng Ye. A far-red light-inducible CRISPR-Cas12a platform for remote-controlled genome editing and gene activation. Science Advances, 2021. 7(50): eabh2358. 

11. Guiling Yu, Mingliang Zhang, Ling Gao, Yang Zhou, Longliang Qiao, Jianli Yin, Yiwen Wang, Jian Zhou, Haifeng Ye. Far-red light-activated human islet-like designer cells enable sustained fine-tuned secretion of insulin for glucose control in T1D mice. Molecular therapy: the journal of the American Society of Gene Therapy, 2022. 30(1): 341-354.

12. Haifeng Ye^†, Mingqi Xie^†, Shuai Xue, Ghislaine Charpin-El Hamri, Jianli Yin, Henryk Zulewski, Martin Fussenegger. Self-adjusting synthetic gene circuit for correcting insulin resistance. Nature Biomedical Engineering, 2017 (0005) 

13. Jiawei Shao, Shuai Xue, Guiling Yu, Yuanhuan Yu, Xueping Yang, Yu Bai, Sucheng Zhu, Linfeng Yang, Jianli Yin, Yidan Wang, Shuyong Liao, Sanwei Guo, Mingqi Xie, Martin Fussenegger, Haifeng Ye. Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice. Science Translational Medicine, 2017 Apr 26; 9 (387)