叶进

2011/9-2015/6，东北农业大学，生命科学学院，本科

2015/9-2020/7，中国科学技术大学，生命科学学院，硕博连读

2020/8-2021/8，中国科学技术大学，生命科学与医学部，博士后

2021/9-2024/6，圣路易斯华盛顿大学，医学院，博士后

2024/7-2025/9，圣路易斯华盛顿大学，医学院，讲师（Instructor)

2025/10-至今，华东师范大学，生命科学学院，青年研究员，博士生导师

叶进，华东师范大学生命科学学院，青年研究员，博士生导师，华东师范大学紫江优秀青年学者。主要研究方向为：神经递质的突触囊泡转运机理及囊泡神经递质转运体的药理学研究。已取得的研究成果包括：1）揭示囊泡单胺类神经递质转运体的工作理及药理学特性；2）揭示GABARAP调控GABAA受体的转运及细胞膜动态分布，进而影响抑制性突触信号转导和突触可塑性的功能分子机制；3）揭示神经支架蛋白Ankyrin-G/Ndel1复合物在神经轴突起始段处维持神经细胞极性的生理功能。入选国家海外高层次人才青年项目，上海市海外高层次人才青年项目。

1）突触囊泡神经递质转运体的工作机理及药理学研究。

2）神经系统中新型磷脂通道和磷脂受体的鉴定及其功能的研究。

1. 国家海外高层次人才青年项目，主持，2026/01-2028/12。

2. 华东师范大学双百人才计划，主持，2025/10-2032/01。

3. 国家自然科学基金青年项目，主持，结题。

1. Jin Ye, Huaping Chen, Aaron Ammerman, Yi Wang, Kaituo Wang, Jinbin Xu*, Bin Liu*, Weikai Li*.  Molecular basis of vesicular monoamine transport and neurological drug interactions. Cell reports. 2025. 44(11):116490.

2. Jin Ye, Huaping Chen, Kaituo Wang, Yi Wang, Aaron Ammerman, Samjhana Awasthi, Jinbin Xu, Bin Liu*, Weikai Li*.  Structural insights into vesicular monoamine storage and drug interactions. Nature. 2024. 629, 235–243.

3. Jin Ye^#, Guichang Zou^#, Ruichi Zhu, Chao Kong, Chenjian Miao, Mingjie Zhang, Jianchao Li*, Wei Xiong*, and Chao Wang*. Structural basis of GABARAP-mediated GABA_A receptor trafficking and functions on GABAergic synaptic transmission. Nat Commun. 2021. 12:297.

4. Jin Ye^#, Jianchao Li^#, Fei Ye, Yan Zhang, Mingjie Zhang, and Chao Wang^*. Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance. PNAS. 2020. 117(2):1207-1215.

5. Yanshen Zhang#, Zhiwen Zhong#, Jin Ye*, and Chao Wang*. Crystal structure of the PDZ4 domain of MAGI2 in complex with PBM of ARMS reveals a canonical PDZ recognition mode. Neurochem Int. 2021, 149:105152.

6. Qingyang Zhang, Juan Zhang, Jin Ye, Xiaohui Li, Hongda Liu, Xiaolin Ma, Chao Wang, Keqiang He, Wei Zhang, Ji Yuan, Yingjun Zhao, Huaxi Xu*, Qiang Liu*. Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing. Mol Neurodegener. 2021, 16(1):66.

7. Jia Zhou#, Qinli Hu#, Xinlong Xiao, Deqiang Yao, Shenghong Ge, Jin Ye, Haojie Li, Rujie Cai, Renyang Liu, Fangang Meng, Chao Wang, Jian-Kang Zhu, Mingguang Lei*, Weiman Xing*. Mechanism of phosphate sensing and signaling revealed by rice SPX1-PHR2 complex structure. Nat Commun. 2021, 12(1):7040

8. Yi Huang, Huanyu Wang, Yize Hao, Hualong Lin, Menghao Dong, Jin Ye, Lei Song, Yunzhi Wang, Qingqing Li, Benjie Shan, Yizhou Jiang, Hongqi Li, Zhiming Shao, Guido Kroemer, Huafeng Zhang, Li Bai, Tengchuan Jin, Chao Wang, Yuting Ma, Yongping Cai, Chen Ding, Suling Liu^*, Yueyin Pan^*, Wei Jiang^* and Rongbin Zhou^*. Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Nat Cell Biol. 2020. 22(6):716-727.

9. Hongbin He^#, Hua Jiang^#, Yun Chen^#, Jin Ye, Aoli Wang,Chao Wang, Qingsong Liu, Gaolin Liang, Xianming Deng*, Wei Jiang*, and Rongbin Zhou*. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun. 2018. 9(1):2550.

10. Wengen Zhu^#, Cen Wang^#, Jinzhu Hu^#, Rong Wan, Jianhua Yu, Jinyan Xie, Jianyong Ma, Linjuan Guo, Jin Ge, Yumin Qiu, Leifeng Chen, Huarong Liu, Xia Yan, Xiuxia Liu, Jin Ye, Wenfeng He, Yang Shen, Chao Wang, Peter Mohler^*, and Kui Hong^*. Ankyrin-B Q1283H variant linked to arrhythmias via loss of local protein phosphatase 2A activity causes ryanodine receptor hyperphosphorylation. Circulation. 2018. 138(23):2682-2697.

11. Hua Jiang^#, Hongbin He^#, Yun Chen^#, Wei Huang, Jinbo Cheng, Jin Ye, Aoli Wang, Jinhui Tao, Chao Wang, Qingsong Liu, Tengchuan Jin, Wei Jiang*, Xianming Deng*, Rongbin Zhou*. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 2017. 214(11):3219-3238.

2025，上海市海外高层次人才青年项目。