韦秀梅

2005年9月-2010年7月：中国海洋大学，水生生物学博士

2001年9月-2005年7月：中国海洋大学，水产养殖学学士

2021年9月-至今：华东师范大学生命科学学院，副教授

2017年7月-2021年9月：华东师范大学生命科学学院，专任副研究员

2014年12月-2017年6月：山东省海洋资源与环境研究院，副研究员

2010年10月-2014年12月：山东省海洋资源与环境研究院，助理研究员

  致力于水产动物比较免疫学的研究工作。以刺参、贝类和鱼类等水产动物为对象，揭示了不同进化地位动物的免疫识别、信号转导、免疫应答等过程的调控机制，研究成果对于了解免疫系统进化、指导水产动物病害防控具有重要意义。主持国家自然科学基金2项，授权发明专利8项；发表SCI论文30余篇，获得山东省渔业科学技术二等奖1项。

鱼类适应性免疫

细胞生物学

细胞生物学实验

动物学前沿与科学思维

国家自然科学基金面上项目，MAPK/ERK通路调控尼罗罗非鱼T细胞免疫的分子机制，2020年1月-2023年12月，在研

国家自然科学基金青年项目，短蛸清道夫受体的多样性及其介导的免疫防御机制研究，2014年1月-2016年12月，结题

上海市自然科学基金，Ca²⁺-AMPK通路通过代谢重编程调控尼罗罗非鱼T细胞免疫的机制，2020年7月-2023年6月，在研

山东省自然科学基金，短蛸C型凝集素的多样性及其免疫防御机制研究，2013年10月-2016年10月，结题

  以第一或通讯作者在The FASEB Journal、The Journal of Immunology、Journal of Biological Chemistry、Frontiers in Immunology、Developmental and Comparative Immunology等期刊发表SCI论文20余篇。

1. Kunming Li, Jiahua Zhu, Kang Li, Wei Liang, Jiansong Zhang, Qian Zhang, Xinying Jiao, Xiaodan Wang, Xiumei Wei*, Jialong Yang*. High-fat diet blunts T-cell responsiveness in Nile tilapia. Developmental and Comparative Immunology. 2022,135:104495. doi: 10.1016/j.dci.2022.104495.

2. Wei Liang, Kunming Li, Qian Zhang, Kang Li, Kete Ai, Jiansong Zhang, Xinying Jiao, Jiaqi Li, Xiumei Wei*, Jialong Yang. Interleukin-2 inducible T cell kinase (ITK) may participate in the anti-bacterial immune response of Nile tilapia via regulating T-cell activation. Fish & Shellfish Immunology. 2022,127:419-426.

3. Xiumei Wei, Cheng Li, Yu Zhang, Kang Li, Jiaqi Li, Kete Ai, Kunming Li, Jiansong Zhang, Jialong Yang*. Fish NF-κB couples TCR and IL-17 signals to regulate ancestral T-cell immune response against bacterial infection. FASEB J. 2021,4,35(4):e21457.

4. Jiaqi Li, Wei Liang, Kang Li, Xinying Jiao, Kete Ai,Yu Zhang, Xiumei Wei*, JialongYang*. ZAP70 activation is an early event of T cell immunity that involved in the anti-bacterial adaptive immune response of Nile tilapia. Developmental and Comparative Immunology. 2021,124:104177.

5. Kete Ai , Jie Yan , Kang Li, Cheng Li, Yu Zhang, Wei Liang, Jiaqi Li, Xiumei Wei*, Jialong Yang*. Akt1/mTORC1 signaling modulates adaptive immune response of Nile tilapia by promoting lymphocyte activation and proliferation.Developmental and Comparative Immunology. 2021,104042.

6. Yu Zhang, Kang Li, Cheng Li, Wei Lian, Kunming Li, Jiaqi Li, Xiumei Wei*, Jialong Yang*. An atypical KLRG1 in Nile tilapia involves in adaptive immunity as a potential marker for activated T lymphocytes. Fish & Shellfish Immunology. 2021,113.51-60.

7. Xiumei Wei, Huiying Li, Yu Zhang, Cheng Li, Kang Li, Kete Ai, Jialong Yang*. Ca²⁺-Calcineurin Axis-Controlled NFAT Nuclear Translocation Is Crucial for Optimal T Cell Immuniy in an Early Vertebrate. The Journal of Immunology.2020,2.204 (3),569-585.

8. Xiumei Wei, Yu Zhang, Cheng Li, Kete Ai, Kang Li, Huiying Li, Jialong Yang*. The evolutionarily conserved MAPK/Erk signaling promotes ancestral T-cell immunity in fish via c-Myc-mediated glycolysis. Journal of Biological Chemistry.2020,3.295(10):3000-3016.

9. Cheng Li, Junkun Yu, Kete Ai, Huiying Li, Yu Zhang, Tianyu Zhao, Xiumei Wei*, Jialong Yang*. IκBα phosphorylation and associated NF-κB activation are essential events in lymphocyte activation, proliferation, and anti-bacterial adaptive immune response of Nile tilapia. Developmental and Comparative Immunology. 2020,2.103:103526.

10. Kunming Li,Xiaotong Shen, Hong Qiu, Tianyu Zhao, Kete Ai, ChengLi, Yu Zhang, Kang Li, Ming Duan*, Xiumei Wei*, Jialong Yang. S6K1/S6 axis-regulated lymphocyte activation is important for adaptive immune response of Nile tilapia.  Fish & Shellfish Immunology. 2020,106:1120-1130.

11. Xiumei Wei, Kete Ai, Huiying Li, Yu Zhang, Kang Li, Jialong Yang*. Ancestral T Cells in Fish Require mTORC1-Coupled Immune Signals and Metabolic Programming for Proper Activation and Function.The Journal of Immunology. 2019,9.203(5),1172-1188.

12. Kang Li, Xiumei Wei*, Libin Zhang, Heng Chi, Jialong Yang*. Raptor/mTORC1 Acts as a Modulatory Center to Regulate Anti-bacterial Immune Response in Rockfish. Frontiers in Immunology. 2019,12.10:2953.

13. Huiying Li, Xiumei Wei*,Jialong Yang*, Ranan Zhang, Qin Zhang, Jianmin Yang. The bacteriolytic mechanism of an invertebrate-type lysozyme from mollusk Octopus ocellatus. Fish & Shellfish Immunology. 2019,10. 93:232-239.

14. Xiumei Wei, Tianyu Zhao, Yu Zhang, Kete Ai, Huiying Li, Jialong Yang*. Involvement of H-Ras in the adaptive immunity of Nile tilapia by regulating lymphocyte activation. Fish & Shellfish Immunology.2019,6. 89:281-289.

15. Xiumei Wei, Tianyu Zhao, Kete Ai, Yu Zhang, Huiying Li,Jialong Yang*. c-Raf participates in adaptive immune responseof Nile tilapia via regulating lymphocyte activation. Fish & Shellfish Immunology.2019,3.86:507-515.

16. Tianyu Zhao, Xiumei Wei*, Jialong Yang, Sheng Wang, Yu Zhang. Galactoside-binding lectin in Solen grandis as a pattern recognition receptor mediating opsonization. Fish & Shellfish Immunology. 2018,11.82:183-189.

17. Xiumei Wei, Tianyu Zhao, Kete Ai, Huiying Li, Xu Jiang, Cheng Li, Qianqian Wang,Jianmin Yang, Ranran Zhang, Jialong Yang*. Role of scavenger receptor from Octopus ocellatus as a co-receptor of Toll-like receptor ininitiation of TLR-NF-κB signaling during anti-bacterial response. Developmental and Comparative Immunology. 2018,7.84:14-27

18. Xiumei Wei, Dinglong Yang, Huiying Li, Tianyu Zhao, Hailin Jiang, XiangquanLiu, Jialong Yang*. Peptidoglycan recognition protein of Solen grandis (SgPGRP-S1) mediates immune recognition and bacteria clearance. Fish & Shellfish Immunology. 2018,2.73:30-36.

19. Xiumei Wei, Dinglong Yang, Huiying Li, Hailin Jiang, Xiangquan Liu, Qin Zhang*, Jialong Yang*. Sialic acid-binding lectins (SABLs) from Solen grandis function as PRRs ensuring immune recognition and bacterial clearance. Fish & Shellfish Immunology. 2018,1.72:477-483.

20. Xiumei Wei, Xianquan Liu, Jianmin Yang, Sheng Wang, Guohua Sun, Jialong Yang*. Critical roles of sea cucumber C-type lectin in non-self recognition and bacterial clearance. Fish & Shellfish Immunology. 2015,8.32:312-140.

21. Xiumei Wei, Jie Xu, Jianmin Yang, Xiangquan Liu, Ranran Zhang, Weijun Wang, Jialong Yang*. Involvement of a Serpin serine protease inhibitor (OoSerpin) from mollusc Octopus ocellatus in antibacterial response. Fish & Shellfish Immunology. 2015,32:312-140. 

22. Dinglong Yang, Xiumei Wei*, Jianmin Yang, Jialong Yang, Jie Xu, Jinghui Fang, Sheng Wang, Xiangquan Liu*. Identification of a LPS-induced TNF-α factor (LITAF) from mollusk Solen grandis and its expression pattern towards PAMPs stimulation. Fish & Shellfish Immunology. 2013,10.35(4):1325-8.

23. Xiumei Wei, Jialong Yang*, Jianmin Yang, Xiangquan Liu*, Meijun Liu, Dinglong Yang, Jie Xu, Xiaoke Hu. A four-domain Kunitz-type proteinase inhibitor from Solen grandis is implicated in immune response. Fish & Shellfish Immunology. 2012,12.33(6):1276-84.

24. Xiumei Wei, JianminYang, Xianguan Liu*, Dinglong Yang, Jie Xu, Jinghui Fang, Weijun Wang, Jialong Yang*. Identification and transcriptional analysis of two types of lectins (SgCTL-1 and SgGal-1) from mollusk Solen grandis. Fish & Shellfish Immunology. 2012,8.33(2):204-212.

25. Jialong Yang *, Xiumei Wei*, Xiangquan Liu, Jie Xu, Dinglong Yang, Jianmin Yang, Jinghui Fang, Xiaoke Hu. Cloning and transcriptional analysis of two sialic acid-binding lectins (SABLs) from razor clam Solen grandis. Fish & Shellfish Immunology.2012,32(4):578-585.

26. Xiumei Wei, Jianmin Yang, Dinglong Yang, Jie Xu, Xiangquan Liu*, Jialong Yang*, Jinghui Fang, Hongjin Qiao. Molecular cloning and mRNA expression of two peptidoglycan recognition protein (PGRP) genes from mollusk Solen grandis. Fish & Shellfish Immunology. 2012,1.32(1):178-185.

27. Xiume Wei, Liu Xiangquan, Jianmin Yang, Jinghui Fang, Hongjin Qiao, Ying Zhang, JialongYang*. Two C-type lectins from shrimp Litopenaeus vannamei that might be involved in immune response against bacteria and virus. Fish & Shellfish Immunology. 2012,1.32(1):132-140.

28. KangLi, HongQiu, JieYan, Xiaotong Shen, XiumeiWei, MingDuan*,JialongYang*. The involvement of TNF-α and TNF-β as proinflammatory cytokines in lymphocyte-mediated adaptive immunity of Nile tilapia by initiating apoptosis. Developmental and Comparative Immunology. 2021,115.103884.

29. Jialong Yang*, Xiumei Wei, Jie Xu, Dinglong Yang, Xiangquan Liu, Jianmin Yang, Jinghui Fang, Xiaoke Hu. A sigma-class glutathione S-transferase from Solen grandis that responded to microorganism glycan and organic contaminants. Fish & Shellfish Immunology. 2012,32(6):1198-204.

30. Jialong Yang, Limei Qiu, Xiumei Wei, Leilei Wang, Lingling Wang, Zhi Zhou, Huan Zhang, Lin Liu, Linsheng Song*. An ancient C-type lectin in Chlamys farreri (CfLec-2) that mediate pathogen recognition and cellular adhesion. Developmental and Comparative Immunology. 2010,34(12):1274-82.

31. Jialong Yang, Wan Wang, Xiumei Wei, Limei Qiu*, Lingling Wang, Huan Zhang, Linsheng Song*. Peptidoglycan recognition protein of Chlamys farreri (CfPGRP-S1) mediates immune defenses against bacterial infection. Developmental and Comparative Immunology. 2010.34(12):1300-7.

32. Jialong Yang, Limei Qiu*, Lingling Wang, Xiumei Wei, Huan Zhang, Ying Zhang, Lin Liu, Linsheng Song*. CfLGBP, a pattern recognition receptor in Chlamys farreri involved in the immune response against various bacteria. Fish & Shellfish Immunology.2010,29(5):825-31.

33. Yingbo Lin, Wenbin Zhan*, Qiang Li, Zhidong Zhang, Xiumei Wei, Xiuzhen Sheng. Ontogenesis of haemocytes in shrimp (Fenneropenaeus chinensis) studied with probes of monoclonal antibody. Developmental and Comparative Immunology. 2007,31(11):1073-81.

34. 韦秀梅,杨顶珑,王圣,姜绪,刘相全*,杨建敏,房景辉. 氯化钾诱导仿刺参(Apostichopus japonicus)幼虫附着变态的研究.海洋与湖沼. 2015,46(2):389-395.

35. 韦秀梅,杨顶珑,杨建敏,杨嘉龙,徐洁,刘相全*,张艳敏.大竹蛏(Soleng grandis)翻译控制肿瘤蛋白(TCTP)基因的分子克隆和表达特征分析.海洋与湖沼,2013,44(3):584-589.

36. 韦秀梅,绳秀珍,唐小千, 邢婧,战文斌*. 兔抗对虾白斑症病毒(WSSV)独特型抗体的制备及其特性分析. 海洋与湖沼.  2010, 41(2):286-292.

37. 刘佳乐,韦秀梅,杨顶珑,童潼,刘相全*. 大竹蛏β-整合素基因SgβInt的特性分析和重组表达.渔业科学进展. 2018,39(1):120-127.

38. 王腾腾,韦秀梅,常城, 韩慧宗,姜海滨*. 一株许氏平鲉(Sebastes schlegelii)肠道乳酸菌的分离鉴定及特性分析. 海洋与湖沼. 2017,48(1):94-100.

39. 姜绪,韦秀梅,冯艳微,韩慧宗,王圣,刘相全*,童潼.莱州湾海域小刀蛏(Cultellus attenuatus)繁殖生物学研究.渔业科学进展. 2017,38(6):107-111.

40. 李根瑞,任利华,孙国华*,杨建敏,韦秀梅,刘兆存,李尚俊,姜汉. 低溶氧胁迫对刺参（Apostichopus japonicus）氧化应激指标的影响. 2016, 37(5): 133-139.

41. 赵海峰,冯艳微*,刘相全*,姜绪,韦秀梅,刘佳乐,江海林.不同卵色皱纹盘鲍(Haliotis discus hannai)幼鲍的生长与免疫比较.渔业科学进展.2016,37(6):110-114.

42. 张冉冉,韦秀梅,杨建敏,王卫军,刘相全*,冯艳微. 短蛸(Octopus ocellatus)酪氨酸蛋白激酶基因的克隆及其mRNA在细菌刺激后的表达规律. 海洋与湖沼. 2015, 46(1): 173-180.

43. 房景辉,刘相全*,赵海峰,王圣,韦秀梅,冯艳微,刘义豪.投喂频率对刺参(Apostichopus japonicus)生长、体成分组成和能量收支的影响.渔业科学进展. 2014,35(5):55-60.

44. 房景辉,韦秀梅,王忠全,刘相全,宋向军,周全利,方建光,姜海滨*. 光照强度对许氏平鲉幼鱼的生长、体组分和能量收支的影响. 中国海洋大学学报（自然科学版）. 2013, 43(9): 47-53.

45. 徐洁,韦秀梅,王卫军,杨建敏*,刘相全,杨顶珑,陈建强. 短蛸（Octopus ocellatus）过氧化物还原酶（OoPrx-4）基因的克隆及其对鳗弧菌胁迫的转录调控分析. 海洋与湖沼. 2013, (2): 342-347.

46. 董根,杨建敏*,王卫军,郑小东,宋向军,冯艳微,韦秀梅,孙国华. 短蛸（Octopus ocellatus）胚胎发育生物学零度和有效积温的研究. 海洋与湖沼. 2013, (2):476-481.

47. 王育红,杨建敏*,张明亮,宋向军,王卫军,孙国华,韦秀梅. 黄河三角洲海参养殖池塘微型浮游植物多样性研究.海洋与湖沼. 2013, (2):415-420.

48. 乔洪金,刘相全*,孙国华, 房景辉,韦秀梅,张滔. 大竹蛏（Solengrandis）cDNA文库中微卫星标记的筛选.  海洋与湖沼. 2012，   43(6): 1128-1133.  

49. 房景辉, 田相利,姜海滨,刘相全,张锡佳,韦秀梅,董双林. 不同循环投喂模式对半滑舌鳎的生长、体成分组成、代谢和能量收支的影响. 水产学报. 2011, 35(7):1090-1097.

黄河三角洲刺参池塘稳产关键技术开发与应用，山东省海洋与渔业科学技术奖，渔业科学技术二等奖，第二完成人，2017年8月15日。

海水工厂化循环水养殖技术，山东省海洋与渔业科学技术奖，渔业技术推广三等奖，第五完成人，2017年8月15日。

鱼类淋巴囊肿病毒单克隆抗体研制及检测诊断技术与流行病学研究，神农中华农业科技奖，三等奖，第九完成人，2009年12月10日。