翁杰敏

1989-1994 Ph.D. in Microbiology and Molecular Genetics, University of Vermont, USA

1984-1987 M.S. in Cell Biology, Shanghai Institute of Cell Biology, Academy of Science

1980-1984 B.S. in Microbiology, Wuhan University (Wuhan, China)

2020. 9-2025.9    Dean of The School of Life Sciences, East China Normal University

2014-2020. 9        Professor and Associate Dean, The School of Life Sciences, East China Normal University

2007-present        Professor and Associate Director, The Institute of Biomedical Sciences, East China Normal University

2003-2007            Associate Professor, Department of Molecular and Cellular Biology, Baylor College of Medicine, USA

1997-2003            Assistant Professor, Department of Molecular and Cellular Biology, Baylor College of Medicine, USA

1994-1997           Postdoctoral Fellow at Lab. of Molecular Embryology, NICHD/NIH.

1987-1989           Research Assistant, Shanghai Institute of Organic Chemistry, Shanghai, China.

翁杰敏博士，华东师范大学生命科学学院特聘教授、博士生导师，上海市调控生物学重点实验室PI，副主任，长期从事表观遗传调控与基因转录调控研究，在DNA甲基化修饰、组蛋白修饰机制与功能、肿瘤表观调控等方面取得系列系统性成果，最近二十年来的研究包括：组蛋白去甲基化酶的鉴定与研究；组蛋白修饰识别蛋白的鉴定与研究；DNA甲基化建立与维持的分子机制研究；胚胎干细胞核心转录因子SOX2的翻译后修饰对其蛋白稳定性的调控机制及在调控干细胞稳态与分化选择中的作用；多个调控食道癌/肺癌SOX2蛋白稳定性和功能及机制的研究，为通过靶向这些通路下降SOX2表达/治疗SOX2高表达食道癌/肺癌提供了理论基础；哺乳动物细胞中催化组蛋白巴豆酰化修饰的关键酶体系鉴定及其在转录调控中的重要作用；糖异生关键酶丙酰化修饰在糖尿病发生发展中的作用与机制；SUMO修饰对细胞整体转录活性的调控作用。已发表论文150余篇（Cell、Nature、Science、Cell Research等），文章引用超24000次，曾荣获2023年度江苏省科学技术二等奖。2014年至今连续入选“中国高被引学者”榜单；主持国家自然科学基金重点项目7项、国家重点研发计划项目（首席科学家）1项。主要学术兼职有中国遗传学会表观遗传分会副主任，中国细胞生物学会染色质生物学分会副主任。

中国遗传学会表观遗传分会副主任

中国细胞生物学会染色质生物学分会主任

Associate Editor of Cell & Bioscience

Associate Editor of Nuclear Receptor

中国生物化学与分子生物学报编委

随着人类基因组测序的完成‚表观遗传学已成为引领生物学发展的重要前沿领域。表观遗传学主要研究细胞在增殖、分化、发育过程中的基因表达谱式建立及其维持的机制‚进而阐明基因表达谱式如何决定和维持细胞的表型特性。由于在增殖、分化、发育过程中基因组序列并不发生变化‚表观遗传学也定义为研究在基因序列不改变的情况下细胞所发生的可以遗传的表型变异机制。我们实验室主要研究：

1. 表观遗传调控机制与肿瘤发生发展

2. 脂酰化修饰及其生物学功能

3. 核心转录因子SOX2在肿瘤发生发展中的调控作用

4. 糖异生关键酶丙酰化修饰在糖尿病发生发展中的作用与机制

表观遗传学

生物化学与分子生物学原理与技术

1. 糖异生关键酶丙酰化修饰在糖尿病发生发展中的作用与机制研究（国家自然科学基金重点项目，32130051）278万元，2022-2026。

2. DNA甲基化修饰在发育分化过程中精准遗传的分子机制及其异常与肿瘤发生发展关系（国家自然科学基金重点项目，32330020）210万元，2024-2028。

3.核心染色质修饰在组织器官发育中的作用机制、功能与干预（科技部重点研发计划项目，2023YFA800400）1900万，2023-2027.

翁杰敏教授近十年发表论文

1. Lan Fang, Jun Zhang, Hui Zhang, Xiaoqin Yang, Xueling Jin, Ling Zhang, David G. Skalnik, Ying Jin, Yong Zhang, Xingxu Huang, Jiwen Li and Jiemin Wong*. (2016) The H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivactor Essential for Generation of Oct4 Positive Inner Cell Mass. Stem Cells. 34(3):565-80

2. Yuanhui Jia, Pishun Li, Lan Fang, Haijun Zhu, Liangliang Xu, Hao Cheng, Junying Zhang, Fei Li, Yan Feng, Yan Li, Jialun Li, Ruiping Wang, James X. Du, Jiwen Li, Taiping Chen, Hongbin Ji, Jackie Han, Wenqiang Yu, Qihan Wu, and Jiemin Wong* (2016) Negative Regulation of DNMT3A De Novo DNA Methylation by Frequently Overexpressed UHRF Family Proteins as a Mechanism for Widespread DNA Hypomethylation in Cancer. Cell Discovery doi: 10.1038/celldisc. eCollection 2016.

3. Fang J, Cheng J, Wang J,Zhang Q, Liu M, Gong R, Wang P, Zhang X, Feng Y, Lan W, Gong Z, Tang C,Wong J, Yang H, Cao C, Xu Y (2016) Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition. Nature Communications. 7:11197. doi: 10.1038/ncomms11197

4. Guangjin Ding, Peilin Chen, Hui Zhang, Xiaojie Huang, Yi Zang, Jiwen Li,Jia Li*, and Jiemin Wong* (2016) Regulation of Ubiquitin-like with PHD and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery. JBC. 291(38):20125-35.

5. Qian Zhao, Jiqin Zhang, Ruoyu Chen, Lina Wang, Bo Li, Hao Cheng, Xiaoya Duan, Haijun Zhu, Wei Wei, Jiwen Li, Qihan Wu, Jing-Dong J. Han, Wenqiang Yu, Shaorong Gao, Guohong Li* and Jiemin Wong*. (2016) Dissecting the Precise Role of H3K9 Methylation in Crosstalk with DNA Maintenance Methylation in Mammals. Nature Communications 24（7）12464. doi: 10.1038/ncomms12464。

6. Tong D, Liu Q, Liu G, Yuan W, Wang L, Guo Y, Lan W, Zhang D, Dong S, Wang Y, Xiao H, Mu J, Mao C,Wong J, Jiang J. (2016) Oncogenesis. 5(12):e283. doi: 10.1038/oncsis.2016.74.

7. Chen R, Zhang Q, Duan X, York P, Chen GD, Yin P, Zhu H, Xu M, Chen P, Wu Q, Li D, Samarut J, Xu G, Zhang P, Cao X, Li J*,Wong J*. (2017) The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required forNormalLevels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory.J Biol Chem. 292(11):4533-4543.

8. Wu M, Wei W, Chen J, Cong R, Shi T, Li J,Wong J*, Du JX*. (2017) Acidic domains differentially read histone H3 lysine 4 methylation status and are widely present in chromatin-associated proteins.SciChinaLife Sci. 60(2):138-151

9. Wei W, Mao A, Tang B, Zeng Q, Gao S, Liu X, Lu L, Li W, Du JX, Li J,Wong J*, Liao L*. (2017) Large-Scale Identification of Protein Crotonylation Reveals Its Role in Multiple Cellular Functions.J Proteome Res. 16(4):1743-1752.

10. Wei W, Liu X, Chen J, Gao S, Lu L, Zhang H, Ding G, Wang Z, Chen Z, Shi T, Li J, Yu J* and Wong J*. (2017) Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription. Cell Research (7):898-915.

11. Liu X, Wei W, Liu Y, Yang X, Wu J, Zhang Y, Zhang Q, Shi T, Du JX, Zhao Y, Lei M, Zhou JQ, Li J and Wong J*. (2017) MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300. Cell Discovery 17016. doi: 10.1038/celldisc

12. Guan W, Guyot R, Samarut J, Flamant F, Wong J*, Gauthier KC*. (2017) Methylcytosine dioxygenase TET3 interacts with thyroid hormone nuclear receptors and stabilizes their association to chromatin. Proc Natl Acad Sci U S A. 114(31):8229-8234.

13. Gao S, Wang Z, Wang W, Hu X, Chen P, Li J, Feng X, Wong J*, Du JX*. (2017) The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling. J Biol Chem. 292(30):12702-12712 

14. Graf U, Casanova EA, Wyck S, Dalcher D, Gatti M, Vollenweider E, Okoniewski MJ, Weber FA, Patel SS, Schmid MW, Li J, Sharif J, Wanner GA, Koseki H, Wong J, Pelczar P, Penengo L, Santoro R, Cinelli P. (2017) Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways. Nat Cell Biol. 19(7):763-773

15. Dan J,  Rousseau P, Hardikar S, Veland N, Wong J, Autexier C, Chen T. (2017) Zscan4 inhibits maintenace DNA methylation to facilitate telomere elongation in mouse embryonic stem cells.  Cell Rep 20(8):1936-1949.

16. Li P, Wang L, Bennett BD, Wang J, Li J, Qin Y, Takaku M, Wade A, Wong J, Hu G. (2017) Rif1 promotes a repressive chromatin state to safeguard against endogenous retrovirus activation. Nucleic Acids Res 45(22):12723-12738.

17. Wong J, Hsia SV.  The expanding functions of thyroid hormone. (2017)  Cell & Bioscience 7:53.

18. Yu F, Shi G, Cheng S, Chen J, Wu SY, Wang Z, Xia N, Zhai Y, Wang Z, Peng Y, Wang D, Du JX, Liao L, Duan SZ, Shi T, Cheng J, Chiang CM, Li J,Wong J*. (2018) SUMO suppresses and MYC amplifies transcription globally by regulating CDK9 sumoylation.  Cell Res 28(6)-670-685.

19. Zhang L, Carnesecchi J, Cerutti C, Tribollet V, Périan S, Forcet C,Wong J*, Vanacker JM*. (2018) LSD1-ERRa complex requires NRF1 to positively regulate transcription and cell invasion.  Sci Rep 8(1):10041.

20. LiY,Zhang Z,Chen J,Liu W,Lai W,Liu B,Li X,Liu L,Xu S,Dong Q,Wang M,Duan X,Tan J,ZhengY,Zhang P,Fan G,Wong J,Xu GL,Wang Z,Wang H,Gao S,Zhu B^*.(2018) Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1.Nature.2018 Dec;564(7734):136-140.

21. Li J, Wang R, Hu X, Gao Y, Wang Z, Li J, Wong J*. (2019) Activated MEK/ERK Pathway Drives Widespread and Coordinated Overexpression of UHRF1 and DNMT1 in Cancer cells. Sci Rep 9:907.

22. Wang Z, Kang L, Zhang H, Huang Y, Fang L, Li M, Brown PJ, Arrowsmith CH, Li J, Wong J*: (2019) AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation. Oncogene 38:5250-5264.

23. Zhang H, Gao Q, Tan S, You J, Lyu C, Zhang Y, Han M, Chen Z, Li J, Wang H, Liao L, Qin J, Li J*, Wong J*. (2019) SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1. Nucleic Acids Res 47(17):9053-9068. doi: 10.1093/nar/gkz626.

24. Peng Y, Wang, Z, Wang Z, Yu F, Li J*, Wong J*. (2019) SUMOylation down-regulates rDNA transcription by repressing expression of upstream-binding factor and proto-oncogene c-Myc. J Biol Chem. 294:19155-19166.

25. Dou X,  Boyd-Kirkup JD,  McDermott J,  Zhang X,  Li F,  Rong B,  Zhang R,  Miao B,  Chen P, Cheng H, Xue J, Bennett D, Wong J, Lan F, Han JJ*. (2019) The strand-biased mitochondrial DNA methylation and its regulation by DNMT3A. Genome Res  29:1622-1634. 

26. Peng J, Tang L, Cai M, Chen H, Wong J*, Zhang P*. (2019) RECQL5 Plays an Essential Role in Maintaining Genome Stability and Viability of Triple-Negative Breast Cancer Cells. Cancer Med 8:4743-4752.

27. Chen J, Ge X, Zhang W, Ding P, Du Y, Wang Q, Li L, Fang L, Sun Y, Zhang P, Zhou Y, Zhang L, Lv X, Li L, Zhang X, Zhang Q, Xue K, Gu H, Lei Q, Wong J, Hu W*. (2020) PI3K/AKT Inhibition Reverses R-CHOP Resistance by Destabilizing SOX2 in Diffuse Large B Cell Lymphoma. Theranostics 10:3151-3163.

28. Pan H, Jiang N, Sun S, Jiang H, Xu J, Jiang X, Gao Q, Li L, Wu H, Zheng H, Qi Q, Li T, Zhang M, Zhang L, Wan X, Lin X, Wong J, Shi Q*, Li R*. (2020) UHRF1-repressed 5'-hydroxymethylcytosine Is Essential for the Male Meiotic Prophase I. Cell Death Dis 11:142.

29. Zhao Y, Li X, Tian G, Zhao X, Wong J, Shen Y, Wu J.(2020) Ubiquitin-Specific-Processing Protease 7 Regulates Female Germline Stem Cell Self-Renewal Through DNA Methylation. Stem Cell Rev Rep. doi: 10.1007/s12015-020-10076-9

30. She P, Zhang H, Peng X, Sun J, Gao B, Zhou Y, Zhu X, Hu X, Lai KS, Wong J, Zhou B, Wang L, Zhong TP. (2020) The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase. Development 147(18):dev190678. doi: 10.1242/dev.190678

31. Li J, Wang R, Jin J, Han M, Chen Z, Gao Y, Hu X, Zhu H, Gao H, Lu K, Shao Y, Lyu C, Lai W, Li P, Hu G, Li J, Li D, Wang H, Wu Q*, Wong J*. (2020) USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment. Cell Discov. 6:58. doi: 10.1038/s41421-020-00188-4

32. Han M, Li J, Cao Y, Huang Y, Li W, Zhu H, Zhao Q, Han JJ, Wu Q, Li J, Feng J*, Wong J*. (2020) A role for LSH in facilitating DNA methylation by DNMT1 through enhancing UHRF1 chromatin association. Nucleic Acids Res. 48(21):12116-12134. doi: 10.1093/nar/gkaa1003

33. Li L, Duan Q, Zeng Z, Zhao J, Lu J, Sun J, Zhang J, Siwko S, Wong J, Shi T, Zhang X, Liu M, Chen J, Li D. (2020)  UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β-catenin signaling.  Int J Cancer 147(8):2239-2252. doi: 10.1002/ijc.33036.

34. Duan X, Huang Y, Chen X, Wang W, Chen J, Li J, Yang W, Li J, Wu Q, Wong J*. (2021) Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis. Oncogenesis 10(5):38. doi: 10.1038/s41389-021-00328-9

35. Xiao Y, Li W, Yang H, Pan L, Zhang L, Lu L, Chen J, Wei W, Ye J, Li J, Li G, Zhang Y, Tan M, Ding J*, Wong J*. (2021) HBO1 is a versatile histone acyltransferase critical for promoter histone acylations. Nucleic Acids Res.  49(14):8037-8059. doi: 10.1093/nar/gkab607.

36. Wang W, Zhao X, Shao Y, Duan X, Wang Y, Li J, Li J, Li D, Li X*, Wong J*.(2021)  Mutation-induced DNMT1 cleavage drives neurodegenerative disease.Sci Adv. 7(36):eabe8511. doi: 10.1126/sciadv.abe8511.

37. Chen Z, Zhang Y, Guan Q, Zhang H, Luo J, Li J, Wei W, Xu X, Liao L, Wong J*, Li J*. (2021) Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z.J Biol Chem. 297(4):101200. doi: 10.1016/j.jbc.2021.101200.

38. Xu X, Ding G, Liu C, Ding Y, Chen X, Huang X, Zhang CS, Lu S, Zhang Y, Huang Y, Chen Z, Wei W, Liao L, Lin SH, Li J, Liu W, Li J, Lin SC, Ma X*, Wong J*. (2022) Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function.Cell Res. 32(1): 54-71.

39. Moreno-Yruela C, Zhang D, Wei W, Bæk M, Liu W, Gao J, Danková D, Nielsen AL, Bolding JE, Yang L, Jameson ST, Wong J, Olsen CA, Zhao Y (2022). Class I histone deacetylases (HDAC1-3) are histone lysine delactylases. Sci Adv 8(3): eabi6696.

40. Tan D, Wei W, Han Z, Ren X, Yan C, Qi S, Song X, Zheng YG, Wong J, Huang H (2022). HBO1 catalyzes lysine benzoylation in mammalian cells. iScience 25(11): 105443.

41. Xue L, Sun J, Liu J, Hu C, Wu D, Nie C, Zhang K, Wang Y, Zhao L, Li X, Lu Y, Zhang L, Zhang D, Fan M, Qian H, Jiang H, Wong J, Li Y, Ying H, Chow BK, Wang L, Li Y (2022). Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring. EMBO Reports 23(7): e54132.

42. Guan Q, Chen Z, Yu F, Liu L, Huang Y, Wei G, Chiang CM, Wong J*, Li J*. (2023) MYC promotes global transcription in part by controlling P-TEFb complex formation via DNA-binding independent inhibition of CDK9 SUMOylation. Sci China Life Sci. doi: 10.1007/s11427-022-2281-6

43. Kang L, Zhang H,Wang Y, Chu M, He J, Xue M, Pan L, Zhang Y, Wang Z, Chen Z, Huang Y, Chen Z, Li E, Li J, Xu L, Zhang R*, Wong J*. (2023) Control of SOX2 Protein Stability and Tumorigenic Activity by E3 Ligase CHIP in Esophageal Cancer Cells. Oncogene 42(30):2315-2328. doi: 10.1038/s41388-023-02745-z.

44. Kang L, Liu Y, He J, Wang Y, Xue M, Wu X, Wang Z, Zhang Y, Chu M, Li J, Wei W, Li J, Li E, Liao L, Xiao J, Zhang R, Xu L*, Wong J*.(2023) GSK3β-driven SOX2 overexpression is a targetable vulnerability in esophageal squamous cell carcinoma. Oncogene 42(30):2297-2314. doi: 10.1038/s41388-023-02748-w.

45. Li J，Lu L, Liu L, Ren X, Chen J, Yin X, Xiao Y, Li J, Wei G, Huang H*, Wei W*, Wong J*. (2023) HDAC1/2/3 Are Major Histone Desuccinylase Critical for Promoter Desuccinylation. Cell Discov. 9(1):85. doi: 10.1038/s41421-023-00573-9.

46. Liu Y, Hu L, Wu Z, Yuan K, Hong G, Lian Z, Feng J, Li N, Li D, Wong J, Chen J, Liu M, He J, Pang X.(2023)Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons.Nat Communs 14(1):4225. doi: 10.1038/s41467-023-39943-y.

47. Chen Z, Luo J, Zhang Y, Zheng S, Zhang H, Huang Y, Wong J*, Li J*.(2024)SUMOylation is enriched in the nuclear matrix and required for chromosome segregation.J. Biol. Chem.300(1):105547. doi: 10.1016/j.jbc.2023.105547.

48. Sun, D., Kang, L., Chen, X., Xue, J., Wu, X., Wong, J., Wei, Q., and Liu, S. (2024) Identification of DDX5 as a Potential Therapeutic Target of Osteosarcoma Using Thiazolone Probes. ACS Chem Biol19, 1803-1812.

49. Xue, M., Kang, L., Zhang, Y., Yuan, X., Li, J., Zhang, R. *, and Wong, J*. (2025) AKT1 as a therapeutic target for platinum-resistant SOX2 positive ovarian cancer cells. Sci Rep15, 15096

50. Xue, J., Li, M., Kang, L., Wang, M., Yin, J., Sun, D., Deng, Y., Wei, Q., Wong, J., Zhu, T., and Liu, S. (2025) Identification of Nogo-B as a potential therapeutic target of osteosarcoma via stereochemically selective covalent probes. Cell Death Dis16, 537

51. Xiao, J., Wang, J., Li, J., Xiao, J., Liu, C., Tan, L., Tu, Y., Yang, R., Pei, Y., Wang, M., Wong, J., Zhou, B. P., Li, J., and Feng, J. (2025) L3MBTL3 and STAT3 collaboratively upregulate SNAIL expression to promote metastasis in female breast cancer. Nat Communs16, 231

52. Wang, Z., Dai, R., Kang, L., Yang, H., Chen, Z., He, J., Shu, L., Zhong, Y., Zhang, Y., Hua, Z., Huang, Y., Jiang, Y., Li, J., Xu, L., Lan, F*., Lin, S. H*., and Wong, J*. (2025) SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape. Nat Communs16, 8190

53. Blanco, C., Xiang, W., Boumpas, P., Buvry, E., Scorcelletti, M., Hermon, A. S., Wong, J., Merabet, S., and Carnesecchi, J. (2025) Synergistic DNA and RNA binding of the Hox transcription factor Ultrabithorax coordinates splicing and shapes in vivo homeotic functions. Nucleic Acids Res53

54. Liu, Y., Kang, L., Luo, J., Yang, M., Wang, D., Ye, J., Yang, X., Wan, W., Wong, J*., and Xiao, J*. (2025) Targeting AKT as a promising strategy for SOX2-positive, chemoresistant osteosarcoma. Bone Res13, 25

55. Huang, Y., Sun, Y., Qi, H., Jiang, Q., Li, J., Chang, M., Li, X., Shu, L., Duan, X., Wang, Y., Fang, K., Mao, H., Han, M., Weng, Y., Zhang, Q., Chen, Z., Wei, W., Song, G., Zhang, Q., Li, J., Han, J. J., Chen, C. D., and Wong, J*. (2025) A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization. Nature 647(8090), 786-797.

56. Bhatt B, Wei Y, Pradhan AK, Dhakshnamoorthy J, Zofall M, Xiao H, Vijayakumari D, Jain S, Folco HD, Qi H, Ball DA, Karpova TS, Wheeler D, Wong J, Grewal SIS. (2026). Stress controls heterochromatin inheritance via histone H3 ubiquitylation. Nature 650 (8102), 768-778.

57. Toda T, Zang J, Qi H, Fang Y, Jiang P, Shan CM, Wong J, Jia S. (2026) An H3K14ub-H3K9me3 feedback circuit governs heterochromatin spreading and inheritance in fission yeast. Nat Communs 17(1):3483. doi: 10.1038/s41467-026-70276-8

58. Chen F, Sun M, Chang M, Dai Z, Chen Z, Li J, Duan Y, Li J, Cao X, Huang Y, Wong J*. (2026) CDCA7 targets LSH to DNA maintenance methylation in S phase and transcription regulation in interphase via two distinct DNA-binding modes. Nucleic Acids Res2026 May 20;54(10):gkag559.doi: 10.1093/nar/gkag559

59. Kang Z, Zhao W, Jin W, Sun Y, Peng Y, Wong J, Guo D, Chen Y. (2026) Discovery of a potent STAT3 inhibitor WR-S-647 for the treatment of ADPKD. Arch Pharm Res. 2026 Jan;49(1):174-196. doi: 10.1007/s12272-026-01594-0.Epub 2026 Feb 3 

* Corresponding author

2001年美国内分泌协会优秀青年科学家奖

Baylor 医学院细胞与分子生物学系2005优秀科研奖

2014年上海市优秀学术带头人

2023年度江苏省科学技术二等奖。