商鹏程

本科（09/2006 - 07/2010）：山东农业大学动物医学院。

硕士（09/2010 - 07/2013）：中国农业大学动物医学院，杨汉春老师实验室

博士（01/2014 - 12/2018）：美国堪萨斯州立大学（Kansas State University）兽医学院，Dr. Ying Fang实验室

博后（01/2019 - 12/2023）：美国匹兹堡大学医学院（University of Pittsburgh School of Medicine），国际著名病毒学家Dr. Terence Dermody实验室。

Research Instructor （01/2024 - 07/2024）: 美国匹兹堡大学医学院，Dermody实验室。

紫江优秀青年学者（08/2024 - 至今）：华东师范大学，上海市野生动物疫源疫病研究院

本课题主要钻研分子病毒学，研究病毒如何感染、复制和致病，同时也关注宿主的抗病毒先天性免疫反应。

分子病毒学

（1）野生动物携带的病毒传人的风险

（2）野生动物携带的具备传人风险的病毒在动物模型中的致病机理

（3）非囊膜病毒入侵细胞的机制和可能的宿主拮抗机制

Roles of papain-like protease (PLP)-containing proteins of nidoviruses in virus pathogenesis and evolution (PhD study)

1) Li Y, Shang P, Shyu D, Carrillo P. Naraghi-Arani C, Renukaradhya G, Henningson J, Firth A, Snijder E, Fang Y. Nonstructural proteins nsp2TF and nsp2N of porcine reproductive and respiratory syndrome virus (PRRSV) play important roles in suppressing host innate immune responses. Virology. 2018 Apr; 517:164-176. (Co-first author).

2) Shang P, Misra S, Hause B, Fang Y. A naturally occurring recombinant enterovirus expresses torovirus deubiquitinase. J Virol. 2017 Jun 26;91(14). (Selected as JVI spotlight feature).

3) Yan X, Shang P, Yim-Im W, Sun Y, Zhang J, Firth A, Lowe J, Fang Y. Molecular characterization of emerging variants of PRRSV in the United States: new features of the -2/-1 programmed ribosomal frameshifting signal in the nsp2 region. Virology. 2022 Aug; 573:39-49. (Co-first author).

4) Cook G, Brown K, Shang P, Li Y, Soday L, Dinan A, Tumescheit C,  Mockett A, Fang Y, Firth A, Brierley I. Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression. Elife. 2022 Feb 28;11:e75668.

Biochemical features of arterivirus nsp2-related proteins and significance for virus replication and evolution (PhD study)

1) Shang P, Yuan F, Misra S, Li Y, Fang Y. Hyper-phosphorylation on nsp2-related proteins of porcine arterivirus regulates the accumulation of viral RNA transcripts. Virology. 2020 Apr; 543: 63–75.

Reovirus receptors and functions in reovirus entry and pathogenesis (Post-doc study)

1) Shang P, Simpson J, Taylor G, Sutherland D, Welsh O, Aravamudhan P, Natividade R, Schwab K, Michel J, Poholek A, Wu Y, Rajasundaram D, Koehler M, Alsteens D, Dermody T. Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus. Nat Commun. 2023 May 5;14(1):2615.

2) Shang P, Natividade R, Taylor G, Ray A, Welsh O, Fiske K, Sutherland D, Neetu N, Alsteens D, Dermody T. NRP1 is a receptor for mammalian orthoreovirus engaged by distinct capsid subunits. Cell Host & Microbe. 2024.