秦居亮

2013.09-2018.06   理学博士  华东师范大学生命科学学院 

2009.09-2013.06   理学学士  南京师范大学生命科学学院（国家理科基地班）

2020.10-至今     副研究员，华东师范大学

2018.07-2020.09   博士后，华东师范大学 

华东师范大学生命科学学院/上海市调控生物学副研究员，长期从事固有免疫调控在抗感染免疫和肿瘤免疫调控中的研究工作，近五年来以第一或通讯作者（含共同）身份先后在Advanced Science（2022）、Cancer Immunology Research （2020）、Cellular & Molecular Immunology（2020, 2018）、Mucosal Immunology （2020）、Journal of Immunology（2016）、Science China-Life Sciences（2021，2017）、European Journal of Medicinal Chemistry（2019）以及参与在Cancer Research（2018）、PLoS Pathogens（2019）、Nutrition Research（2016）等国际知名期刊上发表十余篇SCI论文，同时在加拿大Cell symposia、中国免疫学大会等国内外学术会议中做海报展示或口头学术报告交流。曾获得中国博士后科学基金一等资助项目、上海市青年科技英才扬帆计划、上海市超级博士后、国家自然科学基金青年项目和面上项目等项目和荣誉称号。此外还担任Journal of Immunology Research, Advanced Science, Molecular Nutrition and Food Research, Bio-protocol的审稿人以及流式细胞术实验手册Bio-protocol eBook的特邀评委。

1. 上海市免疫学会会员

2. 中国细胞生物学学会会员

3. 担任Advanced Science,Journal of Immunology Research, International Journal of Molecular Medicine，Bio-protocol审稿人以及流式细胞术实验手册Bio-protocol eBook的特邀评委

固有免疫在炎症性疾病以及肿瘤免疫微环境中的调控研究

1. 国家自然科学基金面上项目“羟化胆固醇受体GPR183调控巨噬细胞促进肿瘤转移的功能和机制研究”(82173099) 2022/01-2025/12 项目主持人

2. 国家自然科学基金青年项目“P2X7介导的巨噬细胞免疫调控在肺癌发生、发展中的功能和机制研究”(81902892) 2020/01-2022/12 项目主持人

3. 上海市青年科技英才扬帆计划项目“P2X7对巨噬细胞介导的肿瘤免疫微环境的调控研究” (19YF1414400)  2019/04-2022/03 项目主持人

 4. 中国博士后科学基金会博士后基金面上项目一等资助（2018M640364），2018-2020 项目主持人，已结题

5. 国家自然科学基金重点项目“KRAS与肿瘤微环境关键调控GPCR的协同致死效应与分子机制研究”（81830083）2019/01-2022/12 研究骨干

6. 国家重点研发计划“GPCR结构解析、配体发现以及信号转导机制研究”（2018YFA0507000）2018/05-2023/05 研究骨干

（1）Su Zhang#, Fangfei Yu#, Anran Che, Binghe Tan, Chenshen Huang, Yuxue Chen, Xiaohong Liu, Qi Huang, Wenying Zhang, Chengbin Ma, Min Qian, Mingyao Liu*, Juliang Qin*, Bing Du*, Neuroendocrine Regulation of Stress-Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway Advanced Science (Weinh), 2022, May 9, doi: 10.1002/advs.202104132 

（2）Xiaoyu Zhang,# , Wenxiang Zhao#, Yihan Zhao, Zeda Zhao, Zhangsheng Lv, Zhen Zhang, Hua Ren, Qin Wang, Mingyao Liu, Min Qian, Bing Du*, Juliang Qin*, Inflammatory macrophages exacerbate neutrophil-driven joint damage through ADP/P2Y1 signaling in rheumatoid arthritis Science China Life Sciences, 2021, Aug 31, doi: 10.1007/s11427-020-1957-8  

（3）Juliang Qin^#, Xiaoyu Zhang^#, Binghe Tan^#, Su Zhang, Qi Xue, Zhen Zhang, Hua Ren, Jinlian Chen, Mingyao Liu,       Min Qian, Bing Du*，Blocking P2X7-Mediated Macrophage Polarization Overcomes Treatment Resistance in Lung  Cancer.Cancer Immunology Research, 2020， November , doi: 10.1158/2326-6066 

（4）Juliang Qin^#, Zhen Zhang^#, Zhixiang Fu, Hua Ren, Mingyao Liu, Min Qian, Bing Du*.UDP/P2y6 axis promotes lung metastasis of melanoma via remodeling pre-metastatic niche. Cellular &Molecular Immunology, 2020, Mar 6,doi: 10.1038/s41423-020-0392-0  

（5）Chengfei Zhang^#, Juliang Qin^#, Su Zhang, Na Zhang, Binhe Tan, Stefan Siwko, Ying Zhang, Qin Wang, Jinlian Chen, Min Qian, Mingyao Liu*, Bing Du*, ADP/P2Y1 aggravates inflammatory bowel disease through ERK5 mediated NLRP3 inflammasome activation. Mucosal Immunology, 2020, Jun 9, doi: 10.1038/s41385-020-0307-5 

（6） Pei Haixiang^#, Qin Juliang^#, Wang Fengmian, Tan Binghe, Zhao Zeda, Peng Yangrui, Yu Fangfei, Li Ennian, Liu Mingyao, Zhang Rong, Liu Bo*, Du Bing*, Chen Yihua*. Discovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages.European Journal of Medicinal Chemistry, 2019, Dec 1;183:111741 

（7）Xiaoyu Zhang^#, Juliang Qin^#, Junyan Zou, Zhangsheng Lv, Binghe Tan, Jueping Shi, Yihan Zhao, Hua Ren, Mingyao Liu, Min Qian and Bing Du*, Extracellular ADP facilitates monocyte recruitment in bacterial infection via ERK signaling. Cellular &Molecular Immunology, 2018, Jan;15(1):58-73 

（8）Juliang Qin^#, Xiaoyu Zhang^#, Ziqiang Wang, Jinju Li, Zhen Zhang, Liangcai Gao, Hua Ren, Min Qian* & Bing Du*, Presenilin 2 deficiency facilitates Aβ-induced neuroinflammation and injury by upregulating P2X7 expression. Science China Life Sciences, 2017, Feb;60(2):189-201 (Highlighted by National Science Review, 2017, 4: 158–160)  

（9）Juliang Qin, Guangxu Zhang, Xiaoyu Zhang, Binghe Tan, Zhangsheng Lv, Mingyao Liu, Hua Ren, Min Qian, and Bing Du*, TLR activated gap junction channels protects mice against bacterial infection through extracellular UDP release. Journal of Immunology, 2016, Feb 15;196(4):1790-8 

（10）Xiaoyu Zhang, Juliang Qin, Yihan Zhao, Jueping Shi, Rong Lan, Yunqiu Gan, Hua Ren, Bing Zhu, Min Qian, Bing Du, Bing Du*, Long-term ketogenic diet contributes to glycemic control but lipid accumulation and hepatic steatosis in type 2 diabetic mice. Nutrition Research, 2016, Apr;36(4):349-358  

（11） Binghe Tan, Xiujuan Shi, Jie Zhang, Juliang Qin, Bing Du*, Mingyao Liu*, Rspo-Lgr4 facilitates tumor growth by switching tumor associated macrophage polarization. Cancer Research, 2018, Sep 1;78(17):4929-4942（Cover story and Issue Highlight） 

（12）Wu Nannan#, Nguyen XN#, Wang Li#, Appourchaux R, Zhang Chengfei, Panthu B, Gruffat H, Journo C, Alais S, Qin Juliang, Zhang Na, Tartour K, Catez F, Mahieux R, Ohlmann T, Liu Mingyao, Du Bing*, Cimarelli A*, The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation. PLoS Pathogens, 2019 Oct 10;15(10):e1008093   

（13）Chengcong Yin , Long Cheng, Jiajia Pan, Lili Chen, Qi Xue, Juliang Qin, Shaoying Wang, Bing Du, Mingyao Liu, Ying Zhang, Wenzheng Jiang, Min Qian*, Hua Ren*, Regulatory role of Gpr84 in the switch of alveolar macrophages from CD11b lo to CD11b hi status during lung injury process. Mucosal Immunology, 2020, Jul 27, doi: 10.1038/s41385-020-0321-7 

1. 2018年上海市“超级博士后”获得者

2. 2019年上海市“青年科技英才扬帆计划”获得者