邱瑾

2018.09-2022.06 华东师范大学生命科学学院，生物化学与分子生物学，博士

2022.07-2025.12 博士后，华东师范大学 

2026.03-至今 副教授，华东师范大学

邱瑾，博士，现任华东师范大学生命科学学院副教授。于2022年在华东师范大学获得生物化学与分子生物学博士学位，随后在该校从事博士后研究，期间入选2022年上海市“超级博士后”激励计划。

长期聚焦于脂肪代谢与组织间对话，综合运用转录组、蛋白质组及脂质组等多组学前沿技术，深入解析脂肪组织响应衰老应激及调控系统性代谢稳态的核心机制。她重点关注铁代谢及以外泌体、离子和代谢物为媒介的跨器官通讯在肥胖、代谢性综合征与肿瘤等重大疾病中的病理生理学基础，并致力于探索靶向脂肪组织改善糖脂代谢的新型干预策略。先后主持了国家自然科学基金青年科学基金及中国博士后科学基金等多项重要科研项目，并在 Advanced Science, Biomaterials, PLoS Biology, Metabolism 等国际知名学术期刊上以第一作者或共同第一作者身份发表了多篇高质量研究论文，在代谢调控与机制研究领域取得了丰硕的学术成果。

主要研究领域为脂肪代谢与组织间对话：

a. 脂肪组织响应衰老应激，参与代谢稳态调控的关键分子和作用机制；

b. 脂肪组织糖脂代谢的稳态调控影响代谢性疾病和肿瘤等重大疾病的病理生理学基础；

c. 应用新技术新手段靶向脂肪组织改善能量平衡和糖脂代谢防治肥胖及代谢性疾病；

d. 以外泌体、离子、代谢物为媒介的脂肪组织与其他组织间交流的机制研究。

国家自然科学基金青年科学基金(主持)

博士后科学基金(主持)

1. Qiu J*, Guo Y*, Guo X*, Liu Z, Li Z, Zhang J, Cao Y, Li J, Yu S, Xu S, Chen J, Wang D, Yu J, Guo M, Zhou W, Wang S, Wang Y, Ma X#, Xie C#, Xu L#. Ucp1 Ablation Improves Skeletal Muscle Glycolytic Function in Aging Mice. Adv Sci (Weinh). 2024 Nov 21:e2411015.

2. Qiu J*, Fan Q*, Xu S, Wang D, Chen J, Wang S, Hu T, Ma X, Cheng Y, Xu L. A fluorinated peptide with high serum- and lipid-tolerence for the delivery of siRNA drugs to treat obesity and metabolic dysfunction. Biomaterials. 2022 Jun;285:121541.

3. Qiu J*, Zhang Z*, Wang S*, Chen Y, Liu C, Xu S, Wang D, Su J, Ni M, Yu J, Cui X, Ma L, Hu T, Hu Y, Gu X, Ma X, Wang J, Xu L. Transferrin Receptor Functionally Marks Thermogenic Adipocytes. Front Cell Dev Biol. 2020 Nov 5;8:572459.

4. Qiu J*, Ma L*, Wang T, Chen J, Wang D, Guo Y, Li Y, Ma X, Chen G, Luo Y, Cheng X, Xu L. Bioinformatic analysis of single-cell RNA sequencing dataset dissects cellular heterogeneity of triple-negative breast cancer in transcriptional profile, splicing event and crosstalk network. Clin Transl Oncol. 2023 Jun;25(6):1856-1868.

5. Qiu J*, Zhang Z*, Hu Y*, Guo Y, Liu C, Chen Y, Wang D, Su J, Wang S, Ni M, Xu S, Yu J, Hu T, Song G, Ma X, Gu X, Wang J, Xu L. Transferrin receptor levels and its rare variant are associated with human obesity. J Diabetes. 2023 Aug 30.

6. Qiu J, Han H, Sun B, Chen L, Yu C, Peng R, Yao Q. Residue mutations of xylanase in Aspergillus kawachii alter its optimum pH. Microbiol Res. 2016 Jan;182:1-7.

7. Xu X*, Qiu J*, Li X, Chen J, Li Y, Huang X, Zang S, Ma X, Liu J. Perilipin5 protects against non-alcoholic steatohepatitis by increasing 11-Dodecenoic acid and inhibiting the occurrence of ferroptosis. Nutr Metab (Lond). 2023 Jun 22;20(1):29. 

8. Cheng X*, Qiu J*, Wang S, Yang Y, Guo M, Wang D, Luo Q, Xu L. Comprehensive circular RNA profiling identifies CircFAM120A as a new biomarker of hypoxic lung adenocarcinoma. Ann Transl Med. 2019 Sep;7(18):442. 

9. Guo M*, Qiu J*, Shen F, Wang S, Yu J, Zuo H, Yao J, Xu S, Hu T, Wang D, Zhao Y, Hu Y, Shen F, Ma X, Lu J, Gu X, Xu L. Comprehensive analysis of circular RNA profiles in skeletal muscles of aging mice and after aerobic exercise intervention. Aging (Albany NY). 2020 Mar 17;12(6):5071-5090.  

10. Peng RH*, Qiu J*, Tian YS, Gao JJ, Han HJ, Fu XY, Zhu B, Xu J, Wang B, Li ZJ, Wang LJ, Yao QH. Disulfide isomerase-like protein AtPDIL1-2 is a good candidate for trichlorophenol phytodetoxification. Sci Rep. 2017 Jan 6;7:40130. 

11. Yu J*, Qiu J*, Zhang Z*, Cui X, Guo W, Sheng M, Gao M, Wang D, Xu L, Ma X. Redox Biology in Adipose Tissue Physiology and Obesity. Adv Biol (Weinh). 2023 Sep;7(9):e2200234. 

12. Meng M*, Cao Y*, Qiu J*, Shan G, Wang Y, Zheng Y, Guo M, Yu J, Ma Y, Xie C, Hu C, Xu L, Mueller E, Ma X. Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner. Metabolism. 2024 Mar;152:155784.

13. Wang D*, Cao Y*, Meng M*, Qiu J*, Ni C, Guo X, Li Y, Liu S, Yu J, Guo M, Wang J, Du B, Qiu W, Xie C, Zhao B, Ma X, Cheng X, Xu L. FOXA3 regulates cholesterol metabolism to compensate for low uptake during the progression of lung adenocarcinoma. PLoS Biol. 2024 May 28;22(5):e3002621.

14. Zhang J*, Hu M*, Wu X*, Guo M*, Ma Y*, Qiu J, Wang S, Cao Y, Zhong Y, Chen F, Wang Y, Wei W, Lu Y, Zhang Y, Xiao J, Gan Z, Hu C, Ma X, Xu L. Skeletal Muscle HSF1 Alleviates Age-Associated Sarcopenia and Mitochondrial Function Decline via SIRT3-PGC1α Axis. Adv Sci (Weinh). 2025 Dec 16:e10368.

15. Liu C*, Meng M*, Xu B, Xu Y, Li G, Cao Y, Wang D, Qiu J, Yu J, Xu L, Ma X, Hu C. Fibroblast Growth Factor 6 Promotes Adipocyte Progenitor Cell Proliferation for Adipose Tissue Homeostasis. Diabetes. 2023 Apr 1;72(4):467-482. 

16. Wang D*, Cheng X*, Li Y, Guo M, Zhao W, Qiu J, Zheng Y, Meng M, Ping X, Chen X, Wang S, Luo J, Luo Q, Ma X, Xu L. C/EBPδ-Slug-Lox1 axis promotes metastasis of lung adenocarcinoma via oxLDL uptake. Oncogene. 2020 Jan;39(4):833-848.

17. Li G, Zhu L, Guo M, Wang D, Meng M, Zhong Y, Zhang Z, Lin Y, Liu C, Wang J, Zhang Y, Gao Y, Cao Y, Xia Z, Qiu J, Li Y, Liu S, Chen H, Liu W, Han Y, Zheng M, Ma X, Xu L. Characterisation of forkhead box protein A3 as a key transcription factor for hepatocyte regeneration. JHEP Rep. 2023 Sep 12;5(12):100906.

18. Guo M, Shen F, Guo X, Zhang J, Ma Y, Wu X, Zuo H, Yao J, Hu Y, Wang D, Li Y, Li J, Qiu J, Yu J, Meng M, Zheng Y, Chen X, Gong M, Liu K, Jin L, Ren X, Zhang Q, Zhao Y, Gu X, Shen F, Li D, Gao L, Liu C, Zhou F, Li M, Wang J, Ding S, Ma X, Lu J, Xie C, Xiao J, Xu L. BMAL1/PGC1α4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise. J Sport Health Sci.2023.24:100968.

19. Xu L, Ma X, Verma N, Perie L, Pendse J, Shamloo S, Marie Josephson A, Wang D, Qiu J, Guo M, Ping X, Allen M, Noguchi A, Springer D, Shen F, Liu C, Zhang S, Li L, Li J, Xiao J, Lu J, Du Z, Luo J, Aleman JO, Leucht P, Mueller E. PPARγ agonists delay age-associated metabolic disease and extend longevity. Aging Cell. 2020 Nov;19(11):e13267.

20. Yue L, Zhao W, Wang D, Meng M, Zheng Y, Li Y, Qiu J, Yu J, Yan Y, Lu P, Sun Y, Fu J, Wang J, Zhang Q, Xu L, Ma X. Silver nanoparticles inhibit beige fat function and promote adiposity. Mol Metab. 2019 Apr;22:1-11. doi: 10.1016/j.molmet.2019.01.005. Epub 2019 Jan 24.

21. Zhou B, Liu C, Xu L, Yuan Y, Zhao J, Zhao W, Chen Y, Qiu J, Meng M, Zheng Y, Wang D, Gao X, Li X, Zhao Q, Wei X, Wu D, Zhang H, Hu C, Zhuo X, Zheng M, Wang H, Lu Y, Ma X. N6 -Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes. Hepatology. 2021 Jan;73(1):91-103.

22. Han H, You S, Zhu B, Fu X, Sun B, Qiu J, Yu C, Chen L, Peng R, Yao Q. Characterization and high expression of recombinant Ustilago maydis xylanase in Pichia pastoris. Biotechnol Lett. 2015 Mar;37(3):697-703.  

23. Yu J, Chen X, Zhang Y, Cui X, Zhang Z, Guo W, Wang D, Huang S, Chen Y, Hu Y, Zhao C, Qiu J, Li Y, Meng M, Guo M, Shen F, Zhang M, Zhou B, Gu X, Wang J, Wang X, Ma X, Xu L. Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents. Theranostics. 2022 Jan 1;12(3):1187-1203. 

2022年上海市“超级博士后”