Jiangwenzheng

B.S., 1990~1994, Sanitary Examination of Animal Food, Quartermaster University of PLA, Changchun, Jilin province, China.

M.S., 1994~1997, Microbiology & Immunology, Quartermaster University of PLA, Changchun, Jilin province, China.

Ph.D., 1999~2003,Virology, Key Laboratory of Genetic Engineering of PLA, Quartermaster University of PLA, Changchun, Jilin province, China.

Assistant, 1997.7~ 1999.9, Dept. of Microbiology, Quartermaster University of PLA, Changchun, Jilin Province, China. 

Lecturer, 1999.9 ~ 2003.9, Dept. of Microbiology, Quartermaster University of PLA, Changchun, Jilin Province, China.

Postdoctoral fellow, 2003-2005, Immunology, State Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, China

Postdoctoral fellow, 2008-2010, Immunology, National Institute of Neurological Disease and Stroke (NINDS), NIH, USA

Associate Professor/Supervisor of Graduate Students,2005.10-2011.12, School of Life Sciences, East China Normal University, Shanghai, China

Professor/Supervisor of Ph.D Candidates, 2011.12 ~ present, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China.

Excutive Council Member of Shanghai Pharmaceutical Association

Director Member of Biochemical and Biotechnological Drug Professional Committee, Shanghai Pharmaceutical Association

Deputy Director Member of Education and Training Division of the Chinese Society of Biochemistry and Molecular Biology

Standing Editorial Board Member of 《Biology Teaching in University (Electronic Edition)》

Editorial Board Member of 《Chinese Journal of Biotechnology》

Member of Anti-inflammatory Immunopharmacology Specialized Committee, Chinese  Pharmacological Society

Member of American Association of Immunologists

Member of Chinese Society for Immunology

Member of Chinese Society for Microbiology

Member of Chinese Society for Biological Engineering

Member of Chinese  Pharmacological Society

Invited reviewer for EMBO J, Front Immunol, OncoImmunology, Int J Mol Sci, Cells, Vaccine‚ Immunology, Immunobiology, Viral Immunol, Biology, Arch Virol‚ J Med Virol‚ J Viral Hepatitis, Int J Mol Med, Acta Pharmacologica Sinica (APS), Acta Biochimica et Biophysica Sinica (ABBS), Immunol Invest, CNS Neurosci Ther, Oncol Lett, Clin Cardiol, Mol Med Rep, Exp Ther Med, Biomed Rep, etc.

1. Immune cell therapy on tumor (CAR-T, CAR-NK)

2. The immunomodulation of GPCRs on innate immune cells (DC, NK, T cells ) and their molecular mechanisms

3. The effect of GPCRs on autoimmune diseases (MS/EAE, IBD) and theirs molecular mechanisms

Immunological Principle and Technology

Microbiology

Talking about Life Sciences

Selected papers:

1.  Su Q, Yao J, Farooq MA, Ajmal I, Duan Y, He C, Hu X, Jiang W*. Modulating cholesterol metabolism via ACAT1 knockdown enhances anti-B-cell lymphoma activities of CD19-specific chimeric antigen receptor T cells by improving the cell activation and proliferation. Cells, 2024,13(6):555.

2. Zhou Y, Farooq MA, Ajmal I , He C, Gao Y, Guo D, Duan Y,  Jiang W*. Co-expression of IL-4/IL-15-based inverted cytokine receptor in CAR-T cells overcomes IL-4 signaling in immunosuppressive pancreatic tumor microenvironment. Biomed Pharmacother. 2023, 168: 115740.

3. Farooq MA, Ajmal I, Hui X, Chen Y, Ren Y , Jiang W*. β2-adrenergic receptor mediated inhibition of T cell function and its implications for CAR-T cell therapy. Int J Mol Sci. 2023, 24: 12837.

4. Guo D, Jin C, Gao Y, Lin H, Zhang L, Zhou Y, Yao J, Duan Y, Ren Y, Hui X, Ge Y, Yang R, Jiang W*. GPR116 receptor regulates the antitumor function of NK cells via Gαq/HIF1α/NF-κB signaling pathway as a potential immune checkpoint. Cell Biosci. 2023, 13(1): 51.

5. Khan MZI, Nazli A, Al-Furas H, Asad MI, Ajmal I, Khan D, Shah J, Farooq MA, Jiang W*. An overview of viral mutagenesis and the impact on pathogenesis of SARS-CoV-2 variants. Front Immunol. 2022, 13: 1034444.

6. Yu Y, Wu X, Wang M, Liu W, Zhang L, Zhang Y, Hu Z, Zhou X, Jiang W, Zou Q, Cai F, Ye H. Optogenetic-controlled immunotherapeutic designer cells for post-surgical cancer immunotherapy. Nat Commun. 2022, 13(1): 6357.

7. Ajmal I, Farooq MA, Abbas SQ, Shah J, Majid M, Jiang W*. Isoprenaline and Salbutamol inhibit pyroptosis and promote mitochondrial biogenesis in arthritic chondrocytes by downregulating β-arrestin and GRK2. Front Pharmacol. 2022, 13: 996321. 

8. Gao Y, Lin H, Guo D, Cheng S, Zhou Y, Zhang L, Yao J, Asad Farooq M, Ajmal I, Duan Y, He C, Tao L, Wu S, Liu M, Jiang W*. Suppression of 4.1R enhances the potency of NKG2D-CAR T cells against pancreatic carcinoma via activating ERK signaling pathway. Oncogenesis. 2021, 10: 62.

9. Li Z, Gao Y, He C, Wei H, Zhang J, Zhang H, Hu L, Jiang W*. Purinergic receptor P2Y6 is a negative regulator of NK cell maturation and function. J Immunol, 2021, 207(6): 1555-1565.

10. Guo D, He L, Gao Y, Jin C, Lin H, Zhang L, Wang L, Zhou Y, Yao J, Duan Y, Yang R, Qiu W, Jiang W*. Obeticholic acid derivatives,T-2054 suppresses osteoarthritis via inhibiting NF-κB signaling pathway. Int J Mol Sci. 2021, 22: 3807. 

11. Zhang J, Wencker M, Marliac Q, Berton A, Hasan U, Schneider R, Laubreton D, Cherrier DE, Mathieu AL, Rey A, Jiang W, Caramel J, Genestier L, Marçais A, Marvel J, Ghavi-Helm Y, Walzer T. Zeb1 represses TCR signaling, promotes the proliferation of T cell progenitors and is essential for NK1.1+ T cell development. Cell Mol Immunol. 2021, 18(9): 2140-2152.

12. Tao L, Asad Farooq M, Gao Y, Zhang L, Niu C, Ajmal I, Zhou Y, He C, Zhao G, Yao J, Liu M, Jiang W*. CD19-CAR-T cells bearing a KIR/PD-1-based inhibitory CAR eradicate CD19⁺HLA-C1^- malignant B cells while sparing CD19⁺HLA-C1⁺ healthy B cells. Cancers. 2020, 12(9)：2612. 

13. He C, Zhou Y, Li Z, Asad Farooq M, Iqra Ajmal I, Zhang H, Zhang L, Tao L, Yao J, Du B, Liu M, Jiang W*. Co-expression of IL-7 improves NKG2D-based CAR T Cell therapy on prostate cancer by enhancing the expansion and inhibiting the apoptosis and exhaustion. Cancers.2020;12(7): 1969. 

14. Li Z, He C, Zhang J, Zhang H, Wei H, Wu S, Jiang W*. P2Y6 Deficiency Enhances DC-mediated Th1/Th17 Differentiation and Aggravates Experimental Autoimmune Encephalomyelitis. J Immunol. 2020, 205(2): 387-397.  

15. Yin C, Cheng L, Pan J, Chen L, Xue Q, Qin J, Wang S, Du B, Liu M, Zhang Y, Jiang W, Qian M, Ren H. Regulatory role of Gpr84 in the switch of alveolar macrophages from CD11b lo to CD11b hi status during lung injury process. Mucosal Immunol. 2020,13(6): 892-907.

16. Hu X, Zhong Y, Lambers TT, Jiang W*. Anti‑inflammatoryactivity of extensively hydrolyzed casein is mediatedby granzyme B. Inflamm Res. 2019, 68(8): 715-722. 

17. Zhang L, Zhu X, Wu S, Chen Y, Tan S, Liu Y, Jiang W*, Huang J*. Fabricationand evaluation of a γ-PGA-based self-assembly transferrin receptor-targetinganticancer drug carrier. Int J Nanomedicine. 2018, 13: 7873-7889.  

18. Shi Y, Li Z, Chen R, Zhang J, Hu X, He C, Su Q, Ma H, Ren H, Qian M, Cui S,Jiang W*. Immethridine, histamine H3-receptor (H3R) agonist, alleviated experimental autoimmune encephalomyelitis viainhibiting the function of dendritic cells. Oncotarget. 2017,.8:.75038-75049.  

19. Zhang J, Li Z, Hu X, Su Q, He C, Liu J, Ren H, Qian M, Liu J, Cui S,Jiang W*. Knockout of P2Y12 aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and Th17 cell differentiation by dendritic cells. Brain Behav Immun. 2017, 62: 245-255.

20. Shi J, Zhang X, Wang S, Wang J, Du B, Wang Z, Liu M,Jiang W, Qian M, Ren H. Gpr97 is dispensable for metabolic syndrome but is involved in macrophage inflammation in high-fat diet-induced obesity in mice. Sci Rep. 2016，6：24649.

21. Shi JP, Wang SY, Chen LL, Zhang XY, Zhao YH, Du B,Jiang WZ, Qian M, Ren H. P2Y6 contributes to ovalbumin-induced allergic asthma by enhancing mast cell function in mice. Oncotarget. 2016, 7(38): 60906-60918.

22. Shi JP, Li XN, Zhang XY, Du B,Jiang WZ, Liu MY, Wang JJ, Wang ZG, Ren H, Qian M. Gpr97 is dispensable for inflammation in OVA-induced asthmatic mice. PLoS One. 2015, 10(7): e0131461.

23. Ren H, Teng Y, Tan B, Zhang X, Jiang W, Liu M,Jiang W, Du B, Qian M. Toll-like receptor-triggered calcium mobilization protects mice against bacterial infection through extracellular ATP release. Infect Immun. 2014, 82(12): 5076-5085.

25. Jiang W*, Chen R, Kong X, Long F, Shi Y. Immunization with adenovirus LIGHT-engineered dendritic cells induces potent T cell responses and therapeutic immunity in HBV transgenic mice. Vaccine. 2014, 32(35):4565-4570.

25. Wen J, Hao W, Fan Y, Du J, Du B, Qian M,Jiang W*. Co-delivery of LIGHT expression plasmid enhances humoral and cellular immune responses to HIV-1 Nef in mice. Arch Virol. 2014, 159(7): 1663-1669. 

26. Du J, Wu X, Long F, Wen J, Hao W, Chen R, Kong X, Qian M,Jiang W*. Improvement in efficacy of DNA vaccine encoding HIV-1 Vif by LIGHT gene adjuvant. Viral Immunol. 2013, 26(1): 68-74.

27. Jiang W*.Blockade of B7-H1 enhances dendritic cell-mediated T cell response and antiviral immunity in HBV transgenic mice. Vaccine. 2012‚ 30(4): 758-766.

28. Jiang W‚ Chai NR‚ Maric D‚ Bielekova B. Unexpected Role for Granzyme K in CD56bright NK Cell-Mediated Immunoregulation of Multiple Sclerosis. J Immunol. 2011‚ 187(2): 781-790.  

29. Fan Y‚Jiang W*‚ Wen J‚ Hao W‚ Du J‚ Liu X‚ Qian M. B7-DC-silenced dentritic cells induce stronger anti-HBV immunity in transgenic mice. Arch Virol. 2009‚ 154(11): 1813-1821. 

30. Zhang Y‚Jiang W*‚ Fan Y‚ Wen J‚ Hao W‚ Qian M. Engineering enhancement of immune response to HBV DNA vaccine in mice through the use of LIGHT gene adjuvant. J Virol Methods, 2008. 53(2): 142-148. 

31. Jiang W*‚ Fan Y‚ Liu X‚ Zhang Y‚ Wen J‚ Hao W‚ Qian M. Therapeutic potential of dendritic cell-based immunization against HBV in transgenic mice. Antivir Res. 2008‚ 77(1): 50-55. 

32. Jiang W‚ Ren L‚ Jin N.HIV-1 DNA vaccine efficacy is enhanced by coadministration with plasmid encoding IFN-α. J Virol Methods. 2007‚ 146(1-2): 266-273.  

33. Zhang LS‚ Jin NY‚ Song YJ‚ Wang H‚ Ma HW‚ Li ZJ‚Jiang WZ. Construction and characterization of a recombinant fowlpox virus containing HIV-1 multi epitope-p24 chimeric gene on mice. Sci China Ser C. 2007‚ 50(2): 212-220.  

34. Jiang W‚ Jin N‚ Cui S‚ Li Z‚ Zhang L‚ Wang H‚ Han W. Enhancing immune responses against HIV-1 DNA vaccine by coinoculating IL-6 expression vector. J Virol Methods. 2006‚ 136(1-2):1-7.  

35. Jiang W‚ Jin N‚ Cui S‚ Li Z‚ Zhang L‚ Zhang H‚ Wang H‚ Han W. Construction and characterization of recombinant fowlpox virus coexpressing HIV-1CN gp120 and IL-2. J Virol Methods. 2005‚ 130(1-2)：95-101.  

36. Jiang W‚ Jin N‚ Li Z‚ Zhang L‚ Wang H‚ Zhang Y‚ Han W. Expression and characterization of Gag protein of HIV-1_CNinPichia pastoris. J Virol Methods. 2005‚ 123(1): 35-40.  

37. Wang HW‚ Cole D‚Jiang WZ‚ Jin HT‚ Fu N‚ Chen ZL‚ Jin NY. Engineering and functional evaluation of a single-chain antibody against HIV-1 external glycoprotein gp120. Clin Exp Immunol. 2005‚ 141(1) 72-80.

38. Jin NY‚ Zhang HY‚ Yin GG‚ Zheng M‚ Liu T‚Jiang WZ‚ Li ZJ. Immunogenicity of recombinant fowlpox virus co-expressing structural protein precursor P1-2A and proteinase 3C of FMDV. Chinese Sci Bull. 2004‚ 49(8): 823-827.  

39. Zhang YJ‚ Jin NY‚Jiang WZ‚ Zhu XJ‚ Shen JC. Cloning and expression of external glycoprotein gene mutant from HIV-2 in methyltrophic yeast‚Pichia pastoris and identification of the glycoprotein. Biotechnol Appl Biochem. 2001‚ 34:1-4.