党永岩

1. 皮肤癌的机制研究

2. 皮肤损伤与修复的机制研究

3. 毛发再生的机制研究

3. 靶向明确的化妆品活性成分研发

主讲《生物化学A》和《生物化学》

1. 国家自然科学基金面上项目，GPR87通过Hippo-YAP-SOX2信号途径调节皮肤鳞癌的发生发展 

2. 国家自然科学基金面上项目，G蛋白偶联受体P2Y6作为皮肤鳞状癌新靶点的分子机制研究，

3. 国家自然科学基金青年项目，PSME3在未分化甲状腺癌发生发展中的作用和分子机制

4. 上海市自然科学基金项目，PA28 gamma在皮肤鳞状癌发生发展中的作用和分子机制

5. 上海市自然科学基金项目，PA28γ通过Hippo-YAP信号通路参与结肠癌的分子机制

6. 冷冻抑制黑色素细胞合成和转运黑色素的分子机制研究

代表性论文(*通讯作者）

1.    Peng Xu , Caibing Wang , Wan Xiang , Yiyi Liang , Ying Li , Xilin Zhang , Chunyuan Guo, Mingyao Liu, Yuling Shi , Xiyun Ye , Yongyan Dang*. P2RY6 Has a Critical Role in Mouse Skin Carcinogenesis by Regulating the YAP and b-Catenin Signaling Pathway. Journal of Investigative Dermatology, 2022;142(9):2334-2342.（通讯作者，IF=8.679）

2.     Chan Jiao, Lin Li, Pei Zhang, Li Zhang, Ke Li, Riqun Fang, Lei Yuan, Kaixuan Shi, Linan Pan, Qiannan Guo, Xiao Gao, Geng Chen, Shichen Xu, Qingwei Wang, Di Zuo, Wei Wu, Shanlou Qiao, Xiaoshuang Wang, Robb Moses, Jianru Xiao, Lei Li, Yongyan Dang*, Xiaotao Li*. REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway. Cell Death and Differentiation 2020：27, 497–508.（并列通讯作者，IF=15.828）

3.     Xiaolin Ren, Weili Xia, Peng Xu, Hongyang Shen, Xing Dai, Mingyao Liu, Yuling Shi, Xiyun Ye*, Yongyan Dang*. Lgr4 deletion delays the hair cycle and inhibits the activation of hair follicle stem cells. Journal of Investigative Dermatology 2020,140（9）：1706-1712（并列通讯作者，IF=8.551）.

      4.   Wang Q, Gao X, Yu T, Yuan L, Dai J, WangW, Chen G, Jiao C, Zhou W, Huang Q, Cui L, Zhang P, Moses RE, Yang J, Chen F,Fu J, Xiao J, Li L, Dang Y, Li X.REGγ Controls Hippo Signaling and Reciprocal NF-κB-YAP Regulation toPromote Colon Cancer. Clinical Cancer Research 2018;24(8):2015-2025.（并列通讯作者）

5. Li L,Dang Y, Zhang J, et al. REGγis critical for skin carcinogenesis by modulating the Wnt/β- catenin pathway.Nature Communications2015;6:6875.(并列第一作者）

6. Xu P, Dang Y, Wang L, Liu X, Ren X, Gu J, Liu M, Dai X, Ye X.Lgr4 is crucial for skin carcinogenesis by regulating MEK/ERK and Wnt/β-catenin signaling pathways.Cancer Lett. 2016;383(2):161-170.(并列第一作者）

7.  Caibing Wang 1, Kai Zang , Zexin Tang , Ting Yang , Xiyun Ye , Yongyan Dang. Hordenine Activated Dermal Papilla Cells and Promoted Hair Regrowth by Activating Wnt Signaling Pathway. Nutrients. 2023 Jan 30;15(3):694. （并列通讯作者）

8.   Ting Fu, Xiaofeng Qin , Yining Ma, Xinyue Yuan , Siyun Wu , Xiyun Ye , Yongyan Dang. Yohimbine hydrochloride inhibits skin melanin synthesis by regulating wnt/β-catenin and p38/MAPK signal pathways, J Dermatological Science 2022 Jul;107(1):17-23. （并列通讯作者）

9.      Xiao Gao, Qingwei Wang, Lei Yuan, Chan Jiao, Ying Yu, Xiaoshuang Wang, Peng Xu, Yining Ma, Yelin Wu, Zhipeng Wu, Lei Li*, Jianru Xiao*, Yongyan Dang*. REGγ regulates hair cycle by activating Lgr5 positive hair follicle stem cells. J Dermatological Science 2021;102(2):101-108. （并列通讯作者）

10.   Ting Fu, Bowen Chai, Yuling Shi, Yongyan Dang*, Xiyun Ye*. Fargesin inhibits melanin synthesis in murine malignant and immortalized melanocytes by regulating PKA/CREB and P38/MAPK signaling pathways. J Dermatological Science 2019; 94(1):213-219.  (并列通讯作者）

11.  Chen H, Gao X, Sun Z, Wang Q, Zuo D, Pan L, Li K, Chen J, Chen G, Hu K, Li K, Shah AS, Huang T, Muhammad Zeeshan B, Tong L, Jiao C, Liu J, Chen T, Yao L, Dang Y(*), Liu T(*), Li L(*). REGγ accelerates melanoma formation by regulating Wnt/β-catenin signalling pathway. Experimental Dermatology, 2017, 26(11):1118-1124.（并列通讯作者）

12. Yang X, Li L, Huang Q, Xu W, Cai X, Zhang J, Yan W, Song D, Liu T, Zhou W, Li Z, Yang C,Dang Y*, Xiao J*. Wnt signaling through Snail1 and Zeb1 regulates bone metastasis in lung cancer.American Journal of Cancer Research2015; 5(2):748-55.（并列通讯作者）

13.Qin Y, Qin X, Xu P, Zhi Y, Xia W, Dang Y(*), Gu J(*), Ye X(*). Potential role of S100A8 in skin rejuvenation with the 1064-nm Q-switched Nd:YAG laser.Lasers Med Sci 2018; 33(3):581-588.（并列通讯作者）

14.Ren X, Ge M, Qin X, Xu P, Zhu P,Dang Y*, Gu J, Ye X.S100a8/NF-κB signal pathway is involved in the 800-nm diode laser-induced skin collagen remodeling. Lasers Med Sci. 2016;31(4):673-8.（并列通讯作者）

15.Li Lei，Zhao D, Wei H, Yao L,Dang Y, Amjad A,et al. REGγ deficiency promotes premature aging via the casein kinase 1 pathway. PNAS; 110: 11005-11010; 2013.