Yiyun Cheng

2000-2004‚  Deparment of Polymer Science and Engineering‚ University of Science and Technology of China‚ B.S.

2004-2008‚  School of Life Sciences‚ University of Science and Technology of China‚ PhD

2009‚  Department of Biomedical Engineering‚ Washingtion University in St. Louis‚ Postdoctoral Reaearch Fellow;

2010-now‚  School of Life Sciences‚ East China Normal University‚ Professor.

2020-now：Editorial board member of Giant

2019-now：Editorial board member of Biomaterials Science

2019-now：Editorial board member of Chinese Chemical Letters

2014-now：Editorial board member of Letters in Drug Design & Discovery

2010-now：Editorial board member of Current Drug Discovery Technologies

2016：Guest editor of Topics in Current Chemistry  

* Design of efficient and safe polymeric carriers for gene therapy

* Design of stimuli-responsive polymeric drug carriers for cancer therapy

* Development of new strategies and novel biomaterials for the treatment of magnilant tumors

* NMR techniques in the design and optimization of polymeric drug formulations

Selected Publications

1)   Xu J, Lv J, Zhuang Q, Yang Z, Cao Z, Xu L, Pei P, Wang C, Wu H, Dong Z, Chao Y, Wang C, Yang K, Peng R*, Cheng YY*, Liu Z*. A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy. Nat. Nanotechnol., 2020, https://doi.org/10.1038/s41565-020-00781-4.

2)   Lv J., Wang C, Li H, Li Z, Fan Q, Zhang Y, Li Y. Wang H*, Cheng YY*. Bifunctional and bioreducible dendrimer bearing a fluoroalkyl tail for efficient protein delivery both in vitro and in vivo. Nano Lett., 2020,  DOI:10.1021/acs.nanolett.0c03287.

3)   Rong GY, Wang CP, Chen LJ, Yan Y, Cheng YY*. Fluoroalkylation promotes cytosolic peptide delivery. Science Advances, 2020, 6, eaaz1774. 

4)  Shen W, Wang R, Fan Q, Gao X, Wang H, Shen Y, Li YW*, Cheng YY*. Natural Polyphenol Inspired Polycatechols for Efficient siRNA Delivery. CCS Chem., 2020, 2(3), 146–157.

5)   Ren L, Lv J, Wang H, Cheng YY*. A Coordinative Dendrimer Achieves Excellent Efficiency in Cytosolic Protein and Peptide Delivery. Angew. Chem. Int. Ed., 2020, 59, 4711-4719. 

6)  Liu CY, Wang T, Wang H, Zhang S, Ping Y*, Cheng YY*. A Boronic acid-rich Dendrimer with Robust and Unprecedented Efficiency for Cytosolic Protein Delivery and CRISPR-Cas9 Gene Editing. Science Advances, 2019, 5, eaaw8922. 

7)  Zhang S, Wang CP, Chang H, Zhang Q*, Cheng YY*. Off-On Switching of Enzyme Activity by Near-infrared Light-Induced Photothermal Phase Transition of Nanohybrids, Science Advances, 2019, 5, eaaw4252. 

8) Zhang ZJ, Shen WW, Ling J, Yan Y, Hu JJ, Cheng YY*. The Fluorination Effect of Fluoroamphiphiles in Cytosolic Protein Delivery, Nat. Commun., 2018, 9, 1377. (Highlighted by Nature Research Chemistry Community; Chemistry of Life)  

9) Shen W, Wang Q, Shen Y, Gao X, Li L, Yan Y, Wang H, Cheng YY*. Green Tea Catechin Dramatically Promotes RNAi Mediated by Low Molecular Weight Polymers, ACS Cent. Sci., 2018, 4, 1326-1333. (Highlighted by ACS, ScienceDaily, EurekAlert, World Tea News, Phys.Org, Science Foundation in China)

10) Wang CP, Sang H, Wang Y, Zhu F, Hu X, Wang X, Wang X, Li Y*, Cheng YY*. Foe to Friend: Supramolecular Nanomedicines Consisting of Natural Polyphenols and Bortezomib, Nano Lett., 2018, 18, 7045-7051. 

11) Wang CP, Zhang Q, Wang X, Chang H, Zhang S, Tang Y, Xu J, Qi R, Cheng YY*. Dynamic Modulation of Enzyme Activity by Near-infrared Light, Angew. Chem. Int. Ed., 2017, 56, 6767-6772 (Highlighted by Advanced Science News).  

12)  Chang H, Lv J, Gao X, Wang X, Wang H, Chen H, He X, Li L, Cheng YY*. Rational Design of a Polymer with Robust Efficacy for Intracellular Protein and Peptide Delivery, Nano Lett., 2017, 17, 1678-1684. (Highlighted by Faculty of 1000) 

13) Zhou ZJ, Wang YT, Yan Y, Zhang Q*, Cheng YY*. Dendrimer-templated Ultrasmall and Multifunctional Photothermal Agents for Efficient Tumor Ablation, ACS Nano, 2016, 10, 4863-4872. 

14) Yang JP, Zhang Q, Chang H, Cheng YY*. Surface-engineered Dendrimers in Gene Delivery, Chem. Rev., 2015, 115(11), 5274-5300. (Cover Story, ESI 1% highly cited papers)

15)  Wang H, Wang YT, Wang Y, Li TF, Liu HM, Zhang Q, Cheng YY*. Self-assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery. Angew. Chem. Int. Ed., 2015, 54, 11647-11651. 

16)  Wang MM, Liu HM, Li Lei, Cheng YY*. A Fluorinated Dendrimer Achieves Excellent Gene Transfection Efficiency at Extremely Low Nitrogen to Phosphorus Ratios, Nat. Commun., 2014,  5, 3053. (ESI 1% highly cited papers)

17)  Wang XY, Cai XP, Hu JJ, Shao NM, Wang F, Zhang Q, Xiao J*, Cheng YY*. Glutathione-triggered Off-on Release of Anticancer Drugs from Dendrimer-encapsulated Gold Nanoparticles,  J. Am. Chem. Soc., 2013, 135, 9805-9810.  

18)   Liu HM, Wang H, Yang WJ, Cheng YY*. Disulfide Cross-linked Low Generation Dendrimers with High Gene Transfection Efficacy, Low Cytotoxicity, and Low Cost, J. Am. Chem. Soc.‚ 2012‚ 134, 17680-17687. 

19)   Hu JJ, Xu TW, Cheng YY*. NMR Insights into Dendrimer-based Host-guest Systems, Chem. Rev., 2012, 112, 3856-3891.

20) Cheng YY*‚ Zhao LB‚ Li YW‚ Xu TW*. Design of Biocompatible Dendrimers for Cancer Diagnosis and Therapy: Current Status and Future Perspectives‚ Chem. Soc. Rev.‚ 2011‚ 40‚ 2673-2703. (ESI 1% highly cited papers)

21) Zhao LB‚ Wu QL‚ Cheng YY*‚ Zhang JH‚ Wu JH‚ Xu TW*. High-throughput Screening of Dendrimer-binding Drugs‚ J. Am. Chem. Soc.‚ 2010‚ 132‚ 13182-13184. 

22)   Yavuz MS†‚ Cheng YY†‚ Chen JY†‚ Cobley CM‚ Zhang Q‚ Rycenga M‚ Xie JW‚ Kim C‚ Schwartz AG‚ Wang LV‚ Xia YN*. Gold Nanocages Covered by Smart Polymers for Controlled Release with Near-infrared Light‚ Nat. Mater.‚ 2009‚ 8, 935-939. (†Co-first author; Highlighted by Science Daily‚ The New York Times; ESI 1% highly cited papers)

23)  Gao X, Li L, Cai X, Huang Q, Xiao J*, Cheng YY*. Targeting Nanoparticles for Diagnosis and Therapy of Bone Tumors: Opportunities and Challenges. Biomaterials. 2021, 265, 120404.

24) Lv J, Fan Q, Wang H, Cheng YY*. Polymers for Cytosolic Protein Delivery, Biomaterials, 2019, 218, 119358. 

25) Liu CY, Shen WW, Li BN, Li TF, Chang H, Cheng YY*. Natural Polyphenols Augment Cytosolic Protein Delivery by a Functional Polymer, Chem. Mater., 2019, 31, 1956-1965. 

26) Li MY, Wang H, Hu JF, Hu J, Zhang S, Yang Z, Li YW, Cheng YY*. Smart Hydrogels with Antibacterial Properties Built from All Natural Building Blocks, Chem. Mater., 2019, doi: 10.1021/acs.chemmater.9b02547. 

27) Li GZ, Yuan S, Deng D, Ou T, Li Q, Sun R, Lei Q, Wang X, Shen W, Cheng YY*, Liu Z*, Wu S*. Fluorinated Polyethylenimine to Enable Transmucosal Delivery of Photosensitizer-conjugated Catalase for Photodynamic Therapy of Orthotopic Bladder Tumors Postintravesicle Instillation. Adv. Funct. Mater., 2019, 1901932. 

28) Xu J, Wang H, Xu LG, Chao Y, Wang C, Han X, Dong Z, Chang H, Peng R*, Cheng YY*, Liu Z*. Nanovaccine Based on a Protein-delivering Dendrimer for Efffective Antigen Cross-presentation and Cancer Immunotherapy, Biomaterials, 2019, 207, 1-9.

29) Li G, Lei Q, Wang F, Deng D, Wang S, Tian L, Shen W, Cheng YY*, Liu Z*, Wu S*. Fluorinated Polymer Mediated Transmucosal Peptide Delivery for Intravesical Instillation Therapy, Small, 2019, 1900936.

30) Zhou ZJ, Fan T, Yan Y, Zhang S, Zhou Y, Deng H, Cai X, Xiao J, Song D, Zhang Q*, Cheng YY*. One Stone with Two Birds: Phytic Acid-capped Platinum Nanoparticles for Targeted Combination Therapy of Bone Tumors, Biomaterials, 2019, 194, 130-138. 

31) Zhou Z, Yan Y, Wang L, Zhang Q*, Cheng YY*. Melanin-like Nanoparticles Decorated with an Autophagy-inducing Peptide for Efficient Targeted Photothermal Therapy, Biomaterials, 2019, 203, 63-72. 

32) Lv J, He B, Yu J, Wang Y, Wang C, Zhang S, Wang H, Hu J, Zhang Q, Cheng YY*. Fluoropolymers for Intracellular and In Vivo Protein Delivery, Biomaterials, 2018, 182, 167-175. 

33) Wang CP, Wang D, Dai TJ, Xu P, Wu PL, Zou Y, Yang P, Hu JJ, Li YW*, Cheng YY*. Skin Pigmentation-Inspired Polydopamine Sunscreens, Adv. Funct. Mater., 2018, 1802127. 

34) Wang Y, Huang Q, He X, Chen H, Zou Y, Li Y, Lin K, Cai X, Xiao J, Zhang Q*, Cheng YY*. Multifunctional Melanin-like Nanoparticles for Bone-targeted Chemo-photothermal Therapy of Malignant Bone Tumors and Osteolysis, Biomaterials, 2018, 183, 10-19. 

35)  Hu JJ, Chen YH, Li YQ, Zhou ZJ, Cheng YY*. A Thermo-degradable Hydrogel with Light-tunable Degradation and Drug Release, Biomaterials, 2017, 112, 133-140. (Highlighted by Faculty of 1000)

36) Zhou Z, Yan Y, Hu K, Zou Y, Li Y, Ma R, Zhang Q*, Cheng YY*. Autophagy Inhibition Enabled Efficient Photothermal Therapy at a Mild Temperature, Biomaterials, 2017, 141, 116-121. 

37)  Wang X, Wang CP, Wang XY, Wang YT, Zhang Q*, ‍Cheng YY‍*. A Poly(dopamine) Nanoparticle-Knotted Poly(ethylene glycol) Hydrogel for On-demand Drug Delivery and Chemo-photothermal Therapy, Chem. Mater., 2017,  29, 1370-1376. 

38) Wang YT, Yang J, Liu HM, Wang XY, Zhou ZJ, Huang Q, Song DW, Cai XP, Li L, Lin KL, Xiao JR, Liu PF*, Zhang Q*, Cheng YY*.Osteotropic Peptide-mediated Bone Targeting for Photothermal Treatment of Bone Tumors, Biomaterials, 2017, 114, 97-105. 

39) Hu JJ, Quan YC, Lai YP, Zheng Z, Hu ZQ, Wang XY, Dai TJ, Zhang Q, Cheng YY*. A Smart Aminoglycoside Hydrogel with Tunable Gel Degradation, on-demand Drug Release, and High Antibacterial Activity, J. Control. Release, 2017,  247, 145-152. 

40)  Zhou ZJ, Hu KW, Ma R, Yan Y, Ni B, Zhang YJ, Wen LP, Zhang Q*, Cheng YY*. Dendritic Platinum-Copper Alloy Nanoparticles as Theranostic Agents for Multimodal Imaging and Combined Chemo-photothermal Therapy, Adv. Funct. Mater., 2016, 26, 5971-5978. (Cover Story) 

41) Wang CP, Wang XY, Dong KY, Luo J, Zhang Q*, Cheng YY*. Injectable and Responsively Degradable Hydrogel for Personalized Photothermal Therapy, Biomaterials,  2016, 104, 129-137.  

42) Wang XY, Zhang JS, Wang YT, Wang CP, Xiao J*, Zhang Q*, Cheng YY*. Multi-responsive Photothermal-chemotherapy with Drug-loaded Polydopamine Nanoparticles for Synergetic Tumor Ablation, Biomaterials, 2016, 81, 114-124. (ESI 1% highly cited papers)

43) Wang CP, Cai XP, Zhang JS, Wang XY, Wang Y, Ge H, Yan H, Huang Q, Xiao J*, Zhang Q*, Cheng YY*. Trifolium-like Platinum Nanoparticle-mediated Photothermal Therapy Inhibits Tumor Growth and Osteolysis in a Bone Metastasis Model. Small, 2015, 11, 2080-2086. (Highlighted by MaterialsViews China)

44) Wang F, Wang YT, Wang H, Shao NM, Chen YY,Cheng YY*.Synergistic Effect of Amino Acids Modified on Dendrimer Surface in Gene Delivery, Biomaterials,  2014, 35, 9187-9198. (Highlighted by Faculty of 1000)

45)  Liu HM, Wang Y, Wang MM, Xiao JR, Cheng YY*. Fluorinated Poly(propylenimine) Dendrimers as Gene Vectors, Biomaterials, 2014, 35, 5407-5413.  

46) Wang MM, Cheng YY*. The Effect of Fluorination on the Transfection Efficacy of Surface-engineered Dendrimers‚ Biomaterials‚ 2014, 35, 6603-6613. 

47) Hu JJ, Su YZ, Zhang HF, Xu TW*, Cheng YY*. Design of Interior-functionalized Fully Acetylated Dendrimers for Anticancer Drug Delivery, Biomaterials, 2011, 32, 9950-9959.