张文

生物电分析化学

荧光分析

化学修饰电极

主持的主要科研项目：

国家自然科学基金项目：

1. 基于生物大分子模板构建荧光纳米探针用于金属离子与神经退行性疾病相互蛋白相互作用研究

2. 内源性神经毒素对帕金森氏病神经原损伤毒理机制的电分析化学研究

3. 半导体复合纳米材料光电分析方法在乙酰胆碱酯酶活性检测中的应用研究

4. 细胞表面聚糖表达水平的电化学检测及其在肿瘤细胞分析中的应用研究

5. 纳米过氧化物电极及其对水体中细菌的快速计数和作用机理的电化学分析研究

上海市科委基础研究重点项目：

基于纳米氧化物催化材料的可控合成、功能化及分子识别

作为主要研究人员参加的科研项目：

国家自然科学基金重点项目：神经退行性疾病分析新方法的研究

国家自然科学基金仪器专项：新型COD分析方法、理论的研究及其仪器的开发

国家自然科学基金面上项目：

用纳米科技建立电分析化学的新原理、新方法研究

神经系统损伤病理和药理的电分析方法研究

超微传感器在心肌细胞损伤和修复中的应用研究

化学修饰电极电色效应和电色材料及其在分析仪器中的应用研究

上海市科委重点项目：

纳米氧化物紫外屏蔽性能的评价方法及其分析

仪的研究与开发

纳米氧化物材料性能评估仪器的研究

国家“九五”科技攻关项目：

国产电化学仪器的改进及新电极、传感器的研制

国家“十五”重点科技攻关项目：

纳米COD传感器及其快速在线COD

电化学检测仪的研制与开发

863项目子课题：

水质自动检测系统及关键技术及集成设备研制

近年来发表的代表性论文：

1. Yi Lai, Yingying Zhu, Zhiai Xu*, Xianli Hu, Madiha Saeed, Haijun Yu, Xingxing Chen, Jun Liu, Wen Zhang*, Engineering Versatile Nanoparticles for Near-Infrared Light-Tunable Drug Release and Photothermal Degradation of Amyloid β.  Adv. Funct. Mater.2020, 30, 1908473.

2.  Li Lei, Min Li, Sufen Wu, Zhiai Xu*, Ping Geng, Yang Tian, Ying Fu, and Wen Zhang*, Non-invasive In-situ Ratiometric Imaging of Biometals Based on Self-Assembling Peptide Nanoribbon. Anal. Chem. 2020, 92(8), 5838-5845.

3.  Yijing Dang, Fengyang Wang, Lingling Li, Yi Lai, Zhiai Xu*, Zhi Xiong, Ao Zhang, Yang Tian, Chunyong Ding, and Wen Zhang* Activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice. Chem. Commun. 2020, 56, 707-710

4.  Yi Lai, Zhiai Xu, Xianli Hu, Li Lei, Lingling Li, Liang Dong, Haijun Yu, Wen Zhang*. Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor. Small2019, 15, 1904397.

5.  Chunyong Ding, Fengyang Wang, Yijing Dang, Zhiai Xu, Lingling Li, Haijun Yu, Yi Luo, Ruimin Huang, Ao Zhang, and Wen Zhang, Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity. Anal. Chem. 2019, 91, 24, 15577-15584.

6.  Li Lei, Rui Geng, Zhiai Xu*, Yijing Dang, Xianli Hu, Lingling Li, Ping Geng, Yang Tian, Wen Zhang*. Glycopeptide Nanofiber Platform for Ab-Sialic Acid Interaction Analysis and Highly Sensitive Detection of Ab. Anal. Chem. 2019, 91, 8129-8136.

7.  Rui Geng, Danqin Lu, Yi Lai, Sufen Wu, Zhiai Xu* and Wen Zhang*, Peptide nanotube for carbon dioxide chemisorption with regeneration properties and water compatibility. Chem. Commun. 2019, 55, 26, 3797-3800.

8.  Li Lei, Zhiai Xu*, Xianli Hu, Yi Lai, Jie Xu, Bo Hou, Ya Wang, Haijun Yu, Yang Tian, Wen Zhang*. Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging-Guided Treatment of Metastatic Melanoma. Small 2019, 15(22), 1900157

9.  Liang Dong, Zhiai Xu,Shangjie An, Xiaodan Jia, Wen Zhang and Xiue Jiang. A glutathione-depleted prodrug platform of MnO2-coated hollow polydopamine nanospheres for effective cancer diagnosis and therapy. New Journal of Chemistry, 2020, 44, 7838--7848.

10.  Liang Dong, Chao Wang, Wenyao Zhen, Xiaodan Jia, Shangjie An, Zhiai Xu, Wen Zhang and Xiue Jiang. Biodegradable iron-coordinated hollow polydopamine nanospheres for dihydroartemisinin delivery and selectively enhanced therapy in tumor cells. J. Mater. Chem. B, 2019, 7, 6172-6180.

11.  F. Wang, Y. Zhu, J. Xu, Z. Xu*, G. Cheng, W. Zhang*. Highly selective and ratiometric fluorescent nanoprobe for the detection of cysteine and its application in test strips.  Analytical and Bioanalytical Chemistry, 2018, 410, 4875-4884.

12.  Y. Wang, J. Xu, L. Lei, F. Wang, Z. Xu*, G. Cheng, W. Zhang*. Multi-functional carbon dots-based nanoprobe for ratiometric enzyme reaction monitoring and biothiol analysis. Sensors and Actuators B-Chemical, 2018, 264, 296-303.

13.  F. Wang, C. Feng, Z. Xu*, W. Zhang*. A ratiometric fluorescent probe for rapid and sensitive detection of biothiols in fetal bovine serum, Talanta, 2017, 169, 149-155.

14.  Q. Huang, Y. Wang, L. Lei, Z. Xu*, W. Zhang*, Photoelectrochemical biosensor for acetylcholinesterase activity study based on metal oxide semiconductor nanocomposites, J. Electroanal. Chem. 2016, 781, 377-382.

15.  F. Wang, Q. Sun, B. Feng, Z. Xu*, J. Zhang, J. Xu, L. Lu, H. Yu, M. Wang, Y. Li and W. Zhang*, Polydopamine-functionalized graphene oxide loaded with gold nanostars and doxorubicin for combined photothermal and chemotherapy of metastatic breast cancer, Adv. Healthc. Mater. 2016, 5, 2227–2236.

16.  J. Zhang, J. Liu, Y. Zhu, Z. Xu*, J. Xu, T. Wang, H. Yu and W. Zhang*, Photodynamic micelles for amyloid β degradation and aggregation inhibition, Chem. Commun. 2016, 52, 12044-12047.

17.  Y. Wang, L. Lu, H. Peng, J. Xu, F. Wang, R. Qi, Z. Xu* and W. Zhang*, Multi-doped carbon dots with ratiometric pH sensing properties for monitoring enzyme catalytic reactions. Chem. Commun., 2016, 52, 9247-9250.

18.  P. Geng, C. Feng, L. Zhu, J. Zhang, F. Wang, K. Liu, Z. Xu, and W. Zhang*, Evaluation of sialic acid expression on cancer cells via an electrochemical assay based on biocompatible Au@BSA Architecture and lectin-modified Nanoprobes, Electroanalysis 2016, 28, 1331 – 1339.

19.  L. Zhu, J. Zhang, F. Wang, Y. Wang, L. Lu, C. Feng, Z. Xu*, W. Zhang*. Selective amyloid β oligomer assay based on abasic site-containing molecular beacon and enzyme-free amplification, Biosens. Bioelectron., 2016, 78, 206-212.